Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 32, Issue 4
Displaying 1-13 of 13 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1983 Volume 32 Issue 4 Pages Cover19-
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.Cover19
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1983 Volume 32 Issue 4 Pages Cover20-
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.Cover20
    JOURNAL FREE ACCESS
    Download PDF (39K)
  • [title in Japanese]
    Article type: Bibliography
    1983 Volume 32 Issue 4 Pages Misc7-
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.Misc7
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1983 Volume 32 Issue 4 Pages App5-
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.App5
    JOURNAL FREE ACCESS
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  • EVALUATION OF BRONCHIAL HYPERRESPONSIVENESS IN ADULT BRONCHIAL ASTHMATICS MONITORED BY THE FORCED OSCILLATION METHOD
    Makoto Tanaka, Hisao Tomioka, Itsuo Iwamoto, Akira Kumagai, Haruhisa S ...
    Article type: Article
    1983 Volume 32 Issue 4 Pages 183-192
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.183
    JOURNAL FREE ACCESS
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    Changes in respiratory resistance (Rrs) upon methacholine inhalation in adult asthmatics were monitored by a new device"Astograph", which measured the Rrs by the forced oscillation method. 215 cases of adult asthma, 20 and 17 cases of acute and chronic bronchitis, 7 cases of allergic rhintitis and 24 cases of healthy adults were subjected to examination as to bronchial hyperresponsiveness. The method proved to be useful in the evaluation of bronchial hyperresponsiveness with respect to reproducibility, safety and convenience. The analysis of different parameters in an "Astogram"recorded by the"Astograph"gave some clues to understanding the mechanisms of bronchial hyper-responsiveness: 1. The values of control respiratory resistance (Rrs. cont), which were measured during the inhalation of the saline aerosol by subjects with the various diseases showed significant correlation with FEV_<1.0>% and % FEV_<1.0>, showing the state of airway obstruction. 2. The values of two important parameters, Dmin, which reflected bronchial sensitivity, and St for bronchial reactivity, showed no significant correlation within each disease group or among the healthy individuals. These results suggest that bronchial sensitivity and reactivity might be regulated by different physiologic mechanisms. 3. These two parameters (Dmin and St), migrated differently in the following way in accordance with the nature of the disease. a) In the case of bronchial asthma, both atopic and nonatopic, Dmin and St were higher than those parameters in the other disease groups examined. b) In allergic rhinitis, Dmin was nearly the same level as in normal individuals; however, the value of St was close to that of subjects with bronchial asthma. c)In the bronchitis group, the value of Dmin was lower than the of the control group, while St showed a higher value than that of the control group.
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  • PARTICIPATION OF CHOLESTATIC FACTOR IN THE PATHOGENESIS OF INTRAHEPATIC CHOLESTASIS IN ACUTE VIRAL HEPATITIS
    Yasuhiro Mizoguchi, Yoshihide Sakagami, Hiroko Tsutsui, Takeyuki Monna ...
    Article type: Article
    1983 Volume 32 Issue 4 Pages 193-198
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.193
    JOURNAL FREE ACCESS
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    To elucidate the immunopathogenesis of intrahepatic cholestasis in acute viral hepatitis, the authors investigated the possible participation of cholestatic factor. Peripheral lymphocytes from patients with acute viral cholestatic hepatitis were stimulated with either HB_s antigen or liver specific lipoprotein in vitro and the culture supernatant was fractionated by gel filtration, using a Sephadex G-75 column. When a definitive fraction (fraction 4) was injected into the mesenteric vein of rats, a marked reduction of bile flow was observed. A dilated bile canaliculi with diminution of microvilli and increased vesicles around the dilated canaliculi were observed in liver tissues by electron microscopy three hours after injection of the active fraction into rats. These results strongly suggest not only that the sensitized lymphocytes produce the cholestatic factor(s) which causes intrahepatic cholestasis by specific stimulation, but also that this factor is significantly involved in the pathogenesis of intrahepatic cholestasis, which is observed in patients with acute viral hepatitis.
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  • SUPPERSSION OF IgE ANTIBODY PRODUCTION BY ANTIGEN PULSED ALLOCENEIC SPLEEN CELLS : Study of Genetical Regulation in the Induction of Immediate Tolerance and Suppressor Cells
    Saeko Yagi
    Article type: Article
    1983 Volume 32 Issue 4 Pages 199-208
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.199
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    The induction of Immediate tolerance and suppressor cells in lgE antibody production was studied in mice injected with allogeneic spleen cells which had been preincubated with either genetically restricted or non restricted antigen. The following results were obtained. 1)The induction of immediate tolerance in IgE antibody production by antigen pulsed spleen cells did not require MHC compatibility between the donor of the antigen pulsed spleen cells and the recipient. 2)Non responder C3H/He spleen cells pulsed with beef insulin could induce immediate tolerance to responder BALB/c mice. 3)Suppressor cells were induced in F_1 (C3H/He×BALB/c) mice by i.v.administration of nonresponder C3H/He spleen cells pulsed with beef insulin as well as responder BALB/c spleen cells.
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  • PLASMA HISTAMINE LEVELS AND ALLERGIC DISEASES : II. Relationship Between Plasma Histamine Levels and Severity of Asthmatic Attack
    Yoshiro Imada, Shoji Nagata, Hideki Teshima, Yukihiro Ago, Yoshihiko M ...
