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Volume 40, Issue 3-1
Displaying 1-18 of 18 articles from this issue
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Article type: Cover
1991 Volume 40 Issue 3-1 Pages Cover16-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Cover
1991 Volume 40 Issue 3-1 Pages Cover17-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (744K) -
Article type: Appendix
1991 Volume 40 Issue 3-1 Pages App5-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 3-1 Pages App6-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (119K) -
Masahiro Hasegawa, Takao Fujisawa, Mikihiko Komada, Yukinori Uchida, C ...Article type: Article
1991 Volume 40 Issue 3-1 Pages 173-180
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the possibility of a relationship between the serum levels of eosinophil cationic protein (ECP) and the clinical parameters in asthma. A specific question was whether or not serum ECP Changes with a circadian rhythm. Eighty nine children with bronchial asthma and sixteen normal, non-atopic subjects were studied. Serum ECP, eosinophil counts (Eo) and pulmonary functions were measured 4 or 5 times a day. ECP was quantitated by a spetific radioimmunoassay. Serum ECP and Eo were significantly higher in the patients with bronchial asthma than in non-atopic subjects. Serum ECP levels were higher during asthma attacks and at 24 hours after attacks than those in stable conditions (free of attacks for more than 7 days). Although no circadian rhythm was observed in ECP changes, the patients with bronchial asthma showed a significantly greater variation of serum ECP levels than the non-atopic subjects. There was no significant correlation between serum ECP levels and 2- or 8-week attack score before the ECP measurement. These results suggest that serum ECP increases in bronchial asthma, especially in its acute exacerbation phase, and may reflect eosinophil activation in vivo.View full abstractDownload PDF (834K) -
Nobuhisa Terada, Eiko Ito, Tatsuo Sugiyama, Kiyoshi Togawa, Akiyoshi K ...Article type: Article
1991 Volume 40 Issue 3-1 Pages 181-190
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSOn fourteen volunteers with Japanese cedar pollinosis, nasal lavage and the determination of nasal airway resistance (NAR) were carried out periodically for twelve hours after an antigen challenge using antigen disk. The percentage of EG2 positive eosinophils, the number of activated eosinophils (EG2 positive eosinophils) and the amount of ECP in each sample of nasal lavage fluid were determined. 1. The percentage of activated eosinophils increased during the late phase compared with that before the challenge and during the early phase. The number of activated eosinophils and the amount of ECP increased during both phases, but more markedly during the late phase. 2. The number of activated eosinohils and the amount of ECP were compared between the group with late phase response and that without a marked late response. Both the number of activated eosinophils and the amount of ECP showed a tendency to increase in the positive group. 3. There was a statistically significant correlation between the percentage of increase in NAR and the number of activated eosinophils. The correlation coefficient during the late phase was considerably higher than in the early phase. From these findings, the increased number of activated eosinophils observed during the late phase response is assumed to have a significant relationship with increased NAR and also the hyperreactivity of nasal mucosa.View full abstractDownload PDF (1204K) -
Michiko Haida, Matsunobu Suko, Hirokazu Okudaira, Koji Ito, Terumasa M ...Article type: Article
1991 Volume 40 Issue 3-1 Pages 191-204
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSince the histamine release test is more complicated than some of the other tests, there are smaller number of clinical studies employing this method. In this study, we selected 25 males and 20 females, allergic to the house dust mite, to undergo the histamine release test challenged by 7 serial concentrations of the mite allergen diluted from 10 times to 10 million times the original allergen at a concentration of 0.01%. Histamine release was expressed as a percentage of the total histamine concentration contained in the cells. Allergen induced dose response curve of histamine release was drawn for each patient, and in order to characterize each curve, 5 different indices were selected and were averaged according to the clinical backgrounds of the patients. Significant increases