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Volume 40, Issue 11
Displaying 1-19 of 19 articles from this issue
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Article type: Cover
1991 Volume 40 Issue 11 Pages Cover7-
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Cover
1991 Volume 40 Issue 11 Pages Cover8-
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (717K) -
[in Japanese]Article type: Article
1991 Volume 40 Issue 11 Pages 1357-1361
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Tamotsu Ishizuka, Motohiro Kurosawa, Ichiro Hirata, Masakazu Adachi, T ...Article type: Article
1991 Volume 40 Issue 11 Pages 1362-1369
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe measured the expression of the IgE Fc receptor, Fcε RII, on peripheral blood monocytes isolated from asthmatic patients and normal subjects by laser flowcytometry. After peripheral blood mononuclear cells were incubated with monoclonal antibodies, H107, which recognize Fcε RII, FITC-labeled second antibodies were reacted with them. The cells were then incubated with PE-labeled Leu M3 monoclonal antibodies and the ratios of H107 positive monocytes were measured by two color analysis. The ratio of H107 positive monocytes in atopic asthmatic patients was significantly greater than the ratio in normal subjects. But the ratio was not higher in 9 out of the 14 atopic asthmatic patients. This indicated that atopic asthmatic patients are divided into two groups by the expression of Fcε RII on monocytes. Total serum IgE level was not related to the ratio of H107 positive monocytes.View full abstractDownload PDF (837K) -
Atsuo Urisu, Eiko Wada, Yasuto Kondo, Fumiya Horiba, Mitsutoshi Tsurut ...Article type: Article
1991 Volume 40 Issue 11 Pages 1370-1376
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe allergenic activity of Rice protein 16 KD (RP16KD) isolated from water soluble rice proteins was examined by radioallergosorbent test (RAST), RAST inhibition and histamine release assay. All of the 31 sera which showed positive RAST values for rice grain extract were positive for RP16KD RAST. Furthermore, there was a significant correlation (r=0.56, p<0.01) between these RAST values. PR16KD effectively inhibited IgE binding to the rice grain extract disc in RAST inhibition assays using 4 sera with positive RAST valued for both antigens. In 17 subjects with positive RAST values for rice grain extract, a significant positive correlation (r=0.53, p<0.05) was found between the maximum percent histamine releases from their leukocytes by rice grain extract and RP16KD. These data strongly suggest that RP16KD is one of major allergens of rice grain.View full abstractDownload PDF (688K) -
Mikio Saotome, Hiroki Ninomiya, Akihiro Nomura, Hirotaka Ohse, Takeo E ...Article type: Article
1991 Volume 40 Issue 11 Pages 1377-1383
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEndothelin-1 (ET-1), one of the most potent constrictors of airway smooth muscles, is reported to act on such inflammatory cells as mast cells and release several chemical mediators. We observed a transient relaxation response to ET-1 after an anaphylactic constriction of guinea pig tracheal smooth muscle. The guinea pig was actively sensitized with ovalbumin, and the tracheal strip was challenged with ovalbumin in vitro. ET-1 induced a transient relaxation followed by a constriction of the tracheal strip. The potency of the relaxation induced by 10^<-9>M of ET-1 was 16.0±1.3%, compared to the response to isoproterenol (2×10^<-5> M), and the duration of the relaxation was 7.2±0.7 minutes. Indomethacin (10^<-6> M) had no effect on the response, indicated that prostaglandins have no relation. Mechanical denudation of the tracheal epithelium did not reduce the relaxation, but rather augmented it. These results indicate that ET-1 induces a relaxation, associated with a relaxation factor from non-epithelial tissue.View full abstractDownload PDF (729K) -
Masahiro Irie, Chiharu Kubo, Hiroshi Sogawa, Hiromi Kihara, Haruko Kaw ...Article type: Article
1991 Volume 40 Issue 11 Pages 1384-1390
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe degree of dyspnea when using metered-dose inhalers (MDIs), and the relationship between subjective self assessments and objective peak expiratory flow rates were examined by means of visual analogue scales and mini wright peak flow meters in 16 subjects with asthma. Three subjects who were neurotic in character were found to have a poor perception of the degree of airway obstruction after inhalation compared with objective changes in their condition. Two subjects, one neurotic and one alexithymic, assessed the degree of dyspnea to be worse after inhalation, when objectively there were few changes. However, one neurotic subject perceived an improvement in his condition when, in fact, there was little change. Furthermore, some severe cases used MDIs in the progressive state of airway obstruction. In conclusion, we must pay attention to patients' characters when determining treatment in order to prevent overuse of MDIs or delays in treatments including the use of MDIs.View full abstractDownload PDF (783K) -
Mari Miyoshi, Takashi Sakurai, Soichi KodamaArticle type: Article
1991 Volume 40 Issue 11 Pages 1391-1398
