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Volume 37, Issue 11
Displaying 1-12 of 12 articles from this issue
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Article type: Cover
1988 Volume 37 Issue 11 Pages Cover6-
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (380K) -
Article type: Cover
1988 Volume 37 Issue 11 Pages Cover7-
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (380K) -
Yukiko Ogura, Hideo Ogura, Hideo Morita, Takanobu KurashigeArticle type: Article
1988 Volume 37 Issue 11 Pages 1057-1064
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDermatophagoides farinae specific IgG, IgM, IgA and IgE were measured to evaluate the antibody response to common inhalant allergen in relationship to aging and allergic state. Sera from 152 asthmatic and 216 healthy children, 30 healthy adults and 30 cord blood sera were tested by enzyme-linked immunosorbent assay. 1)In healthy individuals, the IgG antibody levels of cord serum were the same as thouse of adults. Beginning at biuth, the IgG antibody levels dropped steadily until 4-5 months of age, then increased gradually, attaining adult levels at 5-6 years of age. The IgM antibody was detected in some cord serum. Rapid increases in IgM antibody levels started in the first month of post natal life and reached a plateaw at one year of age. The IgA antibody, which was at a low level until three months of age, thereafter rose quickly to reach adult level at 9-11 months of age. The IgE antibody levels were very low in all age groups. 2)In asthmatic children, IgG, IgA, and IgE antibodies wre markedly elevated compared with healthy children. The IgM antibody levels were the same as healthy children in all age groups. 3)High responses of Dermatophagoides farinae specific IgG and IgA antibody in asthmatic children suggest increasd invasion of mite antigen due to IgE mediated allergic inflammation of respiratory mucosa.View full abstractDownload PDF (1049K) -
Manabu TakagiArticle type: Article
1988 Volume 37 Issue 11 Pages 1065-1071
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe incidence of positive skin test to the Japanese cedar(sugi in Japanese) pollen increase among children for the last decade. In order to find out the reason for the increase, we compared the size of sugi forest, the pollen counts, number of automobiles and the incidence of positive skin test of sugi in the 4 hospitals in Saitama prefecture. The hospital in the west locates in the largest sugi forest with the highest pollen count, and it showed the same incidende of positive skin test to sugi pollen to 3 hospotals where they had smoller sugi forest, lower pollen count and more number of automobiles. And the positive test started at 3 years of age and reached to the peak at 10 to 12 years of age. It is suggested that the sensitization with the pollen count as well as air pollution such as automobile exhaust and the sensitization may have started earlier along with environmental change.View full abstractDownload PDF (745K) -
Gen Tamura, Suetsugu Mue, Tamotsu TakishimaArticle type: Article
1988 Volume 37 Issue 11 Pages 1072-1076
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAllergen inhalation challenge was used to investigate the effectiveness of Sm 857 against IgE-mediated hypersensitivity. Five subjects received 300 mg/day of Sm 857 and the remaining 5 subjects received 600 mg/day for one week. Using the single exposure method, allergen inhalation challenges were performed just before and one week after administration of Sm 857. Sm 857 did not alter baseline values of total respiratory resistance(Rrs), but significantly delayed the time from the start of allergen exposure to the beginning of elevation of Rrs(p<0.05) and the time from the start of allergen exposure to the point at which total respiratory conductance decreased by 35% from the baseline values (p<0.05). Therefore, these findings suggest that Sm 857 may inhibit IgE-mediated hypersensitivity in the lung.View full abstractDownload PDF (555K) -
Yasumasa Yoshie, Kunihiko Iizuka, Shunzo Aibara, Mikio Mori, Tsugio Na ...Article type: Article
1988 Volume 37 Issue 11 Pages 1077-1083
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo search possible roles of alpha-2 receptor on bronchial smooth muscle, and mechanism of improvement for bronchial asthma, the effect of midaglizole(2-[2-(4, 5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridine dihydrochloride sesquihydrate, DC-5128), selective alpha-2 adrenoceptor antagonist, on guinea pig's bronchocontraction was investigated. Midaglizole inhibited not only in vivo antigen-induced bronchoconstriction, but also in vitro histamine-induced isolated trachea constriction. Midaglizole clearly enhanced the bronchodilating effect of isoproterenol on histamine-induced bronchoconstriction. Desensitization which occurred by high concentration of isproterenol was recovered with the administration of midaglizole. These experimental findings supported our clinical data that midaglizole was endowed with the ameliorative effect for bronchial asthma, especially intractable asthma, and suggested that alpha-2 adrenoceptor as well as beta receptor, have a bronchodilating effect.View full abstractDownload PDF (806K) -
Masayuki Noguchi, Kunihiko Yoshimura, Tatsuo Nakatani, Naohiko Chonaba ...Article type: Article
1988 Volume 37 Issue 11 Pages 1084-1093