in histamine release were observed in males under 25 and females above 26 years of age. Histamine release rate in patients with RAST score of above 3+ was significantly more enhanced than in those with RAST score of below 2+, though this result was significant only for those under 25 years of age. Blood samples taken in June〜August, and September〜November, showed significant increases in the histamine release, though the indices for enhancement differed in both seasons. When analyzed according to the numbers of years the patient was desensitized, the results showed, contrary to our expectations, a more increased release in the desensitized group than in the non-desensitized group.View full abstractDownload PDF (1309K) -
Hayao Araki, Sohei Kano, Sankei Nishima, Masashi Ogasawara, Moritoshi ...Article type: Article
1991 Volume 40 Issue 3-1 Pages 205-214
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTwelve children with exercise-induced bronchosphasm (EIB) participated in our physical training program to determine whether it improves physical working capacity and EIB. The effect of physical training on the bronchial reactivity to inhaled 3.6% NaCl was also investigated. The training was performed by bicycle ergometor for four weeks every day at 125% of WBPLA_1 (work load at first breaking point of lactic acid). The results obtained were ad follows. 1. Heart rate decleased from 188.5±9.6 bpm before to 178.4±9.7 bpm after training at 150% of WBPLA_1 (p < 0.05). After training at 175% of WBPLA_1 it decreased also from 174.0±11.9 bpm to 165.6±11.3 bpm. Maximum oxygen consumption increased from 34.5±3.5 ml/min/kg to 41.4±4.0 ml/min/kg after training (p < 0.001). 2. Max. % fall in FEV_<10> decreased from 27.1±24.0% before to 18.0±17.1% after training at 150% of WBPLA_1 (p < 0.05). After training at 175% of WBPLA_1 it decreased also from 37.4±17.4% to 30.0±22.1%. 3. The mean dose of inhaled 3.6% NaCl inducing 20% fall in FEV_<10> (PD_<20>) was 4.2±5.9 ml before training. The PD_<20> was significantly higher after training (8.6±4.0 ml). There was no significant change in PD_<20> in the control group. Based on these results, it was concluded that physical training increased physical working capacity and improved EIB and bronchial hyperreactivity to inhaled 3.6% NaCl in asthmatic children.View full abstractDownload PDF (1012K) -
Terumasa Miyamoto, Niroku Koya, Shinichiro Suzuki, Masahiko Arita, Tsu ...Article type: Article
1991 Volume 40 Issue 3-1 Pages 215-223
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSSpecific IgG_4 antibodies in sera were measured by ELISA in allergic patients who were diagnosed as susceptible to one or more allergens among mite, milk, soybean or egg white, and also in a non-allergic control group, and their diagnostic significance was investigated. The results obtained were as follows. 1. The level of specific IgG_4 antibody was significantly higher in each allergic group than in the non-allergic group. 2. The positive rates in the specific IgG_4 antibody determination were higher than those in RAST in the milk-, soybean- and egg white-allergic groups. 3. In each allergic group, the causative allergens were detected more accurately by measuring both specific IgG_4 antibody and IgE antibody (RAST) than IgE alone. 4. The positive rates in the specific IgG_4 antibody determination were higher than those in the skin test in each allergic group. 5. It was demonstrated that the combination of the skin test with specific IgG_4 antibody measurment ensured a more accurate detection of causative allergens than the skin test alone. These results indicated that the measurment of the specific IgG_4 antibody is a helpful method to detect the causative allergens in allergic patients.View full abstractDownload PDF (905K) -
Taka MoroiArticle type: Article
1991 Volume 40 Issue 3-1 Pages 224-230
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated B cell stimulating activity in peripheral blood mononuclear cells from allergic children with positive IgE RAST score to egg white in order to study whether interleukin-4 (IL-4) was participating in production of IgE antibody. B cell stimulating activity in peripheral blood mononuclear cells from allergic children with positive IgE RAST score to egg white stimulated with ovalbumin (OVA) was higher than that observed in allergic children with negative IgE RAST score to egg white. In allergic children with positive IgE RAST score to egg white stimulated with OVA, B cell stimulating activity in peripheral blood mononuclear cells did not correlate each other; age, IgE RIST, IgE RAST score to egg white and IgG_4 antibody to egg white. These results suggest that the production of B cell stimulating activity other than IL-4 may be involved in the patients with egg allergy.View full abstractDownload PDF (644K) -