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo evaluate the clinical relevance of serum eosinophil cationic protein (ECP) levels, we measured serum ECP levels in 126 asthmatic children, and investigated its relationship with some of the clinical backgrounds. Serum was separated at 1 hour after blood was drawn, and ECP was measured by radioimmunoassay. Serum ECP levels were significantly higher in the patients who had asthma attack within 24 hours than those who did not, and were higher in the patients who had asthma attack almost everyday for the past two weeks than those who had not. In addition, serum ECP levels were correlated with severity of asthma in the previous year, and the patients who had longer history of asthma showed higher levels of ECP. Among the patients who had asthma attacks at the time of blood sampling, serum ECP levels were higher in the patients in whom the attack lasted less than 12 hours than those more than 12 hours. However, no significant correlations were observed between serum ECP levels and the sevirities of attacks, between serum ECP levels and eosinophil counts. These results suggest that serum ECP level increases during the asthma attack, especially in its chronic active status. Serum ECP may reflect eosinophil activation in vivo and may be a better parameter than eosinophil counts. It is suggested that the measurement of serum ECP level may be useful to evaluate the clinical status of bronchial asthma.View full abstractDownload PDF (829K) -
Akiyoshi Sasamoto, Seiichi Saito, Hiroyuki Uchiyama, Masaru Kishida, H ...Article type: Article
1991 Volume 40 Issue 11 Pages 1399-1406
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe author made an assessment in his first report, regarding relationship to the degree of skin involvement. As a result, it was suggested that the extent of eczema is a good index for determining the severity of the allergy and also that the severity of the allergy early in the infancy has a good correlation with egg white・specific IgE antibody. Therefore, an assessment had been made this time regarding the clinical characteristics of 32 infants who have strong reactions (egg white・RAST 4+) to egg white. The results were as follows; 1) All the infants with egg white・RAST 4+ had a systemic eczema, and their IgE antibodies showed high values of 445.6±626.9 IU/ml. 2) There were many cases with positive multiple allergens. Particularly, all the infants with egg white・RAST 1+〜2+ were negative to rice and wheat, while 7 cases positive RAST score to rice and 9 cases to wheat were seen out of the 32 who showed the RAST 4+ to egg・white early in the infancy (rice; p<0.02 and wheat; p<0.01). 3) If the growth curves of the group from which egg and milk were completely eliminated are compared with the curves of the healthy infants, the height and head circumference were entirely in the normal range while the weight and Kaup index had a trend of being a little low, though they were within the normal range. 4) Regarding family history of allergies, past histories of atopic dermatitis on the mother's side were observed at a high rate.View full abstractDownload PDF (851K) -
Tokuya Omi, Oichi Kawanami, Mitsuyoshi Honda, Hiroshi AkamatsuArticle type: Article
1991 Volume 40 Issue 11 Pages 1407-1414
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe made histochemical and ultrastructural studies of mast cells of the skin and airways in human fetuses (7 to 40 weeks' gestation) and newborn infants. Epithelial differentiation of the skin and bronchial airways was assessed of immunohistochemical characteristics, especially on their basal cells. Histological phenotype and the characteristics to anti-total keratin antibody became identical with the phenotype in the adult by the 11th and 36th week of gestation, respectively. Interstitial fibroblastoid cells appeared oval in shape and remained relatively immature to the termination. Mast cells were first recognized by electron microscopy in the fetal skin of 18-week-old fetuses and histochemically detected in both skin and airways of 24-week-old fetuses. Mast cell counts under high power magnification (40× optical lens) light microscopy gradually increased and made a relatively dramatic rise in the early postnatal periods. The cytoplasm of mast cells showed irregular pseudopod-like elongations which gradually developed microvillous protrusions. It contained immature granules composed of varieties of morphology such as amorphous dense bodies, vesicles with dense cores, particulates and their compound forms. They were located in a corner of the cytoplasm surrounded by lamellated rough-surfaced endoplasmic reticulum. These granules became scattered widely in the cytoplasm showing distinct particulate type. Granules typical of the scroll type became dominant in the process of maturation, and the transformation of crystal-substructures occasionally took place. Prior to birth, mast cell granules fully developed as mature as those in the adult. This process of granule maturation is indicative of a reversed proceeding of slow degranulation, which is commonly seen in the so-called mucosal mast cells.View full abstractDownload PDF (1688K) -
Shozo Maeda, Akihiro Morikawa, Masahiko Kato, Yoichi Motegi, Makoto Sh ...Article type: Article
1991 Volume 40 Issue 11 Pages 1415-1420
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe reported 11 cases of patients who developed moderate to severe anaphylactic reactions induced by the ingestion of grand keyhole limpet (GKL) and abalone. Specific IgE-mediated hypersensitivity to these shellfish was demonstrated by history, skin prick test, RAST and immunoblotting. The RAST inhibition technique revealed crossantigenecity between GKL, abalone and keyhole limpet hemocyanin. By immunoblotting analysis, the major antigens of GKL are shown in the MW range of about 38 Kd and 80 Kd.View full abstractDownload PDF (687K) -
Article type: Appendix
1991 Volume 40 Issue 11 Pages 1421-1424
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 11 Pages 1425-1431
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 11 Pages 1432-
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 11 Pages 1432-
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (68K) -
Article type: Appendix
1991 Volume 40 Issue 11 Pages 1433-
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 11 Pages 1434-1436
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Bibliography
1991 Volume 40 Issue 11 Pages 1437-
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Cover
1991 Volume 40 Issue 11 Pages Cover9-
Published: November 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (99K)
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