Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 38, Issue 10
Displaying 1-18 of 18 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1989 Volume 38 Issue 10 Pages Cover1-
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.Cover1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1989 Volume 38 Issue 10 Pages App1-
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.App1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1129-1135
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1129
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  • IN VITRO DETECTION OF OVALBUMIN-SPECIFIC IgA PRODUCING CELLS FROM LYMPHOCYTES OF PATIENTS WITH HEN-EGG ALLERGY
    Koichi Yamaguchi, Minoru Baba, Tsuyoshi Noma, Junichi Yata
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1136-1141
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1136
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    We studied antigen-specific IgA production from the peripheral lymphocytes of children with hen-egg allergy by using the method of indirect plaque forming cell (PFC) assay. The number of OVA-specific IgA-PFC generated from the patient lymphocytes was low (6±3/7×10^4 non T cells) in comparison with age-matched normal children (112±18/7×10^4 non T cells). The numbers of OVA-specific IgG-PFC and IgM-PFC generated from the patient lymphocytes were not so different from those of the age-matched normal children. This indicates that the activity of OVA-specific IgA-antibody production was reduced in patients with hen-egg allergy.
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  • IMMUNOCHEMICAL QUANTIFICATION OF THE AIRBORNE MITE ALLERGENS
    Masatomo Matsuno, Masako Kayahara, Yohko Adachi, Yuichi Adachi, Gyokei ...
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1142-1149
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1142
    JOURNAL FREE ACCESS
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    We collected airborne particle from indoor air by using a high-volume air sampler, and measured mite allergens in the air-filter extract by use of RAST inhibition assay. The results obtained were as follows: 1) The assay revealed the presence of house dust mite allergen in the indoor air varying from 690 to 129000 pg/m^3. 2) In apartments, seasonal fluctuations of house dust mite allergen in the indoor air demonstrated a peak in autumn (September and October), and showed a tendency to increase in spring. In our outpatient clinic, the quantity of house dust mite allergen in the indoor air varied from 690 to 5670 pg/m^3, while there were few mites on the floor, and showed a tendency to increase in winter. 3) There was a significant correlation between the quantity of house dust mite allergen in the indoor air and the number of mite in house dust (r=0.535, p<0.01). 4) The amount of D.f. allergen in the indoor air was significantly decreased by using air cleaners (p<0.005). These results showed that the quantification of house dust mite allergen was useful from the clinical point of view as a parameter of mite pollution indoors, and it was important for asthmatics to live in clean environment, and to decrease the number of mites in house dust.
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  • ALLERGEN TESTS WITH MIDGE ALLERGENS IN MORIYAMA CITY, LOCATED ON THE SOUTH COAST OF LAKE BIWA
    Tsuneo Matsubara, Koji Ito, Terumasa Miyamoto, Toshiro Shibuya, Kiseko ...
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1150-1156
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1150
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    The main species of midge which emerge from the Lake Biwa, the biggest lake in Japan, are Tokunagayusurika akamusi (TA) and Chironomus pulmons. In order to determine how the existence of Lake Biwa affects the positivity to allergen tests with midge allergens, randomly selected asthmatic patients were examined by skin test and RAST. Out of 129 patients, 35 (27%) were positive to scratch tests with an extract of Chironomus yoshimatsui (CY). Out of 64 patients, 16 (25%) were positive to TA RAST and 12 (19%) were positive to CY RAST. The positive rate of skin tests was highest in the patients aged between 20 and 39. The positive rate of TA RAST was not significantly higher than the rates reported in other districts of Japan.
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  • COMPARISON OF A NEW SPECIFIC IgE ASSAY QUIDEL ALLERGY SCREEN TO SKIN PRICK TEST, INTRADERMAL TEST, AND RAST
    Itsuo Iwamoto, Hiroomi Yamazaki, Akira Kimura, Kenichi Ochiai, Makoto ...
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1157-1162
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1157
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    Quidel Allergy Screen (QAS), an enzyme-liked immunosorbent assay, has been developed for measuring IgE antibodies against 9 allergens (HD 1, HD 2, Mite 1, Mite 2, Japanese cedar, ragweed, cat dander, sweet vernal grass, and egg white) at the same time. To determine whether this assay is useful in screening allergen-specific IgE antibody, we compared the titers of IgE antibodies against the 9 allergens measured by QAS to those obtained in skin prick tests, in intradermal tests and by RAST in 93 atopic asthmatics and 25 normal subjects. We found a good agreement between the reactivity of skin prick tests and the reactivity of QAS. There was a significant correlation between the threshold doses of intradermal tests and the titers of QAS. We also found a good agreement between the reactivity of RAST and the reactivity of QAS, and a strong correlation between the titers of RAST and the titers of QAS. Thus, it is concluded that QAS is useful in screening IgE antiboeis against multiple allergens simultaneously.
