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Volume 39, Issue 6
Displaying 1-16 of 16 articles from this issue
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Article type: Cover
1990 Volume 39 Issue 6 Pages Cover27-
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (291K) -
Article type: Cover
1990 Volume 39 Issue 6 Pages Cover28-
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (291K) -
Article type: Appendix
1990 Volume 39 Issue 6 Pages App5-
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (76K) -
Article type: Appendix
1990 Volume 39 Issue 6 Pages App6-
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (278K) -
[in Japanese], [in Japanese]Article type: Article
1990 Volume 39 Issue 6 Pages 495-501
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (892K) -
Akira Ishii, Koji Ito, Naomi Yamashita, Terumasa Miyamoto, Junji Shiga ...Article type: Article
1990 Volume 39 Issue 6 Pages 502-508
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe established an experimental animal model for IgE-mediated asthma by the use of intravenous injection of rabbit anti guinea pig IgE in normal guinea pigs. The degree of asthmatic airway obstruction was quantitatively estimated by Mead's apparatus which enabled us to use unanesthetized guinea pigs. With the injection of anti IgE, only an early asthmatic response was observed. Inhalation of Anti IgE did not trigger asthma. Histo-pathological changes in the lung obtained immediately after the injection of anti IgE resembled those reported in human asthma. This system may be used for pathological and pharmacological studies of the IgE-dependent early asthmatic response.View full abstractDownload PDF (997K) -
Makoto Hashizume, Dentaro Kurokawa, Satoshi Nishii, Fumi Yoshioka, Shi ...Article type: Article
1990 Volume 39 Issue 6 Pages 509-519
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the effect of AA-2414, a TXA_2 recepter antagonist, on platelet function in 12 asthmatic patients, 6 males and 6 females, whose mean age was 43.6 years. AA-2414 was orally administered to each patient at 20 mg/day for two weeks and then at 40 mg/day for the following two weeks. Platelet aggregation, plasma concentration of TXB_2, and serum concentrations of AA-2414 and its metabolites were measured before and after the administration of each dose. Platelet aggregation induced by U-46619(an analogue of PGH_2), STA_2(a stable analogue of TXA_2) and arachidonic acid with the administration of AA-2414 was significantly inhibited. The degree of this inhibition was proportional to the serum level of the drug. Plasma concentration of TXA_2 tended to be lowered by administration of AA-2414, but it was not statistically significant. Eight(75.0%) of the 12 patients showed clinical improvement. In the cases where the drug was ineffective, the inhibition of platelet aggregation after administration of AA-2414 was less than in those cases where it was effective. We conclude that AA-2414 might exert its antiplatelet and antiasthmatic effects through antagonism of the TXA_2 receptor. Investigation of the response to AA-2414 may be useful in assessing the clinical effect of this compound.View full abstractDownload PDF (1377K) -
Susumu Masuda, Atsuo Urisu, Yasuto Kondo, Yuko Ichikawa, Fumiya Horiba ...Article type: Article
1990 Volume 39 Issue 6 Pages 520-525
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSOne hundred and twenty-six allergic subjects were divided into three groups based on the RAST results for Dermatophagoides pteronyssinus(D.p)and Japanese ceder(J.C). We compared sex, age of examination for RAST, serum IgE, family history of allergic diseases, prevalence rate of bronchial asthma(BA)and allergic rhinitis(AR), and onset of AR among three groups. No significant difference in the other variables except serum IgE and prevalence rate of BA was found between the group with D.p-positive and J.C.-positive RAST and the group with D.P-positive and J.C.-negative RAST. The group with positive RAST for D.p and J.C. showed lower age of the examination, higher serum IgE, higher incidence of allergic family history, higher prevalence rate of BA, and lower onset age of AR than the group with negative RAST for D.p and positive RAST for J.C. We suggested that in J.C. RAST-positive group there might be two different subgroups distinguished by RAST result for D.p Similar results were obtained from the assesment of RAST for Orchard grass instead of J.C.View full abstractDownload PDF (644K) -
