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Article type: Cover
2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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Mitsuhiro Okano
Article type: Article
2004 Volume 53 Issue 1 Pages
1-7
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Kazumi Fukagawa
Article type: Article
2004 Volume 53 Issue 1 Pages
8-13
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Hiroshi Shinmoto, Toshihiro Takahashi, Michie Shinmoto
Article type: Article
2004 Volume 53 Issue 1 Pages
14-18
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To establish immortalized human B-cells secreting antibodies to cedar pollen allergens, peripheral blood lymphocytes from 13 donors were transformed with Epstein-Barr virus. Of 5000 micro culture wells with transformed cell growth, supernatants from 88 wells were found to contain antibodies to pollen allergens. Fourteen supernatants reacted with a cedar allergen Cry j1 and 10 reacted with Cry j2. IgM class antibodies were Dredominant.
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Ryoko Ito, Katsushi Miura, Yasuhei Odajima, Tadakatsu Shimamura
Article type: Article
2004 Volume 53 Issue 1 Pages
19-23
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Human basophils may play a role in bronchial asthma. The effect of pranlukast on histamine release and LTC4 generation from human peripheral basophils was examined. Histamine release induced by FMLP and C5a was inhibited by pranlukast in concentration-dependent manner, whereas anti-IgE Ab-induced histamine release was not affected. Both anti-IgE Ab-and FMLP-induced LTC_4 were inhibited by pranlukast. These results suggest that pranlukast may improve symptoms of bronchial asthma by inhibiting basophil function in addition to antagonizing Cys-LT receptor.
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Komei Ito, Masashi Morishita, Akemi Ito, Tatsuo Sakamoto, Shinpei Tori ...
Article type: Article
2004 Volume 53 Issue 1 Pages
24-33
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Food allergy is frequently associated with atopic dermatitis (AD) in children. Appropriate elimination diet is necessary in the case of immediate food hypersensitivity, regardless it causes worsening of the chronic eczema or not. Here we report the prevalence of immediate type food allergy diagnosed by oral food challenge or the episodes of apparent acute allergic reaction in the AD patients (n = 182, average age 4.9±5.1), who visited our clinic within one year. The prevalence of food allergy in the AD patients was 85.7% in age 0 years, 75.6% in age 1,65.4% in age 2, and declined to 13.9% in age 7 years old or more. The offending foods were egg, milk, wheat, fish and so on. The symptoms of food allergy included skin, gastrointestinal or respiratory manifestations, and also anaphylaxis. In conclusion, immediate type food allergy is frequently associated with childhood AD, and appropriate elimination of the offending food is necessary to avoid the acute allergic reaction including anaphylaxis.
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Yukie Yamaguchi, Takahisa Uchida, Hiroyuki Osuna, Zenro Ikezawa
Article type: Article
2004 Volume 53 Issue 1 Pages
34-37
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A 30-year-old female with paroxysmal supraventricular tachycardia (PSVT) underwent catheter ablation. About 30 minutes later, urticaria and dyspnea occurred suddenly. Blood pressure decreased to 62/41 mmHg, and she fell into the state of anaphylactic shock. She recovered within one hour following treatment. We initially suspected the onset of anaphylaxis was caused by either the local anesthetic or the intravenous antibiotic administered. Following thorough investigation (skin tests and challenge tests), we concluded that the anaphylaxis was not drug induced. Subsequently, we suspected latex allergy. Skin prick test showed a positive reaction to rubber gloves. The specific test for IgE antibody against latex was positive at 10.8 UA/ml. From these results, anaphylactic shock caused by latex (probably medical gloves) was diagnosed. Doctors should take preventive measures against latex allergy not only in operating rooms but also during minor treatments. It is possibile that latex allergy is responsible for some cases of anaphylaxis of unknown origin.
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Sayuri Fujie, Akiko Yagami, Kayoko Suzuki, Hirohiko Akamatsu, Kayoko M ...
Article type: Article
2004 Volume 53 Issue 1 Pages
38-42
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The subject was a 34-year-old female with asthma and atopic dermatitis who had previously undergone a Cesarean section. In December 1995, the patient had an acute abdominal pain, so she underwent a barium enema examination. During the procedure, severe anaphylactic shock developed, and the examination was stopped. The patient responded well to appropriate emergency therapy, and her symptoms were resolved. However, the woman visited our outpatient clinic because the symptoms of her atopic dermatitis got worse. She indicated that she felt itchy when using rubber gloves. Also, at the age of thirty, she had uriticaria and dyspnea after drinking a glass of fruit juice. Subsequently radioallergosorbent testing demonstrated the presence of specific IgEs against latex, banana, kiwi, grapefruit, and avocado. Skin prick tests were positive for banana, grapefruit, avocado, and latex extract at a dilution of 1:1000. A scratch test was positive to an extract of a balloon catheter which included 0.3μg/g latex proteins by the LEAP method. In conclusion, the patient was diagnosed with an anaphylaxis to the latex contained in a ballon catheter used for the barium enema.
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[in Japanese]
Article type: Article
2004 Volume 53 Issue 1 Pages
43-44
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
45-46
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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2004 Volume 53 Issue 1 Pages
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Article type: Appendix
2004 Volume 53 Issue 1 Pages
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Article type: Cover
2004 Volume 53 Issue 1 Pages
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