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSFor the purpose of safe and effective use of intravenous theophylline therapy, serum levels of theophylline were measured in 36 patients with status asthmatics. Volume of distribution was caluculated from the initial loading therapy. Theophylline clearance was also caluculated from the serum theophylline levels in continuous infusion on steady state. Relationship between adverse effect and serum levels of theophylline was examined during the intravenous theophylline therapy. Volume of distribution was 0.532±0.142L/kg. Theophylline clearance in steady state was 0.0373±0.0175L/kg/hr and positive relationship was obseved between thephylline clearance and age of the patients. Number of adverse effects such as cardiovascular and/or central nervous system was often observed as the concentration of serum theophylline was increased. From our data a loading dose of 7.5mg/kg/30 min (aminophylline)was recommanded as an initial loading therapy. In continuous intravenous theophylline therapy a dose of(125-age)×10mg/kg/hr was recommanded to get the median effective serum concentration. However in clinical practice, we should pay great attention to the serum theophylline concentration especially in intractable asthma, because a lot of conditions and factors alter the theophylline cearance.View full abstractDownload PDF (1028K) -
Hiroshi Takenaka, Hitoshi Shoji, Fumikazu Mizukoshi, Taeko Kushumi, Ta ...Article type: Article
1988 Volume 37 Issue 11 Pages 1094-1100
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the effect of AA-673 on antigen-induced histamine release from peripheral blood leukocytes in 14 patients with allergic rhinitis. We measured histamine release in vitro and histamine release together with the plasma level of AA-673 during two-week oral administration of AA-673, and evaluated its clinical effects. AA-673 inhibited histamine release dose-dependently in vitro at concentrations from 10^<-6> to 10^<-4>M, while the administration of the compound, for two weeks at a dose of 150 mg/day had no significant effect on in vitro histamine release. After two-week administration of AA-673 at 150 mg/day, patients who exhibited a moderate or marked improvement showed higher plasma level of AA-673 than did those who exhibited a slight improvement or no change.View full abstractDownload PDF (826K) -
Kanata Miyakawa, Yoshio Hirai, Junko Miyakawa, Tomomi Sugiyama, Taira ...Article type: Article
1988 Volume 37 Issue 11 Pages 1101-1110
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDiagnostic criteria, clinical severity, IgE-RAST score and serum IgE value were statitically analysed in the 1006 patients of atopic dermatitis(AD)with typical and atypical eruptions. The results are as follows:1)Definite AD who were diagnosed by the presence of 4 items, such as itching, clinical course of more than one year, atopic history, and typical eruption, was 44.8%(451/1006)of patients examined. The other patients(552/1006;55.2%)were considered as indefinite AD. The statistical analysis indicated that especially the presence of typical eruption among the 4 items was most essential for diagnosing a patient to be AD. 2)The severity, RAST-positivity and serum IgE values of the definite AD patients were significantly higher than those of the other groups(indefinite AD patients). Among the definite AD patients, the RAST-positivity of the food antigens, such as rice, egg white, and so on, was very high in the severe patients but low in the mild patients. 3)Each RAST-posibivity of many antigens increased in correspondence with the clinical severity of AD. But the RAST-posibivity of the food antigens, especially of rice antigen increased more remarkably than that of the inhalant antigens, such as mite or house dust. 4)A statistical analysis of correlationship among the RAST scores of the several inhalant and food antigens revealed a strong correlation(r=0.9248)between DF(Dermatophagoides farinae)and HD1, and relatively strong correlations(r=0.6437 to 0.7830)between egg white and milk, between soy bean and rice, between rice and wheat, and between wheat and soy bean. An analysis of multiple correlationship between the clinical severity(from 1 to 3)and each RAST score of the DF, egg white, and rice suggested a strong contiribution of the rice to the severity. From the results above mentioned, a probable involvement of the food antigens, especially of rice antigen, in the development of severe AD was discussed in comparison with that of the inhalant antigens such as mite and house dust.View full abstractDownload PDF (1191K) -
Fumihiko Imai, Teruhiko Suzuki, Toshiko Ishibashi, Toshiro Katagiri, K ...Article type: Article
1988 Volume 37 Issue 11 Pages 1111-1117
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDendritic cells(DC) successfully obtained from the peripheral blood of systemic lupus erythematosus(SLE) patients were investigated for cluster formation by co-culture with autologous T cells. DC from SLE had the ability to form clusters. However, proliferative response of SLE clusters was found at significantly low levels compared with normal clusters as assessed by ^3H-thymidine incorporation(p%lt;0.01). A similar result was obtained in further experiments using secondary culture of isolated clusters. Supernatants of cluster cultures contained a factor to drive SAC-stimulated B cells into antibody secreting cells, but supernatants of SLE clusters contained less of this factor than normal clusters(p<0.001). No significant augmentation was observed by pretreating DC from SLE with interleukin-1(IL-1)in contrast to DC from normal volunteers. These results might suggest that an abnormality was present in SLE clusters.View full abstractDownload PDF (972K) -
Article type: Appendix
1988 Volume 37 Issue 11 Pages 1118-1121
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (278K) -
Article type: Cover
1988 Volume 37 Issue 11 Pages Cover8-
Published: November 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (123K)
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