Japanese Journal of Allergology

[title in Japanese]

Article type: Cover
1991 Volume 40 Issue 7 Pages Cover30-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.Cover30

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[title in Japanese]

Article type: Cover
1991 Volume 40 Issue 7 Pages Cover31-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.Cover31

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages App11-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.App11

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[title in Japanese]

[in Japanese]

Article type: Article
1991 Volume 40 Issue 7 Pages 653-659
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.653

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THE CHANGES OF CELL POPULATION AND CHEMICAL MEDIATORS IN BALF FOLLOWING LOCAL ALLERGEN CHALLENGE

Kenji Sunouchi, Mitsuru Adachi, Shigeru Maruyama, Masao Mizuno, Kouki ...

Article type: Article
1991 Volume 40 Issue 7 Pages 660-668
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.660

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In eight subjects who showed dual asthmatic response (DAR) in bronchial provocation tests (BPT) with specific allergens, local allergen challenge (LAC) was conducted using a flexible bronchofiberscope. We examined the concentrations of histamine, leukotriene B_4 and C_4 (LTB_4 and LTC_4) and cell populations in bronchoalveolar lavage fluid (BALF) collected before LAC (control), during the immediate response phase (IR), and the late response phase (LR). Control BALF was collected from the left lingula (B^4 or B^5), and BALF in the IR or LR phase from the right middle lobe (B^4 or B^5). Each BAL was conducted with 50 ml of saline at 37℃ and repeated three times in succession. It was noted that histamine increased significantly (p<0.05) in IR-BALF from the control level. In addition, the concentrations of LTC_4 and the numbers of eosinophils increased in IR-BALF. In LR-BALF, the numbers of eosinophils (p<0.01), and the concentrations of histamine (p<0.05), LTC4 (p<0.05) and LTB_4 increased. From these results, it was suggested that infiltration of eosinophils and various chemical mediators in the bronchial mucosa play important roles in the development of late asthmatic response.

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EFFECT OF SN-408 (SALMETEROL HYDROXYNAPHTHOATE) ON PASSIVE CUTANEOUS ANAPHYLAXIS AND ANAPHYLACTIC CHEMICAL MEDIATOR RELEASE IN RATS AND GUINEA PIGS

Hideki Yamamura, Shigekatsu Kohno, Katsuya Ohata

Article type: Article
1991 Volume 40 Issue 7 Pages 669-679
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.669

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The influence of SN-408 (salmeterol hydroxynaphthoate), a new selective β_2-stimulant, on homologous passive cutaneous anaphylaxis (PCA), histamine- or serotonin-induced skin reaction and anaphylactic chemical mediator release was investigated in rats and guinea pigs, and its efficacy was compared with that of salbutamol, isoproterenol or disodium cromoglycate (DSCG). Intravenous administration of SN-408 (0.1〜10 μg/kg) 1 min before the antigen challenge dose-dependently inhibited rat homologous PCA to a similar extent to salbutamol. The inhibitory effect of these β-agonists was quickly attenuated along with time between the administration of the drug and the antigen challenge. SN-408, however, still showed significant inhibition at the time of administration 5 min before the antigen challenge at which other agonists did not significantly affect any more. Ten μg/kg of SN-408 exhibited approximately 50% inhibition of skin reaction induced by either histamine or serotonin in rats. In addition, the compound represented concentration-dependent inhibition of the anaphylactic histamine release from the isolated rat peritoneal exudate cell, indicating that the inhibitory effect of SN-408 on rat homologous PCA is due to the suppression of mediator release in addition to the antagonism to mediator(s) released. The anaphylactic release of either histamine, immunoreactive (i-) leukotriene (LT)B_4 or i-LTC_4 from guinea pig lung fragments was concentration-dependently inhibited by 10^<-10>〜10^<-7> g/ml SN-408, and the inhibitory potency appeared to be enhanced by prolongation of the pretreatment interval with the drug. From these results, it was suggested that SN-408 is expected to have a potent and long-acting prophylactic effect as well as the bronchodilatory effect on allergic asthma.

