Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 50, Issue 12
Displaying 1-19 of 19 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    2001 Volume 50 Issue 12 Pages Cover7-
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.Cover7
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    2001 Volume 50 Issue 12 Pages Cover8-
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.Cover8
    JOURNAL FREE ACCESS
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  • PATHOPHYSIOLOGY AND TREATMENT OF SEVERE INTRACTABLE ASTHMA
    Yasuyuki Sano
    Article type: Article
    2001 Volume 50 Issue 12 Pages 1127-1130
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1127
    JOURNAL FREE ACCESS
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  • EFFECT OF ENDOTHELIN ON DNA SYNTHESIS IN HUMAN BRONCHIAL EPITHELIUM : ROLE OF MAP KINASE CASCADE
    Kazuyuki Nishimura, Jun Tamaoki, Kazuo Isono, Kazutetsu Aoshiba, Atsus ...
    Article type: Article
    2001 Volume 50 Issue 12 Pages 1131-1135
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1131
    JOURNAL FREE ACCESS
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    To elucidate the effect of endothelin(ET) on airway epithelial cell proliferation, we measured intracellular DNA levels and assessed a possible contribution of mitogen activated protein kinase(MAPK) cascade to the ET action. Incubation of transformed human bronchial epithelial(16 HBE) cells with ET in the serum-free medium caused time-dependent increases in DNA synthesis and MTT reduction, an effect that was attenuated by the MAPK kinase inhibitor PD 98059 in a concentration-dependent manner. Western blot analysis showed that ET induced the expression of phosphorylated MAPK protein, indicating an activation of MAPK, and that this effect was inhibited in the presence of PD 98059 or the ET_A receptor antagonist BQ-123. These results suggest that ET may stimulate the proliferation of human airway epithelium via ET_A receptors and the concomitant activation of MAPK cascade.
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  • COMPARISON BETWEEN REAL-TIME POLLEN MONITOR KH-3000 AND BURKARD SAMPLER
    Yuichi Takahashi, Shigeto Kawashima, Toshio Fujita, Chiyoko Ito, Rumi ...
    Article type: Article
    2001 Volume 50 Issue 12 Pages 1136-1142
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1136
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    Special apparatus capable of instantly measuring airborne Crytomeria japonica pollen grains were recently appeared on the market. We examined one of them called real-time pollen monitor KH-3000(Yamato Manufacturing Co.Ltd.). To confirm the accuracy of the monitor, comparison was made with conventional Burkard Seven-Day Recording Volumetric Spore Trap operating simultaneously at the same place. Most peaks from KH-3000 were coincided with Cry j 1 from Burkard sampler, and the greater part of the counts from KH-3000 had a strong resemblance to the counts from Cry j 1. Therefore, it is confirmed that KH-3000 counts the numbers of airborne C.japonica pollen grains. KH-3000 sometimes counts particles which do not belong to pollen grains, however. It is also confirmed thst some pollens other than C.japonica, such as walnaut(Juglans spp.) pollen, a part of grass pollen were counted.
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  • CHANGES IN THE PREVALENCE OF ASTHMA-LIKE SYMPTOMS AND RISK FACTORS IN SCHOOL CHIDREN IN YOKOHAMA FROM 1986 TO 1991
    Chiaki Nakai, Jun Kagawa, Satoru Shimizu, Michiko Nohara, Aya Shigetom ...
    Article type: Article
    2001 Volume 50 Issue 12 Pages 1143-1151
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1143
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    We conducted a questionnaire survey of first graders from six elementary schools in three areas of Yokohama annually from 1986 to 1991(about 700 children each year) to investigate the changes in prevalence of asthma-like symptoms and association with potential risk factors. The prevalence rate of asthma-like symptoms increased from 7.6% to 11.0% in boys and from 6.5% to 8.8% in girls from 1986 to 1991. The ratio of affected boys was consistently higher than that in girls, but there were no signigicant regional differences. We found statistically significant odds ratios for the effect of a precious history of allergies, respiratory disease before age two, wheezing or difficulty in breath before age two and cough without respiratory tract infections on the prevalence of asthma-like symptoms.