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  • STUDY ON THE EFFECT OF DISODIUM CROMOGLYCATE (DSCG) ON ANTIGEN INDUCED IL-2 RESPONSIVENESS
    Kunio Ichikawa, Minoru Baba, Izumi Yoshizawa, Takeshi Noma
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1163-1168
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1163
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    We tested the effects of disodium cromoglycate (DSCG) on antigen-induced IL-2 responsiveness in lymphocytes from patients with atopic dermatitis and/or bronchial asthma. Patient lymphocytes pretreated with 5×10^3μg/ml DSCG for 24 or 48 hours failed to induce the responsiveness to IL-2 on stimulation with Dermatophagoides farinae (Df) or ovalbumin (OVA) antigen. DSCG-treated adherent cells were blocked to present the antigen to nonadherent responding cells for induction of IL-2 responsiveness. In contrast, DSCG-treated non-adherent cells, recombined with antigen-activated adherent cells, acquired IL-2 responsiveness. However Con A-activated lymphocytes from the same patients were not affected by the same treatment. The results indicate that DSCG is capable of suppressing antigen-induced IL-2 responsiveness but not the response induced by mitogen such as Con A.
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  • CELLULAR IMMUNOREGULATION IN ATOPIC DERMATITIS : Hyperreponsiveness to Interleukin-4 and Hyporesponsiveness to Interleukin-2
    Mamitaroh Ohtsuki, Fuyuki Ogata, Masutaka Furue, Yasumasa Ishibashi
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1169-1172
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1169
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    We examined the responsiveness to Interleukin-4 (IL-4) and Interleukin-2 (IL-2) of peripheral blood lymphocytes from patients with atopic dermatitis (AD) and non-AD controls. The IL-4 responsiveness of the AD patients was found to be higher than that of the non-AD controls. In contrast, the IL-2 responsivenes of the AD patients was relatively lower than that of the non-AD controls. When IL-4/IL-2 responsiveness ratio was compared, the IL-4/IL-2 responsiveness ratio of the AD patients (54.1±18.5) was significantly higher than that of the non-AD controls (24.8±9.9, p<0.001). The high IL-4/IL-2 responsiveness ratio found in the AD patients may possibily be related to the pathogenesis of AD.
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  • CLINICAL STUDY OF ALLERGIC GRANULOMATOUS ANGITIS (AGA) WITH ACCOMPANYING GASTROINTESTINAL PERFORATIONS : Our Case and Other Cases in Japanese Literature
    Yoshimasa Kin, Kiyoshi Hoshino, Yutaka Mizushima, Hiromi Kato, Takashi ...
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1173-1179
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1173
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    We present here the case of a patient with allergic granulomatous angitis (AGA) who had two small intestine perforations in a short interval, and we reviewed 11 cases, including our own, of AGA with accompanying gastrointestinal perforations reported so far in Japan. Our case was a twenty-three yeat old man who had been treated with steroid hormone in an outpatient clinic. He re-entered our hospital complaining of severe abdominal pain. At first admission, there had been no evidence of parasite disease, and this time, we found severe duodenal erosion on upper gastrointestinal endoscopy. Abdominal angiography revealed stenotic and tapering changes probably due to angitis in both the superior and inferior mesenteric arteries. Steroid pulse theapy was not effective in reducing the severity of abdiminal pain, but the administration of a large amount of PGE_1 was very effective. In spite of the therapy, the patient had small intestine perforations on his 27th day in hospital and two months thereafter, and was operated on twice. The death rate in AGA patients with accompanying gastrointestinal peforations is relatively high in our country, and 2 out of 11 cases had recurrent perforations. Therefore, it is considered essential to pay great attention to abdominal manifestations in AGA patients.
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  • THE INHIBITORY EFFECT OF OXATOMIDE, AN ANTI-ALLERGIC AGENT, ON EOSINOPHIL-MEDIATED AND EOSINOPHILIC CELL LINE-MEDIATED NATURAL CYTOTOXICITY AGAINST BRONCHIAL EPITHELIAL CELLS
    Junichi Chihara, Renzo Sugihara, Hirokazu Kubo, Takahiro Yamamoto, Nao ...
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1180-1184
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1180
    JOURNAL FREE ACCESS
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    Recently, eosinophils have been implicated as inflammatory effector cells in allergic and inflammatory reactions such as bronchial asthma. In this study eosinophil-mediated and eosinophilic cell line-mediated natural cytotoxicity against bronchial epithelial cells and the effects of oxatomide, an anti-allergic agent, on their cytotoxicity were investigated. Treatment with oxatomide diminished both eosinophil-mediated and eosinophilic cell line-mediated natural cytotoxicity in vitro. We concluded from these results that oxatomide not only has anti-allergic activity but also anti-inflammatory properites for eosinophils. In addition this method for isolating eosinophills seems to well serve the purpose of evaluating eosinophil function as in this investigation, as we have reported previously.
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1185-1186
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1185
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1989 Volume 38 Issue 10 Pages 1187-1188
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1187
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  • [title in Japanese]
    Article type: Appendix
    1989 Volume 38 Issue 10 Pages 1189-1196
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1189
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  • [title in Japanese]
    Article type: Appendix
    1989 Volume 38 Issue 10 Pages 1197-
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1197
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  • [title in Japanese]
    Article type: Appendix
    1989 Volume 38 Issue 10 Pages 1198-
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1198
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1989 Volume 38 Issue 10 Pages 1199-1201
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.1199
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1989 Volume 38 Issue 10 Pages Cover2-
    Published: October 30, 1989
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.38.Cover2
    JOURNAL FREE ACCESS
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