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Volume 34, Issue 12
Displaying 1-15 of 15 articles from this issue
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Article type: Cover
1985 Volume 34 Issue 12 Pages Cover10-
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (272K) -
Article type: Cover
1985 Volume 34 Issue 12 Pages Cover11-
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (272K) -
Article type: Bibliography
1985 Volume 34 Issue 12 Pages Misc4-
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
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Takao Igarashi, Gyokei Murakami, Yuichi Adachi, Masatomo Matsuno, Yoko ...Article type: Article
1985 Volume 34 Issue 12 Pages 1055-1062
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe previously reported a new method for examining bronchial sensitivity which involved measuring the transcutaneous oxygen pressure(tcPo_2)during inhalation of histamine. Its application in preschool children with bronchial asthma requires a knowledge of factors that will affect the response. We measured the dose and distribution of radiolabeled aerosol(^<99m>Tc-DTPA) in the airway(trachea and both lungs)by the scintilation camera. When aerosol is inhaled by tidal breathing, there are adequate correlations between the total dose of aerosol in the airway and both the age and height of the patients. However, the distribution rate of aerosol in the central and peripheral airways did not differ significantly with age and height. When aerosol was inhaled while crying, little deposit within the airways in children aged under 1 year and relatively more aerosol in the central airways of a 2 year-old child were shown. The respiratory threshold to histamine(RT-Hist) was measured by our method in 106 children with bronchial asthma and 11 control children, both groups aged 2-6 years old. The geometrical means of RT-Hist among the asthmatic and control children were 1182μg/ml and 4414μg/ml, respectively. This difference is statistically significant (p<0.01). RT-Hist was measured by a standard Japanese method in 108 children with bronchial asthma, 7-14 years of age and 8 control children, 8-14 years of age. The geometrical means of RT-Hist in asthmatic and control children were 600μg/ml and 4263μg/ml(p<0.01). So, in asthmatic children, RT-Hist in preschoolers is higher than in school-aged children(p<0.001). The clinical severity of bronchial asthma correlated with RT-Hist in school-aged children, but not in preschool children.View full abstractDownload PDF (1014K) -
CLINICAL EPIDEMIOLOGY OF BRONCHIAL ASTHMA IN CHILDREN REPORT : No.II Prognosis and House-EnvironmentKazuko Inoue, Takeshi Ohotani, Morio Araki, Toshiro Tango, Shiusuke Ku ...Article type: Article
1985 Volume 34 Issue 12 Pages 1063-1071
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESS -
Kazuhito JujhoArticle type: Article
1985 Volume 34 Issue 12 Pages 1072-1080
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESS -
Kazumasa Yasuda, Kyoko HiranoArticle type: Article
1985 Volume 34 Issue 12 Pages 1081-1086
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSPBS-extracted fish antigens were examined for cross reactivity and antigenic activity in a 3-year-old girl with multi-allergic fish urticaria and by open patch test and in vitro tests using the serum of this patient. Four fishes were used as materials; grunt and cod as white meat fish and tuna and mackerel as red meat fish. 1.The antigenic activity of the white meat fish was 1000 times stronger than that of the red meat fish, when determined by the end-point titration test using the open patch test. 2.The end-point titration test using the P-K reaction showed that the antigenic activity of grunt was 10 times of that of cod, 1000 times of that of tuna, and 10000 times of that of mackerel. 3. The IgE-ELISA revealed that the white meat of grunt and cod was class 3 and that the red meat of tuna and mackerel was class 2 and class 1 respectively. 4.The in vivo neutralization test using the P-K reaction and the in vitro IgE-ELISA inhibition test suggested that white meat and red meat fish had cross antigenicity.View full abstractDownload PDF (804K) -
Motohiro Kurosawa, Tetsuji Tanaka, Sakae Aoki, Yasushi Igarashi, Tamot ...Article type: Article
1985 Volume 34 Issue 12 Pages 1087-1093
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSGranules were isolated from sonicated rat mast cells on a Percoll gradient and incubated with [γ^<32>P]ATP in the presence of Mg^<2+>. After stopping the reaction, SDS/PAG electrophoresis was performed and autoradiographs were prepared to determine the incorporation of ^<32>P into proteins. Granules developed two broad and two narrow radioactive bands corresponding to the major granule proteins in 26-40K range. Because of no effect of cyclic AMP on this phosphorylation, it is apparant that rat mast cell granules contain an endogenous non-cyclic AMP-dependent protein kinase phosphate acceptor proteins for this kinase. When cyclic AMP-dependent protein kinase were incubated with [γ^<32>P]ATP under the standard condition, the enzyme was able to phosphorylate itself irrespective of cyclic AMP. This cyclic AMP-dependent protein kinase autophosphorylation was inhibited by cyclic AMP in the presence of granules. It is known that an abundant protease activity is located in rat mast cell granules. When protease inhibitors pretreated granules were incubated with exogenous cyclic AMP-dependent protein kinase, no obvious new radioactive bands were observed even if defferent amounts of cyclic AMP-dependent protein kinase were used. Interestingly, the autophosphorylation of cyclic AMP-dependent protein kinase was enhanced with granules. These systems mentioned above may be of possible significance in mediator release from activated mast cells.View full abstractDownload PDF (1224K) -
