Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 44, Issue 1
Displaying 1-16 of 16 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1995 Volume 44 Issue 1 Pages Cover1-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.Cover1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1995 Volume 44 Issue 1 Pages Cover2-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.Cover2
    JOURNAL FREE ACCESS
    Download PDF (701K)
  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 1 Pages App1-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.App1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1995 Volume 44 Issue 1 Pages 1-6
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.1
    JOURNAL FREE ACCESS
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  • SENSITIZATION AND ONSET OF JAPANESE CEDAR POLLINOSIS IN CHILDREN
    Akiko Mori
    Article type: Article
    1995 Volume 44 Issue 1 Pages 7-15
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.7
    JOURNAL FREE ACCESS
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    Recently, increases in cases of Japanese cedar pollinosis have been found, especially in children. School children, junior high school students and high-school students in Mibu-machi, Tochigi prefecture were given questionnaires, rhinoscopic examinations were done and nasal secretions and blood samples were taken. The following results for the process of sensitization and the onset of Japanese cedar pollinosis were found. According to the questionnaire, the percentage of positive Japanese cedar pollinosis was about 10% in 6-year-olds and about 25% in 17-year-olds. However, according to the blood samples, Japanese cedar pollen antibodies abruptly increased in 7-year-olds. We found age risk factors. Sensitization to Japanese cedar pollinosis appeared in 7-year-old, with symptoms of pollinosis developing in 8-year-olds. We compared the percentage of positive rate of antibodies of Japanese cedar pollen with percentage of Dermatofihagoides farinae (Der f) from the student's blood samples. Children having Der f antibodies showing higher positive rate of Japanese cedar pollen antibodies than children who do not have Der f antibodies. Sensitization to Japanese cedar pollen is dependent on Der f. We paid attention to resident environments. Children having Japanese cedar pollen antibodies were higher in children living in the urban than in rural. The percentage of onset of symptoms was higher in apartment buiIdings than in detached houses. In conclusion, sensitization to Japanese cedar pollen occurs mostly at age 6-7, is influenced by type of dwelling (apartment or house), (specially by Der f) and it's onset is affected by urban or rural.
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  • PSYCHOLOGICAL PROFILES OF PATIENTS WITH BRONCHIAL ASTHMA : First Report : Analysis According to the Difference in Severity of Asthma
    Michiko Haida, Koji Ito, Sohei Makino, Terumasa Miyamoto
    Article type: Article
    1995 Volume 44 Issue 1 Pages 16-25
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.16
    JOURNAL FREE ACCESS
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    Although it is well known that asthma is influenced by psycho-social factors, the present medical system does not take any measures to deal with these underlying factors. Many physicians are unable to assist patients with psycho-social problems due to the lack of time they are allowed for each patient. We have employed a variety of psychological test scales to assist in screening patients. As a result, we found that many severe asthmatics lack enthusiam for therapy, possess pessimistic feelings toward their prognosis. They also have personality traits of extroversion in combination with psychological instability, which may given them problems of compliance, while some manifest a tendency to flight to illness. These factors may lead to further difficulty in treatment, including steroid dependency and death from asthma. Early intervention must be contemplated to prevent such outcomes.
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  • ANALYSIS OF T CELL RECEPTOR Vβ GENE EXPRESSION IN BRONCHOALVEOLAR LAVAGE FULUID LYMPHOCYTES FROM PATIENTS WITH IDIOPATHIC INTERSTITIAL PNEUMONIA
    Atsushi Yoshitomi, Atsuhiko Sato, Hiroshi Hayakawa, Kingo Chida, Atsus ...
