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Volume 39, Issue 10
Displaying 1-17 of 17 articles from this issue
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Article type: Cover
1990 Volume 39 Issue 10 Pages Cover5-
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (366K) -
Article type: Cover
1990 Volume 39 Issue 10 Pages Cover6-
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (366K) -
Article type: Appendix
1990 Volume 39 Issue 10 Pages App1-
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1990 Volume 39 Issue 10 Pages 1369-1373
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (635K) -
Itsuo Iwamoto, Hiroomi Yamazaki, Akira Kimura, Kenichi Ochiai, Noriaki ...Article type: Article
1990 Volume 39 Issue 10 Pages 1374-1379
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo determine whether a novel liquid-phase enzyme immunoassay AlaSTAT for allergen-specific IgE antibody determination can be used to measure the absolute amounts of serum IgE antibodies, we examined the amounts of anti-house dust (HD) and anti-mite IgE antibodies in sera of 32 HD-sensitized allergic asthmatics and 14 normal subjects by this immunoassay. The amounts of anti-mite IgE antibody in serum measured by this immunoassay were found to be consistent with those assessed by the difference in serum total IgE proteins before and after the absorption with mite allergen (the value determined by this immunoassay was 113% of the latter one, n=4). Neither nonspecific IgE protein (50 to 10000 IU/ml) nor the heat-inactivated blocking serum affected the measurement of allergen-specific IgE antibody by the liquid-phase immunoassay. There were strong correlation between the values of anti-HD and anti-mite IgE antibodies by RAST and those by AlaSTAT (r=0.90, P<0.001 and r=0.86, p=<0.001, n=46, respectively). Our results indicate that the commercially available liquid-phase allergen-specific IgE enzyme immunoassay can be used to measure the absolute amounts of serum IgE antibodies without interference of nonspecific IgE protein or IgG blocking antibody.View full abstractDownload PDF (753K) -
Toshimichi Imai, Fumio Nanbu, Mitsuru Adachi, Terumi Takahashi, Chisat ...Article type: Article
1990 Volume 39 Issue 10 Pages 1380-1387
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the effect of leukotriene B_4 (LTB_4) inhalation on airway responsiveness in 12 dogs. LTB_4 (10μg/ml) was delivered as an aerosol, generated from a Devilbiss 646 nebulizer for ten miniutes. Airway responsiveness to inhaled methacholine was determined by modified astograph (7 Hz oscillation method) 1 hr (n=6) and 6 hr (n=6) after LTB_4 inhalation. After measurement of airway responsiveness, total cell counts, differential cell counts, thromboxane B_2 (TxB_2) and 6-kate-prostaglandin (PG)F_<1α> levels in bronchoalveolar lavage fluid (BALF) were measured. The total cell counts in BALF increased after LTB_4 inhalation (p<0.05), and the neutrophil counts in BALF increased significantly 1 hr (p<0.05) and 6 hr after (p<0.01) LTB_4 inhalation. Airway responsiveness to inhaled methacholine decreased significantly 1 hr (p<0.05) and 6 hr (p<0.01) after LTB_4 inhalation. There were no significant changes in the levels of TxB_2 or 6-keto-PGF_<1α> in BALF 1hr and 6 hr after LTB_4 inhalation. These results suggest that inhaled LTB_4 causes neutrophil recruitment into the airway but does not increase airway responsiveness to inhaled methacholine, and the possibility that LTB_4 reduces airway responsiveness to inhaled methacholine exists in dogs.View full abstractDownload PDF (991K) -
Hideko Iguchi, Masano Ueda, Tatsuo Sakamoto, Masanori Yamada, Shimpei ...Article type: Article
1990 Volume 39 Issue 10 Pages 1388-1396
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRecently, moulds are considered to be important allergens for bronchisl asthma. To comfirm this fact, 76 asthmatic patients(mean age 12.5, range 6-17 years)admitted to National Chubu Hospital were investigated for 16 different mould allergens by Pharmacia RAST RIA to measure specific-IgE for moulds. The results were as follows. 1) The frequency of positive RASTs (score≧2) varied from 4% to 21% depending on the allergen. Because 21 patients were RAST positive to one or more allergens, ultimately 26 patients (34%) appeared to be RAST positive to more than one of the 16 mould allergens. 2) According to the number of positive RASTs, the patients were devided into 3 groups, i.e. group 1 with more than five, group 2 with less than four and group 3 with zero. The ratio of patients with severe and moderate asthma to the total subjects was not significantly different between three groups before admission, but significantly high in group 1 and group 2 in order compared to groups 3(x^2_<4df>=18.81, p<0.005) one year after admission. This tendency was already apparent even one month after admission. 3) The frequency of positive RASTs for mould allergens was higher in patients with atopic dermatitis than in those without it. From these results, positive RAST for mould allergen seems to have considerable influence to intractable asthma and atopic dermatitis in young asthmatic patients.View full abstractDownload PDF (1086K) -
