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Volume 37, Issue 7
Displaying 1-15 of 15 articles from this issue
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Article type: Cover
1988 Volume 37 Issue 7 Pages Cover27-
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (88K) -
Article type: Cover
1988 Volume 37 Issue 7 Pages Cover28-
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (88K) -
Article type: Appendix
1988 Volume 37 Issue 7 Pages App11-
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1988 Volume 37 Issue 7 Pages 397-403
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
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Yuichi Adachi, Masako Sawai, Yohko Saeki, Masatomo Matsuno, Gyokei Mur ...Article type: Article
1988 Volume 37 Issue 7 Pages 404-410
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn order to examine the changes in bronchial hypersensitivety in preschool children with bronchial asthma, thirty two asthmatics were evaluated by histamine inhalation test for two or three years. We used a previously reported method for examining bronchial hypersensitivity: measuring the transcutaneous oxygen pressure. Although there was no relation between respitatory threshold to histamine(RT-Hist) and the severity of asthma in the first test, the geometric mean of RT-Hist in the severe group was lower than the geometric means in the remission, mild and moderate groups in the last test(p<0.01, p<0.05), respectively. In patients aged four to six years old there was no relation between RT-Hist and the severity of asthma, but the geometric mean in RT-Hist in the severe group was lower than the geometric means in the remission and the mild groups(p<0.01, p<0.05) and that of the moderate group was lower than that of the remission group(p<0.05) in patients aged seven to nine years old. Although there was no relation between the changes of RT-Hist in the remission and the improved groups, RT-Hist was significantly decreasd in the deteriorated group(p<0.01). The subjects in the remission and the improved groups were divided into three subgroups as follows; A)those whose RT-Hist did not change from a level of 1250μg/ml or higher, B)those whose RT-Hist did not change from a level of 625μg/ml or lower, C)those whose RT-Hist increased. In group B, there were more subjects who had a family history or asthma than in the other groups(p<0.05).View full abstractDownload PDF (770K) -
Makoto HoshinoArticle type: Article
1988 Volume 37 Issue 7 Pages 411-418
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBronchialasthma patients were divided into two groups according to the presence(A-group)or absence(N-A group) of allergic predispotion, and each subject's asthma was classified by clinical severity. In order to discriminate between these two types of asthma, in light of clinical severity, we investigated (i)movement of ventilation during asthma attack, and (ii)the relationships among ventilatory parameters. That is, after pulmonary function tests were carried out, we measured bronchial severity(Dmin) and bronchial reactivity(sGrs) by the astograph method; made breath-by-breath expiratory gas analysis by mass spectrometry; and measured arterial oxygen saturation(SaO_2) and local perfusion by oximeter. The results obtained were as follows: 1)In the N-A group, asthmatic patients having severe symptoms tended to show lower FEV_<1.0>% than did those with milder symptoms. FEV_<1.0>% was lower in the moderate N-A group than in the corresponding A group. 2)There were no significant differences in Dmin and sGrs between the two types of asthmatic patients. The severest asthmatics in both groups clinically presented lower Dmin. 3)V_T, V_A and SaO_2 were all reduced during bronchoconstriction, although V_D/V_T was elevated. This tendency was more remarkable in the N-A group than in the A group, and showed a correlation to the clinical severity of asthma. 4)It was possible to discriminate between the two types of asthma by principal component analysis(82.1%). The main factors were alveolar ventilation volume and airway hypersensitivity. The clinical severity of asthma corresponds to the degree of alteration of alveolar ventilation.View full abstractDownload PDF (949K) -
Yasuhei Odajima, Toshio Kastunuma, Akira Akazawa, Tomomi Kondou, Kenic ...Article type: Article
1988 Volume 37 Issue 7 Pages 419-426
