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Volume 39, Issue 12
Displaying 1-22 of 22 articles from this issue
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Article type: Cover
1990 Volume 39 Issue 12 Pages Cover11-
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (137K) -
Article type: Cover
1990 Volume 39 Issue 12 Pages Cover12-
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (137K) -
[in Japanese]Article type: Article
1990 Volume 39 Issue 12 Pages 1549-1555
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
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Mayumi SasagawaArticle type: Article
1990 Volume 39 Issue 12 Pages 1556-1566
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo evaluate the pathogenetic role of leukotrienes in bronchial asthma, the levels of leukotrienes released from leukocytes stimulated by calcium ionophore A23187 were measured by the HPLC-RIA method in 32 asthmatic patients(12 infectious type, 12 non-hyposensitized atopic type, and 8 hyposensitized atopic type). The following results were obtained:1)The level of leukotrienes released from the leukocytes of asthmatic patients were higher than those of healthy subjects, but there was no significant difference in the levels of leukotrienes between mild and moderate asthmatic patients. 2)The levels of leukotriene B_4 released from the leukocytes of the infectious-type asthmatic patients were higher than those of the atopic asthmatic patients(non-hyposensitized group). There was a tendency for levels of leukotriene C_4 released from the leukocytes of the infectious-type asthmatic patients to be higher than those of the atopic-type asthmatic patients. 3)The levels of peptide leukotriene released from the leukocytes of the atopic hyposensitized patients were lower than those of the patients in the atopic non-hyposensitized group, but there were no significant differences in leukotriene B_4 between the groups. In addition, the levels of leukotriene C_4 released spontaneously from the leukocytes of the hyposensitized group of patients were lower than those in the non-hyposensitized group. 4)Though the mechanism of the efficacy of hyposensitization has not been completely clarified, the reduction of leukocyte ability to release peptide leukotrienes through immunotherapy seems to be part of this mechanism. These results suggest that leukotrienes may play some role in the pathogenesis of both atopic- and infectious-type bronchial asthma.View full abstractDownload PDF (1149K) -
Hidetsugu Ogata, Shinji Motojima, Takeshi Fukuda, Sohei MakinoArticle type: Article
1990 Volume 39 Issue 12 Pages 1567-1575
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSCreola bodies(CrB)are characteristically present in sputa from patients with asthma. We studied the relationship among the numbers of CrB, the course of asthmatic attacks and the concentration of sputum eosinophil cationic protein(ECP). Twenty-two asthmatic attacks in 17 patients were studied. Sputum collections pulmonary function tests were made before of during treatment in patients who came to the outpatient clinic or emergency room. Smears of 100 microliters of sputum were made on glass slides and CrB were studied over the whole area of each glass slide stained with Papanicolaou's stain. CrB scores were determined from the number and the size of CrB on each slide. In hospitalized patients the CrB scores, the concentrations of sputum ECP and the severity scores of asthmatic attacks were highest on the day of admission, decreasing in association with each other and returning to the baseline level in approximately 5 days. There were significant correlations among the CrB score, the concentration of sputum ECP and %FEV1.0(<0.001). The CrB score on the day of clinical appraisal significantly correlated with the number 6f days of treatment needed for remission. There results are in keeping with the hypothesis that eosinophils cause desquamation of respiratory epithelial cells resulting in prolongation of asthmatic attacks. Observation of CrB seemed to be useful as a marker of duration of asthmatic attacks.View full abstractDownload PDF (1243K) -
Tatsuya Yokoyama, Hiroyuki Mochizuki, Makoto Shigeta, Akihiro Morikawa ...Article type: Article
1990 Volume 39 Issue 12 Pages 1576-1580
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effects of pH and osmolarity on cough receptors were evaluated by inhalation of aqueous aerosol in 37 children with bronchial asthma. Each of 3 different pH solutions(low 1.85〜3.25, neutral 6.9〜7.1, high 8.0〜8.4)was combined with 3 different osmolarities(hypo 0〜31, iso 254〜292, hyper 830〜1117 mOsm/kg), and 9 solutions were prepared. To evaluate the effect of low chloride ion concentration, neutral pH and iso-osmolar solution including low chloride ion was also prepared. These aqueous aerosols were administered from a Devilbiss 646 nebulizer for 10 seconds. Coughing was induced in 28 subjects(76%)by inhalation of low pH and hyperosmolar solution, in one subject(3%)by low pH and hypo-osmolar, in three(8%)by neutral pH and hypo-osmolar, and in none by any of the other solutions. It was suggested that the alteration of pH or osmolarity alone could not induce coughing effectively, and that the combination of pH and osmolarity was the important factor for the induction of coughing.View full abstractDownload PDF (594K) -