Saijin KatoArticle type: Article
1990 Volume 39 Issue 10 Pages 1398-1415
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe specified three standard leves of IgE RIST (10, 20, 60 IU/ml) for the ninety-four (94) allergic clients of 0-year infants, who classified with three groups. Each group was furthermore divided in two groups such as a group under the standard level and group exceeding the level respectively. Next, using the Multiple Factor Analysis Type II, we examined quantative analysis that each of three classified groups was influenced on 12 allergic factors of sex, existence and inesistence of wheezing and atopic dermatitis, family history of allergic diseases, eosinophil counts. IgE RAST scores and antibody titers against egg white, milk and soybean, IgE RAST scores to Dermatophagoides farinae, while the we discussed how the standard levels were adequately reacted to the analysis. As a results, strong allergic factors which influenced the three groups commonly were two factors of IgE RAST scores to egg white and D.f. In particular, the factor which influenced the group of 10 IU/ml standard level was eosinophil counts and family history of allergic diseases. Furthermore, the strong factors which influenced the group classfied on 60 IU/ml standard outstandingly appeared in IgE RAST scores to soybean, however, we did not find any difference between three groups. On the other hand, when we specified the standard level at 100/mm^3, 200 /mm^3, 400/mm^3 in regard to the eosinophil counts under the same method and examined results, we found strong allergic factors which influenced family history of allergic diseases. IgE RAST scores to egg white and soybean. However, the study scarcely recognize any difference between the three groups.View full abstractDownload PDF (1419K) -
Shin-ichi Sumimoto, Masahiko Kawai, Yoshiki Kasajima, Torata HamamotoArticle type: Article
1990 Volume 39 Issue 10 Pages 1416-1421
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe CAP system is a new method to detect specific IgE antibodies and is an advanced method of the traditional paper disc RAST. Our result suggests a signficant correlation between scores obtained with the CAP system and those with the traditional RAST. Since specific IgE antibodies againt multiple allergens can be measured with the CAP system, we studied 5 food allergen specific IgE antibodies (Fx5) in cases of infantile atopic dermatitis. This study indicates a good correlation between the Fx5 scores and clinical symptoms of these patients. Thus, it is concluded that the CAP system is useful for screening IgE antibodies against multiple food allergens in cases of infantile atopic dermatitis.View full abstractDownload PDF (634K) -
Masaru Kishida, kenzo Hukushima, Yoji IikuraArticle type: Article
1990 Volume 39 Issue 10 Pages 1422-1426
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe have reported that the morning mean rate of absorption (k_a) in immediate release aminophylline tablest is significantly faster than the evening one without any obvious change in AUC, the distribution(Vd), the rate of elimination (kel) or the elimination half-time (t1/2) and this altered absorption is a cause of circadian variation of theophylline concentrations with susteined-release preparations. Now, we examined the effect of posture on theophylline absorption. Seven asthmatic children were given immediate release aminophylline tablets at the same time in the morning on two separate occasions. On one day they remained standing and on the other lying. Serum theophylline concentration was measured at 0, 0.5, 1, 2, 3, 4, 5 hours after dosing. Mean theophylline levels were higher in the standing position at all time and only the mean rate of absortion (k_a) was significantly faster without any obvious change in parameters of pharmacokinetics. This result was almost consistent with differences of day and night theophylline kinetics. We conclude that slowness of absortion in the evening is mainly induced by difference in posture.View full abstractDownload PDF (532K) -
Hiroko Segawa, Yoji IikuraArticle type: Article
1990 Volume 39 Issue 10 Pages 1427-1436
