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Volume 44, Issue 12
Displaying 1-17 of 17 articles from this issue
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Article type: Cover
1995 Volume 44 Issue 12 Pages Cover10-
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Cover
1995 Volume 44 Issue 12 Pages Cover11-
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (884K) -
[in Japanese]Article type: Article
1995 Volume 44 Issue 12 Pages 1355-1360
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Kataro Ozasa, Hiroshi Takenaka, Nobuo Takagi, Akira AoikeArticle type: Article
1995 Volume 44 Issue 12 Pages 1361-1368
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSFrequency of and factors associated with sensitization by Japanese cedar pollen (JCP) and Japanese cedar pollinosis (JCPS) were analyzed by a cross-sectional method. Four hundred and five primary school children in a rural town were examined by a questionnaire filled out by their parents and a serum test in May, 1994. Children with positive JCP specific IgE antibody (CAP-RAST score > =1) comprised 39%, and those with a score of 2 or more, 35%. Prevalence of JCPS defined as positive IgE antibody and "definite symptoms" (any nasal and/or conjunctival symptom continuing for three weeks or more in March and/or April) was 8%, and that of JCPS defined as positive IgE antibody and "definite or possible symptoms"(no condition for duration) was 22%. Children with a high total IgE antibody level (> =250 U/ml)comprised 26%. The JCP specific IgE antibody level revealed a strong positive correlation with the total IgE antibody level. Past and family history of allergic disease in general was associated with a total IgE antibody level stronger than the JCP specific IgE antibody level, and the history was also associated with allergic-like symptoms except for JCPS stronger than the symptoms of JCPS. Passive smoking by family and use of kerosene stove were negatively associated with the highest level of JCP specific IgE antibody and was not associated with other levels. One explanation may be that allergic disposition influences smoking habits, but the unique condition of nasal mucosa for allergic reaction should be considered.View full abstractDownload PDF (879K) -
Noriko ShiigaiArticle type: Article
1995 Volume 44 Issue 12 Pages 1369-1378
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEighty asthmatic and 53 non-asthmatic children were evaluated in order to find out the relationship between the onset of bronchial asthma and allergic rhinitis of parents. The results are as it follows. Total serum IgE levels relate to current symptoms but not to the onset of parents' allergic diseases. Child-onset allergic diseases have more asthmatic children than adult-onset ones. Child has more asthma when either father or mother has asthma than allergic rhintis. Child-onset asthma of parents has higher incidence of asthma in children than child-onset allergic rhinitis, adult-onset asthma and allergic rhinitis. We concluded that information on the onset of parents' allergic diseases could help us to predict bronchial asthma in their children, and both environmental and psychological factors is aggravating asthmatic attacks in children.View full abstractDownload PDF (1034K) -
Hajime KokubuArticle type: Article
1995 Volume 44 Issue 12 Pages 1379-1386
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSInhalation of aerosolized aminophylline solution (Neophylline^<【〇!R】>) was examined for it's bronchodilating effect. Tests were done on the patient with bronchial asthma aged from 8 to 16 years of age which were divided into two groups, i.e., 21 wheezy patients, 8 non-wheezy patients and on another 14 under normal controls. 1.2 ml. of neophylline (30 mgs. of aminophylline) was inhaled to each patient by the micro-nebulizer for 6 minutes. VC, FEV_1, PFR, V^^・_<50> and V^^・_<25> were measured by a Flow-volume recorder OST 7OD just before and after inhalation. The results showed that the bronchodilating effect of inhaled neo-phylline was detected in the wheezy patients group but not in the non-wheezy patients group nor in the control group. Furthermore, the duration of the bronchodilating effect was examined on another 19 wheezy patients by a peak flow meter. The effect appeared to be sustained for 4 hours after inhalation. Inhalation of serosolized neophylline is considered to be useful because of the fact that the bron-chodilation can be obtained without an elevation of serum concentration of theophylline.View full abstractDownload PDF (685K) -
Ryo Soda, Kiyoshi Takahashi, Akihiko Tamaki, Yasu Tanimoto, Chiharu Ok ...Article type: Article
1995 Volume 44 Issue 12 Pages 1387-1393
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIntroduction of Guideline for asthma treatment proposed by the committee of Japanese allergology have a tremendous impact on patients with bronchial asthma. Intractable asthmatics who have had to take some oral steroid to overcome disease severity, may have also some merrit by this treatment, so that some of them might be no longer considered as intractable asthmatics. To clarify this, multicentrial study was conducted. In this study, a case who have had more than 5 mg of prednisolone and/or 800μg of beclomethasone dipropionate throughout the year, was diagnosed as intractable asthmatics. In 845 case, 14.7%, 123 cases were diagnosed as intractable. These cases were significantly to be non-atopic and adult onset. Also, they have a significant tendency to be deteriorated by infection and careless drug administrations. Using the multiquantification method to examine the most powerfull factor on intractable asthmatics, type of asthmatics was the most important and the past history of severe attack was the second. When intractable asthmatics diagnosed mainly by their BDP usage (BDP-intractable) were compared with intractable diagnosed by oral PSL (PSL-intractables), BDP-intractables were significantly atopic compared to PSL-intractables.View full abstractDownload PDF (694K) -
