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Volume 44, Issue 10
Displaying 1-18 of 18 articles from this issue
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Article type: Cover
1995 Volume 44 Issue 10 Pages Cover4-
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Cover
1995 Volume 44 Issue 10 Pages Cover5-
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (656K) -
Article type: Appendix
1995 Volume 44 Issue 10 Pages App2-
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
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[in Japanese]Article type: Article
1995 Volume 44 Issue 10 Pages 1193-1198
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
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Motoshi Wakugawa, Nobuo Yamada, Hidemi Nakagawa, Kunihiko TamakiArticle type: Article
1995 Volume 44 Issue 10 Pages 1199-1206
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo elucidate the active process of eosinophil infiltration in atopic dermatitis (AD), we performed patch testing using crude mite allergens on normal-appearing skin in adult AD patients with high levels of mite-specific IgE antibodies and analized positive reaction sites chronologically by histological and immunohistological methods. Positive reactions were observed in 6 out of 9 AD patients (66.7%), whereas none of 7 non-AD control subjects showed positive reactions. Skin biopsies were obtained from positive reaction sites at 2, 6, 12, 24 and 48 hours after allergen challenge. Eosinophils were seen within postcapillary venules at 2 hours, followed by increased perivascular eosinophil infiltration at 6 hours which peaked at 24 and 48 hours. Epidermal eosinophilic spongiosis was also observed at 48 hours. The majority of infiltrating eosinophils showed positive reactions for BMK-13 and 15-59% of them were EG2 positive activated eosinophils. BMK-13, EG2 and anti-EP positive reactions were scattered throughout connective tissue and their areas were time-dependently increased. These findings suggest that eosinophil transmigration and activation play an important role in initiating early AD lesions induced by transepidermal mite allergen permeation.View full abstractDownload PDF (1279K) -
Yoichi Onoue, Gyoukei Murakami, Miki Takayanagi, Masako Iwaya, Masako ...Article type: Article
1995 Volume 44 Issue 10 Pages 1207-1215
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThe specific IgE antibodies to 4 species of cockroach were measured in sera from 51 asthmatic children 6 to 16 years old by RAST and CAP system. Positive rates of RAST to Periplaneta fuliginosa, Blattela germanica, Periplaneta americana and Periplaneta japonica were 17.6%, 29.4%, 19.6% and 15.7%, respectively and those of CAP system to Periplaneta fuliginosa and Blattela germanica were 15.7%, respectively. Among those with positive RAST to 4 species of cockroach there were significant correlations. Significant correlations were observed also between the RAST titer for the whole bodies and feces of Periplaneta fuliginosa and Blattela germanica and immunoblotting analysis of sera obtained from two cockroach-positive patients revealed common sensitive fraction between whole body and feces. Immediate bronchial response was detected by bronchial provocation test. RAST inhibition study indicated no cross-reacting allergenicity between cockroach and mite. Collectively, cockroach is one of important inhalent allergens in asthmatic children.View full abstractDownload PDF (801K) -
Masaki Ohnishi, Ryuta Takizawa, Kazuhiko Yokoshima, Kimihiro Okubo, Mi ...Article type: Article
1995 Volume 44 Issue 10 Pages 1216-1222
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAccumulation of mast cells and eosinophils in the nasal epithelial layer occurs in nasal allergic reaction. However the mechanism of accumulation of these cells has not yet been well clarified. We hypothesized that cytokines generated from the nasal epithelial cells contributed to the accumulation of these cells in the nasal epithelial layer. Recently tumor necrosis factor (TNF) was shown to promote polymorphonuclear neutrophils and eosinophils migration. And also TNF increased eosinophil binding to vascular endothelial cells. In this in vitro study we examined whether or not nasal epithelial cells can produce TNF-α, and also whether or not glucocorticosteroid fluticasone propionate (FP) can modulate TNF-α production from nasal epithelial cells. Nasal epithelial cells constitutively produce TNF-α in accordance with the nasal epithelial cell's number and this was substantially increased in the state of nasal epithelial cell's proliferating. FP significantly reduced the level of TNF-α in the supernatant of cultured nasal epithelial cells for a period of 6 days. In addition, preincubation of nasal epithelial cells with FP for 6 days caused significant reduction of TNF-a level in the supernatant of cultured nasal epithelial cells during a further period of 6 days without FP. These data support the concept that structural cells play an active role in the control of allergic and related inflammatory processes.View full abstractDownload PDF (687K) -
