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Volume 35, Issue 12
Displaying 1-15 of 15 articles from this issue
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Article type: Cover
1986 Volume 35 Issue 12 Pages Cover9-
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (310K) -
Article type: Cover
1986 Volume 35 Issue 12 Pages Cover10-
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (310K) -
Article type: Appendix
1986 Volume 35 Issue 12 Pages App2-
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
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Koji Ito, Nobuyuki Kobayashi, Terumasa Miyamoto, Hiroshi Yasueda, Yasu ...Article type: Article
1986 Volume 35 Issue 12 Pages 1139-1148
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt is known that degranulation and the release of chemical mediators such as histamine from human basophils can be observed when the cells are challenged by allergens. Basophils usually occupy less than 1% of peripheral leucocytes. A method for obtaining a basophil-rich fraction by the addition of mixture of sodium metrizoate and ficoll to peripheral blood followed by centrifugation has been established by Dry et al. The Pasteur Institute (France) has produced the "Allergolam" a human basophil degranulation test (HBDT) kit, for the identification of allergens. It works by calculating the decrease in the number of stainable basophils after the reaction of a basophil-rich fraction in wells coated with allergens. We studied the usefullness of the kit using 202 blood samples from normal subjects and atopic patients in 5 institutes. The correlation between the results of HBDT and RAST was 84.3%, 83.8% and 73.0% in the case of house dust (HD), mite and a mixture of cat- and dog hair (CD) respectively. The correlation between the results of HBDT and skin test was 70.1%, 68.3%, 68.5% and 76.9% in the case of HD, mite, CD and a mixture of mould and fungi respectively. The correlation coefficient between HBDT and histamine release test was 0.81 and 0.73 in the case of HD and mite respectively. Therefore, HBDT using these kits was thought to be useful for the identification of allergens and for studies of allergic reactions.View full abstractDownload PDF (1164K) -
Michiharu IshizakiArticle type: Article
1986 Volume 35 Issue 12 Pages 1149-1157
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAllergic responses of on the conjunctiva on the experimental model using guinea pigs which were passively sensitized with antiserum of Japanese cedar pollen was studied. Immediate response, i.e., hyperemia and edema in the conjunctiva of passively sensitized guinea pigs, was observed about 20 minutes after the challenge with cedar pollen. Observation of time-course changes in histological findings, showed that infiltration of eosinophils in the conjunctiva reached its peak 6 hours after the antigen challenge, and that of neutrophils at 6-8 hours. The mast cell count was lowest two hours after the challenge and highest at 12 hours. There was a defect in the conjunctival epithelium accompanied by cellular infiltration 8 hours after the challenge. Anti-allergic agents were instilled in the eyes, and responses 6 hours after the challenge were investigated. The eosinophil and neutrophil counts were significantly lower in eyes given DSCG or ketotifen than those of the controls. The results of the present study, showed that this experimental model can be useful for allergic response on conjunctival study.View full abstractDownload PDF (1603K) -
Yasuko Sakuma, Hruhisa MitaArticle type: Article
1986 Volume 35 Issue 12 Pages 1158-1162
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe lacrimal level of histamine was determined by fluorometric assay with an autoanalyzer in 15 patients with pollen conjunctivitis, 20 with chronic allergic conjunctivitis, 30 with vernal conjunctivitis and 12 normal healthy subjects. The level was 2.2 ± 1.6 ng/ml in the healthy subjects, 4.5 ± 2.3 ng/ml in patients with pollen conjunctivitis, 4.3 ± 3.9 ng/ml in those with chronic allergic conjunctivitis, and 18.8 ± 16.6 ng/ml in those with vernal conjunctivitis, showing significant differences between the healthy subjects and those with pollen conjunctivitis (p<0.01), chronic allergic conjunctivitis (p<0.05) and vernal conjunctivitis (p<0.001). The lacrimal level of histamine in the palpebral type of vernal conjunctivitis was 21.0 ± 16.7 ng/ml and 4.2 ± 3.2 ng/ml for the bulbar type, showing that the level for the palpebral type was significantly (p<0.001) higher than that for the bulbar type. When determining the lacrimal level of histamine according to the severity of vernal conjunctivitis, it was 4.2 ± 2.2 ng/ml in mild cases, 18.4 ± 15.2 ng/ml in moderate cases and 34.5 ±16.1 ng/ml in severe cases, showing significant (p<0.01) differences between the level in mild cases and those in moderate and severe cases. The lacrimal level of histamine in vernal conjunctivitis associated with corneal lesions was significantly high, suggesting a possible close relationship between the lacrimal level of histamine and the pathogenesis of corneal lesions.View full abstractDownload PDF (628K) -
Tsugio Nakazawa, Shigeru Matsui, Akira Saito, Yoshio Umegae, Yasumasa ...Article type: Article
1986 Volume 35 Issue 12 Pages 1163-1169
