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Volume 33, Issue 7
Displaying 1-14 of 14 articles from this issue
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Article type: Cover
1984 Volume 33 Issue 7 Pages Cover27-
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (370K) -
Article type: Cover
1984 Volume 33 Issue 7 Pages Cover28-
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (370K) -
Article type: Bibliography
1984 Volume 33 Issue 7 Pages Misc10-
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (319K) -
Atsushi OgiwaraArticle type: Article
1984 Volume 33 Issue 7 Pages 369-375
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo clarify the role of the immune system in Kawasaki disease, the author measured the surface T cell, B cell and macrophage/monocyte antigen in peripheral blood mononuclear cells from 14 patients who ranged in age from 5 months to 5 years. These surface antigens were measured by fluorescence-activated cell sorter using monoclonal antibodies(Leu series). The results were as follows: 1.Percent Leu 4 positive cells(pan T cells), Leu 2 positive cells(suppressor/cytotoxic T cells)and Leu 3 positive cells(helper/inducer T cells)were not significantly different in acute and convalescent stages. Percent Leu 7 positive cells(natural killer/killer cells)showed no remarkable difference in acute and convalescent stages. 2.Percent Leu 10 positive cells(B cells/macrophages)was significantly higher at the convalescent stage. 3.In 5 out of 14 patients, there was an increased percent Leu M3 positive cells(macrophages/monocytes)during the acute stage. In these cases, the CRP test was positive for a long time, and percent Leu M3 positive cells subseqently returned to normal values during the convalescent stage. 4. In 2 out of 14 patients, percent HLA-DR positive cells was significantly higher at the acute stage and returned to a normal range at the convalescent stage. 5.In a case with coronary involvement, percent Leu 4, Leu 2 and Leu 3 positive cells in the acute stage was significantly low, while percent Leu M3 and HLA-DR positive cells were significantly high. These results suggest that the activites of peripheral blood lymphocytes and macrophages may contribute to the pathogenesis and symptoms of Kawasaki disease.View full abstractDownload PDF (758K) -
Kazuhiko Muto, Michio HirataniArticle type: Article
1984 Volume 33 Issue 7 Pages 376-380
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA 20-month-old boy with status asthmaticus and generalized tonic-clonic convulsion was admitted. He had been treated with intravenous infusion(1500ml)for 15 hours. He had developed neither dehydration nor edema. Laboratory examination on admission revealed an increased PaCO_2 level(48mmHg)and decreased serum levels of both sodium(122mEq/l)and osmolarity(246mOsm/kg). Because of continued generalized convulsion with increased hypercapnia after admission, the patient was treated with assisted ventilation and infusion of bothe dexamethasone and D-mannitol under limitation of parenteral fluid. After 96 hours, he was completely recoverd. It is presumed that the generalized convulsion resulted from dilutional hyponatremia, which was probably induced by SIADH complocated with severe status asthmaticus.View full abstractDownload PDF (509K) -
Hisashi Kondo, Mitsutoshi Tsuruta, Youichi Hayakawa, Tsutomu Nakahara, ...Article type: Article
1984 Volume 33 Issue 7 Pages 381-388
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBronchial provocation test(BPT)was performed on asthmatic children with positive skin test reaction to Candida antigen. A relationship between the results of BPT, and specific IgE and IgG antibodies to Candida cells was also studied. The results obtained were: 1)Twenty-five out of 73 skin test positive patients(34%)showed positive BPT to Candida antigen. Among these BPT-positive cases, 12cases(48%)were IAR(immediate asthmatic response), 10 cases(40%)were DAR(dual asthmatic response)and 3 cases(12%)were LAR(late asthmatic response). 2) Levels of specific IgE antiblcy to Candida cells was significantly higher in BPT positive/IAR group than BPT negative group, and that could also be observed in some cases in BPT positive/DAR group. 3) Levels of specific IgG antibody to Candida cells was not significantly different in the positive and negative groups on the BPT. 4) Bronchial reactivity to acetylcholine and histamine was significantly higher in the DAR group than IAR group.View full abstractDownload PDF (925K) -
Yoshiro Tanizaki, Haruki Komagoe, Michiyasu Sudo, Hiroshi Morinaga, Ju ...Article type: Article
1984 Volume 33 Issue 7 Pages 389-395
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSFourteen patients with bronchial asthma, including 13 steroid-dependent cases, had a spa therapy(swimming training in a hot spring pool)for three months. The clinical effects of the spa therapy on intractable asthma were then evaluated by ventilatory function test and clinical symptoms. 1.Ventilatory functioon tests demonstrated that the values of FVC, FEV_<1.0>, MMF, PEFR, V_<50> and V_<25> were not affected by 30 minutes' swimming training in the hot spring pool. 2.Improvement of the ventilatory function observed in the majority of the asthmatic subjects during the 3 months' swimming training led to the reduction of the corticosteroid dose administered. The rate of increase in each parameter after 3 months'training was 100.5% in FVC, 110% in FEV_<1.0>, 124.8% in PEFR, 123.2% in MMF, 126.9% in V_<50> and 130.6% in V_<25>. 3. The swimming training was more effective in bronchiolar obstruction and bronchospasm-hyperscretion types of bronchial asthma than in bronchospasm type.View full abstractDownload PDF (890K) -
Itsuo Suzuki, Takashi Mitsubayashi, Kazuko Maruki, Toru Akasaka, Kazui ...Article type: Article
1984 Volume 33 Issue 7 Pages 396-402