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis study examined the relationship between long-term theophylline therapy and behavior problems in 14 asthmatic children that includes 5 intractable cases and 24 non-asthmatic children. Asthmatic children have received theophylline thepray and cromolyn inhalation for 3.6±3.8 years. Subjects were tested on neuropsychologic batteries; behavior promblems and personality of children questionnaire, child behavior checklist, caffeine-like side effects questionnaire, manifest anxiety scale, visual attention test, Uchida-Kraepelin test and soft neurological signs. These tests were repeated with an interval of 1 to 12 weeks. Parents noted caffeine-like side effects, stomachache and difficulty in sleeping, in their child during the theophylline therapy. The caffeine-like side effects decreased after stopping theophylline therapy. The rate of mistake in Uchida-Kraepelin test for the asthmatic group and for the intractable cases was significantly higher than that of the control group. Time of the sequential fingerthumb opposition of the soft neurological signs was significantly prolonged in asthmatic group. There was no significnat change in the other tests between asthmatic and non-asthmatic children and before and after stopping theophylline therapy. It seems that behavior problems and learning disability observed in the asthmatic children are due to the pathogenesis or symptoms of asthma rather than the effect of long-term theophylline therapy.View full abstractDownload PDF (1255K) -
Kotaro Ukai, Yasuo Sakakura, [in Japanese], Shunkichi Baba, Atsushi Us ...Article type: Article
1990 Volume 39 Issue 10 Pages 1437-1447
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe treated perennial nasal allergy with specific desensitization in combination with or without Neurotropin^[○!R] injections (NSP) from March 1983 to September 1984, and analyzed blood anti-mite IgG and IgG4 levels in relation to therapeutic efficacy. Desensitization and NSP were given once a week and seventy subjects (33 from the desensitization group and 37 from the desensitization + NSP group) were evaluated at 24, 36 and 48 weeks. 1) In total cases clinical usefulness showed no significant difference between the desensitization group and combined group at 24 weeks, While in"useful or more" cases significantly better results were attained in the latter at 24 weeks and 48 weeks (P<0.05, respectively). 2)Dermatophagoides pteronyssinus (D.p.) specific IgG antibody showed no significant difference between both groups as well as in each group during the overally examination period. 3) In total cases both D.p. specific and D.farinae (D.f.) specific IgG4 were significantly higher in the combined group at 24 and 36 weeks (D.p.:p<0.01 and D.f.:p<0.05, respectivery), whereas in "useful or more" cases only D.p. specific IgG4 showed a signficant elevation in the combined group at 24 weeks (p<0.05). These results suggest that specific desensitization in combination with NSP can promote early production of mite specific IgG4, which tend to rise in correlation with clinical efficacy.View full abstractDownload PDF (1151K) -
Atsuo Urisu, Kiyoshi Iimi, Yasuto Kondo, Fumiya Horiba, Susumu Masuda, ...Article type: Article
1990 Volume 39 Issue 10 Pages 1448-1454
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAmlexanox, an anti-allergic drug, showed a concentration-dependent inhibition against hrIL-3-induced enhancement of in vitro histamine release from human leukocytes by anti-IgE. The significant inhibitory action of amlexanox was observed in one out of nine and six out of nine allergic subjects at concentrations of 10^<-5>M and 10^<-4>M, respectively. This means that the inhibitory effect of amlexanox varied from patient to patient. Post-treatment as well as simultaneous treatment with amlexanox produced an inhibitory action on the enhancing effect of hrIL-3, suggsting that hrIL-3-induced enhancement of releasability is a reversible reaction. AA-861, OKY-046, superoxide dismutase and prostaglandin E_2 showed no effects on the hrIL-3-induced enhancement of histamine releasability. The inhibitory action of amlexamox to the hrIL-3-induced enhancement of histamine releasability may be a new anti-allergic mechanism, details of which remains unclear.View full abstractDownload PDF (780K) -
Article type: Appendix
1990 Volume 39 Issue 10 Pages 1455-
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (64K) -
Article type: Appendix
1990 Volume 39 Issue 10 Pages 1456-
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (29K) -
Article type: Appendix
1990 Volume 39 Issue 10 Pages 1457-1460
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (274K) -
Article type: Cover
1990 Volume 39 Issue 10 Pages Cover7-
Published: October 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (204K)
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