Shunichi Mita, Naruhito Oda, Mitsuru AdachiArticle type: Article
1995 Volume 44 Issue 12 Pages 1394-1400
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe measured serum IgE antibodies by the MAST and the CAP RAST in 90 patients refered to our asthma clinic and compared their results. Furthermore the patients with CAP positive/MAST negative were investigated by bronchial provocation test with allergen, skin test and CAP RAST inhibition test. Significant correlations were obtained between the results of the MAST and those of the CAP RAST for house dust 2 (r=0.617), for Dermatophagoides farinae (r=0.776) and for Japanese cedar (r=0.609), but not for all 3 mold allergens. CAP positive/MAST negative results were found in 1.4-27.8% and MAST positive/CAP negative results were found in 0-2.7%. The presences of specific IgE antibodies were confirmed by a positive bronchial provocation test with allergen, skin test and CAP RAST inhibition test in CAP positive/MAST negative results. Those results indicate that the CAP RAST is more sensitive than the MAST.View full abstractDownload PDF (680K) -
Katsuji Uno, Ariyoshi KondoArticle type: Article
1995 Volume 44 Issue 12 Pages 1401-1409
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn 71 patients suspected of drug-induced pneumonitis, the identification of the allergenic drugs were studied by leukocyte migration inhibition test (LMIT). The LMIT was positive in 61 cases (85.9%).Leukocyte migration activating factor (LMAF) was detected in 22 cases (30.9%), and leukocyte migration inhibitory factor (LMIF) in 39 cases (54.9%), which was found significantly higher than LMAF (p < 0.05). There was no considerable difference in the LMIT-positive rate between interstial and eosinophilic pneumonia. The LMIT-positive drugs were detected in 66 of all 180 suspected drugs, in which 33 drugs (50%) were antibacterial agents and 11 were Kampo prescriptions. β-Lactam antibiotics accounted for about half the number (16 drugs) in antibacterial agents. LMAF was detected more frequently in β-lactam antibiotics-induced pneumonitis, which LMIF was detected more often in Kampo prescriptions-induced pneumonitis (p < 0.005). Furthermore, the latent period from drug intial to the onset of pneumonitis were about 10 days in β-lactam antibiotics-induced pneumonitis and a few months in Kampo prescriptions-induced pneumonitis (p < 0.001). Our findings indicate that LMIT is valuable to identify the allergenic drugs in drug-induced hypersensitivity pneumonitis and that delayed-type hypersensitivity (DTH), with which LMIF is related closely, plays a major role in the pathogenesis of this lung lesion. Furthermore, the pathogenic mechanism of β-lactam antibiotics-induced pneumonitis may be different from that of Kampo prescriptions-induced pneumonitis.View full abstractDownload PDF (984K) -
Katsuhiro Ojio, Yoshikatsu Nakamura, Hideo Miyata, Yoshiko Banno, Shig ...Article type: Article
1995 Volume 44 Issue 12 Pages 1410-1417
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWestern blot analysis shows the presence of protein kinase C (PKC) α, β1, β2, δ, ε, ζ isozymes in rat basophilic leukemia (RBL-2H3) cells. Antigen stimulation caused preferential translocation of protein kinase C (PKC) δ and ε to membranes. On the other hand, when the cells were stimulated by phorbol 12-myristate 13-acetate (PMA) or ionophore (A23187), PKCα and β were predominantly translocated. Phospholipase D (PLD) was activated by three stimulants in order: A23187>PMA>>antigen. Therefore, PKCα and β seem to be involved in the activation of PLD in RBL cells. The translocation of all PKC isozymes in A23187 stimulation was weak. Therefore, PLD activation in A23187 stimulation may require some other factors than PKC which are associated with the increase of Ca^<2+> in the cells. The cells stimulated by antigen secreted serotonin to the same level as the cells stimulated by A23187. In both stimulation, PKCα and ε were translocated to almost similar level, suggesting that PKCα and ε are involved in the secretion. All PKC isozymes except g were markedly translocated in PMA stimulation, but secretion did not occur. These results indicate that translocation of PKCα and β may be associated with PLD activation and also that both translocation of PKCα and ε and intracellular calcium increase are required for serotonin secretion in RBL cells.View full abstractDownload PDF (1056K) -
Katsuya Fujimori, Kinzo Sakurai, Akira YoshizumiArticle type: Article
1995 Volume 44 Issue 12 Pages 1418-1421
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1995 Volume 44 Issue 12 Pages 1422-
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Index
1995 Volume 44 Issue 12 Pages 1423-1431
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Index
1995 Volume 44 Issue 12 Pages 1432-1434
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Index
1995 Volume 44 Issue 12 Pages 1435-1439
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1995 Volume 44 Issue 12 Pages 1440-1445
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Cover
1995 Volume 44 Issue 12 Pages Cover12-
Published: December 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (251K)
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