Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
Volume 48, Issue 7
Displaying 1-17 of 17 articles from this issue
  • Article type: Cover
    1999 Volume 48 Issue 7 Pages Cover24-
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Article type: Cover
    1999 Volume 48 Issue 7 Pages Cover25-
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Article type: Bibliography
    1999 Volume 48 Issue 7 Pages Misc1-
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1999 Volume 48 Issue 7 Pages App8-
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Mitsuru Adachi, Toshimichi Imai, Kenji Minoguchi
    Article type: Article
    1999 Volume 48 Issue 7 Pages 683-685
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Hiroshi Kawaguchi, Mizue Takeuchi, Yoshitomo Tanaka, Ikuyo Takahashi, ...
    Article type: Article
    1999 Volume 48 Issue 7 Pages 686-690
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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    The prevalence rate of atopic dermatitis was investigated in 4-month-old infants, who were examined by dermatologists at regular health checks at a health center. Among 739 infants examined, 150 were diagnosed as having atopic dermatitis, giving a prevalence rate of 20.3%. Most of the cases were mild, and no severe cases were observed. The prevalence rate in spring and autumn was significantly higher than that in summer and winter. The eruptions were seen mainly on the head, face, and trunk. A familial history of atopic dermatitis was positively correlated with infant atopic dermatitis in this series, whereas a familial history of bronchial asthma and allergic rhinitis showed no such correlation. It is important to make a correct diagnosis of mild atopic dermatitis by differentiation from other diseases by dermatologists, and it will be of interest to observe the condition of the infants when they attend for their next physical examination at the age of 18 months.
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  • Hiroshi Ogasawara, Shiro Yoshimura, Misao Goto, Masakazu Tuyu, Tetsuzo ...
    Article type: Article
    1999 Volume 48 Issue 7 Pages 691-699
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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    We investigated the changing total number of airborne pollen grains of Sugi (Cryptomeria japonica) due to abnormal weather during pollen scattering season. The pollen season was divided into 7 periods by the discrepancies in forest flowering time for observations. The observation forests were located at an altitude of 150 m, 220 m, 350 m, 500 m, and 800 m in the Rokko mountains. These were located at equal spaces, when altitude was taken in the logarithm. The distribution percentage of pollen counts from 1993 to 1998 showed an almost normal distribution level. This was demonstrated by the Log-Normal Probability paper, with a middle level altitude of a 350 m forest. We could estimate the relative rate of 5 different altitude forests against the corresponding amount of pollen as shown under, 0.09 at 150 m forest, 0.34 at 220 m forest, 0.31 at 350 m forest, 0.16 at 500 m forest, 0.10 at 800 m forest. The percentage of pollen counts at the 500 m forest in 1994 and at the 350 m forest in 1995 were decreased from 95% confidence interval. We regarded the decrease in the percentage of pollen counts during these two time, as a cause weak wind velocity and wrong wind direction in Tanba mountains. It was shown that the method for dividing pollen season in different observation forests in which altitude differs, will be useful for pollen forecasts and the pollen source countermeasure.
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  • Fumio Kokubu, Hajime Suzuki, Yasuyuki Sano, Norio Kihara, Mitsuru Adac ...
    Article type: Article
    1999 Volume 48 Issue 7 Pages 700-712
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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    We have developed a tele-medicine system to monitor the airway status at home for patients with poorly controlled asthma, whereby a nurse provides instructions to individuals via the telephone to help them manage exacerbation under the supervision of their physicians. We examined the effectiveness of this system with a randomized control study. Patients with high hospitalization risk were enrolled in the study by screening patients for those with multiple previous emergency room visits and randomly assigned to either the tele-medicine or control group. After six months of participation in the program, the number of emergency room visits decreased significantly and the activities of daily living were improved in the tele-medicine group. Most of the patients in the tele-medicine group were able to continue measuring and transmitting peak expiratory flow (PEF) value successfully, and at six months had noticed an improvement in PEF. We therefore conclude that the system effectively contributes to the management of poorly controlled asthma. In addition, further consideration suggests that the reduction of emergency room visits may lead to reduction in hospitalization since we found a good correlation between number of emergency room visits and hospitalization from the studies published previously.
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  • Katsuya Fujimori, Eiichi Suzuki, Masaaki Arakawa, Fumitake Gejyo
    Article type: Article
    1999 Volume 48 Issue 7 Pages 713-718
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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    Chronic persistent cough (CPC) is a common medical problem. We determined the value of the methacholine inhalation challenge (MIC) in the evaluation of CPC. We also sought other clinical factors that affect MIC. Patients were selected for the study if 1) CPC was the only presenting symptom, 2) a current roentgenogram did not contribute to the diagnosis, and 3) spirometry revealed a normal FEV_1. We measured the minimum dose of methacholine (bronchial sensitivity, Dmin) by the "Asthograph" method. We determined the correlation between log Dmin and demographic and clinical variables, i.e. age, %FVC, %FEV_1, FEV_1%, %V_<50>, %V_<25>, eosinophil count in peripheral blood, and serum IgE level. The causes of CPC in 51 patients (20 men and 31 women, mean age 41 years) were cough-variant asthma in 29 patients, postinfectious persistent cough in 13 patients, atopic cough in 6 patients, and others in 3 patients. Log Dmin significantly but weakly correlated with% V_<25> (r=0.3l, p=0.02).The sensitivity and specificity of Dmin (_<10 units) in diagnosing cough-variant asthma was 93% and 87%, respectively. Demographic or clinical variables other than Dmin were not useful for the diagnosis of cough-variant asthma. We conclude that MIC is useful for the differential diagnosis of CPC while the usefulness is limited in some cases.
