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Volume 40, Issue 9
Displaying 1-19 of 19 articles from this issue
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Article type: Cover
1991 Volume 40 Issue 9 Pages Cover35-
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Cover
1991 Volume 40 Issue 9 Pages Cover36-
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (1082K) -
Article type: Appendix
1991 Volume 40 Issue 9 Pages App13-
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 9 Pages App14-
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 9 Pages App15-
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
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Kiri Honma, Masahiko Aoyagi, Kimiyuki Saito, Toshiyuki Nishimuta, Kazu ...Article type: Article
1991 Volume 40 Issue 9 Pages 1167-1175
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo delineate the antigenic determinants on ovalbumin (OA) and ovomucoid (OVM) recognized by specific IgG and IgE antibodies in sera from patients with allergy to hen's egg, we studied the binding activities of IgG and IgE antibodies to native OA or OVM and seven different OA or OVM preparations, i.e. heated OA or OVM (100℃ for 3 min and 80℃ for 30 min) or 0.3 M NaOH, dithiothreitol (DTT), sodium dodecyl sulfate (SDS), 6 M urea or HCl treated OA or OVM. Eight patients with IgE anti-OA antibodies and 12 patients with IgE anti-OVM antibodies were used in these studies. The binding activities of IgG and IgE antibodies to physically or chemically denatured OA were partially decreased compared with those to native OA, whereas IgG and IgE antibodies in sera from patients bound well to denatured OVM with similar binding activities to native OVM. These results strongly suggest that antibodies to OA recognize partially conformational antigenic determinants on OA, whereas antibodies to OVM mainly recognize sequential antigenic determinants on OVM, and that antigenic determinants of OVM recognized by antibodies in sera from patients are more stable than those of OA under these denaturation conditions. In addition, the binding activities of IgE antibodies to denatured OA or OVM were significantly different from those of IgG antibodies to these OA or OVM, suggesting that the specificities of IgE antibodies to OA or OVM may be different from those of IgG antibodies to OA or OVM.View full abstractDownload PDF (1211K) -
Koji FukutaniArticle type: Article
1991 Volume 40 Issue 9 Pages 1176-1185
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe effects of long-term administration of theophylline on the pituitary-thyroid axis were investigated. In the first study, the changes in serum thyroid hormone, TSH and cortisol levels were examined before and after 2 week-administration of sustained-release theophylline in 5 normal and 10 asthmatic subjects. In the normal subjects, the hormone levels did not change before or after theophylline administration. On the other hand, in the asthmatics, serum TSH levels increased (p<0.05) and serum free T_3 levels decreased (p<0.05) after 2 weeks. In the asthmatics, basal T_4 levels had a significant correlation with both basal T_3 and rT_3 levels, but T_4 levels after 2 weeks correlated significantly with rT_3 alone. In the second investigation, the effects of long-term administration were studied in 15 asthmatics not on theophylline (group 1), 20 asthmatics on theophylline (group 2), and 20 asthmatics on theophylline and glucocorticoids (group 3). TSH levels in group 2 were significantly higher than those in groups 1 and 3. Although in group 1 there was a significant correlation between T_4 levels and T_3 and rT_3 levels, in group 2 T_4 levels correlated significantly with rT_3 levels alone. In conclusion, these results suggest that although long-term theophylline treatment may increase the secretion of TSH from the pituitary in asthmatics, in the peripheral tissue it may decrease the conversion of T_4 to T_3, resulting in the diminution of active hormones.View full abstractDownload PDF (879K) -
Yasuo Horiuchi, Toshihiko Takemura, Kazuyuki UenoArticle type: Article
1991 Volume 40 Issue 9 Pages 1186-1193
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThree different theophylline preparations, theophylline syrup, granule and tablets, were examined to determine their pharmacokinetics and changes in urinary metabolites for each steady state phase. The theophylline syrup was as rapidly and as essentially bioavailable as the theophylline granule preparation. In addition, peak to trough differences in serum theophylline concentrations were largest for theophylline syrup and lowest for tablets. Tmax was greater in theophylline tablets and a significant difference was apparent in the tablet-syrup and tablet-granule populations. AUC and T1/2 were similar in these populations. Cmax and Cmin achieved satisfactory therapeutic theophylline levels in three different preparations, and t-test showed no significant difference between them. CL and Vd were also similar. The urinary metabolites of theophylline were expressed as internal standard equivalents on a molar basis. There were no significant changes between either tested preparations different or different age groups. Therefore, we concluded that theophylline syrup and granules should be administered on a 3-times-daily basis, considering trough plasma theophylline levels. Theophylline tablets are preferable, if they can be taken.View full abstractDownload PDF (770K) -
