Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 48, Issue 1
Displaying 1-22 of 22 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    1999 Volume 48 Issue 1 Pages Cover1-
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.Cover1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1999 Volume 48 Issue 1 Pages Cover2-
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.Cover2
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages App1-
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.App1
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages App2-
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.App2
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages App3-
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.App3
    JOURNAL FREE ACCESS
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  • CLINICAL SIGNIFICANCE OF ALLERGEN ANALYSIS : FOOD ALLERGENS
    Atsuo Uris
    Article type: Article
    1999 Volume 48 Issue 1 Pages 1-4
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.1
    JOURNAL FREE ACCESS
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  • VIRAL RESPIRATORY INFECTION BRONCHIAL ASTHMA
    Shunsuke Suzuki
    Article type: Article
    1999 Volume 48 Issue 1 Pages 5-8
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.5
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  • ALLERGIC INFLAMMATION AND CYTOKINE NETWORK
    Itsuo Iwamoto
    Article type: Article
    1999 Volume 48 Issue 1 Pages 9-12
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.9
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  • DEXAMETHASONE-INDUCED APOPTOSIS IN PERIPHERAL T LYMPHOCYTES FROM PATIENTS WITH ASTHMA
    Kazumi Oneda
    Article type: Article
    1999 Volume 48 Issue 1 Pages 13-22
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.13
    JOURNAL FREE ACCESS
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    The corticosteroid is effective for treating allergic inflammation. However, the mechanisms of the effectiveness are still unclarified. In this study, we examined whether dexamethasone, one of corticosteroids, can induce apoptosis in peripheral T cells from patients with asthma. Dexamethasone induced significantly greater apoptosis in T cells from patients with asthma than from normal subjects at 10^<-4>M and 10^<-5>M (ρ<0.05). Apoptosis was assessed by flow cytounetry, DNA fragmentation. By examining the function of T cell subsets, the augmentation of apoptosis was ascribed to CD4+HLADR+CD25+subsets. Elimination of HLADR+CD25+subsets from T cells caused a great reduction in IL-5 production and proliferation to mite on Day 3, suggesting that the subset might be primed by mite allergen. Dexamethasone may reduce allergen specific T cells through apoptosis, which is one of the mechanisms of effectiveness of dexamethasone in asthmatics.
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  • COUGH VARIANT ASTHMA IMPR0VING WITH AVOIDANCE OF PET RABBIT
    Takeshi Ohgou, Takumi Kishimoto
    Article type: Article
    1999 Volume 48 Issue 1 Pages 23-26
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.23
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    The concenpt of cough variant asthma (CVA) has been defined recently, but little is known about the relation between CVA and antigen. A case of CVA due to pet rabbit was presented here. A 49-year-old man who kept a pet rabbit indoors was admitted our hospital with nocturnal dry cough. Both serum total IgE level and eosinophil count were elevated (IgE 5580 IU/L, Eosinophil 1183/L). According to Sato's criteria, this case was diagnosed to be CVA. After the patient was kept out of contact with the rabbit, his coughing disappeared and never recurred and IgE (RAST) against rabbit decreased. The out come of this case clearly shows that CVA improved due to avoidance of the antigen. These facts suggest that the cause of CVA in this case in due to mainly an immunogloblin E-mediated allergic reaction.
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  • ANNUAL CHANGE OF THE PET IN ALLERGIC PATIENTS HOME FOR TEN YEARS
    Yugi Maeda, Makoto Kudoh, Shogo Tomita, Maki Hasegawa, Kazuo Akiyama
    Article type: Article
    1999 Volume 48 Issue 1 Pages 27-32
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.27
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    There are only few paper in Japan which reports the prevalence of pet keepers in the allergic population and also of the type of pets they keep. We made investigation on these points in 1337 allergic patients employing a questioner. Among 1337 patients, allergic conjunctivitis patients were found in 67, eczema patients in 118, allergic rhinitis patients in 368 and bronchial asthmatic patients in 1043. These number contained those number who overlapped in symptoms. Approximately 43% of allergy patients are currently keeping the pet at present while 1l.2% of the patient had kept the pet in the past. There were two peaks in the age when they began to keep a pet, 6 to 12 and 30 to 40 years of age. Trend in the past decade showed that both the dog and cat bred in foreign countries were increasing. About 80% of patients who own the foreign bred dogs keep them indoor. This ratio is increasing gradually. Another conspicuous change is the sharp increase in those who keep hamsters which occupied 2O% of all the pet keeper in 1997. Percentages of the patient who recognizes the aggravation of their symptoms in eye, nose, skin and also as asthma often pet keeping is a about 10%. One out of 4 patients who keep the pet has a family member with rhinitis and/or asthma. We concluded that too many of the allergic patients keep the pet against their benefit and they must be informed that the pet could be the cause of allergy symptoms.
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  • ANTIDIURETIC HORMONE IN SEVERE CASES OF ATOPIC DERMATITIS
    Hiroko Taniguchi, Akiko Yokoyama, Sayuri Yamazaki, Satoru Nakamura, Ma ...