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEgg white, milk, soy-bean and Dermatophagoides farinae(Df)-specific IgG and IgE antibodies in 1012 allergic children, 286 normal mothers and their neonates were measured. Age related changes in allergen-specific IgG and IgE were examined, as were age-related also changes in IgE RIST. According to age, positive egg-white, milk and soy-specific IgG antibodies in allergic patients without marked skin lesions declined over 8 years. However, egg-white, milk and soy bean-specific IgG antibodies in patients with marked skin lesions showed high-percentage of positivity compared with patients without skin lesions, milk-specific and Df-specific IgG antibodies showed high percentage of positivity percent in naonates and milk-specific IgG antibodies showed high percentage positivity in infancy. The positive rate of milk-specific IgG antibodies increased in child patients with skin lesions. These results suggest that milk-specific IgG antibodies must be taken in to consideration as a factor in the transmission of atopic diseases between generations. According to age, percentage of egg-white, milk specific IgE antibodies were declined. Egg-white, milk specific IgE antibodies in patients with marked skin lesions showed high percentage of positivity compared with patients without skin lesions. IgE RIST were increasing accoding to age, and IgE RIST in patients with skin lesions showed high compared with patients without skin lesions.View full abstractDownload PDF (919K) -
Hitoshi Matsuoka, Hisamitsu Uno, Kiyohide Kawano, Kazunori Tsuda, Haru ...Article type: Article
1988 Volume 37 Issue 7 Pages 427-437
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe immune responses to Dermatophagoides pteronyssinus(Dp) were studied to elucidate the immunological mechanism involved in the pathogenesis of mite related bronchial asthma. The allergenic fraction Dp2 was isolated from Dp body, and its molecular weight was estimated as approximately 15,000. Dp specific IgE in pooled sera from Dp-related asthmatics was almost completely absorbed with Dp2, indicating that Dp2 was a major allergen of Dp body. The positive ratios of Dp2 specific IgE and IgG antibodies were 71.1% and 53.9% in the sera from asthmatics, and 0% and 21.0% in the sera from non-asthmatics, respectively. The frequency distributions of specific IgE antibody titers were different from those of specific IgG titers in asthmatics and non-asthmatics, suggesting that production of specific IgE and IgG antibodies might be controlled by separate mechanisms. High response of Dp2-induced peripheral blood lymphocyte proliferation was observed only in asthmatics. The lymphocytes responding to Dp2 were CD4 positive cells, and this response was specific to Dp2. The stimulation index of Dp2-induced lymphocyte proliferative response did not correlate with the values of serum specific IgE or IgG antibody titers in asthmatics. The frequencies of HLA-All and HLA-Bw61 in asthmatics with high specific IgE titers were slightly increased compared with those in non-asthmatics. The frequency of HLA-Bw62 in asthmatics with high lymphocyte response was significantly increased compared with that in non-asthmatics(p<0.05). The production of Dp2-specific IgE antibody in vivo seemed to be controlled by different T-cell subsets which proliferated to Dp2 in vitro, since there was no correlation between the titer of Dp2 specific IgE in the sera and the grade of lymphocyte proliferation in vitro, and furthermore no concordance of the associated HLA class I antigens between them.View full abstractDownload PDF (1315K) -
Toshio Kawashima, Hisao Tomioka, Sho YoshidaArticle type: Article
1988 Volume 37 Issue 7 Pages 438-447
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effect of a new anti-allergic agent, 9-methy1-3-(1H-tetrazol-5-y1)-4H-pyrido [1, 2-a] pyrimidin-4-one potassium salt(TBX) on the release of chemical mediators from human leukocytes and lung fragments was examined. TBX dose-dependently inhibited antigen-induced histamine release from the peripheral leukocytes of patients with mite-sensitive asthma at a concentration of 1×10^<-4>M or higher and the maximum inhibitory rate was 74.9% at 1×10^<-2>M. Anti-human lgE antibody-induced histamine and SRS-A release from the human lung fragments sensitized passively with human IgE myeloma protein were inhibited dose-dependently at a concentration of 1×10^<-6>M or higher and the maximum inhibitory rate was 50.1% at 1×10^<-2>M and 74.0% at 1×10^<-3>M. TBX also dose-dependently inhibited histamine and SRS-A release from the lung fragments of guinea pigs sensitized passively or actively. On the other hand, disodium cromoglycate(DSCG) did not inhibit the release of these chemical mediators. This result suggests that TBX has a different anti-allergic activity from DSCG.View full abstractDownload PDF (1094K) -
