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Article type: Cover
1996 Volume 45 Issue 4 Pages
Cover15-
Published: April 30, 1996
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Article type: Cover
1996 Volume 45 Issue 4 Pages
Cover16-
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
App3-
Published: April 30, 1996
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Zenro Ikezawa
Article type: Article
1996 Volume 45 Issue 4 Pages
363-370
Published: April 30, 1996
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Yuichi Takahashi, Shigeto Kawashima, Shogo Aikawa
Article type: Article
1996 Volume 45 Issue 4 Pages
371-377
Published: April 30, 1996
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We have developed a simulation method of airborne Cryptomeria japonica pollen distribution on a map displayed visually on a TV screen. Each patient can be available the information where the place he or she lives. The pollen season in 1995, we served the information about airborne pollen distribution on a map and C. japonica flowering areas on a map to local resident through TV broadcasting. To verify the simulation method, comparison was made between the result from actual pollen counting and from simulation. It was clarified that both results were comparatively agreed on daily basis. Problem about compatibility among personal computers were solved to rewrite the program of displaying the image using Visual Basic for MS-Windows and create image files. The files call be read continuously by animation software. We think the information can be offered to local resident, local clinicians and patients waiting at the clinics by use of computer networks.
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Susumu Nakamura
Article type: Article
1996 Volume 45 Issue 4 Pages
378-385
Published: April 30, 1996
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The author has investigated the incidence of Japanese cedar pollinosis among university students, for the purpose of making a study of the relation between sensitizing to pollen antigen and manifestation of symptoms. In this report are summerized the results of seven years investigation since 1988. The percentage of specific antibody carriers in freshmen was 27.4% in 1988, and has kept the level of 32.0-38.1% from 1989 to 1993. And the incidence of pollinosis sufferers in freshmen was 12.0% in 1988, and has kept the level of 15.5-17.4% from 1989 to 1993. However in 1994 they reduced to lower levels of 29.3% and 14.7%, and this was considered to be connected with the decrease of pollen counts owing to the abnormal weather conditions of preceding year. In addition to this the author has also investigated the transition of the percentage of specific antibody carriers and the incidence of pollinosis sufferers while in college. Among the students who were matriculated before the year of 1990, the incidence of these kinds when fourth grade increased clearly (antibody carriers 38.6-43.0%, pollinosis sufferers 23.1-24.9%). However in whom matriculated in 1991, they reduced to lower levels ill 1994 related to the decrease of pollen counts (antibody carriers 25.2%, pollinosis sufferers 13.6%). From above-mentioned results of investigation, it is concluded that the revelation of pollinosis symptoms has connection directly with the degree of exposure to the pollen antigen.
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Masatsugu Kurokawa, Shin-ichi Konno, Yoshiki Gonokami, Yasurou Kouno, ...
Article type: Article
1996 Volume 45 Issue 4 Pages
386-392
Published: April 30, 1996
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Recently, endothelin-1 (ET-1) has a potent of contractive effect to bronchial smooth muscle, and it suggests that ET-1 contributes to pathophysiology of bronchial asthma. To study the role of endothelin-1 (ET-1) in allergic asthma, we measured ET concentration in plasma and in sputum of nine allergic subjects following allergen provocation by using sandwich-enzyme immunoassay (EIA). ET-1 concentration in plasma were higher during IAR (2.31±0.24 pg/ml) (0.05 <p <0.1) and LAR (2.55±0.27 pg/ml) (0.05 < p < 0.1) than prechallenge value (1.99±0.23 pg/ml) but there was no significant difference. On the other hand ET-1 concentration in sputum were significantly higher during IAR (14.75±2.77 pg/ml) (p < 0.05) and LAR (18.51±4.57 pg/ml) (p < 0.05) than prechallenge values (4.29±2.55 pg/ml). Thus these results suggest that ET-1 play a role of allergic bronchoconstraction (IAR and LAR) after allergen challenge.
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Kenji Ohmori, Hidee Ishii, Yasuo Sasaki
Article type: Article
1996 Volume 45 Issue 4 Pages
393-397
Published: April 30, 1996
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We studied the effect of KW-4679, an antiallergic drug, on inhaled antigen-induced airway microvascular leakage in rats passively sensitized with mouse monoclonal IgE antibody. Inhaled antigen increased extravasation of Evans blue dye content in tracheal and main bronchus tissues. KW-4679 (0.3-10 mg/kg,p.o.) reduced antigen-induced microvascular leakage in trachea with an ED_<40> value of 4.9 mg/kg. KW-4679 also reduced antigen-induced microvascular leakage in main bronchus with an ED_<40> value of 0.47mg/kg. The inhibitory effect of KW-4679 was more potent than those of ketotifen and terfenadine. These results suggest that KW-4679 clearly reduces airway microvascular leakage mediated by antigen-antibody reaction.
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Misa Sakurai
Article type: Article
1996 Volume 45 Issue 4 Pages
398-408
Published: April 30, 1996
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House dust mite lipids were investigated in atopic dermatatis (AD) patients. The analysis showed that eicosapentaenoic acid (EPA) was present at 0.88% in total lipid of Dermatophagoides farinae (Df). In the patch tests with crushed 3 live Dfs, the difference of positive rates between AD patients and controls was statistically significant. In the patch test with secretions from opisthonotal glands of mites, 2% citral contained in both D. pteronyssinus (Dp)s and Dfs showed higher rate of positivity with AD patients than controls without statitically significance. In the patch test with the fatty acids of house dust mites, EPA showed higher rate of positivity with AD patients than controls. There was a statitical significance with 100% (as is) EPA. Histopathological findings by hematoxylin and eosin staining with the skin lesions of AD patients and the positive reactions of patch test with crushed 3 live mites and EPA revealed spongiosis in the epidermis and infiltration of mononuclear cells in the upper dermis. The positive subsets of the mononuclear cells were mostly CD4, HLA-DR and ICAM 1, while CD8 positive cells were rare. Based on these findings, not only mite protein but also mite lipids including secretions from mites should be investigated as mite contact allergens in AD.
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Jun-ichi Hirao, Shigeki Hibi, Tamotsu Andoh, Tohju Ichimura
Article type: Article
1996 Volume 45 Issue 4 Pages
409-412
Published: April 30, 1996
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Time course of interleukin-10 (IL-10) in plasma of patients with Kawasaki disease was measured. The results are as follow: (1) IL-10 concentration in plasma of patients in acute phase of Kawasaki disease (median 37.8 pg/ml) was high, compared with that in convalescent phase (5.77 pg/ml) or that of control children (10.2 pg/ml). (2) From the examination of IL-10 concentration in plasma collected by following its time course, it was revealed that most of cases with this disease showed transiently high figure in the acute phase, then the figure diminished promptly afterwards.
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Akiko Inoue, Akinobu Shoji, Atsuko Kuwano, Haruo Kutsuna, Masamitsu Is ...
Article type: Article
1996 Volume 45 Issue 4 Pages
413-415
Published: April 30, 1996
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
1996 Volume 45 Issue 4 Pages
416-421
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
423-
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
423-
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
423-
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
424-
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
424-
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
425-429
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
430-
Published: April 30, 1996
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Article type: Appendix
1996 Volume 45 Issue 4 Pages
431-434
Published: April 30, 1996
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Article type: Cover
1996 Volume 45 Issue 4 Pages
Cover17-
Published: April 30, 1996
Released on J-STAGE: February 10, 2017
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