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn an attempt to find the pathogenesis which induce a low plasma cortisol level observed during LAR(late asthmatic responses), the functions of the adrenal cortex and pituitary glands were studied in asthmatic patients who showed LAR, DAR(dual asthmatic responses) and IAR(immediate asthmatic responses). No apparent abnormalities in serial plasma ACTH levels were noted when they were compared with diurnal levels in each group. Both LAR and DAR groups showed slightly low responses to ACTH stimulation as compared with the responses of the IAR group, although the responses of the 3 groups were within the range of the healthy subjects. These findings suggest that low cortisol levels occurring during LAR may be partly due to a dysfunction of the adrenal cortex itself.View full abstractDownload PDF (875K) -
Hiroshi Shuto, Kazukiyo Nakagami, Hazime Suzuki, Eisei NoguchiArticle type: Article
1986 Volume 35 Issue 12 Pages 1170-1180
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe applied ILF (Interferential Low Frequency) therapy, ordinarily used as physical therapy for neuropathy, muscular disease, osseous disease, articular disease etc., to the chests of patients with bronchial asthma. We expected 1)that ILF therapy would induce expectoration by making sputum on the surface of the bronchi mobile, and 2)that shoulder stiffness muscular fatigue and myalgia in the chest and upper back regions would be reduced or disappear. ILF of 70Hz ± 50% was applied for 10 min. The following results were obtained: 1. The ILF therapy was performed a total of 149 times on 46 patients and it was found that FEV_<1.0>, PFR and R-r improved significantly. 2. After ILF therapy an improvement in expectoration was observed 48 times (32.2%), the improvement of subjective symptomes was found 147 times (98.7%) and the improvement of chest auscultatory findings was found 33 times (63.5%). 3. In the present therapy, no abnormal changes in the ECG, blood presure and pulse rate were noted. 4. Regarding EEG results, a finding indicative of a sedative effect was noted. 5. As to the changes in cyclic nucleotides, cyclic AMP and the ratio of cyclic AMP/cyclic GMP increased significantly. 6. Another group consisting of 9 cases underwent ILF therapy for 5 successive days and it was found that FEV_<1.0%> and R-r improved significantly. We concluded that ILF therapy would be a valuable subsidiary therapy for bronchial asthma and that it would not produce any side effects.View full abstractDownload PDF (1379K) -
Kazuhito JujhoArticle type: Article
1986 Volume 35 Issue 12 Pages 1181-1187
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo clarify the mechanism of hyperimmunoglobulinemia, E, IgE-bearing B cell were investigated by fluorescence activated cell sorter with two-colour immunofluorescence staining in ten patients, aged from 8 to 20 years old, with bronchial asthma. The results were as follows: 1)In healthy adults, IgE-bearing B cells constituted 0.28 ± 0.23% of peripheral blood B cells, and 0.03 ± 0.02% of all lymphocytes. 2)In patients with bronchial asthma, IgE-bearing B cells constituted 2.8 ± 2.4% of peripheral blood B cells, and 0.38 ± 0.37% of all lympocytes. There was a quantitative correlation between IgE-bearing B cells of peripheral blood B cells or lymphocytes and the serum IgE level. These results suggest that hyperimmunoglobulinemia E in patients with bronchial asthma may be affected by the increased number of IgE-bearing B cells.View full abstractDownload PDF (685K) -
Shigenori Tanaka, Katsuhiko Akashi, Hideo Yamaguchi, Koichi Kuribayash ...Article type: Article
1986 Volume 35 Issue 12 Pages 1188-1195
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the effect of the active oxygens generated by human granulocytes on the cytotoxicity of erythrocytes. Human granulocytes were prepared from peripheral blood. The absorbance at 410nm of the supernatant in the reaction mixture was measured as an index of the cytotoxixity. Granulocytes generated active oxygens when zymosan or phorbol myristate acetate (PMA) were added. The effects of scavengers (SOD, catalase, D-mannitol, DABCO, L-histidine) or myeloperoxidase inhibitors (NaN_3, KCN) on the cytotoxicity of erythrocytes induced by active oxygens were studied. The results obtained were as follows. 1) Active oxygens generated by human granulocytes stimulated with PMA or zymosan lysed erythrocytes. 2) ・OH and ^1O_2 are final mediators in the cytotoxicity of erythrocytes induced by active oxygens. But, H_2O_2 is not involved in the cytotoxicity of erythrocytes. 3) It was suggested that myeloperoxidase is also involved in the cytotoxicity of erythrocytes.View full abstractDownload PDF (874K) -
Article type: Index
1986 Volume 35 Issue 12 Pages 1196-1202
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
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Article type: Index
1986 Volume 35 Issue 12 Pages 1203-1206
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
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Article type: Index
1986 Volume 35 Issue 12 Pages 1207-1227
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1986 Volume 35 Issue 12 Pages 1228-1230
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
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Article type: Cover
1986 Volume 35 Issue 12 Pages Cover11-
Published: December 30, 1986
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (192K)
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