Masayuki OsabeArticle type: Article
1991 Volume 40 Issue 3-1 Pages 231-238
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTranilast (N-5') as a mast-cell stabilizer is widely used in cases of bronchial asthma and nasal allergy. Some reports showed that N-5' is effective against keroids and ulcerative colitis. So, it is considered that N-5' inhibits cell-mediated immunity. N-5' inhibited BCG-CWS-stimulated lymphocyte proliferation which was proved to be mainly operated by OKT4 positive T cells. Production of the lymphokine from BCG-CWS-stimurated lymphocytes was suppressed by the addition of N-5'. Thus, it is demonstrated that N-5' inhibits delayed type hypersensitivity in vitro.View full abstractDownload PDF (657K) -
Toru Takenaka, Shuji Kishi, Masato Tsujimoto, Jiro MaedaArticle type: Article
1991 Volume 40 Issue 3-1 Pages 239-247
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAlthough it is well-known that Leu3a-epitope on CD4 molecule functions as a receptor for human immunodeficiency virus (HIV), the function of OKT4-epitope is still obscure. In order to learn the significance of OKT4-epitope, we performed immunological and functional studies on lymphocytes obtained from individuals with incomplete/complete OKT-4 epitope deficiency. Their lymphocytes did not show any abnormality in their susceptibility to HIV infection, the internalization of CD4 molecules by TPA-treatment, the capability of producing IL-2 in vitro or the expression of IL-2R (α/β-chain) by PHA-stimulation. By flow cytometric analysis it was demonstrated that quantity of OKT4-epitopes in the incomplete deficiency was approximately one-half lesser than that of normal individuals. Coupled with this fact and DNA analysis previously reported, individuals with incomplete/complete OKT4-epitope deficiency were considered to be heterozygote and homozygote, respectively. These results led us to the conclusion that OKT4-epitope deficiency was inherited as an autosomal codominant trait. Individuals with complete OKT4-epitope deficiency was found in 7 cases out of 1486 random samples (0.47%), from which individuals with incomplete OKT4-epitope deficiency were estimated to account for 12.8%.View full abstractDownload PDF (756K) -
Tsutomu Kimura, Nobuhiro Ishikawa, Kenkichi ShinkaiArticle type: Article
1991 Volume 40 Issue 3-1 Pages 248-255
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt appears to be significant for the analytical studies of drug allergy that a comparison is made among inbred strains of mice, with different H-2 haplotypes with respect to the antibody response to low-molebular compounds. Such studies has been demonstrated by several investigators usint high-molecular antigens, such as the synthetic polypeptides and natural proteins. The present experiments were undertaken, therefore, to clarify the differences in antibody responses to a low-molecular compound, TNBS in inbred strains of mice. Mice of four different strains, A/J (H-2^a), C57BL/6 (H-2^b), DBA/2 (H-2^d) and C3H/He (H-2^k) were immunized with TNBS (30 & 300 μg/body) plus FCA by the routed of ip or sc. Responses of IgG and IgE fantibody productions were estimated by HA in serum samples treated with 2-ME and rat PCA reaction in untreated serum samples, respectively. As the results, DBA/2 (H-2^d) mice showed high responses on IgE antibody production whereas C3H/He (H-2^k) mice on IgG antibody production. A/J (H-2^a) mice displayed high responses both on IgG and IgE antibody productions. C57BL/6 (H-2^b) mice denoted low to intermediate respondes both on IgG and IgE antibody productions. The above phenomenon may be interpreted by the fact that H-2^a haplotype of A/J mice has a crossover on K region〜E_α subregion of H-2^k and S・D regions of H-2^d.View full abstractDownload PDF (824K) -
Article type: Appendix
1991 Volume 40 Issue 3-1 Pages 256-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 3-1 Pages 257-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 3-1 Pages 257-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (32K) -
Article type: Appendix
1991 Volume 40 Issue 3-1 Pages 258-261
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Cover
1991 Volume 40 Issue 3-1 Pages Cover18-
Published: March 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (230K)
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