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  • INDUCTION OF ATOPIC DERMATITIS-LIKE SKIN LESION IN NC/Nga MICE : The Influence of the Skin Barrier Destroying Solution to the Induction of Dermatitis
    Tetsushi Unno, Hajime Suto, Takashi Yoshiike, Hideoki Ogawa, Chisei Ra
    Article type: Article
    2001 Volume 50 Issue 12 Pages 1152-1162
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1152
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    NC/Nga mouse is well known as a mouse model for atopic dermatitis. In general, when NC/Nga mouse are raised under specific pathogen free(SPF) conditions no skin lesions are detected, but when under non-filtrated(conventional) condition, atopic dermatitis like skin lesions appear spontatneously. However, this dermatitis develops in 70〜90% of mice(not 100%), which makes it difficult to perform reproducible experiments every time.This study was performed under SPF conditions, using the four solutions(2% SDS, 4% SDS, ethanol, acetone/ether) to destroy the skin barrier function, and thereafter, applying the extracted solution of mite : Dermatophagoides pteronyssinus, which is a very popular antigen in pathogenesis of human atopic dermatitis. The extracted soution of mite was applied repeatedly on the NC/Nga mice with a pretreatment of barrier destroying solution and after 8 weeks the mice developed severe dermatitis(clinical skin condition score of 7-10.2 points) with marked elevation of plasma IgE level, whereas mice coated only with the barrier destroying solution showed weak skin lesion with no elevation of plasma IgE level. BALB/c mice, which are employed as control, showed weak skin lesion(clinical skin condition score of 0-3.8 points) and slight elevation of plasma IgE level after repeated application of the extracted solution of mite with a pretreatment of the barrier destroying solution, whereas mice coated only with the barrier destroying solution showed weak skin lesion and the no elevation of plasma IgE level was observed. In this study, using several solutions to disturb the skin barrier function before applying the antigen, we have found a suitable condition and types of solutions in inducing dermatitis in NC/Nga mice.
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  • PREVALENCE OF ASTHMA IN ADULTS IN MENDA TOWN RURAL-MOUNTAIN AREA IN JAPAN
    Seigoh Hirayama, Hirotsugu Kohrogi, Atsushi Ueda, Chikage Kiyofuji, Na ...
    Article type: Article
    2001 Volume 50 Issue 12 Pages 1163-1170
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1163
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    Several reports have suggested that the prevalence of asthma in adults is currently increasing. However, recent prevalence of asthma has not reported in Japan, especially in rural-mountain areas. To investigate the prevalence of asthma in adults in Japan, we conducted clinical epidemiological research on 5066 inhabitants of Menda town, in a rural-mountain area of Japan. The study population comprised 98.7% of adults in the town, including senior high school students whose age were more than 15 years old. The prevalence of asthma among adults was 3.6%. The ratio of prevalence in males to prevalence in females was 1.44. Peaks prevalences were observed in the age ranges of 15〜19 and>70 years old in males, and 15〜19, 40〜49 and>70 years old in females.
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  • A CASE OF MINOCYCLINE-INDUCED PNEUMONITIS AFTER PERCUTANEOUS INSTILLATION INTO RENAL CYSTS
    Koichi Takahashi, Yoshifumi Fujimoto, Toshihiko Jou, Kazuhiko Kumagai, ...
    Article type: Article
    2001 Volume 50 Issue 12 Pages 1171-1174
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1171
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 12 Pages 1175-1204
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1175
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 12 Pages 1205-1212
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1205
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 12 Pages 1213-
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1213
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 12 Pages 1214-
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1214_1
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 12 Pages 1214-
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1214_2
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  • [title in Japanese]
    Article type: Index
    2001 Volume 50 Issue 12 Pages 1215-1222
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1215
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  • [title in Japanese]
    Article type: Index
    2001 Volume 50 Issue 12 Pages 1223-1225
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1223
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  • [title in Japanese]
    Article type: Index
    2001 Volume 50 Issue 12 Pages 1226-1228
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1226
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  • [title in Japanese]
    Article type: Appendix
    2001 Volume 50 Issue 12 Pages 1229-1235
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.1229
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  • [title in Japanese]
    Article type: Cover
    2001 Volume 50 Issue 12 Pages Cover9-
    Published: December 30, 2001
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.50.Cover9
    JOURNAL FREE ACCESS
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