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Volume 37, Issue 2
Displaying 1-14 of 14 articles from this issue
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Article type: Cover
1988 Volume 37 Issue 2 Pages Cover12-
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (86K) -
Article type: Cover
1988 Volume 37 Issue 2 Pages Cover13-
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (86K) -
Article type: Appendix
1988 Volume 37 Issue 2 Pages App4-
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1988 Volume 37 Issue 2 Pages App5-
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (218K) -
Kunihiro Namba, Kiyoshi Takahashi, Sinya Tada, Kazuki Simizu, Kenichi ...Article type: Article
1988 Volume 37 Issue 2 Pages 67-74
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo elucidate the mechanism of late asthmatic response (LAR), which is related to intractable asthmatic attacks, cellular and humoral components of LAR were examined by bronchoalveolar lavage fluid(BALF)obtained after bronchial inhalation test with house dust allergen. BAL examination was carried out at 2 hours after remission of LAR, and differential cell counts and measurements of leukotrienes(LTs)in BALF and peripheral blood were investigated by high performance liquid chromatography. An increase in the percentage of neutrophils, eosinophils, basophil-mast cells was evident in BALF after LAR compared with the level in the non-attack state or after IAR. The level of LTC_4 was significantly higher in BALF after LAR(p<0.05), and LTB_4 was also dominant at LAR. However LTD_4 was only detectable in BALF after LAR in a few cases. On the other hand, the percentage of neutrophils and the LTB_4 level in circulating blood showed a peak before LAR, and then decreased markedly during LAR. These results suggest that neutrophils, eosinophils, and basophil-mast cells may release leukotriene-dominant chemical mediators which provoke asthmatic attack in the late phase following the inhalation of allergens.View full abstractDownload PDF (904K) -
Jun TakedaArticle type: Article
1988 Volume 37 Issue 2 Pages 75-85
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis study was undertaken to clarify the time-sequential changes in respiratory resistance durings the inhalation of cold air, and the relationship between bronchial hyperresponsiveness and inhalation of cold air. Respiratory resistance was continuously monitored in 23 patients with chronic obstructive pulmonary disease(COPD)and 5 healthy subjects with no history of cardiopulmonary disease(normal)by a novel system developed to test the effect of cold air inhalation under otherwise physiological conditions. Bronchial hyperresponsiveness to methacholine was also measured by astograph, and the relationship between bronchial hyperresponsiveness to methacholine and the increase in respiratory resistance induced by the inhalation of cold air was examined. Respiratory resistance increased significantly after the inhalation of cold air in the COPD group. All patients in the COPD group showed changes which could be divided into three categories: a gradual increase upon inhalation of cold air, a rapid increase with a gradual decrease thereafter, and a rapid increase with few subsequent changes. The normal group showed few changes. The degree of increase in respiratory resistance induced by the inhalation of cold air was correlated with bronchial sensitivity to methacholine in the COPD group(r=0.768, p<0.01). It was suggested that bronchial responsiveness to the inhalation of cold air was useful from the clinical point of view as a parameter of bronchial hyperresponsiveness.View full abstractDownload PDF (1128K) -
Yoichi Hatano, Akiyoshi Konno, Kiyoshi Togawa, Kazuki MiuraArticle type: Article
1988 Volume 37 Issue 2 Pages 86-93
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEnzyme-linked immunosorbent assay(ELISA)was used to measure specific IgG, IgA and IgM antibody titers to mite(Dermatophagoides farinae)in sera from patients with allergic rhinitis and normal individuals. These antibody titers were also measured by ELISA in nasal secretions from patients with allergic rhinitis. IgG and IgA antibody titers to mite in sera were significantly higher in patients with allergic rhinitis than in normal controls. A significant correlation was observed between IgG and IgA antibody titers to mite in sera from allergic patients. When the immunoglobulins were quantified, IgG antibody was found to be dominant in sera and IgA antibody in nasal secretions. A significant correlation was observed between the IgG antibody titers in sera and in nasal secretions. The same tendency was obtained for IgM antibody. This could be due to plasma transudation caused by nasal allergen challenge. On the other hand, no significant correlation concerning IgA antibody titers was observed between sera and nasal secretions. This result could reflect abundant IgA antibody in nasal secretions which had been produced locally prior to nasal allergen challenge. Thus, it is deemed that IgA antibody, as the main antibody in nasal secretion, might play an important role when allergens enter the nasal mucosa.View full abstractDownload PDF (1013K) -
Chung-Liang Chao, Munehiko Ishii, Hideya Iijima, Kohei Yamauchi, Gen T ...Article type: Article
1988 Volume 37 Issue 2 Pages 94-98
