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Volume 51, Issue 7
Displaying 1-15 of 15 articles from this issue
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Article type: Cover
2002 Volume 51 Issue 7 Pages Cover20-
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (37K) -
Article type: Cover
2002 Volume 51 Issue 7 Pages Cover21-
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (37K) -
Article type: Appendix
2002 Volume 51 Issue 7 Pages App11-
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
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Minoru OkudaArticle type: Article
2002 Volume 51 Issue 7 Pages 541-543
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
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Hiroyuki Ohbayashi, Hirohiko YamaseArticle type: Article
2002 Volume 51 Issue 7 Pages 544-551
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe often find some residual Fluticasone propionate(FP) dry powder after using a specialized inhalant instrument (Diskhaler) in daily clinical use. In this study, we evaluatd the relationship between residual powder and peak inspiratory flow (PIF). and the therapeutic necessity of using the reductive method of the residual powder. Method:70 patients with bronchial asthma including 18 patients concurrently with COPD were measured for their maximum PIF, the residual dose of FP dry powder and FP content of the residual powder after inhalation. We also investigated effective methods to reduce residual powder. Result: The residual powder volume may be dependently affected by maximum PIF. More than 50%residual powder after 1 inhalation occured in asthmatic patients with a PIF of less than 50L/min. Discovering almost the same FP content of dry powder residues as before inhalation, we recognized the therapeutic significance of the decreased residual dry powder. Although the method of increased inhalation frequency alone was limited, the combined use of nail-tapping vibration of the Diskhaler and increased inhalation frequency may significantly decrease the residual dry powder. After carrying out the nail-tapping vibration method over 3 months, we obtained significant increases in daily Peak expiratory flow values with no increased pharyngeal Candidiasis. Oral abnormal dry sensation was found in one person as an additional side effect. Conclusion : We showed the quantitative evaluation of the relationship between PIF and residual FP dose, while making clear the the rapeutic meaning of the reduction of residual powder. Our nail-tapping method may be a clinically effective method to reduce risidual FP dry powder.View full abstractDownload PDF (80K) -
Masaomi Yamashiro, Yukari Okubo, Yukihiko Kato, Tsuyoshi Tamaki, Michi ...Article type: Article
2002 Volume 51 Issue 7 Pages 552-558
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAtopic dermatitis (AD) is a common inflammatory skin disease characterized by several clinical, immunological and biochemical alterations. Comparing the patients with the 'extrinsic' and 'intrinsic' types of AD, we investigated the role of immunological mechanisms in the pathogenesis of AD. To confirm it, we calcu-lated serum markers of T lymphocyte activation : soluble interleukin-2 receptor (sIL-2R), interleukin-4 (IL-4), interleukin-10 (IL-10) and interferon-y (IFN-y). The soluble CD14 (sCDl4) and tumor necrosis factor-α (TNF-α) in serum were measured as monocyte/macrophage activation markers. We examined 29 patients with the 'extrinsic' type AD (serum IgE>10000IU/ml:High-AD), 23 patients with theintrinsic' type AD (serum IgE<37IU/ml:Low-AD) and 11 healthy controls. Serum sIL-2R levels were increased in High-AD and Low-AD compared with the controls. They were also significantly increased in High-AD compared with Low-AD. Serum sCDl4 levels were increased in High-AD compared with Low-AD and the controls. Severity index of AD were correlated with serum sIL-2R levels but not with sCD14 levels in sera. In conclusion, IgE may not relate with the pathogenesis of atopic dermatitis. Serum sIL-2R levels may be increased according to inflammatory skin lesionsand it may be exaggerated with the immunological activation in the patients withthe 'extrinsic' type AD.View full abstractDownload PDF (70K) -
Hidetoshi Kawahara, Yutaka Morisawa, Toshio Katunuma, Yukihiro Ohya, H ...Article type: Article
2002 Volume 51 Issue 7 Pages 559-564
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe investigated the safety of administration of influenza vaccine to patients with positive CAP-RAST to egg white. The content of OVA in the influenza vaccine preparations was measured by Sandwich ELISA. The concentration of OVA in the vaccine preparations ranged from 2 to 8 ng/ml. We administered influenza vaccine to 36 high risk patients who had positive CAP-RAST (>4 score) to egg white and/or had experienced immediate type hypersensitivity after ingestion of egg. One out of them showed local sweelling. All the rest of the patients received influenza vaccine without any serious systemic adverse reactions. We also investigated the incidence of immediate adverse reactions after vaccination in the group of 104 patients with positive CAP-RAST to egg white compared to the group of 98 patients with negative CAP-RAST. No significant difference wasfound in the incidence of adverse reaction between the two groups (group of positive CAP-RAST to egg white:0.5%, negative group:2.2%). These results demonstrate that most of the patients with positive CAP-RAST to egg white, even those with allergic reactions after egg ingestion, cansafely receive an influenza vaccine.View full abstractDownload PDF (64K) -