Toshihiko Jyo, Masao Kuwabara, Yoshiyuki Kodomari, Takashi Katsutani, ...Article type: Article
1991 Volume 40 Issue 9 Pages 1194-1199
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSHoya (sea-squirt) asthma is a typical type I occupational asthma. A total of 22 females with this disease whose age ranged from 22 to 69 years were treated for two years with high concentration purified sea-squirt antigen named Ei-M having a molecular weight of 22,800. One case who developed ordinary bronchial asthma abandoned the immunotherapy during the early stage of the therapy, but in the remaining 21 cases remarkable effects were rapidly observed from the early stage of treatment. These cases did not develop asthmatic attacks even through they engaged in oyster shucking work and no symptomatic therapy was indicated. Serum anti-Ei-M IgG antibody was significantly elevated after the therapy. None of the treated cases developed any side effects.View full abstractDownload PDF (625K) -
Hideaki Taira, Hidetoyo Teranishi, Yukiko Kenda, Youichiro Keyaki, Kik ...Article type: Article
1991 Volume 40 Issue 9 Pages 1200-1209
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the geographical distribution of sugi (Cryptomeria Japonica D. Don) forests and the male flower-setting conditions of them in Toyama prefecture. The relationships between our findings and the atmospheric pollen scattering patterns were also studied. The results were as follows. 1. Atmospheric pollen counts and their scattering patterns were fairly easily explainded by the geographical distribution of 30-year old sugi forests, the male flower-setting conditions and the first day pollen was scattered in those forests. 2. Total atmospheric counts and maximum sugi pollen peaks were significantly affected by the proximity of sugi forests at altitudes of less than 200 meter. 3. In the atmospheric pollen survey, the detected pollen counts decreased according to the the distance between the observation sites and the sugi forests. And few pollen grains were observed from natural sugi forests growing at distances of 20 km to 30 km from the observation sites.View full abstractDownload PDF (927K) -
Takashi WatanabeArticle type: Article
1991 Volume 40 Issue 9 Pages 1210-1217
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAcute ingestion of alcoholic beverages causes no changes in the expiratory airflow rates of most Occidental asthmatic patients. However, asthmatic symptoms are worsened after drinking small amounts of alcohol in Japanese asthmatic patients. Our laboratory results showed that the ingestion of pure ethanol caused a fall in FEV_<1.0> in about half of the Japanese asthmatic patients tested. The mechanism of ethanol-induced bronchoconstriction remains unclear. In order to investigate this mechanism, we performed oral-provocation tests with 10% ethanol in vivo, and leukocyte histamine release assay induced by ethanol and acetaldehyde in vitro. 55% of asthmatics showed a significant fall in FEV_<1.0> after ingestion of 10% ethanol (responder). There was no difference in the rise of blood ethanol concentration between the responder group and non-responder group. Acetaldehyde and histamine concentration in the responder group were significantly higher than in the non-responder group. Leukocyte histamine release assay showed that acetaldehyde (2μM-100μM) caused dose-dependent histamine release, whereas, ethanol (2 μM-100 μM) had no effect on histamine release. Our data indicate that histamine release from mast cells (or basophils) caused by acetaldehyde may play an important role in ethanol-induced bronchoconstriction. This is the first report on the mechanism of ethanol-induced bronchoconstriction in Japanese asthmatic patients.View full abstractDownload PDF (782K) -
Hiroshi Yasueda, Kazuo Akiyama, Yuji Maeda, Tetsuo Hayakawa, Fujito Ka ...Article type: Article
1991 Volume 40 Issue 9 Pages 1218-1225
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA simple enzyme-linked immunosorbent assay (ELISA) has been developed for the quantitation of the major allergens of sugi pollen, Cry j I and of Dermatophagoides mites, Der I (Derp pI/Der f I) and Der II (Der p II/Der f II) for use in the in vitro standardization of allergen extracts. Polystyrene microplates coated with a IgG fraction of rabbit antiserum were incubated first with allergen extracts and then with biotinylated antiserum IgG. The bound allergen-biotinylated antibody complex was detected with commercially available streptavidin-enzyme conjugate followed by the addition of colorimetric substrate. The assay was very sensitive (〜0.2 ng/ml) and reproducible (CV%=1.9〜13.8%). The ELISA was compared with the radioimmunoassay previously described, and the results showed a very good correlation between the assays (r=0.967〜0.990). The allergen content in three sugi pollen and three house dust extracts measured by the ELISA also demonstrated a god agreement with the relative potency of these extracts as determined by the intradermal skin test. These results indicate that the ELISA could be useful in the standardization of allergen extracts.View full abstractDownload PDF (815K) -