    Article type: Article
    1983 Volume 32 Issue 4 Pages 209-212
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.209
    JOURNAL FREE ACCESS
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    Plasma histamine levels of asthmatic patients were assayed during on and off attack, and showed in the relation to the severity according to the diagnostic criteria of the Japanese Society of Allergology. In the mild attacks, the mean value of plasma histamine was significantly higher than that in the asymptomatic state of bronchial asthma. In the severe attacks, the mean value of plasma histamine was significantly lower than that in the asymptomatic state of bronchial asthma. Among the mild, the moderate and the severe groups during the asymptomatic state of bronchial asthma, no significant differences were found in plasma histamine.
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  • ANALYSIS OF CONCANAVALIN A-INDUCED SUPPRESSOR AND HELPER CELLS BY THE USE OF AUTOLOGOUS ERYTHROCYTE ROSETTE TECHNIQUE IN ASSOCIATION WITH MONOCLONAL ANTIBODIES TO T CELL SUBSETS
    Shinsuke Takada, Tsuyoshi Sakane, Yuji Ueda, Yohko Murakawa, Hiroyuki ...
    Article type: Article
    1983 Volume 32 Issue 4 Pages 213-220
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.213
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    Normal human peripheral blood T lymphocytes activated by concanavalin A (Con A) were fractionated into OKT4+ and OKT8+ population. Using autologous erythrocyte rosette technique, each population were further divided into autorosette forming cell (ARFC) and non-autorosette forming cell (NARFC) fractions, and thus a variety of Con A-activated T cell subsets (OKT4+ ARFC, OKT4+ NARFC, OKT8+ ARFC and OKT8+ NARFC) was obtained. The immune regulatory function of these subsets was investigated using pokeweed mitogen-driven B cell plaque-forming cell system. These studies demonstrated 1)that ARFC can exert potent suppressor activity regardless of their surface phenotypes of OKT4+ and OKT8+ antigens, while the very same cells fail to help B cell differentiation, 2)that OKT4+ NARFC serve adequately as helper cells, but are devoid of suppressor cells, 3)and that OKT8+ NARFC are found indetectable for either suppressor or helper activity, suggesting that they may belong to a lymphocyte subset distinct from subsets related to immune regulation. Taken together, our data indicate that the receptor for autologous erythrocytes is a useful marker to identify Con A induced suppressor T cells. Furthermore, our results lead us to the conclusion that there may exist a functional heterogeneity among the OKT4+ populations;one is a helper population and another is a suppressor population.
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  • EFFECT OF ALLERGEN INHALATION SENSITIZATION ON PULMONATY β-ADRENERGIC RECEPTORS
    Shuichi Matsumoto, Kenzo Takagi, Tatsuo Satake
    Article type: Article
    1983 Volume 32 Issue 4 Pages 221-228
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.221
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    We investigated the possible effects of inhalation sensitization on pulmonary β-adrenergic receptors using Konjac-Maiko inhalation sensitized guinea pigs with a radio-binding assay. We also tried to investigate the relationship between the severity of asthma attack and the pulmonary β-receptors. The following results were obtained. (1) Sensitization induced a decrease in the number of pulmonary β-receptors receptors of 17% compared with the controls, but did not affect the dissociation constant (Kd). (2) Re-inhalation of the allergen 3 weeks after the sensitization caused a 13% decrease in the number of β-receptors compared with the controls. (3) In the moderate attack group, a significant decrease in the number of β-receptors was observed without significant changes in Kd compared with the attack-free and mild-attack groups. These results indicate that allergen inhalation sensitization causes a decrease in the number of pulmonary β-adrenergic receptors and suggest that a animal with decreased β-receptors in the lung easily develops severe bronchial asthma attack upon re-inhalation of the allergen.
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  • HISTOLOGICAL CHANGES AND CELLULAR RESPONSES IN LUNG TISSUE IN BRONCHIAL ASTHMA
    Yoshiro Tanizaki, Hiroshi Harada, Hidetoshi Kobashi, Yutaro Shioda, Hi ...
    Article type: Article
    1983 Volume 32 Issue 4 Pages 229-236
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.229
    JOURNAL FREE ACCESS
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    Histological changes and cellular responses were observed in lung biopsy specimens 37 patients with bronchial asthma. 1) Histological changes in lung tissue were frequently observed in the cases older than 60 years, or in 'late onset' asthma patients, their ages at onset of the disease being over 40 years. Observation of cellular response in these cases demonstrated predominant infiltration of macrophages and mononuclear cells in bronchiolo-alveolar regions. 2) Infiltration of eosinophils and mononuclear cells was observed in the bronchiolo-alveolar regions of the cases with high serum IgE levels. 3) A reverse correlation was observed between emergence of macrophages in bronchiolo-alveolar regions and eosinophil count in the peripheral blood. 4) Micronodular shadow on chest X-ray film of bronchial asthma was found to be related to mononuclear cell infiltration in the bronchiolo-alveolar regions.
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  • [title in Japanese]
    Article type: Appendix
    1983 Volume 32 Issue 4 Pages 237-240
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.237
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  • [title in Japanese]
    Article type: Cover
    1983 Volume 32 Issue 4 Pages Cover21-
    Published: April 30, 1983
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.32.Cover21
    JOURNAL FREE ACCESS
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