Hiroshi Kaneshige, Hajime Suzuki, Hajime Takagi, Takanori Akisawa, Mic ...Article type: Article
1988 Volume 37 Issue 7 Pages 448-453
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSalbutamol spray was administered with a metered dose inhaler to asthma patients and it's effects on oral cavities were investigated. 17 patients were divided into three groups(Salbutamol spray administered to 1.oral cavity, 2.bronchus, and 3.oral vavity and bronchus). Salbutamol was administered as two puffs(200μg) of a metered dose inhalation. FEV_<1.0>, respiratory resistance(Rrs) and serum cyclic nucleotides were evaluated before and after 15, 30, 60 nad 120 minutes. Administration of salbutamol to oral cavities achieved signicant changes in FEV_<1.0>, Rrs and cyclic AMP. There were no significant increases in blood pressure or pulse rate. The absorption of salbutamol by oral cavities after metered dose inhalation contributed more than expected to dilatation of the bronchus.View full abstractDownload PDF (660K) -
Tomoyo MatsubaraArticle type: Article
1988 Volume 37 Issue 7 Pages 454-460
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe analysed the populations of peripheral blood monocyte/macrophages in 56 patients using a fluorescence-activated cell sorter, and investigated the possibility in 44 patients that tumor necrosis factor(TNF) might be detectable in serum during the acute phase of Kawasaki disease. Serum TNF levels were measured by an enzyme-linked immunosorbent assay using monoclonal antibodies to react against recombinant TNF. The percentage of peripheral blood monocyte/macrophages among mononuclear cells and serum TNF levels were both seen to increase during the acute phase of the illness, in patients with Kawasaki disease. The percentages of peripheral blood monocyte/macrophages among mononuclear cells in Kawasaki disease patients with coronary involvement, were higher than in patients without coronary involvement. Likewise, the percentage of TNF positive cases in Kawasaki disease patients with coronary involvement, was higher than in patients without coronary involvement. In addition, the increased serum TNF levels correlated with the percentage of peripheral blood monocyte/macrophages among mononuclear cells. Serum TNF levels were not increased in patients with measles, or streptococcal infection, who were examined as infectious disease controls. These results suggest the possibility that immunological activation, accompanied by the secretion of TNF from monocyte/macrophages, is an important predisposing condition for the exacerbation of vascular damage in Kawasaki disease involving coronary lesions.View full abstractDownload PDF (805K) -
Terhiko Suzuki, Fumihiko Imai, Toshiko Ishibashi, Toshiro KatagiriArticle type: Article
1988 Volume 37 Issue 7 Pages 461-464
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAdherent cells in mononuclear cells from peripheral blood were divided into macrophages and dendritic cells(DC) in order to study accessory cell(AC) activity in the concanavalin A(Con A) response of T cells. In the presence of Con A at an optimal concentration(5 μg/ml), the addition of DC as the AC significantly enhanced the T cell response(p<0.01), whereas the addition of macrophages as the AC induced no significant variation. In the presence of Con A at a suboptimal concentration(1-0.1μg/ml), the following results were obtained. In the absence of AC, the T cell response remained low. In the presence of DC as the AC at various concentrations, the response changed dose-dependently. The addition of a massive amount of macrophages as the AC induced an extremely weak response. These results suggest that DC have much potent AC activity.View full abstractDownload PDF (464K) -
Article type: Appendix
1988 Volume 37 Issue 7 Pages 465-
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1988 Volume 37 Issue 7 Pages 466-468
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (278K) -
Article type: Cover
1988 Volume 37 Issue 7 Pages 470-
Published: July 30, 1988
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (238K)
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