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo clarify antigen-specific antibody fluctuation in an animal model of late phase bronchoconstriction responses to ascaris challenge, we used the double immunodiffusion method to measure antigen-specific precipitating antibody titers and adopted Reverse Hemolytic Plaque Assay to count antigen-specific IgE and IgG secreting lymphoid cells from guinea pigs sensitized with this allergen. All the tests revealed that the maximum specific IgG and IgE responses occurred after the second booster injection. These findings are coincidental with the occurrence frequencies of the late pulmonary responses in this animal model. The mean of precipitating antibody titers in the responder group was significantly higher than that of the nonresponder group whereas there was only a weak correlation between the antibody titers and the bronchoconstriction responses among the members of the responder group. These immunological findings suggest that specific antibodies may play an important role in the late pulmonary response.View full abstractDownload PDF (665K) -
Noriki NagaoArticle type: Article
1988 Volume 37 Issue 2 Pages 99-106
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSToluene diisocyanate(TDI), used as a material in the manufacture of polyurethane foam, is known as a sensitizer for the respiratory tract. I have reported previously that TDI-specific IgG antibody has been detected in the serum from a TDI skin-sensitized mouse. In this study, I investiagted the relationship between the changes in the increase rate in ear thickness, the changes in TDI-specific IgG antibody production, and TDI concentration applied to the skin of the back. Crossreactivities between anti TDI-HSA rabbit serum and the other isocyanate conjugated antigens were tested. In addition, the TDI conjugated area at the skin was studied by the immunochemical method. The results were as follows: 1. Contact hypersensitivity was observed on application of a 0.1% TDI. There were no significant differences in the rate of increase in ear thickness after challenge among any of the TDI concentration groups: 1%, 2%, 4% and 5%. 2. TDI-specific IgG antibody wasn't detected in any of the serum samples from the mice applied with a 0.1% TDI solution. By contrast, the mean of TDI-specific IgG antibody titers increased linearly following application of 1% to 5% TDI solution. 3. Anti TDI-HSA rabbit serum was observed to crossreact with p-TMI-HSA, MDI-HSA and HSA. The antiserum strongly reacted with p-TMI-HSA. 4. A positive immunoreaction with anti TDI-HSA rabbit serum was observed not only in the epidermis but also in the dermis. 5. TDI-conjugatd albumin was extracted from the water soluble proteins of the mouse skin applied with TDI by immuno-affinity chromatography.View full abstractDownload PDF (1456K) -
Shuji OhonoArticle type: Article
1988 Volume 37 Issue 2 Pages 107-114
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effects of a traditional Chinese medicine, "Hochuekki-to", on natural killer(NK)-activity in human peripheral blood lymphocytes was investigated in 35 patients with rheumatoid arthritis, Sjogren's syndrome or bacterial infection. In clinical tests, NK activity was statistically elevated from 24.6±13.7% to 30.4±14.4% upon administration of Hochuekki-to for 2 to 4 weeks(p<0.05). Eight of the 35 patients showed improvement in clinical symptoms. In these patients, NK activity was markedly augmented from 19.6±9.6% to 38.2±15.4% through administration of the drug. Fourteen patients with low NK activity(<20%) also demonstrated a marked increase in NK activity (p<0.01) upon administration of Hochuekki-to. On the other hand, 21 patients with high NK activity(>20%)showed a slight decrease in NK activity. Furthermore, an investigation was made into whether Hochuekki-to directly affects NK cells. In vitro treatment of human peripheral blood lymphocytes for 48 hr with 50-500μg/ml concentration of Hochuekki-to resulted in a definite increase in NK activity. In human peripheral blood lymphocytes treated with OKT4(CD4)or OKT(CD8), NK activity was also slightly augmented by culturing for 18 hr with a medium which included Hochuekki-to(200μg/ml). In human peripheral blood lymphocytes which showed high NK activity, however, Hochuekki-to appeared to suppress the NK activity. These data suggest that Hochuekki-to directly affects NK activity in a biphasic manner in vivo and in vitro.View full abstractDownload PDF (888K) -
Takashi Hiraizumi, Hiroaki Nakajima, Naotaka Kashima, Kazuo Kobayashi, ...Article type: Article
1988 Volume 37 Issue 2 Pages 115-120
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe clinical application of autologous blood injection therapy was performed in 26 patients with chronic urticaria. To explore the effectiveness of the therapy in urticaria patients, threshold levels to either the antigens or compound 48/80 as a nonspecific stimulant were studied in 36 patients before and after the therapy. The therapy produced beneficial results in 21 out of 26 patients with chronic urticaria. Elevated threshold levels after autologous blood injection were observed in 6 out of 19 cases in which skin test was performed by antigens and in 5 out of 17 cases in which skin test was done by compound 48/80. In addition more than 50% reduction of wheal was observed in 12 out of 19 cases in which wheal was developed by antigens and in 9 out of 17 cases in which wheal was developed by compound 48/80. The results suggest that autologous blood injection therapy may inhibit the skin reaction induced by either specific or nonspecific irritants. The therapy may, therefore, be effective for patients with urticaria.View full abstractDownload PDF (691K) -
Article type: Appendix
1988 Volume 37 Issue 2 Pages 121-
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1988 Volume 37 Issue 2 Pages 122-124
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (286K) -
Article type: Cover
1988 Volume 37 Issue 2 Pages Cover14-
Published: February 28, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (209K)
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