Atsushi Kusima, Shinji Motojima, Takao Yamai, Sohei MakinoArticle type: Article
1990 Volume 39 Issue 12 Pages 1581-1589
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBronchial hyperresponsiveness(BHR)was evaluated before and after antigen challenge in 12 patients with bronchial asthma as allergic reaction to house dust mites. Six out of the 12 showed an increase in BHR 48 hours after antigen challenge. Although there was no difference in the decrease of FEV1.0 in IAR and LAR between patients with(group A)and without(group B)the increase of BHR after antigen challenge, patients in group A expectorated a significantly larger number of clumps of respiratory epithelial cells(Creola bodies, CrB)in their sputum in both IAR and LAR. In addition, the degree of the increase of BHR significantly correlated with the CrB score, which was determined from the number and the size of CrB. These results suggest that epithelial desquamation participates in the increase of BHR after antigen challenge. The concentration of the eosinophil cationic protein(ECP)in their sputum did not change significantly in IAR and LAR compared with that before antigen challenge. There was no deference in the concentration of ECP in their sputum between the two groups either. One antigen challenge seemed to be too mild to induce an elevation of the concentration of ECP in their sputum. Judging from the fact that CrB could be observed not only at LAR but also IAR, epithelial desquamation seemed to be dependent on the degree of damage before antigen challenge rather than on the activation of eosinophils after antigen challenge.View full abstractDownload PDF (1249K) -
Toshihiko Obata, Takuro Masaki, Yoji IikuraArticle type: Article
1990 Volume 39 Issue 12 Pages 1590-1597
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe examined the changes in arterial blood gas, FEV_1 and V_<50> after the inhalation of procaterol on 19 occasions in 16 asthmatic children. The initial value of PaO_2 had statistically significant correlation with the initial values of %FEV_1 and %V<50>. PaO_2 fell down in 11 out of 19(57.9%)and remarkably decreased more than 5mmHg in 6 out of 19 (31.6%). The fall in PaO_2 was most significant at 5 min after the inhalation in almost subjects. The changes in PaO_2 after the inhalation had good correlation with the initial value of %FEV_1 and %V<50>. The initial values were quite lower in the patients with decreased PaO_2 more than 5mmHg than those with increased PaO_2. Severe patients showed statistically low values of the initial PaO_2 and %V<50> and showed a fall in PaO_2 after inhalation compared with moderate patients. An increase in A-aDO_2 elicited that deteriorations of V/Q ratio caused a decrease in PaO_2 after inhalation. There were no significant changes in heart rates and no complaints of nausea, headache or tremor.View full abstractDownload PDF (1008K) -
Mokoto Dohi, Matsunobu Suko, Haruhito Sugiyama, Naomi Yamashita, Kenji ...Article type: Article
1990 Volume 39 Issue 12 Pages 1598-1604
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSExercise-induced anaphylaxis(EIAn)is a distinct form of physical allergy. As one of the predisposing factors of EIAn, food intake is often cited, and such cases are classified as food-dependent EIAn. Another factor reported is the administration of drugs. Recently we had 3 patients with food-dependent EIAn who showed more severe symptoms when they took aspirin orally. None of them had shown symptoms when they took aspirin alone. Symptoms were provoked only when took aspirin for common cold, headache or toothache followed by certain foods and exercise. Two out of the 3 patients had experienced food-dependent EIAn before. However, after taking aspirin, their anaphylactic symptoms were more severe with more slight degree of exercise. Results of exercise challenge by treadmill showed that exercise alone induced an increase in plasma histamine concentrations in 2 out of the 3 patients 5 to 15 minutes after the challenge. These data suggest the possibility that our patients have an increased histamine releasability from mast cells responding to exercise, and that aspirin intake might enhance the process.View full abstractDownload PDF (829K) -
Katsuji UnoArticle type: Article
1990 Volume 39 Issue 12 Pages 1605-1611
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn 145 suspected cases of β-lactam hypersensitivity, the identities of the allergenic drugs were performed by leucocyte migration inhibition test(LMIT). The involvement of cell-mediated immunity using leucocyte migration activating factor(LMAF)and leucocyte migration inhibitory factor(LMIF)was investigated for each allergic symptom. The proportion of LMIT positives was 74% of all 145 cases, and more than 70% for each allergic symptom except for anaphylactic shock, and in paticular more than 90% for fever and eosinophilia. LMAF and LMIF were detected 39% and 35% of 145 cases, respectively, however LMAF was more frequently detected than LMIF in cases with hepatopathy. LMAF was more frequently detected than LMIF when the latent period(the duration of sensitization)of skin eruption or fever was less than 10 days, whereas LMIF was more frequently detected than LMAF when it was more than 10 days. The same result also was obtained at the boundary between 14 days of the latent period in hepatopathy. These results indicate that in the pathogenesis of β-lactam hypersensitivity, cell-mediated immunity plays a major role. Both LMAF and LMIF are involved, and their production is dependent on the duration of allergenic drug-sensitization, LMAF is produced during the early of period sensitization, whereas LMIF is produced during the late period of sensitization.View full abstractDownload PDF (827K) -
