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Volume 36, Issue 2
Displaying 1-14 of 14 articles from this issue
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Article type: Cover
1987 Volume 36 Issue 2 Pages Cover13-
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (148K) -
Article type: Cover
1987 Volume 36 Issue 2 Pages Cover14-
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (148K) -
Article type: Appendix
1987 Volume 36 Issue 2 Pages App3-
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
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Yoshihiko IshizuArticle type: Article
1987 Volume 36 Issue 2 Pages 61-71
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe atmospheric pollen counts of Cryptomeria japonica recorded in the San-in area between 1982 and 1986 were analyzed, and the following results were obtained. 1. The pollen front, beginning in early or late February and lasting until late April, moved from the west to the east of the area. The west also preceded the east in the onset of Sugi pollinosis. 2. The daily pollen counts closely correlated to the daily mean temperature. 3. Symptoms of Sugi pollinosis appeared mostly on the days when a large quantity of Cryptomeria japonica pollen was first dispersed , or on the following days. 4. In Yonago City, the total yearly pollen counts of a given year correlated significantly to the monthly mean humidity in February and March (r=-0.976 and -0.982;p<0.05 and 0.02;respectively) and the amount of rain fall in February (r=-0.957, p<0.05) of the actual year, but not to the meteorological factors of the preceding year.View full abstractDownload PDF (1105K) -
Fumio Osaka, Hitoshi Kasuga, Minoru Sugita, Hideaki Matsuki, Takeshi M ...Article type: Article
1987 Volume 36 Issue 2 Pages 72-80
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAn ATS-DLD questionnaire (published by the Environment Agency of Japan) was used to carry out a survey of respiratory symptoms and housing environment on 766 elementary school children from Suginami Ward, Tokyo from June to July, 1984. Japanese cedar IgE values in their serum were also measured by RAST. The relationship between allergic histories, their nutritional intake as infants, their housing environment (housing structure and presence of pets) and their cedar IgE positivity rates (RS 2 or more) was studied. The following results were obtained: 1. The proportion of showing those with an allergic history positive cedar IgE was significantly higher than that of those without an allergic history. 2. The proportion of positive cedar IgE values in those who lived in well-ventilated wooden houses was significantly lower than that of those who lived in airtight steel-frame buildings on the 1st and 2nd floors. 3. On the relationship between positive cedar IgE values and the presence of pets or the nutritional intake of the children when they were infants the following observations were made: Cedar IgE positivity rates were significantly higher in the group (1) which had lived with pets (birds) in the house and had been artificial-fed than in the group (2) which had lived whithout pats and had been breast-fed or mix-fed. The positivity rate in group (1) was also significantly higher than in the group (3) which had lived without pets and had been artificial-fed.View full abstractDownload PDF (1035K) -
Gyokei Murakami, Takao Igarashi, Yoko Saeki, Yuichi Adachi, Masatomo M ...Article type: Article
1987 Volume 36 Issue 2 Pages 81-85
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe Chironomidea, of which approximately 10,000 species exist, are found in nearly all types of inland waters. Recently it has been reported that chironomid midges constitute one of the most important inhalation antigens. In Japan, Chironomus plumosus (C.p), Polypedilum kyotoense (P.k), Chironomus yoshimatsui (C.y) and Tokunagayusurika akamushi (T.a) are commonly found. In the present study, cross-reactivity of the antigens between the extracts of these four chironomid species was investigated. Almost all the asthmatics who showed positive reactions to some of the antigens P.k, C.y or T.a were also positive to C.p as revealed by prick test or RAST.Tests for inhibition of RAST were performed by incubation of the allergen extracts with the pooled serum of patients hypersensitive to a midge antigen. The RAST reactions to C.p were inhibited to a degree of 86.3% by P.k, 83.4% by C.y and 81.8% by T.a at an antigen concentration of 10 mg/ml. The RAST reactions to P.k, C.y and T.a antigens were inhibited to a degree of 52.8%, 85.4% and 80.9% respectively by C.p at the same concentration. These results suggest the presence of cross-reactivity between these four chironomid species. C.p is distributed worldwide and are found in great numbers. It is suggested that the C.p antigen is useful as an index when chironomid midge induced bronchial asthma is examined.View full abstractDownload PDF (605K) -
Yoshio Umegae, Susumu Miura, Tsugio Nakazawa, Shigeru Matsui, Kunihiko ...Article type: Article
1987 Volume 36 Issue 2 Pages 86-92