    Article type: Article
    1999 Volume 48 Issue 1 Pages 33-39
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.33
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    32 out of 83 in patients with atopic dermatitis showed a decrease of urine excretion during acute exacerbation and elevated levels of antidiuretic hormone (ADH 23 of 29 cases), renin (18 of 32 cases), angiotensin (22 of 29 cases) and aldosterone (16 of 37 cases). Six cases with high ADH showed severe pitting edema of lower legs with hypoalbuminemia. ADH, volume of urine and edema were improved when their skin symptoms subsided. There was no statistically significant relationship between the dose of steroid ointment and ADH. Also there was no correlation between low 17-0HCS or 17-KS and high ADH or renin.
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  • USEFULNESS OF HYPOALLERGENIC RICE (AFT-R1) AND ANALYSIS OF THE SALT INSOLUBLE RICE ALLERGEN MOLECULE
    Zenro Ikezawa, Kazufumi Tsubaki, Hiroyuki Osuna, Teiyu Shimada, Kazuyu ...
    Article type: Article
    1999 Volume 48 Issue 1 Pages 40-49
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.40
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    An involvement of rice allergy in development and exacerbation of recalcitrant atopic dermatitis (AD) has been suggested in some cases, and it has been also known that elimination diet of rice results in improvement of AD and reduction of the doses of steroid ointment and anti-allergic drugs used for the treatment. We prepared the hypoallergenic rice grain,AFT-R1 (Allergen-free Technology Lab. Inc. -Rice 1), with alkalitreatment from the rice material, Koshihikari, which is popular in Japan. Its usefulness was evaluated clinically and serologically. The serological study with IgE-ELISA showd that the major allergic protein were remarkably reduced to less than 1/6400 of them in the AFT-R1. Then it was applied to the clinical trial, and evaluated as useful by the clinical effect in 14 (93%) out of 15 patients,who were diagnosed to have rice allergy by the elimination (in 15 case) and ingestion (in 12 cases) of the regular rice. The serum taken from thepatient, whom the AFT-R1 was evluated as unuseful in the clinical trial, was shown to have IgE antibodies reactive to the remaining protein in AFT-R1 by IgE-ELISA, and the 60 kd protein band was detected as an IgE-binding component of AFT-R1 by IgE-immunoblotting with the same serum. This 60 kd rice protein was identified as ADP (UDP)-glucose-starch glycosyl transferase (EC : 2.4.1.21) by N-terminal amino acid analysis. These results indicated that AFT-R1 is very useful as a substitute of rice in many AD patients with rice allergy, although IgE-binding component such as the 60 kd protein is remaining in one.
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  • A CASE OF EOSINOPHILIC GASTROENTERITIS COMPLICATED WITH ILEUS AND ASCITES COLLECTION
    Yasuo To, Cyuhei Ogawa, Mamoru Otomo, Yasuo Arai, Yasuyuki Sano, Yuji ...
    Article type: Article
    1999 Volume 48 Issue 1 Pages 50-55
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.50
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    A 30-year-old woman was admitted to our hospital because of ileus and ascites. Laboratory data on admission demonstrated marked eosinophilia (42.5% of WBC) but negative CRP-value. Abdominal CT showed marked ascites and diffuse thickening of intestinal walls. Ascites examination revealed eosinophilic ascites. The level of IL-5 both in the serum and in the ascites were also high. No evidence of eosinophilic infiltration was noted both gastric and colonic mucosal biopsy specimens. Oral prednisolone treatment (50 mg/day) was effective for her. We diagnosed her as a case of sub-serosal type eosinophilic gastroenteritis. It is essential to obtain eosinophilic ascites for correct diagnosis of the disease. And it is possible that serum and ascites IL-5 value would be reliable indicator of the activity of this disease.
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  • EFFECTIVENESS OF HYPOALLERGENIC RICE-BY CAST ANALYSIS
    Fumiko Juji, Hirotsugu Kano, Masami Narita, Noriko Shibuya, Shinichi N ...
    Article type: Article
    1999 Volume 48 Issue 1 Pages 56-63
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.56
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    Rice is the main food taken every day in Japan. We introduced hypoallergenic rice (95% of albumin and globulin were taken off by hyperpressure method) for 4 weeks to 7 atopic dermatitis patients (m 3,f 4), 11 mo-4 y 8 m (mean 3 y 2 m) who showed the RAST score of rice 1 or more. Stimulation Index by CAST (cellular antigen stimulation test) were compared before and after taking the rice (50〜400 g). By albumin (0.1〜1OOμg/ml), maximum decreases of S.I. were 22.4〜96.5% (mean 70.9) and by globulin maximum decreases of S.I. were (0.1〜100μg/ml) 33.3〜97.O% (mean 72.9). In all the patients the skin conditions were improved.
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages 64-80
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.64
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages 81-83
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.81
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages 84-
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.84
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages 85-86
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.85
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages 87-89
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.87
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  • [title in Japanese]
    Article type: Appendix
    1999 Volume 48 Issue 1 Pages 90-94
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.90
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    1999 Volume 48 Issue 1 Pages Cover3-
    Published: January 30, 1999
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.48.Cover3
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