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Volume 36, Issue 3
Displaying 1-12 of 12 articles from this issue
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Article type: Cover
1987 Volume 36 Issue 3 Pages Cover16-
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (92K) -
Article type: Cover
1987 Volume 36 Issue 3 Pages Cover17-
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (92K) -
Article type: Appendix
1987 Volume 36 Issue 3 Pages App4-
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (222K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1987 Volume 36 Issue 3 Pages 117-120
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
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Haruhisa Mita, Yasuo Yui, Hiroshi Yasueda, Takao Shida, Munekazu Tagaw ...Article type: Article
1987 Volume 36 Issue 3 Pages 121-129
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA commercial radioimmunoassy (RIA) kit was examined to test its reliability in quantitating histamine content in supernatant from allergen-challenged leukocytes and human plasma. The various analogues were tested for cross-reactivity, and the major metabolites were shown not to crossreact with the antibody(below 0.01%). An auto-analyzer was used to perform a fluorometric assay on supernatant from allergen-challenged leukocytes, and there was excellent agreement between these results and those obtained by RIA(r=0.970, n=29, p<0.001). In the case of plasma, measurements by direct-RIA correlated significantly with those by RIA with extraction (r=0.951, n=11, p<0.001). When plasma extract was incubated with histamine-N-methyltransferease, the histamine content was reduced to below the detection limit. On the other hand, the content was decreased by 30-70% after incubation with diamine oxidase. There was no significant correlation between measurements by RIA and those by single isotopic enzymatic assay in the quantitation of plasma histamine at levels below 1 ng/ml. These results indicate that the RIA is sufficiently reliable in quantitating histamine in supernatant from allergen-challenged leukocytes and that it is more sensitive than fluorometric assay performed with an auto-analyzer. However, its reliability was not absolutely confirmed in the quantitation of plasma histamine.View full abstractDownload PDF (903K) -
Tetsuo IshimiArticle type: Article
1987 Volume 36 Issue 3 Pages 130-139
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn 77 asthmatic children treated with specific hyposensitization therapy, we took measurements of IgE(RIST), the eosinophile count and IgG every ten weeks until reaching the level of maintenance dose. In all these cases, regression function was applied for the said three factors. The changing patterns of the three factors were;12 in the markedly improved & improved group only, and 4 in the no change group only, and 4 in both groups. The inclination value of IgE was decidedly declined in the markedly improved group compared to the figures for the other two groups. In eosinophile countinclination, the value of the no change group was more elevated than that of the other two groups. The first value of each 3 groups (markedly improved, improved, and no change group) was then classified into two groups;the elevated inclination and the declined inclination group. In markedly improved & improved groups, the first value of eosinophile count on elevated inclination group, was lower than that of no change group. The first value of IgG on elevated inclination group was shown same tendency. Then, by contrast, the first value of IgG on declined inclination group was higher than that of no change group. Thus we have concluded that the regression function method proves beneficial in reviewing the effects of specific hyposensitization therapy in asthmatic children.View full abstractDownload PDF (912K) -
Hajime KokubuArticle type: Article
1987 Volume 36 Issue 3 Pages 140-154
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWhen methacholine inhalation tests were performed on asthmatic children using an Astograph, a new apparatus developed by Takishima, 17 percent of them showed a fall of respiratory resistance (Rrs) curve in spite of the induced broncheal constriction. In order to explain this strange phenomenon, contributing factors to Rrs, i.e. mouth pressure (P) and flow at the mouth (V) were examined. It was found that in the group showing Rrs fall, the difference of phase angle between the two waves was remarkable with the resultant excessively underestimated vale of P. It was considered that this was the most important contributing factor for the occurrence of the above phenomenon. On the other hand, when P-V lissajous'figures (P-V diagrams) in the group showing Rrs fall were analysed, the angles of the lissajous'inclinations before and after methacholine inhalation were both large. Moreover, this finding was consistent with the decreased %FEV_1 of the tested children before provocation with methacholine. From these results, it was suggested that Rrs fall might occur when inhalation tests were performed on patients in whom there was some degree of broncheal constriction even before testing. It would seem that other factors, i.e. the respiratory pattern of the child, the size of the thorax, the site of broncheal obstruction and the presence of air trapping did not contribute to the occurrence of Rrs fall.View full abstractDownload PDF (1468K) -
Sinichirou KoizumiArticle type: Article
1987 Volume 36 Issue 3 Pages 155-161
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to observe the mast cell ultrastructure of human mesenteric connective tissue, a procedure of mechanical and enzymatic dispersion was applied. This procedure yielded approximately 3.0×10^8 nucleated cells per gram wet tissue. The viability of these cells exeeded 87% as judged by dye exclusion of 0.4% trypan blue. The mast cells which were identified as metachromatic in nature by toluidine blue stain constituted about 8% of the total population of nucleated cells. More than 95% of these mast cells chowed a stable and non-degranulating state, having compact granules with a crystal/scroll substructure. Compound 48/80 induced dose dependent degranulation in these mast cells. At a low concentration (10μg/ml)of the compound, each granule tended to move toward the cell membrane and merge with the leaflets of plasma membrane to excrete the granule content by merocrine secretion. At a higher concentration (100 μg/ml)of compound 48/80, fusion of the granules became striking and even a formation of continuous channels (labyrinth) took place, emptying the granule matrix into the extracellular space. These ultrastructures seemed compatible with so-called in vivo "rapid degranulation" which was described in the lung biopsies of patients with anaphylactic disorders such as bronchial asthma and hypersensitivity pneumonitis. It has been previously reported that typical mucosal mast cells also show this process of degranulation in the normal stomach, present results suggest a possibility that connective tissue mast cells could make a morphological transformation into the mucosal counterparts under cetain conditions.View full abstractDownload PDF (1410K) -
Takashi Tomoda, Fumihiko Hamada, Noriko Zushi, Takanobu Kurashige, Isa ...Article type: Article
1987 Volume 36 Issue 3 Pages 162-168
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSNatural killer (NK) activity was studied in 32 patients with insulin dependent diabetes mellitus (IDDM) and 32 normal controls. The results were as follows: 1.In IDDM patients, NK activity was relatively high compared with that in normal controls, but there was no significant difference. 2.18 patients were examined for islet cell antibody (ICA), and NK activity was low in ICA positive IDDM patients (p<0.01). 3.In NK activity from onset to investigation in patients with IDDM, NK activity was low in the group where onset was within one year (p<0.01). 4.There was no significant difference in NK activity in either the well controlled or poorly controlled IDDM groups. 5.Interferon γ was not detected in any IDDM patients. We would like to emphasize that NK activity is low in ICA-positive and newly diagnosed IDDM patients and thus, it is suggested that some defect of cellular immunity may play a role in the pathogenesis of IDDM.View full abstractDownload PDF (664K) -
Article type: Appendix
1987 Volume 36 Issue 3 Pages 169-
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1987 Volume 36 Issue 3 Pages 170-173
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (277K) -
Article type: Cover
1987 Volume 36 Issue 3 Pages Cover18-
Published: March 30, 1987
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (276K)
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