Takashi Doi, Shuhei Takemura, Masahiro Ueda, Masako Deguchi, Naoko Ich ...Article type: Article
1995 Volume 44 Issue 10 Pages 1223-1228
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSThis study was undertaken to clarify the susceptibility to infection of patients with diabetes mellitus. The complement system is activated through the classical and/or the alternative pathways to produce many kinds of anaphylatoxins in the inflammatory process. One of the anaphylatoxins, C5a, possesses both the strong biological activity of a chemotactic factor and the increasing effect of CR1 and CR3 expression on polymorphonuclear leukocytes (PMNs). It is well known that the complement receptors, CR1 and CR3, on PMNs play important roles in the phagocytosis. We studied the changes of the expression of these receptors on PMNs in non-insulin dependent diabetes mellitus after the stimulation with recombinant human C5a. PMNs from 11 patients with non-insulin dependent diabetes mellitus and 11 normal controls were tested. There was no significant difference of CR1 and CR3 expression on PMNs after the addition of 10ng/ml C5a between patients with diabetes mellitus and normal controls. However, by the stimulation with 50 ng/ml C5a, the increase of the CR3 expression on PMNs of patients with diabetes mellitus was significantly smaller than normal controls (p<0.02). The increase of the expression of CR1 on PMNs was not significantly different the two groups. It is suggested that the small increase of the CR3 expression on PMNs by the stimulation with C5a is one of the factors of the susceptibility to infection in patients with diabetes mellitus.View full abstractDownload PDF (541K) -
Toshihiko Kaise, Haruhiko Manabe, Kenji OhmoriArticle type: Article
1995 Volume 44 Issue 10 Pages 1229-1233
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEffect of KW-4679, an antiallergic agent, on the experimetal allergic rhinitis was studied in guinea pigs. 1) KW-4679 inhibited the sneeze response and the nasal rubbing induced after the intranasal administration of antigen in sensitized guinea pigs. The inhibitions were dose-related and significant at 0.03 mg/kg p.o. for sneeze response and 1 mg/kg p.o. for nasal rubbing, respectively. 2) The nasal vascular permeability was increased after the intranasal administration of antigen in sensitized guinea pigs. KW-4679 significantly reduced the increase of the nasal vascular permeability at 1 mg/kg p.o. or higher. From these results, KW-4679 may have inhibitory effects on seeze, nasal irritation and rhinorrhea in clinical use.View full abstractDownload PDF (587K) -
Hiroki Shibata, Shigekatsu Kohno, Katsuya OhataArticle type: Article
1995 Volume 44 Issue 10 Pages 1234-1240
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSEffects of oral administration of MBST on 48 hr homologous passive cutaneous anaphylaxis (PCA) and allergic rhinitis in rats were examined. Administration of MBST (1,000 mg/kg/day) for 5 consecutive days with the final dosing at 1 day before antigen challenge did not effect on PCA. However, the reaction was significantly inhibited when the drug (1,000 mg/kg) was singly given 1 hr before antigen challenge. The drug (1,000 mg/kg, 1 hr prior to antigen challenge) tended to ruduce the dye leakage into nasal cavities by antigen, while it did not affect on the anaphylatic histamine release into the cavities. The component of the chinese plants in the formula inhibiting the dye leakage was found to be Mao. However, 1-ephedrine and d-pseudoephedrine, which are contained in Mao in a large amount, did not contribute to the inhibiting effect on dye leakage. These results suggest that MBST may be therapeutically effective for atopic disease including rhinitis, through the mechanism other than the inhibition of histamine release.View full abstractDownload PDF (689K) -
Mikio Toyoshima, Atsuhiko Sato, Masami Taniguchi, Akihito Todate, Shir ...Article type: Article
1995 Volume 44 Issue 10 Pages 1241-1243
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1995 Volume 44 Issue 10 Pages 1244-1245
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Appendix
1995 Volume 44 Issue 10 Pages 1246-
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Appendix
1995 Volume 44 Issue 10 Pages 1246-
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Appendix
1995 Volume 44 Issue 10 Pages 1246-
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (36K) -
Article type: Appendix
1995 Volume 44 Issue 10 Pages 1247-1248
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (71K) -
Article type: Appendix
1995 Volume 44 Issue 10 Pages 1249-1252
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
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Article type: Cover
1995 Volume 44 Issue 10 Pages Cover6-
Published: October 30, 1995
Released on J-STAGE: February 10, 2017
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