Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 31, Issue 5
Displaying 1-12 of 12 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 5 Pages Cover22-
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover22
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 5 Pages Cover23-
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover23
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1982 Volume 31 Issue 5 Pages Misc8-
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Misc8
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  • IMMUNOLOGICAL DETECTION OF ANTIMYELIN BASIC PROTEIN ANTIBODIES
    Masayoshi Yoshihara
    Article type: Article
    1982 Volume 31 Issue 5 Pages 269-274
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.269
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    It is well-known that the myelin basic protein in the central nervous system is a factor in the experimental allergic encephalomyelitis(EAE). Despite many papers related to the cellular immunity of EAE, studies on the humoral factors have been relatively few. In this report, our purpose is to prepare the specific antimyelin basic protein antibody and to elucidate the nature of the antibody. Myelin basic protein with complete Freund's adjuvant was injected into the flanks of rabbits twelve times weekly. These animals showed high titer of antibody activity, but EAE was not clinically induced in them. The sera prepared from rabbits were separated into IgG and IgM fractions by Sephadex G-200 column chromatography, and these immunoglobulin components showed antibody activity to myelin basic protein by complement fixation test. Treatment of IgM component with 2-mercaptoethanol reduced the antigen-binding capacity to an undetectable level, but similar treatment of the IgG component resulted in no change of the capacity. These results indicated the antimyelin basic protein antibody activity of both IgG and IgM components prepared from the sera of the experimental animals.
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  • STUDY ON FRAGILITY OF MAST CELLS IN SKIN TISSUE IN MICE INFECTED WITH SCHISTOSOMA JAPONICUM
    Tatsushi Ishizaki, Mitsuyoshi Kumada, Keiko Kato
    Article type: Article
    1982 Volume 31 Issue 5 Pages 275-282
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.275
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    Degranulation rate of mast cells by saline challenge was about 20% in mice infected with Schistosoma japonicum and about 10% in normal mice as well as in passively sensitized mice with infected mice serum. The purpose of this study was to verify the truth of fragility of mast cells in detail. Female mice of gpc strain aged eight weeks were divided into the three groups such as mice infected with Schistosoma japonicum, passively sensitized mice with infected mice serum, and normal mice. Degranulation of mast cells in mice skin tissue by challenge of compound 48/80 and/or hypo-osmotic NaCl solutions was investigated quantitatively by Higginbotham-Kumada method. There was a dose response phemonenon between the degranulaion rate of mast cells and the content of compound 48/80 in saline solution challenged to them. A maximal rate of degranulation was observed in a solution of compound 48/80 at the dilution of 1:4×10^4 in normal mice, at that of 1:8×10^4 in passively sensitized mice with infected mice serum, and at that of 1:32×10^4 in mice infected with Schistosoma japonicum. Degranulation rate of mast cells of infected mice was increased according to the difference of challenged hypoosmotic NaCl solutions; the rate was 22% by saline, 40% by 0.75% NaCl solution, and 62% by distilled water. On the other hand, normal and passively sensitized mice showed constantly a degranulation rate as about 10% by challenge of various solutions listed above. The subjected antibody adhered on mast cells during 24 hours and was thermolabile, which charactor showed of reaginic type through the experiment of passively sensitized mice with infected serum. Consequently, the fragility of mast cells in infected mice with Schistosoma japonicum is partly due to adhesion of reaginic antibody on them and partly related ro unknown factor.
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  • STUDIES ON SERUM HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVELS IN PATIENTS WITH BRONCHIAL ASTHMA
    Toru Shibuya, Hurotsugu Ide, Terumi Takahashi
    Article type: Article
    1982 Volume 31 Issue 5 Pages 283-288
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.283
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    The serum levels of high density lipoprotein (HDL-C) were determined in patients with bronchial asthma, with non-bronchial asthma, and in normal subjects. The following results were obtained. 1) The HDL-C level was significantly higher (p<0.001) but the ratio of the total cholesterol/HDL-C was significantly lower (p<0.001) in the bronchial asthma group than in the non-bronchial asthma group and normal group. 2) No significant difference in HDL-C levels was observed with respect to type of asthma or duration of the disease. 3) In observing the severity of asthma and HDL-C levels, there was found to be a significantly higher level of HDL-C in the severer group. 4) In the patients with bronchial asthma, the HDL-C levels were significantly higher in the steroid-treated group than in the non-steroid-treated group.
