Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 31, Issue 6
Displaying 1-13 of 13 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 6 Pages Cover25-
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover25
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 6 Pages Cover26-
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover26
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Bibliography
    1982 Volume 31 Issue 6 Pages Misc9-
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Misc9
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  • FRAGILITY OF SKIN MAST CELLS DUE TO ADHESION OF IgE IN ALLERGIC PATIENTS, MEASURED BY CHALLENGE OF COMPOUND 48/80 SOLUTIONS
    Tatsushi Ishizaki, Ryosuke Ikemori, Takeshi Fukuda, Akiyoshi Saito
    Article type: Article
    1982 Volume 31 Issue 6 Pages 315-323
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.315
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    threshold titer of skin test due to challenge of a seriesof compound 48/80 and/or rabbit anti-IgE serum solutions, and total IgE titer in serum gained by RIST were measured in patients with bronchial asthma, allergic rhinitis and urticaria. In addition, normal subjects and non-allergic patients were also tested with compound 48/80 solutions as the control groups. Allergic patients, especially asthmatic ones of atopic type, showed high sensitivity to compound 48/80 in skin test, compared with normal subjects and patients with other diseases. Total IgE titer in serum was highest in the asthmatic patients, especially of atopic type, and high in patients with allergic rhinitis and urticaria. Among allergic patients, a parallel correlation was recognized between threshold titer of skin test challenged with compound 48/80 solutions and total IgE titer in serum by RIST, with high rate of correlation coefficient. This threshold titer of skin test challenged with compound 48/80 was also parallel with that by the use of anti-IgE serum solutions. Total IgE titer in serum represents the quantity of free IgE from mast cells (not yet adhered), and threshold titer of skin test by challenge of anti-IgE serum solutions is considered to be parallel to the adherence of IgE on skinmast cells. In fact, there was a parallel correlation recognized between total IgE in serum and threshold titer of skin test by anti-IgE serum solutions. Accordingly, the above mentioned results suggest that adherence of IgE on mast cells may enhance degranulation process of mast cells due to challenge of compound 48/80 as one of non specific stimulants.
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  • ASSESSMENT OF BRONCHIAL PROVOCATION BY ^<81m>Kr VENTILATION IMAGE IN ASTHMATIC CHILDREN
    Kazuo Sugimoto, Tsuyoshi Toba, Guio Uchiyama, Noboru Arimizu
    Article type: Article
    1982 Volume 31 Issue 6 Pages 324-333
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.324
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    Allergen- or mediator-induced bronchospasm was studied by ^<81m>Kr ventilation image to determine it's sensitivity and safety as an assessment method. Twelve children with house dust sensitive asthma were subjected to inhalationof house dust, prostaglandin F_2α, or methacholine by ultrasonic nebulizer with ^<81m>Kr gas. During the examination dynamic ventilation images of both lungs were monitored on oscilloscope to see the changes in the ventilation images. This kind of provocation test has the following advantages compared to the conventional provocation tests. 1) There is no induction of severe attack by provocation when inhalation of antigen or mediator is stopped at the initiation of change on the ventilation image. 2) There is no overload to the patient as compared to the conventional provocation tests. 3) Analysis of the ventilation images stored in the computer can reveal the area of ventilation disturbance in the lung and the changes can be expressed quantitatively.
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  • STUDIES ON BASOPHIL PRECURSOR : 1. Basophil Colony Forming Cell
    Hirohisa Saito, Tadaatsu Ito, Yusuke Tomita
    Article type: Article
    1982 Volume 31 Issue 6 Pages 334-342
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.334
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    Methylcellulose culture of bone marrow cells from a child with multiple sulfatase dificiency (MSD) gave rise to colonies consisting of pure basphils. Distinction of the basophils from other cells was made by hitochemical and ultrastructual analysis. Linear relationship was seen between cultured marrow cells and basophil colonies. The peak velocity sedimentation rate of basophil colony forming cells was 5.6mm/hr and differed from other colony forming cells. These results showed that basophil colony forming cells in MSD appeared to be basophilic committed stem cells. Although the reason for basophil colony formation in MSD is unclear, myelogram and suspension culture study showed that this was not a reflection of increase in basophil precursors.
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  • INHIBITORY EFFECY OF NORADRENALINE ON CHOLINERGIC NEUROTRANSMISSION IN ISOLATED GUINEA-PIG TRACHEAL MUSCLE
    Yuichiro Kamikawa
    Article type: Article
    1982 Volume 31 Issue 6 Pages 343-349
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.343
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    Effect of noradrenaline on cholinergic neurotransmission was studied using isolated tracheal stripchain preparation of guinea-pig. Electrical stimulation (1-30 Hz, 0.5msec, 40 pulses and supramaximal voltage) produced a frequency-dependent contraction of the tracheal muscle pretreated with guanethidine (10μM) and indomethacin (2μM). The elicited contraction seems to have been mediated by cholinergic nerve stimulation, since the response was abolished by tetrodotoxin (0.2μM) and atropine (0.2μM). The electrically-induced contractions were inhibited by noradrenaline (0.1-3μM), in a dose-dependent manner. The inhibitory effet of naradrenaline was unaffected by propranolol (2μM) or prazosin (3μM) treatment, but completely reversed by phentolamine (1μM) or yohimbine (2μM). Noradrenalne (3μM) also inhibited contractions of the tracheal muscle induced by exogenously applied acetylcholine (0.1-3μM), which was completely antagonized by propranolol (2μM). These results suggest that noradrenaline inhibits cholinergic neurotransmission in guinea-pig tracheal muscle principally via presynaptic α_2-adrenoceptors and to a very limited degree, via postsynaptic β-adrenoceptors.