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THE STIMULI RELEASING HISTAMINE FROM MURINE BONE MARROW-DERIVED MAST CELLS : 2. Mechanisms Involved in Histamine Release Induced by Extracellular ATP and Its Metabolites

Hirohisa Saito, Naoya Sakaguchi, Motohiro Ebisawa, Kenji Matsumoto, Ak ...

Article type: Article
1991 Volume 40 Issue 7 Pages 680-688
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.680

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Extracellular ATP stimulated histamine release and generation of leukotrience C_4 (LTC_4) accompanied with the formation of inositol phosphates and a rapid increase in intracellular Ca^<2+> ([Ca^<2+>]i) in mouse bone marrow-derived cultured mast cells (BMMC). The rank order of histamine-releasing potency of ATP and its metabolites is ATP>ADP>AMP>adenosine. Nonhydrolyzable ATP analog, adenosine-5'-O-[2-thiotriphosphate] (ATP-S) released more histamine from the cells than ATP. On the other hand, simultaneous addition of adenosine analogues at micromolar concentrations potentiated histamine release from the cells induced by ATP (50μM) or DNP-HSA antigen (0.1 ng/ml) in the following rank order: adenosine>AMP≫ADP=ATP. Histamine release potentiated by adenosine was blocked by the treatment with pertussis toxin, whereas histamine release induced by ATP was not affected by the toxin, suggesting that extracellular ATP stimulate histamine release from BMMC probably via mechanisms independent of the potentiation of histamine release induced by adenosine.

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THE INHIBITORY EFFECT OF OXATOMIDE ON OXYGEN RADICAL PRODUCTS FROM HUMAN EOSINOPHILS AND AN EOSINOPHILIC CELL LINE

Junichi Chihara, Atsushi Yasukawa, Takahiro Yamamoto, Dai Kurachi, Ryu ...

Article type: Article
1991 Volume 40 Issue 7 Pages 689-694
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.689

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Recently, much attention has been pair to the role played by the allergic inflammatory reaction in the role of asthma. Eosinophils are considered to be major inflammatory cells in bronchial asthma. Therefore, in this study, eosinophil-mediated oxygen radicals were examined by means of luminol-dependent chemiluminescence. Also, the effect of oxatomide, an anti-allergic agent, which has an inhibitory effect on eosinophil-mediated natural cytotoxicity against bronchial epithelial cells, on the production of oxygen radicals from eosinophils was studied. The results revealed the inhibitory effects of oxatomide on eosinophil-mediated oxygen radicals products. Furthermore, the inhibitory effect of this agent on oxygen radical products from eosinophilic cell-line named EoL-3, which has been established recently, was observed. We concluded from these results that oxatomide not only has anti-allergic activity but also anti-inflammatory properties for eosinophils.

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COMPARISON OF IMMUNOLOGICAL ACTIVITIES OF GUINEA PIG IgG1 AND IgG2 ANTIBODIES TO LOW-MOLECULAR ANTIGEN

Kenkichi Shinkai, Nobuhiro Ishikawa, Tsutomu Kimura

Article type: Article
1991 Volume 40 Issue 7 Pages 695-703
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.695

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The present study was carried out using a low-molecular antigen to clarify which of the two IgG subclasses (IgG1 and IgG2) of guinea pigs is responsible for the immunological assay systems in ordinary antigenicity tests for the development of a novel drug, and to what extent such IgG subclass antibodies contribute to the assay systems in addition to IgM antibody. Guinea pigs were immunized with TNBS plus FCA (3 mg/body), at intervals of 10 days, 3 times in total. The anti-TNBS serum was fractionated into peak I (IgG2), peak II (IgG1) and peak IV (IgM) by DEAE-cellulose column chromatography, and the immunological activities as well as the functions of the above three peaks were estimated by HA, homologous PCA reaction, PSANA and P-Arthus. The IgM and two IgG peaks possessed immunological activities on HA and P-Arthus, and the following degree of activities was shown in both assay systems: peak II (IgG1)>peak IV (IgM)>peak I (IgG2). In the homologous PCA reaction and PSANA, immunological activities were seen only in peak II (IgG1). It is confirmed that the IgG1 subclass is a homocytotropic antibody involved in the PCA and PSANA assay systems in the case of low-molecular immunogens such as TNBS.