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  • Atsuko Adachi, Tatsuya Horikawa, Masamitsu Ichihashi, Tsutomu Takashim ...
    Article type: Article
    1999 Volume 48 Issue 7 Pages 719-725
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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    We studied whether fungal allergens play a role in exacerbating the clinical symptoms of atopic dermatitis (AD). We found that the percentage of the patients who showed CAP-RAST positive (2≦score) to Candida albicans (Ca) was significantly higher in the patients with severe symptoms and high serum IgE level than those with mild symptoms and lower IgE. This was also true for the patients with CAP-RAST positive to Pityrosporum ovale (Po). AD patients with their symptoms localized to head and neck showed significantly higher tendency to have positive CAP-RAST (2≦score) to Ca and Po when compared to those with their eruption distributing to the extremities. We then evaluated the efficacy of oral therapy with antifungul agents in 140 cases of refractory AD with positive CAP-RAST to Ca. Good or excellent response was obtained in 60% with fluconazole, 35% with itraconazole, 31% with amphotericin B, 28% with nystatin. The present finding that amphotericin B and nystatin, both of which are not absorbed through intestine, were effective for approximately a third of the patients indicates that Ca in the intesitine plays an important role in triggering AD symptoms. Fluconazole was more effective than amphotericin B and nystatin, suggesting that fungal colonizing in other parts of the body but the digesitive tract also play a role in the exacerbation of AD symptoms.
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  • Hideki Ogasawara, Akikatsu Kataura, Kohji Asakura, Toshinori Matsui
    Article type: Article
    1999 Volume 48 Issue 7 Pages 726-736
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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    It is well known that grass pollinosis has been the most representative pollinosis in Hokkaido prefecture, Japan. However, it is also well known that birch (Japanese white birch, Betula platyphylla var. japonica) pollinosis is gradually increasing, which is marked especially in Sapporo and its neighborhood. We analyzed a relationship between the birch pollen count and meteorological factors statistically. Moreover, the principal airborne pollen counts in Sapporo in 1997 were assessed and compared with the previous pollen data. As a results of this study, it was showed a close relationship between the annual amounts of birch pollen and meteorological factors of the year before, especially in May and June might be important. Moreover, there is a strong negative correlation between the birch pollen count and humidity, which seems to affect bringing up flower buds. As for the principal airborne pollen counts, some kinds of tree pollen, including birch pollen, were observed from the end of March, followed by grass (Gramineae) pollen in June and mugwort (Artemisia) pollen from the end of August, respectively. The annual amounts of grass pollen showed a decreasing trend.
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  • Hitoshi Kawamoto, Toshiki Kimura, Masayuki Kambe, Isao Miyamura, Toshi ...
    Article type: Article
    1999 Volume 48 Issue 7 Pages 737-740
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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    Some studies have reported that area under the flow volume curve (AUFVC) can be an index of pulmonary function. However, the significance of AUFVC remains to be clarified. We have clarified that AUFVC reflects the momentum of expired air. Size of flow volume curve (=AUFVC) has been commonly recognized to be changeable visually in patients with asthma. To clarify whether size of flow volume curve (=AUFVC) is a useful index of the course of bronchial asthma, we compared the rate of improvement forced expiratory volume in 1 second (FEV_<1.0>), peak expiratory flow rate (PEFR) or forced vital capacity (FVC) to the rate of improvement in AUFVC after admission in 20 patients with bronchial asthma. The rate of improvement in AUFVC positively correlated with the rate of improvement in FEV_<1.0>, PEFR or FVC. AUFVC demonstrated more marked improvement than other indices. Since AUFVC reflects the momentum of expired air, bronchial asthma's patients could understand visually that the momentum of expired air decreased due to airway stenosis by presenting flow volume curve. Therefore, visual size of flow volume curve helped patients with asthma to understand the condition of asthma. Size of flow volume curve (AUFVC) may be useful index of the course of bronchial asthma.
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  • Article type: Appendix
    1999 Volume 48 Issue 7 Pages 741-
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1999 Volume 48 Issue 7 Pages 742-746
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1999 Volume 48 Issue 7 Pages 747-750
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Article type: Appendix
    1999 Volume 48 Issue 7 Pages 751-754
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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  • Article type: Cover
    1999 Volume 48 Issue 7 Pages Cover26-
    Published: July 30, 1999
    Released on J-STAGE: February 10, 2017
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