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Volume 39, Issue 1
Displaying 1-15 of 15 articles from this issue
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Article type: Cover
1990 Volume 39 Issue 1 Pages Cover1-
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (314K) -
Article type: Cover
1990 Volume 39 Issue 1 Pages Cover2-
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (314K) -
Article type: Cover
1990 Volume 39 Issue 1 Pages Cover3-
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
[in Japanese]Article type: Article
1990 Volume 39 Issue 1 Pages 1-5
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (681K) -
Itsuo Iwamoto, Akira Kimura, Makoto Tanaka, Hisao Tomioka, Sho YoshidaArticle type: Article
1990 Volume 39 Issue 1 Pages 6-11
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSubstance P (SP) is believed to be a major mediator of neurogeneic inflammation. To determine whether the skin reactivity of SP is increased in asthmatics, we examined the reactivity to intradermal injections of SP, the C-terminal and N-terminal peptides SP_<6-11> and SP_<1-9>, respectively, and neurokinin A(10^<-7>-10^<-5>M) in 12 asthmatics and 9 normal subjects. SP and the N-terminal peptide SP_<1-9> indeuced both erythemas and wheals in asthmatics and in normal subjects, whereas the C-terminal peptide SP_<6-11> and neurokinin A primarily induced only wheals in both groups. SP induced greater erythemas and wheals in asthmatics than in normal subjects. SP_<1-9> also induced greater erythemas and wheals in asthmatics than in normal subjects. However, the wheals induced by SP_<6-11> or neurokinin A were not significantly different in either group. Therefore, the increased skin reactivity to SP was the N-terminal peptide dependent, which has been shown to be able to activate skin mast cells. We conclude that the skin reactivity to SP is increased in asthmatics, possibly through the increased reactivity of skin mast cells.View full abstractDownload PDF (631K) -
Susumu NakamuraArticle type: Article
1990 Volume 39 Issue 1 Pages 12-20
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn this report are stated the results of an investigation on the long-term prognosis of occupational asthma, recently sending out enquetes to 28 patients with occupational asthma of various kinds who had been treated and observed in our allergy clinic these 22 years. This study is limited to 17 cases, because 4 questionnaires were not returned, 6 were sent back unopened for the reason that present address was unknown and one patient died in an accident. Eight of the patients were able to avoid exposure to allergens by changing their occupation or work place. The prognosis for there cases were quite favourable, except in one patient with double sensitization to house dust. Of the nine patients who were obliged to continue work in which they were exposed to occupational allergens, two of them benefitted from a change of the materials they used in their work to new ones free from antigenicity. However, for the rest, allergic symptoms continued with their severity for ages in inverse proportion to the the degree of effective countermeasures taken against the allergens. Accordingly, the author would assert that effective measures to improve working conditions and protect workers must be taken as soon as possible.View full abstractDownload PDF (1211K) -
Hideaki Yamamoto, Makoto Nagata, Kazuaki Tabe, Shinobu Suzuki, Hitoshi ...Article type: Article
1990 Volume 39 Issue 1 Pages 21-27
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe examined the inhibitory effect of the long-acting β-adrenergic agonists, mabuterol, clenbuterol and fenoterol on"morning dipping" in ten patients with nocturnal asthma. On the first night, as a control experiment, the subjects received no β-adrenergic agonist. On the succeding three nights at 8:00 PM, each subject was orally administered 50 μg of mabuterol, 40 μg of clenbuterol and 5 mg of fenoterol in a randomized, crossover fashion. Pulmonary function tests(FVC, FEV_<1.0>, PEFR, V_<50> and V_<25>) were performed at 8:00 PM(just before administration of β-adrenergic agonist), 9:00 PM, 10:00 PM, 6:00 AM and 8:00 AM. On the nigh when clenbuterol was administered, there was a significant inhibition of morning dipping at 6:00 AM in FVC(<0.01), FEV_<1.0>(<0.01), PEFR(<0.01), V_<50>(<0.01)and V_<25>(<0.05)compared with the control night. On the nights when mabuterol and fenoterol were administered, there was a significant inhibition of morning dipping at 6:00 AM in FVC(<0.01)and FEV_<1.0>(<0.01)compared with the control night. Palpitations associated with clenbuterol administration were seen in two subjects. The effect of each β-adrenergic agonist varied inconsistently among the subjects. These results indicate that clenbuterol is the most effective in inhibiting morning dipping among the long-acting β-adrenergic agonists examined, but individualization in the choice of β-adrenergic agonist is mandatory in order to achieve the maximum effect.View full abstractDownload PDF (734K) -
Seiko Shigeta, Yoshimi Takao, kazuhisa Ono, Satoru Oka, Toshihiko JyoArticle type: Article
1990 Volume 39 Issue 1 Pages 28-35
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAmong three glycoproteins, DIIIa, Ei-M, and Gi-rep, isolated from sea squirt as antigens capable of eliciting skin reaction specific to sea squirt allergy, only DIIIa induces asthmatic attack and conjunctival reaction, whereas Ei-M and Gi-rep do not. Periodate oxidation eliminated not only the conjunctival allergenicity but also the skin allergenicity from DIIIa, suggesting that the conjunctival and skin allergenicities could both be ascribed to the epitope residing in the carbohydrate chains of DIIIa. On the other hand, proteolysis with Pronase E and chemical modifications of the carboxyl or amino groups by various methods eliminated the conjunctival allergenicity from DIIIa, whereas the skin allergenicity was still retained. Therefore, the expression of conjunctival reaction was expected to be supported by a relatively small structural factor residing in the protein moiety of DIIIa, which we have tentatively designated as conjunctival allergenicity-supporting factor(CASF). CASF might contribute to the permeability of the antigen into mucosa, enabling the carbohydrate epitope to interact with the allergy-specific IgE distributed in conjunctiva and bronchia. In specificity analysis of a rabbit anti-DIIIA serum, a periodate oxidation-and acid-stable but heat-and alkali-unstable epitope(type γ)in the protein moiety of DIIIa was also characterized as a useful marker of the antigen. However, the type γ epitope was apparently independent of CASF that was substantially stable to alkali and heat.View full abstractDownload PDF (918K) -