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  • A CASE OF RHEUMATOID ARTHRITIS ASSOCIATED WITH LEUKOCYTOPENIA DURING D-PENICILLAMINE TREATMENT
    Masao Negishi, Hideki Sato, Fusao Sekine, Shunichi Mita, Isao Ono, Kaz ...
    Article type: Article
    1982 Volume 31 Issue 6 Pages 350-354
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.350
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    D-penicillamine (D-Pc) has been reported to have beneficial effects in treatment of rheumatoid arthritis (RA). A 55-year-old female with RA developed a rapid fall in white blood cell count after 6 weeks of D-Pc treatment at daily dose of 200mg. Bone marrow aspiration showed normal cellularity with a shift to the left. The peripheral white blood cell count result rapidly reversed within 6 days after discontinuation of the drug. We tried readministrating D-Pc (100mg) to her, when fifteen hours after intake of the drug, the white blood cell count decreased again repidly. No anti-leukocyte antibody was detected by the leukocyte lysis phenomenon method. But when the acute stage serum of this patient was added to the lymphocyte transformation response to concanavalin A, the proliferative response was suppressed markedly. Leukocytopenia is a rare side effect of D-Pc but it is potetially more harmful than other side effects. In treatment with D-Pc, therefore, the drug should be carefully administrated and regular blood examinations carried out to prevent the occurrence of this side effect.
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  • STUDIES OF HELIUM FLOW-VOLUME CURVE IN ASTHMATIC CHILDREN : Part 1. The Relationship Between the Site of Airway Obstruction in Exercise-Induced Asthma and the Inhibitory Effect of an Alphaadrenoreceptor Blocking Agent
    Goro Kawamura, Yasuo Arai, Takeshi Mishima
    Article type: Article
    1982 Volume 31 Issue 6 Pages 355-362
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.355
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    The site of airway obstruction in exercise-induced asthma (EIA) was determined from He flow-volume curve, and the inhibitory effect of an alpha-adrenoreceptor blocker (thymoxamine) on EIA was studied. Thirteen asthmatic children with EIA were studied, and these subjects were asked to exercise on a treadmill. A seres of pulmonary function tests was carried out before the exercise, and the results were not signifficantly different according to whether thymoxamine had been administered or not. 13subjects were divided into 8 responders and 5 non -responders according to the classification of Despas et al. (ΔV^^・_<50>≧120%, responder, central airway obstruction; ΔV^^・_<50><120%, non-responder, peripheral airway obstruction). The inhibitory effect of thymoxamin on EIA was studied in 12 of 13 subjects, and inhibition of EIA was observed in all of them. In 5 of them, the ingibition was complete. In relation to the site of airway obstruction, complete or partial inhibition of EIA was observed in 6 of 8 responders ond all of 4 non-responders. These findings indicate that aplha adrenoreceptor blocking agent (thymoxamine) has an inhibitory effect on EIA and acts on effectively both types in which central and peripheral airway obstruction occur in EIA.
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  • DISTRIBUTIONS OF ^<81m>Kr AND PULMONARY RESPONSES AFTER EXERCISE TOLERANCE TEST IN THE ADULY ASTHMATICS
    kazuko Nishikawa, Yoji Iikura
    Article type: Article
    1982 Volume 31 Issue 6 Pages 363-373
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.363
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    In order to assess the presence and severity of EIA in adult asthmatics, ^<81m>Kr inhalation study by bolus method and pulmonary function test were performed on 34 adult asthmatics and 6 normal subjects before and after exercise. Ventilatory abnormalities were detected in 30 out of 34 asthmatics by ^<81m>Kr inhalation study and in 19 out of 32 patients by the pulmonary function test. Patterns of defects on ^<81m>Kr inhalation study were classified into two types, A and B. A type defect: The defect was larger in maximum forced inhalation (MFI) than in static inhalation (SI). B type defect: The defect was larger on the SI than that on he MFI and disappeared when ^<81m>Kr gasses were inhaled at high lung levels. A type defect involves central airway obstruction. In B type defect, there is peripheral airway obstruction and early airway closure is, for the most part, considerable. On the exercise test, sixteen asthmatics ahowed A type dominant, 8 asthmatics showed B type dominant and the 6 asthmatics showed AB type. Exercise-induced changes in FVC after 5 minutes were -3.71±7.77% in the type A dominant group, -17.44±19.92% in the type B dominat group and -15.05±22.06% in the type AB group; and changes in FEV_1.0 were -11.38±11.33%, -20.88±20.55% and -27.66±26.78%, respectively. Percentage changes in FVC and FEV_1.0 were significantly lower in the type B dominant and type AB groups, compared to those in the type A dominant group.
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  • [title in Japanese]
    Article type: Appendix
    1982 Volume 31 Issue 6 Pages 375-376
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.375
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  • [title in Japanese]
    Article type: Appendix
    1982 Volume 31 Issue 6 Pages 377-380
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.377
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  • [title in Japanese]
    Article type: Cover
    1982 Volume 31 Issue 6 Pages Cover27-
    Published: June 30, 1982
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.31.Cover27
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