Masayuki Matsuda, Nobuo Yanagisawa, Naoyuki TsukadaArticle type: Article
1991 Volume 40 Issue 9 Pages 1226-1231
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRecent clinical problems in patients with subacute myelo-optico-neuropathy (SMON) arise mainly from complications associated with the disease. Some of them show the association of autoimmune diseases. Furthermore, it has been reported that some kinds of autoantibody and hyperglobulinemia are frequently seen in patients with SMON. In order to examine whether ageing and clioquinol intoxication in the past may be implicated in the immunological system of the patients, we investigated subsets of peripheral blood lymphocytes including OKT3, OKT4, OKT8, OKIa1 and Leu7, in 31 patients with SMON, who lived in Nagano Prefecture. The levels of OKT8 (% positive cells), which are known to decrease with age actually increased with age in the peripheral blood of patients with SMON. The levels of OKT4 decreased with ageing, as did the OKT4/OKT8 ratios. The percentage of OKIa1 also significantly increased with age in the peripheral blood of patients with SMON compared to that of the controls (p<0.01 or p<0.001). It is considered unlikely that the effect of ageing on subsets of lymphocytes can be implicated in these immunological abnormalities of SMON patients, but it seems likely that the immune systems (B cell or T cell) of SMON patients are activated by factors other than ageing in subsets of lymphocytes.View full abstractDownload PDF (610K) -
Ryuji Koike, Shoji Yoshida, Hidenori TakahashiArticle type: Article
1991 Volume 40 Issue 9 Pages 1232-1238
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe experienced a case of idiopathic hypereosinophilic syndrome (HES) associated with pulmonary infarction. The case was a 22-year-old woman with marked eosinophilia (16835/μl) and peripheral edema and cyanosis. During hospitalization, she suddenly developed lower right chest pain, and infiltrative lesions with pleural effusions in the right lung were prominent. A diagnosis of pulmonary infarction was made after perfusion scan and angiography of the lung. Lupus anticoagulant was found to be positive and a transient increase of anti-cardiolipin antibody slightly in her serum was also observed. Reccurrent thrombosis is known to be complicated by HES but its mechanism remains to be clarified. There has also been no study reported in the literature on the role of lupus anticoagulant in this process; its possible role in this patient is discussed.View full abstractDownload PDF (1281K) -
Midori Akagawa, Toshio Mori, Toru Ando, Hirokazu OkudairaArticle type: Article
1991 Volume 40 Issue 9 Pages 1239-1242
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSFive monoclonal antibodies (Mabs) against Der f II, one of the major allergens of Dermatophagoides farinae, were obtained from mice immunized with the allergen. Western blotting analysis revealed that only one Mab, named 15E11, was specific for Der f II, whereas the other Mabs crossreacted with Der p II, one of the major allergens of Dermatophagoides pteronyssinus. These results indicate the possibility that the Der f II-specific Mab, 15E11, is a useful reagent for specific determination of Der f II.View full abstractDownload PDF (471K) -
Toshimichi Imai, Mitsuru Adachi, Keizou Idaira, Akira Sugeta, Takako H ...Article type: Article
1991 Volume 40 Issue 9 Pages 1243-1246
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo investigate the effect of prostaglandin I_2 (PGI_2) on the increase of airway responsiveness induced by inhaled thromboxane A_2 (TxA_2), we measured the airway responsiveness to inhaled methacholine (Mch) after inhalation of TxA_2 mimetic U-46619 alone and after inhalation of U-46619 in combination with PGI_2 (U-46619/PGI_2) in six dogs. Airway responsiveness to Mch was determined by Astograph (7Hz oscillation method). Inhalation of U-46619 was carried out for five minutes at a half of minimum threshold concentration, and the concentration of PGI_2 was double that of U-46619. Inhaled U-46619 significantly increased airway responsiveness to Mch (p<0.01). However the airway responsiveness to Mch did not increase following inhalation of U-46619/PGI_2, and the increase of airway responsiveness to Mch induced by inhaled U-46619 was inhibited significantly by PGI_2 (p<0.01). PGI_2 inhalation alone did not affect the basal airway responsiveness to Mch. These results indicate that PGI_2 protects the hyperresponsiveness induced by TxA_2 inhalation in dogs.View full abstractDownload PDF (428K) -
Article type: Appendix
1991 Volume 40 Issue 9 Pages 1247-1251
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1991 Volume 40 Issue 9 Pages 1252-1254
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
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Article type: Cover
1991 Volume 40 Issue 9 Pages Cover37-
Published: September 30, 1991
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (247K)
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