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Volume 49, Issue 12
Displaying 1-19 of 19 articles from this issue
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Article type: Cover
2000 Volume 49 Issue 12 Pages Cover7-
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2000 Volume 49 Issue 12 Pages App4-
Published: December 30, 2000
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Gen TamuraArticle type: Article
2000 Volume 49 Issue 12 Pages 1129-1131
Published: December 30, 2000
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Minoru BabaArticle type: Article
2000 Volume 49 Issue 12 Pages 1132-1134
Published: December 30, 2000
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Susumu YoshizawaArticle type: Article
2000 Volume 49 Issue 12 Pages 1135-1137
Published: December 30, 2000
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Sawako Masuda, Akihiko Terada, Takao Fujisawa, Kosei IguchiArticle type: Article
2000 Volume 49 Issue 12 Pages 1138-1145
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSRecently, the number of patients with Japanese cedar(Cryptomeria japonica)pollinosis has increased, especially in children. However, little is known about the incidence in infants. We studied on the rate of sensitization and the onset of pollinosis in children under 6 years old. The percentage of positive CAP-RAST to Japanese cedar pollen was 27.6%, in 76 infants(51 male and 25 female, 2 months〜5 years old)who visited National Mie Hospital pediatric allergy clinic due to bronchial asthma and/or atopic dermatitis. The youngest child who has been sensitized to pollen was 1 year 8 month old boy. The percentage of positive rate of CAP-RAST to house dust mite was 61.8%. Twenty-seven infants(20 male and 7 female, 2〜5 years of age)were diagnosed as Japanese cedar pollinosis in National Mie Hospital Otorhinolaryngology clinic in 1999 and 2000. The youngest child with pollinosis was 2 year 5 month old boy. Most of the 27 infants complained of rhinorrhea and/or eye symptoms and some of them complained cough, snoring, or epistaxis. About 40% were sensitized to Japanese cedar and/or cupressaceae pollen alone, 60% were also sensitized to house dust mite. In conclusion, it is possible that the sensitization to Japanese cedar pollen occurs after 2 season of pollen exposure and pollinosis occurs in 2 years old. Japanese cedar pollen has been an important allergen not only in school children, but also in infants.View full abstractDownload PDF (906K) -
Kazuhiro Hattori, Misa Sasai, Akemi Yamamoto, Shoichiro Taniuchi, Taka ...Article type: Article
2000 Volume 49 Issue 12 Pages 1146-1155
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe studied the intestinal flora of infants with cow milk hypersensitivity fed on casein-hydrolyzed formula(MA-1)and the influence of that supplemented with Raffinose(MA-1[R]). Infants with cow milk hypersensitivity were fed with MA-1 for 2 weeks, after which the formula was changed to MA-1[R]. Fourteen subjects were enrolled in this study and divided into two groups ; three who fed with breast or conventional milk in addition to MA-1 or MA-1[R](BM group)and 11 mainly fed with MA-1 or MA-1[R](TF group). Intentinal flora was inventigated at two weeks after MA-1 feeding and at two weeks after MA-1[R]feeding, respectively. Bifidobacterium was detected as the most predominant bacteria in all examples in the BM group, and that count and the ratio in all becteria remained high even after changing MA-1 to MA-1[R]. On the other hand, bacteria count and ratios of Bifidobacterium in all bacteria were conspicuously low in the TF group as compared with the BM group. And with the change from MA-1 to MA-1[R]in the TF group, the bacterial number and the occupation ratio of Bifidobacterium were increased, and Enterobacteriaceae bacterial count and the occupation ratio were decreased. The change of the intensinal flora with MA-1[R]feeding was mainly caused by the breeding action of Raffinose on bifidobacteria. Further studies are needed from a viewpoint of clinical effectivesess about the influence of normalization of the intestinal flora for the treatment of food hypersensitivity.[View full abstractDownload PDF (944K) -
Joji Ishii, Kensei Naito, Sho Miyata, Yoshio Senoh, Naoki Yokoyama, Re ...Article type: Article
2000 Volume 49 Issue 12 Pages 1156-1162
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo determine the relationship between epithelial damage and eosinophilia in the nasal mucosa of patients with nasal allergy, we examined the nasal mucosa(obtained by surgery)from 74 patients with allergic rhinitis, using light and electron microscopy. The extent of eosinophilia correlated significantly to grades of epithelial damage and torn tight junctions of the epithelial cells. No significant relationships were found between the severity of nasal synptoms and the extents of eosinophilia or grades of torn tight junctions of the epithelial cells. More than 50% specific granules in eosinophils in the allergic nasal mucosa showed normal findings. There were no significant relationships between the extent of eosinophil degranuation and grades of epithelial damage. Based on our results, the release of tubular vesicular structures from the eosinophil granule may be one form of eosinophil degranulation in the nasal mucosa of patients with nasal allergy.View full abstractDownload PDF (1707K) -