Kana Ueno, Kenji Minoguchi, Yasurou Kohno, Naruhito Oda, Kiyoko Wada, ...Article type: Article
2002 Volume 51 Issue 7 Pages 565-570
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIt is well known that allergic rhinitis and asthma often coexist in the same patients. Here, we investigated the influence of Japanese cedar pollinosis on the exacerbation of asthma investigated by questionnaire, daily asthma diary, and peak expiratory flow (PEF) monitoring. Furthermore, airway responsiveness to histamine before pollen season was also investigated in some patients. 333 adult patients with asthma were enrolled into the study and 116 patients (34.8%) were suffering from Japanese cedar pollinosis diagnosed by the presence of nasal allergic symptoms during pollen season and high titer of Japanese cedar-specific IgE antibody. Exacerbation of asthma symptoms, including wheezing, dyspnea, cough, and sputum, was detected in 41 of 116 patients (35.3%) during pollen season. Decrease in morning PEF more than 10% compared with the baseline values before pollen season was observed in 13 of 41 patients (11.2% of total asthmatic patients who complicated with Japanese cedar pollinosis). No significant differences in airway responsiveness to histamine and the titer of Japanese cedar-specific IgE antibodies before pollen season were observed between the patients whose asthma exacerbated and the patients whose asthma was not exacerbated. These results suggest that Japanese cedar pollinosis is one of risk factors for asthma in Japanese adult patients with asthma.View full abstractDownload PDF (55K) -
Masaki Komatsu, Kaori Ikematsu, Hiroshi Tachimoto, Akinori Shukuya, Mo ...Article type: Article
2002 Volume 51 Issue 7 Pages 571-576
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSTo clarify the prognosis of asthmatic children with status asthmatics in early childhood, we retrospectively investigated 113 patients (boys 62, girls 51) who had been treated as status asthmatics since 1995 through 2000 in National Sagamihara Hospital. In this study, the frequency of admission was decreased year by year, 62.8% (1st year), 29.2% (3rd year), and 5% (5th year). All patients were evaluated as severe or moderate patients during the 1st year from the episode of status asthmatics. Three years after the episode, 38% of patients were evaluated as severe or moderate patients. Five years later, only 20% of patients were evaluated as severe or moderate patients and 35% became free from treatment and asthma attack. Most of the patients were treated by DSCG inhalation and RTC therapy. Nine patients needed BDI therapy in addition to DSCG and RTC. With appropriate and careful treatment, the prognosis of the patients who had experienced status asthmatics in the early childhood was kept relatively well.View full abstractDownload PDF (57K) -
Atsushi Yuta, Kotaro Ukai, Yasuo Sakakura, Hideshi Tani, Fukiko Matsud ...Article type: Article
2002 Volume 51 Issue 7 Pages 577-582
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSWe made a prediction of the Japanese cedar (Cryptomeria japonica) pollen counts at Tsu city based on male flower-setting conditions of standard trees. The 69 standard trees from 23 kinds of clones, planted at Mie Prefecture Science and Technology Promotion Center (Hakusan, Mie) in 1964, were selected. Male flower-setting conditions for 276 faces (69 trees × 4 points of the compass) were scored from 0 to 3. The average of scores and total pollen counts from 1988 to 2000 was analyzed. As the results, the average scores from standard trees and total pollen counts except two mass pollen-scattered years in 1995 and 2000 had a positive correlation (r = 0.914) by linear function. On the mass pollen-scattered years, pollen counts were influenced from the previous year. Therefore, the score of the present year minus that of the previous year were used for analysis. The average scores from male flower-setting conditions and pollen counts had a strong positive correlation (r = 0.994) when positive scores by taking account of the previous year were analyzed. We conclude that prediction of pollen counts are possible based on the male flower-setting conditions of standard trees.View full abstractDownload PDF (63K) -
Article type: Appendix
2002 Volume 51 Issue 7 Pages 583-
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2002 Volume 51 Issue 7 Pages 584-
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (46K) -
Article type: Appendix
2002 Volume 51 Issue 7 Pages 585-
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
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Article type: Appendix
2002 Volume 51 Issue 7 Pages 586-590
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
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Article type: Cover
2002 Volume 51 Issue 7 Pages Cover22-
Published: July 30, 2002
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (109K)
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