Japanese Journal of Allergology

[title in Japanese]

Article type: Cover
1998 Volume 47 Issue 6 Pages Cover18-
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.Cover18

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ANALYSES OF ANTIGEN SPECIFIC T CELLS IN IMMUNOLOGICAL DISORDERS

Kazuhiko Yamamoto

Article type: Article
1998 Volume 47 Issue 6 Pages 567-569
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.567

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T CELL SUBSETS, Th1/Th2, AND ALLERGY

Hideo Nariuchi

Article type: Article
1998 Volume 47 Issue 6 Pages 570-572
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.570

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ISOPROTERENOL CONTINUOUS NEBULIZATION OF CHILDHOOD STATUS ASTHMATICUS : II. Efficacy and Side Effects of Low-Dose Method Comparing with High-Dose Method

Tetsuya Takamasu, Kazuyuki Kurihara, Kazuko Goto, Naoko Inomata

Article type: Article
1998 Volume 47 Issue 6 Pages 573-581
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.573

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We investigated the efficacy and side effects of "low-dose isoproterenol continuous nebulization" for childhood status asthmaticus, and compared them with those of "high-dose method". "Low-dose" is defined as 10ml or less of 0.5% dl-isoproterenol solution diluted in 500ml of normal saline. Subjects were 23 children who were hospitalized and underwent the nebulization therapy. The period of continuous nebulization was 26.3±12.5 hours. The Wood's clinical score clearly decreased in 22 cases, the average score changing from 7.3±1.2 to 2.8±1.5. Heart rate was not elevated significantly during the nebulization period, and decreased gradually (142±22/min at the start of the nebulization, 145±22/min at 1 hour, and 134±23/min at 3 hours, and 103±13/min at the cessation of the nebulization). Serum GOT, LDH, CPK, and potassium were decreased after the nebulization compared with the values before the treatment, the changes of the last 2 items being statistically significant. Two subjects who had vomited before the nebulization therapy complained nausea during the procedure, and one experienced transient finger tremor. We conclude that "low-dose isoproterenol continuous nebulization" is an effective and safe method for childhood status asthmaticus. We expect that this method will be familliar to all clinicians.

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THE QUESTIONNAIRE CONCERNED WITH THE START AND END POINT OF THE TREATMENT FOR NASAL ALLERGY

Masashi Imanaka, Hiroshi Takenaka

Article type: Article
1998 Volume 47 Issue 6 Pages 582-590
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.582

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The precise primary end point of the treatment for nasal allergy has never been indicated. In this study, we conducted a questionnaire of specialists who actually treat with nasal allergy. The questionnaire is about start and end point of the treatment for nasal allergy. Answers were obtained from 49 doctors. The results were as follows. 1. About the goal at the start of the treatment. Perennial nasal allergy was put stress on control of the symptom, keeping of remission and improvement of quality of life. Pollinosis was put stress on control of the symptom, prevention of acute exacerbation and improvement of quality of life. No significant difference was observed between adult and child. 2. About the condition at the end point of the treatment. Perennial nasal allergy was put stress on the condition that symptoms were indisposition, no obstacle to daily life and no or a little medication was necessary. Pollinosis was put stress on the condition that symptoms were indisposition, no obstacle to daily life, and a little medication was necessary or that symptoms were continually stable and acute exacerbation was very rare. No significant difference was observed between adult and child.

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PERIPHERAL EOSINOPHIL COUNTS RELATES THE IMPROVEMENT OF THE SKIN LESIONS OF ATOPIC DERMATITIS PATIENTS MORE SENSITIVE THAN SERUM EOSINOPHIL CATIONIC PROTEIN LEVELS

Masayoshi Nishimoto, Toshihiko Numahara, Kuniyuki Nakashima, Tomoko Yo ...