    Article type: Article
    1995 Volume 44 Issue 1 Pages 26-33
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.26
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    T lymphocytes in bronchoalveolar lavage (BAL) from idiopathic interstitial pneumonia (IIP) patients are considered to recognize unknown antigens, such as dust, fume, virus or degenerated autoantigens. To analyse the nature of these T lymphocytes, we investigated T cell receptor (TCR) Vβ gene usage (22 kinds) in BAL Lymphocytes and Peripheral blood lymphocytes from 10 11P patients and 9 normal controls, using reverse transcriptase-polymerase chain reaction method. In BAL lymphocytes, predominant usage of Vβgenes (>15% of the sum of all Vβ transcripts) was recognized in 7 of 10 IIP patients, which appeared to vary in individuals (Case 1: Vβ14, case 2: Vβ3, Vβ5.1, case 5: Vβ2, case 6: Vβ6, case 7: Vβ8, case 8: Vβ7, Vβ20, case 9: Vβ6), whereas no predominant Vβ usage was demonstrated in normal controls. It remains to be elucidated whether the BAL lymphocytes expressing predominant Vβ genes are involved in the activation of alveolar macrophages, fibroblasts, thereby inducing the production of autoantibodies.
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  • EFFECTS OF AN ANTIALLERGIC DRUG, PEMIROLAST POTASSIUM ON TYROSINE PHOSPHORYLATION AND MAP KINASE ACTIVATION IN ANTIGEN-STIMULATED RAT BASOPHILIC LEUKEMIA (RBL-2H3) CELLS
    Yoshikatsu Nakamura, Shigeru Nakashima, Hiroshi Fujimiya, Takahiko Kum ...
    Article type: Article
    1995 Volume 44 Issue 1 Pages 34-44
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.34
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    Aggregation of high affinity IgE Fc receptors (FcεRI) on RBL-2H3 cells results in tyrosine phosphorylation of 33-, 42-, 44-, 72-, 80-, 90-, 125-kDa proteins. The 42 and 44 kDa proteins were identified as mitogen-activated protein (MAP) kinases with immunoblotting of anti-MAP kinase antibody. The effects of an antiallergic drug, pemirolast potassium (TBX) on Ag-induced protein tyrosine phosphorylation and MAP kinase activation were investigated. When RBL-2H3 cells were stimulated with Ag in the presence of TBX, tyrosine phosphorylation of three proteins (33, 42 and 44 kDa) was inhibited concentration-dependently (0.1-10 μg/ml). Inhibition of Ag-induced tyrosine phosphorylation of 33 kDa protein, which could be a β subunit of FcεRI, suggests that TBX may prevent the activation of FcεRI. TBX suppressed activation of MAP kinases (42 and 44 kDa) in response to Ag as well as phorbol myristate acetate (100 nM) or calcium ionophore A23187 (500 nM), implying that the drug acts on signal transduction component(s) between the second messengers and MAP kinases. However, TBX had no effects on protein tyrosine phosphorylation and MAP kinase activation in MC3T3-El osteoblastic cells. These results indicate that TBX may affect FcεRI and also may act as a step distal of Ca^<2+> mobilization and protein kinase C activation leading to MAP kinase activation in RBL-2H3 cells.
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  • EFFECT OF ROXITHROMYCIN ON RESPIRATORY BACTERIAL INFECTION IN MICE
    Yoshiki Gonokami, Shin-ichi Konno, Kazuhito Asano, Masatsugu Kurokawa, ...
    Article type: Article
    1995 Volume 44 Issue 1 Pages 45-49
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.45
    JOURNAL FREE ACCESS
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    The effects of roxithromycin (RXM), an antibiotic of the macrolide family, on respiratory bacterial infection in mice were examined. BALB/c mice were administered with RXM orally at a dose of 5.0 or 2.5 mg/kg once per day for 14 days. On day 2 after the final drug administration, the mice were nasally infected with Haemophilus influenzae. RXM dose dependently inhibited the pathological changes in lung tissues induced by H. influenzae infection. RXM also enhanced 2',5'-oligoadenilate synthetase production in response to infection.
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 1 Pages 50-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.50
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 1 Pages 51-52
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.51
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 1 Pages 53-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.53_1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 1 Pages 53-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.53_2
    JOURNAL FREE ACCESS
    Download PDF (42K)
  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 1 Pages 53-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.53_3
    JOURNAL FREE ACCESS
    Download PDF (42K)
  • [title in Japanese]
    Article type: Appendix
    1995 Volume 44 Issue 1 Pages 54-57
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.54
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1995 Volume 44 Issue 1 Pages Cover3-
    Published: January 30, 1995
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.44.Cover3
    JOURNAL FREE ACCESS
    Download PDF (151K)
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