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  • EFFECTS OF PANCREATIC KALLIKREIN ON CYCLIC NUCLEOTIDE LEVELS OF MURINE LYMPHOCYTES AND ANTIGEN OR MITOGEN INDUCED LYMPHOCYTE PROLIFERATION
    Toshinari Okabe
    Article type: Article
    1982 Volume 31 Issue 5 Pages 289-296
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.289
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    Pancreatic kallikrein extracted from pig pancreas and splenic lymphocytes isolated from female BALB/c mice and same strain nu/nu mice were used. The results obtained were as follows. 1. Pancreatic kallilrein elevated cGMP levels of murine splenic lymphocytes, but did not affect cAMP levels of the lymphocytes. 2. Pancreatic kallilrein at the concentrations between 1-10 BAEE U/ml resulted in mitogenic effect on murine lymphocyte proliferation, but a higher dosage of kallikrein (30 BAEE U/ml) resulted in inhibitory effect on lymphocyte proliferation. 3. Inactivated Pancreatic kallilrein (61℃ 30min) resulted in mitogenic effect on murine lymphocyte proliferation and this effect of inactivated kallikrein did not disappear even at the highest dose equivalent to 30 BAEE U/ml. 4. Pancreatic kallilrein (10 BAEE U/ml) resulted in mitogenic effect on both murine T enriched lymphocytes and B rich lymphocytes. 5. Pancreatic kallilrein significantly augmented Con A, PHA-P or LPS-induced lymphocyte proliferation and also antigen-induced lymphocyte proliferation of immunized mice. 6. Kallikrein inhibitor (S.B.T.I. Or Trasylol) blocked the inhibitory effect of a high dosage of kallikrein against lymphocyte proliferation.
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  • ASTHMATIC CHILDREN AND CHINESE MEDICINE : I. Effect of "Shoseiryuto" on Asthmatic Children and on Guinea Pig Tracheal Smooth Muscle
    Yoshihiro Umesato, Yoji Iikura, Toshikaza Nagakura
    Article type: Article
    1982 Volume 31 Issue 5 Pages 297-303
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.297
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    Sixty-five asthmatic children were admiistered with "Shoseiryuto" for a long time and as a result of following the children its effective ratio was 78.4%. After ten asthmatic children were administered with "Shoseiryuto", their PEFR had a tendency to increase and their EIA had a tendency to be controled. Spiral sample of tracheal smooth muscle, which was extracted from a guinea pig after its death, was placed in a solution of Tyrode's Medium. Various concentration of extracted solution from "Syoseiryuto" were added in turn to the chamber which contained the spiral sample. Tracheal smooth muscle was relaxed by "Shoseiryuto" and when it was contracted by histamine, it was also relaxed by "Shoseiryuto". Nineteen asthmatic children were administered with "Shoseiryuto" before breakfast andd their serum cortisol, ACTH and free fatty acid were examined before and after the drug administration. Nine asthmatic children were examined similarly in a control group. The results of the examination in the group given "Shoseiryuto" were as followa: cortisol increased after thirty minutes and then at one hour intervals (p<0.01) and ACTH was found to be increased at every examination period (p<0.01).
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  • THE INHIBITORY EFFECT OF A BETA-ADRENERGIC AGONIST ON IMMEDIATE SKIN ALLERGIC REACTION
    Tetsuhiro Ohmi, Suetsugu Mue, Gen Tamura, Toshiharu Ishihara, Tamotsu ...
    Article type: Article
    1982 Volume 31 Issue 5 Pages 304-308
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.304
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    We studied the effect of isoproterenol on the immediate skin allergic reaction. The concomitant injection of 10^<-7>M isoproterenol with allergen inhibited the allergic skin reaction, while this dose did not inhibit whealing in reaction both to histamine and compound 48/80. Pretreatment with dibutyryl cAMP at 2 and 20 nmol inhibited the allergic skin reaction. However, 20nmol of dibutyryl cAMP did not reduce the histamine and compound 48/80 skin reaction. These results show that the inhibitory effect of a beta adrenergic agonist on the immediate skin reaction was mainly due to inhibition of chemical mediator release from the mast cell through stimulation of adenylate cyclase, resulting in the elevation of intracellular cAMP levels.
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  • [title in Japanese]
    Article type: Appendix
    1982 Volume 31 Issue 5 Pages 309-
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.309
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  • [title in Japanese]
    Article type: Appendix
    1982 Volume 31 Issue 5 Pages 311-314
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.311
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 5 Pages Cover24-
    Published: May 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover24
    JOURNAL FREE ACCESS
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