Article type: Article
1998 Volume 47 Issue 6 Pages 591-596
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.591

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We described the severity of skin lesions and detected peripheral eosinophil counts (Eos) and seurm eosinophil cationic protein levels (s-ECP) in 81 patients with atopic dermatitis (male 33, female 48, age 20.7±8.8) at the first consultation. Eos were 583.3±560.2/mm^3 and s-ECP were 18.0±21.7μg/l (normal 6.88±3.46). After approximately 30 days treatment, the improvement of dermatitis were estimated and those lavoratory findings were rechecked, Eos were 446.7±367.6/mm^3 and s-ECP were 13.2±11.7μg/l. At 5 percent level, positive correlations were observed between Eos and s-ECP (R=0.75), Eos and the severity of dermatitis (R=0.52) and s-ECP and the severity of dermatitis (R=0.51) at the first consultation. We found a positive correlation between Eos and the improvement of dermatitis (R=0.40) but no correlation between s-ECP and the improvement of dermatitis (R=0.10). Eos related the improvement of the skin lesions of atopic dermatitis more sensitive than s-ECP.

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STUDY OF APPROPRIATE EXPIRATORY VELOCITY WHEN MASURING EXHALED NITRIC OXIDE (NO) CONCENTRATION

Kozo Ikarashi, Kanji Ozawa, Yoshihiro Naganuma

Article type: Article
1998 Volume 47 Issue 6 Pages 597-603
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.597

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We studied the appropriate expiratory velocity when measuring exhaled NO concentration by constant expiratory flow maneuver in relation to height and the required time for measurement, and obtained the following results. 1) There was a significant positive correlation between height and the required time. 2) There was a significant negative correlation between expiratory velocity and the required time. 3) Percent ratios of children who reached the plateau of exhaled NO concentraion were significantly higher when expiratory velocity was over 2000 ml/minute. These findings suggest that expiratory velocity of over 2000 ml/minute may be appropriate when measuring exhaled NO concentration.

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THE EFFECT OF AZELASTINE ON BRONCHIAL MUCOSA IN BRONCHIAL ASTHMA : Suppression of Cytokine mRNA

Jun Shimojo

Article type: Article
1998 Volume 47 Issue 6 Pages 604-613
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.604

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Azelastine is an oral antiallergic drug. Although oral antiallergic drugs are classified as controllers because of the possession of anti-inflammatory effect, the mechanism of action has remained obscure. Thus the author investigated the effects of azelastine on inflammatory cells infiltrating into the bronchial mucosa and on the expression of cytokines in patients with atopic asthma. Biopsy specimens of the bronchial mucosa were bronchoscopically obtained before and after the administration of azelastine for 3 months. Inflammatory cells in the bronchial mucosa, including eosinophils, mast cells, macrophages, and T lymphocytes, were stained immunocytochemistry ; expression of cytokine mRNA [Interleukin (IL)-4 and IL-5] was examined by the in situ hybridization method. The results obtained revealed that the number of eosinophils (p<0.01), T lymphocytes (p<0.01), and cells expressing mRNA of IL-4 (p<0.05) or IL-5 (p<0.01) significantly decreased after the administration of azelastine. These results suggest that azelastine inhibits the action on local infiltration of inflammatory cells and following proinflammatory cytokine production as one mechanism of bronchial asthma.

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IMMUNOHISTOCHEMICAL ANALYSIS OF THE BRONCHIAL MUCOSA IN A PATIENT WITH BRONCHORRHEA BEFORE AND AFTER CORTICOSTEROID THERAPY

Masako Kubo, Takeshi Koshino, Yasuo To, Nobuyuki Kobayashi, Koichiro K ...

Article type: Article
1998 Volume 47 Issue 6 Pages 614-617
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.614

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 618-
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.618

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 619-
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.619

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 620-627
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.620

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 628-639
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.628

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 640-
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.640

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 641-
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.641

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 642-643
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.642

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[title in Japanese]

Article type: Appendix
1998 Volume 47 Issue 6 Pages 644-647
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.644

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[title in Japanese]

Article type: Cover
1998 Volume 47 Issue 6 Pages Cover19-
Published: June 30, 1998
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.47.Cover19

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