Hiroshi Odajima, Minoru BabaArticle type: Article
1990 Volume 39 Issue 6 Pages 526-531
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSForty nine asthmatic children were studied to clarify the relationship between the respiratory threshold of acetylcholine(RT-Ach)and the prognosis for asthma. In those patients who had asthmatic attacks fewer than 60 days in the last year, there was a statistically significant relationship between RT-Ach and the number of the days of asthmatic attacks over the 6 and 12 month periods following the inhalation test. In the younger group(5〜11 years old), there was a statistically significant relationship between RT-Ach and the number of the days of asthmatic attacks over the 6 and 12 month periods following the inhalation test. However, in the elder group(12〜15 years old), no such relationship was recognized. In the elder group, the obstructive index, one of the indices of flow-volume curve, had a statistically significant correlation with the number of asthmatic attacks over the 6 and 12 month periods following the inhalation test. However in the younger group, no such relationship was recognized.View full abstractDownload PDF (573K) -
Yoshihiro SaitoArticle type: Article
1990 Volume 39 Issue 6 Pages 532-541
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAlveolar macrophages(AM)taken from sixteen patients with collagen-vascular diseases with interstitial pneumonia(CVD-IP^+)were cultured with prednisolone(PSL), prostaglandin E_2(PGE_2), colchicine(Colch), D-penicillamine or aggregated IgG(agg-IgG). The culture supernatants were tested on the fibroblast proliferation function and the amounts of fibronectin(Fn)and interleukin 1(IL-1). The fibroblast proliferation was suppressed significantly by the supernatants of AM cultured with PGE_2. The Fn production by AM was significantly suppressed by PGE_2 and Colch. The IL-1 production by AM was not suppressed by these drugs, but was enhanced by Colch. In five patients with CVD-IP^+, the fibroblast proliferation of AM supernatant was enhanced by agg-IgG. In these five patients, Fn and IL-1 production had a tendency to be increased by agg-IgG. The ratio of immune complexes(IC)in broncho alveolar lavage fluids to those in sera was significantly higher in patients with CVD-IP^+ than in patients with CVD without IP suggesting a local production of IC in the lung in the patients with CVD-IP^+.View full abstractDownload PDF (1065K) -
Yuji Akiyama, Teruhiko Suzuki, Masahiko Tanaka, Kosei Kobayashi, Toshi ...Article type: Article
1990 Volume 39 Issue 6 Pages 542-547
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe encountered a patient who developed an overlap syndrome of progressive systemic sclerosis(PSS), systemic lupus erythematosus(SLE), polymyositis(PM)and Sjogren's syndrome(SjS)while we were treating her for mixed connective tissue disease(MCTD). This 42-year-old woman had been photosensitive since 18 years of age. In 1986, Raynaud's phenomenon, swollen hands and arthralgia appeared; therefore, we started to treat this patients based on a diagnosis of MCTD. At that time, her anti-RNP antibody titer was 82,920, but she was negative to anti-Sm antibody. In 1988, she was admitted to our hospital with chief complaints of aggravation of polyarthralgia and myalgia. On physical examination, she showed difficulty in opening her mouth, systemic dermal sclerosis, a decrease in muscular strength and rales. In laboratory tests, her myogenic enzyme level was increased, and she was found to be positive to LE cells, antinuclear antibody, anti-DNA antibody, anti-ENA antibody and anti-SSA antibody. Furthermore, histological features clearly corresponding to those of PSS were found by skin biopsy, myogenic changes by electromyography, evidence of chronic inflammation of the salivary glands by lip biopsy, and proliferative changes in the mesangium were detected by renal biopsy. The concept of MCTD, especially the differences from overlap syndrome, is vague. Therefore we need further study about many cases. Since there have been no reports on cases having sufficient evidence of the development of the overlaps syndrome of PSS, SLE, PM and SjS during a course of MCTD, our patient would provide very useful data contributing to the study of MCTD.View full abstractDownload PDF (1020K) -
Takeshi Fukuda, Ikuo Akutsu, Masahiro Amagai, Toshio Numao, Shinji Mot ...Article type: Article