Yuichi Takahashi, Sakae Inouye, Masahiro Sakaguchi, Susumu KatagiriArticle type: Article
1990 Volume 39 Issue 12 Pages 1612-1620
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe devised a new counting method of pollen allergen particles which improved the fluorescence immunoblotting technique by Schumacher et al(1988). And by which airborne pollen allergens became visible under 10× magnifier or naked eyes. Airborne pollen allergens collected on the Burkard's sampling tape were transfered onto nitrocellulose membrane and were reacted with anti Cry j I rabbit serum or anti Lol p I rabbit serum, and then treated with alkaline phosphatase conjugated F(ab)'_2 anti rabbit IgG. Finally, bluish purple spots were obtained by staining with BCIP/NBT phosphatase substrate system. This technique do not require any skilfull morphological observation, and is more suitable to measure the amounts of airborne pollen allergen for given pollinosis patients because total pollen allergen particles with common antigenicity are measured. In Japanese red cedar pollen counts, we could not count the spots more than 400 grains per 0.16cm^2 of the sample trapping area due to many overlapping spots. In this case, we try to calculate the value from the ratio of buish purple coloured area to one pollen area. However, more suitable method for estimate the content of pollinosis caused airborne allergens may be colorimetric quantitation using densitometry and displaying the value as allergen content.View full abstractDownload PDF (1184K) -
Shohei Nakamura, Hideki Yamamura, Shigekatsu Kohno, Katsuya Ohata, Aki ...Article type: Article
1990 Volume 39 Issue 12 Pages 1621-1628
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe oral anti-allergic effect of 1, 3-bis-(2-ethoxycarbonylchromon-5-yloxy)-2-((s)-lysyloxy)propane dihydrochloride(N-556, KY-556)was investigated. 1)N-556(10-100 mg/kg, p.o.)inhibited dose-dependently the 48-hr homologous PCA in rats, and the duration of action was longer than that of intravenous DSCG. 2)N-556(20 and 100 mg/kg once a day for 20 consecutive days, p.o.)tended to inhibit the histamine release from actively sensitized rat lung fragments. 3)N-556(100 mg/kg, p.o.)showed the prolongation of survival time in the rat systemic anaphylaxis. 4)N-556(100 mg/kg, p.o.)significantly inhibited the increased airway resistance in experimental asthma in rats. These results suggest that N-556 is a promising and orally-active pro-drug of disodium cromoglycate(DSCG)against allergic diseases.View full abstractDownload PDF (848K) -
Matsunobu Suko, Takeshi Koshino, Makoto Dohi, Masato Sugiyama, Hirokaz ...Article type: Article
1990 Volume 39 Issue 12 Pages 1629-1632
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe developed a new apparatus for the measurement of mouse respiratory resistance(Rrs)by an oscillation method. Bronchial responsiveness to methacholine was studied in mice sensitized or not with egg albumin using this apparatus. All of the sensitized mice showed clearly increased bronchial reactivity upon nasal challenge with methacholine compared to normal control mice. The lung obtained from a mouse sensitized mouse showed remarkable contraction of the bronchial smooth muscle, submucosal edema and cell infiltration around the boronchi. These results indicate that mouse Rrs is successfully measured by our newly developed apparatus and suggested that repeated sensitization of mice with allergen render their airway hyper-reactive to methacholine.View full abstractDownload PDF (496K) -
Article type: Appendix
1990 Volume 39 Issue 12 Pages 1633-1646
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1990 Volume 39 Issue 12 Pages 1647-1652
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1990 Volume 39 Issue 12 Pages 1653-
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1990 Volume 39 Issue 12 Pages 1653-
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (67K) -
Article type: Index
1990 Volume 39 Issue 12 Pages 1654-1661
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Index
1990 Volume 39 Issue 12 Pages 1662-1665
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (221K) -
Article type: Index
1990 Volume 39 Issue 12 Pages 1666-1696
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1990 Volume 39 Issue 12 Pages 1697-1702
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (463K) -
Article type: Cover
1990 Volume 39 Issue 12 Pages Cover13-
Published: December 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (306K)
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