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A CASE OF ISOCYANATE-INDUCED HYPERSENSITIVITY PNEUMONITIS AND A COMPRESSION-AIR MASK THOUGHT TO BE EFFECTIVE IN ITS PREVENTION

Jiro Idezuka, Hideo Ikarashi, Satoru Nozawa, Michio Maruyama, Mayumi S ...

Article type: Article
1991 Volume 40 Issue 7 Pages 704-710
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.704

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A 41-year-old paint sprayer, who had worked with polyurethane paint since the spring of 1989, developed exertional dyspnea and dry cough and entered hospital on December 4, 1989. Plain chest X-ray film and a computed tomogram of the lung revealed diffuse micronodular shadows in both lower lung fields. DLco was shown to be significantly decreased in a pulmonary function test. A sample of bronchoalveolar lavage fluid showed increased T lymphocytes and a decreased CD4/8 ratio. A lung biopsy specimen revealed alveolitis, but neither Masson body nor granulomas were seen. Serum antibody specific to TDI-HSA was detected, and an environmental provocation test was positive. From these results, the patient was diagnosed as having isocyanate-induced hypersensitivity pneumonitis. We advised him to wear a compression-air mask when he worked, because he did not want to quit his job. Respiratory symptoms have not been seen since then, but careful observation was though to be necessary. The involvement of type III humoral and type IV cellular immunity was suspected in this case.

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EFFECT OF ANTI-IDIOTYPIC ANTIBODY ON PRODUCTION OF ANTI-DNA ANTIBODIES BY SPLENOCYTES IN LUPUS PRONE MICE

Hitoshi Sugishima, Masahide Minoda

Article type: Article
1991 Volume 40 Issue 7 Pages 711-718
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.711

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It has been suggested that production of autoantibodies is regulated by idiotype-antiidiotype network. In this study, we examined modulatory effect of the antiidiotypic antibody on the synthesis of anti-DNA antibodies by New Zealand black/New Zealand white F1 mice (B/W F1) splenocytes. The antiidiotypic antibodies were prepared by immunization of a monoclonal anti-DNA antibody derived from B/W F1 to rabbits. The prepared antiidiotypic antibody had specificity to the antigen binding site of anti-DNA antibodies. B/W F1 splenocytes were adjusted to 1×10^6 cells/ml and cultured in 1.0 ml aliquots in the presence of varying concentrations of the antiidiotypic antibody for 48 hours. The cells were then washed three times, resuspended in RPMI1640 containing 10% fetal calf serum and cultured again. On days 3 and 7 of the culture, the supernatants were harvested and secretion of anti-DNA antibodies was measured by ELISA. Production of anti-DNA antibodies by B/W F1 splenocytes was suppressed by pretreatment with the antiidiotypic antibody. When the concentration of antiidiotypic antibody was 1 μg/ml, anti-DNA activity of the supernatants decreased 50%, compared with control on day 3, but the effect was reduced on day 7. The treatment of antiidiotypic antibody did not affect the proliferation and viability of B/W F1 splenocytes. The results indicated that anti-DNA antibodies synthesis were regulated by idiotype-antiidiotype network and could be manipulated by the antiidiotypic antibody.

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 719-722
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.719

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 723-745
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.723

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 746-758
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.746

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 759-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.759

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 760-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.760

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 761-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.761_1

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 761-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.761_2

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 762-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.762

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 763-764
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.763

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[title in Japanese]

Article type: Appendix
1991 Volume 40 Issue 7 Pages 765-768
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.765

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[title in Japanese]

Article type: Cover
1991 Volume 40 Issue 7 Pages Cover32-
Published: July 30, 1991
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.40.Cover32

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