1990 Volume 39 Issue 6 Pages 548-552
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSBronchial eosinophilia is a characteristic of asthma. To elucidate the mechanisms of eosinophil accumulation in the airways, the time course of eosinophil infiltration in the airway mucosa after antigen inhalation was examined in actively sensitized and passively sensitized guinea pig models of asthma. The lungs and tracheae were removed at intervals after antigen challenge, fixed and stained. The eosinophil infiltration was quantitated in the tracheal walls by counting the number of cells per square millimeter. Guinea pigs sensitized by intraperitoneal injection of ovalbumin(OA)responded to a single exposure to aerosolized OA with biphasic infiltration of eosinophils in the tracheal walls; a striking early-phase which peaked at 6 hr and a delayed-phase which peaked at 24 hr and persisted for as long as 5 days. These kinetics were different from those observed with passively sensitized animals which showed only early-phase infiltration. Administration of CV-6209, a specific PAF antagonist, before and 12 hrs after antigen challenge significantly(p<0.01)inhibited the early-phase but not the delayed-phase eosinophil infiltration in actively sensitized animals. In contrast, when guinea pigs were treated with Cyclosporin A, a T lymphocyte-selective immunosuppressive agent, throughout the immunization period, the delayed-phase but not the early-phase infiltration was significantly(<0.01)inhibited. These results suggest that PAF may contribute to early-phase and T cell factor(s) may contribute to delayed-phase eosinophil infiltration of the airways.View full abstractDownload PDF (592K) -
Takayoshi Nakamura, Yukio Matsumura, Keiko Ishihara, Motoo Kuriyama, T ...Article type: Article
1990 Volume 39 Issue 6 Pages 553-556
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSJapanese cedar pollinosis is a typical allergic disease and has recently become a big social problem. Many population are suffering from this disease every year from the end of February to the beginning of April. In this study, we planned to examine the role of platelet-activating factor(PAF)in this disease, because PAF has been known to be one of the potent chemical mediators in allergic and inflammatory reactions and many evidences indicated that PAF is deeply involved in the pathogenesis of bronchial asthma, a typical allergic disease. We measured the concentrations of the PAF derivative(lyso-PAF)in serum from patients with cedar pollinosis during the pollen season. The level of lyso-PAF in serum from untreated patients with cedar pollinosis(87.8±8.7 unit.)was significantly higher than that in healthy control(54.9±7.7 unit.). We also tested the effect of an anti-allergic drug on the level of serum lyso-PAF of cedar pollinosis. Eighteen pairs of serum samples from patients with cedar pollinosis were employed in this study. Lyso-PAF levels after two week's therapy with ketotifen(2mg/day), an anti-allergic drug, decreased the levels significantly(from 82.6 unit to 41.3 unit.). These results suggest that PAF could play some important role in cedar pollinosis and that the clinical effect of anti-allergic drug could be partially due to the anti-PAF action.View full abstractDownload PDF (488K) -
Toshifumi Yuuki, Yasushi Okumura, Toru Ando, Hiroshi Yamakawa, Matsuno ...Article type: Article
1990 Volume 39 Issue 6 Pages 557-561
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA cDNA library corresponding to mite protein was screened employing anti-Der f II antibody. Two possible clones were obtained, which contained plasmids, pFL1 and pFL11, respectively. Both plasmids had insertions of about 500 base pairs. The DNA sequences of the two insertions were determined, from which the amino acid sequences were deduced. The amino acid sequence of the purified native Der f II protein could be determined to 45 residues from the N-terminus. As a result of comparison, we concluded that the cDNAs prepared form live mite Dermatophagoides farinae corresponded to the mite allergen, Der f IIView full abstractDownload PDF (524K) -
Article type: Appendix
1990 Volume 39 Issue 6 Pages 562-565
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (330K) -
Article type: Cover
1990 Volume 39 Issue 6 Pages Cover29-
Published: June 30, 1990
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (194K)
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