Masashi MizobeArticle type: Article
1990 Volume 39 Issue 1 Pages 36-41
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe role of alpha-adrenoceptors in asthma is still unclear. However, several studies have shown bronchodilatation after single doses of different alpha-adrenoceptor antagonists in patient's with asthma. The clinical efficacy of midaglizole, a new selective α_2 blocker was demonstrated by a more recent investigation. The present investigation was carried out to examine the effects of midaglizole on isolated airway smooth muscle obtained from humans and guinea pigs. Human bronchial smooth muscle was relaxed in a dose-dependent manner by midaglizole. EC_<50>, molar concentration of midaglizole required to produce 50% reversal of carbachol-induced pre-contraction was(6.0±0.19)×10^<-5>M. Isoproterenol(5×10^<-10>M)and midaglizole(3×10^<-5>M)produced 30.0±9.5% and 40.8±7.0% of maximal relaxation, respectively. However, they produced almost 100% of maximal relaxation when used together. Isoproterenol, in combination with midaglizole, was associated with a significant increase of human bronchial relaxation as compared to either of the drugs singly. The same findings were obtained when the drugs were used on the guinea pig trachea. Midaglizole had no effect on the binding of the radiolabeled β adrenergic antagonist[^3H]dihydroalprenolol to particulates prepared from the lung. Propranolol did not inhibit the relaxant effect of midaglizole on airway smooth muscle. These results suggest that midaglizole may be effective for the treatment of asthma.View full abstractDownload PDF (759K) -
Isao Ohno, Yasuo Tanno, Tamotsu Takishima, Shiroh IdaArticle type: Article
1990 Volume 39 Issue 1 Pages 42-47
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo confirm the existence and investigate the biological significance of IgE virus-specific antibodies, we studied Epstein-Barr virus(EBV)-specific IgE antibody by enzyme-linked immunosorbent assay with an anti human IgE monoclonal antibody. We detected EBV-specific IgE antibody in sera not only from patients with the EBV associated diseases of infectious mononucleosis and nasopharyngeal carcinoma, but also from patients with bronchial asthma, collagen disease and healthy volunteers. However, there was no significant difference in the titers of IgE antibody specific for EBV among these groups. No significant relationship between the titers of EBV-specific IgG and IgE antibody, or between the titers of EBV-specific IgE and the total IgE levels in the sera was observed.View full abstractDownload PDF (693K) -
Yutaka Kawano, Takeshi Noma, Izumi Yoshizawa, Kazuichi Maeda, [in Japa ...Article type: Article
1990 Volume 39 Issue 1 Pages 48-53
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSInterleukin 2(IL2)responsiveness was specifically induced by Dermatophagoides farinae(Df)antigen in Df-sensitized lymphocytes from asthmatic children, but not in normal lymphocytes. Df-induced IL2 responsiveness was also observed in normal lymphocytes pretreated(Day O)with anti-CD45R antibody, which recognize suppressor inducer subset among CD4^+T cells. However anti-CD45R antibody was no longer effective when the lymphocytes were cultured for more than one day with the antigen, suggesting its effect in the initial phase of the reaction. The intensity of the response induced in normal lymphocytes by the anti-CD45R was comparable to that of the patients sensitized to the nominal antigen. The response of the patients was no longer augmented by the anti-CD45R antibody. Taken together, these data suggest that even normal lymphocytes have potentiality to elicit Df-induced IL2 responsiveness and it is probably derepressed by inhibiting suppressor inducer subset with the anti-CD45R antibody. Also suggested is a defective suppressor inducer activity in the lymphocytes which may lead to hyperreactivity to allergens in asthmatic children.View full abstractDownload PDF (776K) -
Kotaro Ukai, Atsushi Yuda, Tsutomu Nonoyama, Yasuo Sakakura, Yasuko As ...Article type: Article
1990 Volume 39 Issue 1 Pages 54-58
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effect of amlexanox given orally for 3 weeks was studied on the IgE-mediated experimental allergic rhinitis in the actively sensitized guinea pigs. The intranasal instillation of antigen(egg albumin)induced the increase of nasal vascular premeability(dye leakage), histamine content in nasal perfusate and nasal resistance in sensitized guinea pig. Amlexanox, 20 and 60 mg/kg/day given orally for 3 weeks significantly inhibited the increase of dye leakage into the nasal cavity, histamine content and nasal resistance in a dose-dependent manner. These results suggest that amlexanox given orally may be useful therapeutic agent for human allergic rhinitis.View full abstractDownload PDF (570K) -
Article type: Appendix
1990 Volume 39 Issue 1 Pages 59-
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1990 Volume 39 Issue 1 Pages 60-63
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (276K) -
Article type: Cover
1990 Volume 39 Issue 1 Pages Cover4-
Published: January 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (93K)
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