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSOne hundred and sixty-six asthmatic children(116 boys, 50 girls)who had been discharged from three residential hospitals were sent a questionnare on the course of their disease after discharge. Mean age of admission was 7 years 9 months for boys and 7 years 7 months for girls, and mean length of hospital stay was 23.6 months and 24.4 months, respectively. The rate of clinical improvement from severe to mild asthma for the children was 72% during hospotalization, 48.4% at a year after discharge and 81.2% at 3 years after discharge. Less improvemnt was found among younger children and girls with asthma compared to older children and boys but there was no statistical difference. It is concluded that prognosis after discharge might depend on the clinical course during hospitalization and that less favorable results were found among younger children and girls in these three residential hospitals for asthmatic children.View full abstractDownload PDF (827K) -
Fumio Kokubu, Mitsuru Adachi, Masayuki Iijima, Terumi TakahashiArticle type: Article
1984 Volume 33 Issue 7 Pages 403-410
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe efficacy of long-term BD treatment in clinical manifestation of asthmatic symptom and airway hyperreactivity to methacholine was studied in 18 adult patients with perennial bronchial asthma. 1.Clinical evaluation of BD treatment was as follows: markedly improved, 3;improved, 10;slightly improved, 4;and no change, 1. 2.No significant changes were observed in pulmonary function(FVC, FEV_<1.0>, PFR, Rrs)before and after BD treatment 3.Airway hyperreactivity to methacholine in these asthmatic patients reduced significantly(P<0.05)after BD treatment. These results indicate that BD treatment can improve clinical manifestation of asthmatic symptom and reduce airway hyperreactivity in asthmatic patients.View full abstractDownload PDF (893K) -
Isao Ohno, Kazuo Kobayashi, Minoru Tabata, Hideki Sato, Fusao Sekine, ...Article type: Article
1984 Volume 33 Issue 7 Pages 411-417
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effect of human IgG, heat-aggregated IgG(Agg-IgG)and frgments of IgG molecule on B lymphocyte proliferative response(LPR)induced by Sepharose 4B binding protein A(S4B-pA)was studied. 1)Both Agg-IgG(1μg/ml or more)and monomeric IgG(10μg/ml or more)dose responsively suppressed the S4B-pA induced LPR. This suppressive effect was also observed when Agg-Fcγ, F(ab′)_2γ and Fabγ were added into the clutures. F(ab′)_2γ was more effective than Fabγ, but monomeric Fcγ had little suppressive effect. 2)The S4B-pA which had been pretreated with F(ab′)_2γ, Fabγ and monomeric Fcγ respectively at 37℃ for 1hour, washed for removal of unbound fragment, and subsequently added to the clutures, showed on effect on S4B-pA mitogenic activity. These results suggest that the suppressive effect of Agg-Fcγ on S4B-pA induced B lymphocyte proliferative response is mediated by IgG-Fc receptor on the cell surfaces, and that suppression by monomeric IgG, F(ab′)_2γ and Fabγ may be mediated by the different sites from IgG-Fc receptor.View full abstractDownload PDF (841K) -
Kenichi Tokuyama, Masato Mitsuhashi, Kimio Tajima, Akihiro Morikawa, H ...Article type: Article
1984 Volume 33 Issue 7 Pages 418-423
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effect of amplicillin(AB-PC)on the measurement of circulating immune complex(CIC)by Clq solid-phase enzyme immunoassay(Clq SPEIA)was studied. The following results were obtained. 1)CIC levels in the sera significantly decreased by preincubation with 20mg/ml of AB-PC(p<0.01). 2)Aggregated human IgG(AHG)measured by Clq SPEIA after preincubation with 0, 0.2, 2 and 20mg/ml of AB-PC revealed the proportional decrease as the dose of AB-PC increased. 3)There was low avidity between AB-PC and Clq or AHG. Although the mechanism of inhibitory effect of AB-PC on Clq SPEIA is unknown, it is emphasized that Clq SPEIA may possibly result in a "false negative" reading in patients receiving massive ampicillin therapy.View full abstractDownload PDF (558K) -
Tsugio NakazawaArticle type: Article
1984 Volume 33 Issue 7 Pages 424-427
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt is wellknown that premedication of corticosteroids inhibits the development of late asthmatic responses(LAR) in allergen inhalation tests on asthmatics. This suggests that some dysfunction in steroid synthesis or regulation may have some roles in induction of LAR. To clarify this possibilities, we performed allergen inhalation tests on asthmatic patients and observed their bronchial responses and serial changes of plasma cortisol levels for about 12 hours. 1.In the group of asthmatics who showed LAR, plasma cortisol levels changed from 9.22±2.96μg/dl in before inhalation to 2.76±0.42μg/dl in LAR development several hours after inhalation. This decrease in cortisol levels was lower than that in circadian rhythm. 2.Cortisol levels of dual asthmatic responses(DAR) group transiently increased in attacks of immediate asthmatic responses(IAR) and markedly decreased when LAR appeared. This drop in LAR also lower than that of circadian rhythm. 3.In IAR group, cortisol levels increased in their attacks and after that gradually decreased within diurnal change. These results may suggest that some of LAR are possibly induced as a result of transient insufficiency of regulation or synthesis of steroids although its mechanism is not known.View full abstractDownload PDF (486K) -
Article type: Appendix
1984 Volume 33 Issue 7 Pages 428-431
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (266K) -
Article type: Cover
1984 Volume 33 Issue 7 Pages Cover29-
Published: July 30, 1984
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (160K)
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