THE EFFECT OF SUPLATAST TOSILATE ON IMMUNOLOGICAL PARAMETERS FOR THE PATIENTS WITH ATOPIC DERMATITISHajime Suto, Kouichi Mitsuishi, Kayako Hira, Takafumi Uchida, Tetsushi ...Article type: Article
2000 Volume 49 Issue 12 Pages 1163-1172
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSA dose of 300 mg/day of suplatast tosilate was administered to one hundred one cases of atopic dermatitis for eight weeks, and the severity scores, peripheral blood eosinophil count, total serum IgE levels, plasma eosinophil cationic protein(ECP)levels, and other immunological parameters before and after the trial were observed and comparatively examined. The results are as follows : 1)Temporary improvements were found in the scores of severity and itchiness on all evaluated skin regions(face, limbs, and trunk). These scores decreased significantly for all observation periods at two, four, six and eight weeks after administration of suplatast tosilate compared with those before the administration(p<0.01). 2)There was no sign of adverse effects on the drug. In the blood tests, one patient displayed elevated levels of GPT and another showed elevated total bilirubin. In the urine test(qualitative test), one case with positive urinary protein was observed. 3)Clinical examinations including assessment of the immunologic parameters were conducted at an average of 8.68+/-0.36 th week. The peripheral blood eosinophil count, the percentage of eosinophil, and plasma ECP levels significantly diminished compared with those before administration, but no significant difference was found in total serum IgE levels and LDH levels. 4)The subjects were divided into two groups, one in which the clinical scores were improved by more than five and another with scores of less than five(including worsening), and the fluctuation of the immunological parameters(values before and after administration of the drug)of the two groups were compared. As a result, a significant difference was observed in the plasma ECP levels(p=0.02)and peripheral blood eosinophil count(p=0.091), but no difference was observed in total serum IgE levels and LDH levels. From the above mentioned results, the high efficacy and safety of suplatast to-silate in the treatment of severe atopic dermatitis were confirmed. At the same time, a decrease in the peripheral blood eosinophil count and the serum ECP levels were observed, suggesting the possibility that these values could be used as indices of the severity of atopic dermatitis.View full abstractDownload PDF (1062K) -
Noriko Oda, Tadashi Ariga, Satoru Ono, Ichiro Kobayashi, Nobuaki Kawam ...Article type: Article
2000 Volume 49 Issue 12 Pages 1173-1180
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSGenetic basis of two patients(AT, MT)with ADA deficiency was studyed. We identified three novel mutations(119Q→Stop, 235R→Q, one base deletion in Exon 4)from the patients. 119Q→Stop was detected in AT and her father. Deletion of one base in Exon 4 which would change the reading frame after codon 105H, was detected in MT, her father and brother. There was no relation between the two families. however, 235R→Q was also detected in both the patients and their mothers. Extremely low ADA activity of PBMCs was revealed in healthy MT's mother and brother just as MT, although their dAXP levels of RBCs showed significantly lower than that of MT. We defined that they shared an additional mutation(310M→T)together with the mutation described above, respectively. EBV-transformed B-cell line(EBV-B)were established from the carriers. To our surprise, ADA activity of their lines was 1/10-1/5 of normal. The result of heat treatment studies using the EBV-B showed that the mutant ADA rapidly lose its enzyme activity without degradation of the protein. It suggests that 310M→T mutant ADA rapidly lost its enzyme activity due to conformational change of the catalytic site of ADA.View full abstractDownload PDF (911K) -
Masanari Watanabe, Kazuhiro Kato, Hiroki Yajima, Hiroyuki Sano, Katsuy ...Article type: Article
2000 Volume 49 Issue 12 Pages 1181-1185
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2000 Volume 49 Issue 12 Pages 1186-1192
Published: December 30, 2000
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Article type: Appendix
2000 Volume 49 Issue 12 Pages 1193-1194
Published: December 30, 2000
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Article type: Appendix
2000 Volume 49 Issue 12 Pages 1195-
Published: December 30, 2000
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Article type: Index
2000 Volume 49 Issue 12 Pages 1196-1203
Published: December 30, 2000
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Article type: Index
2000 Volume 49 Issue 12 Pages 1204-1207
Published: December 30, 2000
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Article type: Index
2000 Volume 49 Issue 12 Pages 1208-1211
Published: December 30, 2000
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Article type: Appendix
2000 Volume 49 Issue 12 Pages 1212-1217
Published: December 30, 2000
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Article type: Cover
2000 Volume 49 Issue 12 Pages Cover8-
Published: December 30, 2000
Released on J-STAGE: February 10, 2017
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