Shigenori Tanaka, Katsuhiko Akashi, Tomohiko Ohno, Koichi Kuribayashi, ...Article type: Article
1985 Volume 34 Issue 12 Pages 1094-1098
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSGranulocytes generate active oxygens such as superoxide anion(O^-_2)that are bactericidal agents by phagocytosis or membrane stimulation. We studied the role of arachidonic acid metabolism on the mechanism of O^-_2 generation from human granulocytes. Granulocytes were prepared from peripheral blood by dextran sedimentation followed by centrifugation on FicollPaque. O^-_2 generation was estimated by the reduction of ferricytochrome C. Granulocytes generated O^-_2 by the addition of zymosan or phorbol myristate acetate(PMA). This O^-_2 generation, induced by zymosan or PMA, was inhibited by phospholipase A_2 inhibitor or lipoxygenase inhibitor, but not by cyclooxygenase inhibitors. Granulocytes also generated O^-_2 by the addition of arachidonic acid. This arachidonic acid-induced O^-_2 generation was enhanced by the addition of cyclooxygenase inhibitors prior to arachidonic acid stimulation. Therefore, it is suggested that the lipoxygenase pathway of arachidonic acid metabolism may play an important role in the mechanism of O^-_2 generation from granulocytes.View full abstractDownload PDF (624K) -
Yoshio Umegae, Tsugio Nakazawa, Shigeru Matsui, Yasumasa Yoshie, Ryuzo ...Article type: Article
1985 Volume 34 Issue 12 Pages 1099-1104
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis study was undertaken to investigate the effect of histamine and its receptor antagonists on IgE antibody production in mice. BALB/c mice were immunized intraperitoneally with 1 mg alum plus 30μg of Ag90, an antigen prepared from the water soluble fraction of"Konnyaku Maiko"precipitated by 90% saturated ammonium sulfate. Histamine receptor antagonists were administered before immunization and histamine at sensitization. The mice were bled 14 days after immunization and anti-Ag90 IgE antibody titers were measured by passive cutaneous anaphylaxis reacton in Sprague-Dawley rats. The titers were expressed as a reciprocal of the highest dilution that yields a positivi reaction. Treatment with histamine did not affect the level of specific IgE antibody. Prior administration of H_1 antagonist to histamine suppressed IgE production significantly. In contrast, Pretreatment with H_2 antagonist augmented IgE antibody production. Injection of H_1 + H_2 antagonists prior to histamine had no effect on antibody production. These results suggested that histamine, in the induction phase, suppressed specific IgE production via H_2 receptor and enhanced it through H_1 receptor.View full abstractDownload PDF (818K) -
Yuji Hinoda, Toshiyuki Higashide, Takafumi Yamashita, Kohzoh Imai, Aki ...Article type: Article
1985 Volume 34 Issue 12 Pages 1105-1109
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSKupffer cells were isolated from the livers of mice and were evaluated in vitro. The results obtained were as follows. 1) The mean yield of Kupffer cells was 1-2×10^6/liver and 93% of the resultant population was stained positively for non-specific esterase. In addition, 62% of Kupffer cells were shown to bear Fc receptors for IgG, and Kupffer cells were shown to bear Fc receptors for IgG, and 41% for I-A antigens respectively. 2)The Kupffer cell were capable of potentiating the lymphocyte blastogenesis to Con A in proportion to the cell numbers added. 3)The interleukin 1-like activity of the thymic T cells was clearly demonstrated in the supernatant of the Kupffer cells when they were stimulated with LPS. This activity was depenedent on the number of Kupffer cells added to the culture. 4)The cytotoxic activity of the Kupffer cells to human cultured hepatoma cells was also shown when the ratio of effector cells to target cells was 100 or 200.View full abstractDownload PDF (715K) -
Article type: Index
1985 Volume 34 Issue 12 Pages 1110-1115
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
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Article type: Index
1985 Volume 34 Issue 12 Pages 1116-1119
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1985 Volume 34 Issue 12 Pages 1120-1125
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
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Article type: Cover
1985 Volume 34 Issue 12 Pages Cover12-
Published: December 30, 1985
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (200K)
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