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis study was undertaken to investigate the effects of various drugs which influence airway smooth muscle tone on IgE antibody production in mice. BALB/c mice were immunized intraperitoneally with 1 mg alum plus 30 μg of Ag90, an antigen prepared from the water soluble fraction of "Konnyaku Maiko" precipitated by 90% saturated ammonium sulfate. Various drugs (acetylcholine, isoproterenol, 2-pyridylethylamine (H_1 agonist), dimaprit (H_2 agonist), PGE_1 and PGF_<2α>) were administered together with the antigen immunization. The mice were bled 14 days after immunization and anti-Ag90 IgE antibody titers were measured by passive cutaneous anaphylaxis reaction in Sprague-Dawley rats. The titers were expressed as a reciprocal of the highest dilution that yields a positive reaction. The results were as follows: 1) Acetylcholine, 2-pyridylethylamine and PGF_<2α>, which are known as bronchoconstrictors significantly augmented IgE antibody production. 2) Isoproterenol, dimaprit and PGE_1 which are thought to relax airway smooth muscle significantly suppressed IgE antibody production. From these results, it could be concluded that bronchoconstrictors enhance IgE antibody production and bronchodilators suppress its production, and is suggested that there is relation between bronchomotor tone and IgE antibody production.View full abstractDownload PDF (891K) -
Takashi Mutoh, Shyozoh Koyama, Osamu Saitoh, Masato Kintaka, Shinichir ...Article type: Article
1987 Volume 36 Issue 2 Pages 93-100
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe relationship between airway hyperresponsiveness and polymorphonuclear leukocytes in the airway has been investigated in recent years. In the present study, airway responsiveness to methacholine and counts of total cells, polymorphonuclear leukocytes and mononuclear cells in bronchoalveolar lavage fluids (BALF) were examined at successive intervals up to six hours after saline or endotoxin inhalation in guinea pigs. The following results were obtained. 1) In the controls, no changes were observed in either cell counts in BALF or airway responsiveness during the six hours after saline inhalation. 2) In the endotoxin (ET)-inhalation groups, counts of total cells and polymorphonuclear leukocytes were unchanged at 30 minutes and 1 hour, but increased remarkably at 3 hours and 6 hours after endotoxin inhalation, although the mononuclear cell count showed no change with time. 3) In the ET-inhalation groups, airway responsiveness was slightly increased at 30 minutes, and then significantly increased at 1 hour and 3 hours after ET-inhalation. At 6 hours, airway responsiveness returned to the base line level and no difference from pre-ET values was found. After ET-inhalation, polymorphonuclear leukocytes infiltrate into the airway. However, the increments of airway responsiveness and of polymorphonuclear leukocytes in BALF showed a time lag indicating no direct correlation between them.View full abstractDownload PDF (834K) -
Tadashi Ariga, Masanori Nakanishi, Tsutomu Ohishi, Yukio Sakiyama, Shu ...Article type: Article
1987 Volume 36 Issue 2 Pages 101-107
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to evaluate the direct effect of histamine on human B cell functions, we added histamine to the in vitro immunoglobulin (Ig) production from B cells stimulated by Staphylococcus aureus Cowan I (SAC) and recombinant interleukin 2 (IL2). We also studied its effect on DNA synthesis and IL2 receptor expression of B cells stimulated by SAC. For further analysis of the mechanism of histamine-effect, antagoist of H1 or H2 receptors was used. The results revealed that histamine enhanced Ig production of the B cells co-stimulated by SAC and IL2 at low concentration (10^<-7>M). It, however, suppressed at high concentration (10^<-3>M). Both effects seemed to be involved not in the process of activation or proliferation of B cells but in the process of differentiation of B cells to Ig secreting cells. It was also suggested that histamine induced enhancement of Ig production via H1 receptor and induces suppression via H2 receptor on B cells.View full abstractDownload PDF (666K) -
Yasuhiro Mizoguchi, Yoshihide Sakagami, Hiroshi Kuboi, Sukeo Yamamoto, ...Article type: Article
1987 Volume 36 Issue 2 Pages 108-111
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAcute hepatic failure was induced by i.v. injection of heat-killed Propionibacterium acnes into BALB/c mice followed by i.v. injection of a minute amount of LPS. Most of the mice died of massive hepatic necrosis within 24 hours of i.v. LPS injection. An i.v. administration of a leukotriene inhibitor, azelastine, simultaneously with LPS, prevented the mice from death due to hepatic failure and diminished the development of histological changes, especially hepatic necrosis. These results suggest that the generation of leukotriene may be involved in the development of acute hepatic failure in the present model.View full abstractDownload PDF (669K) -
Article type: Appendix
1987 Volume 36 Issue 2 Pages 112-
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (54K) -
Article type: Appendix
1987 Volume 36 Issue 2 Pages 112-
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (54K) -
Article type: Appendix
1987 Volume 36 Issue 2 Pages 113-116
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (281K) -
Article type: Cover
1987 Volume 36 Issue 2 Pages Cover15-
Published: February 28, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (298K)
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