Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 55, Issue 10
Displaying 1-31 of 31 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    2006 Volume 55 Issue 10 Pages Cover4-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.Cover4
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Cover
    2006 Volume 55 Issue 10 Pages Cover5-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.Cover5
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages App2-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.App2
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  • AN EVOLUTION AND HORIZON OF ALLERGOLOGY IN THE TWENTY-FIRST CENTURY
    Hiroshi Inoue
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1269-1278
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1269
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  • STEROID OINTMENT-UPDATE
    Ichiro Katayama
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1279-1283
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1279
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  • MALPRACTICE SUIT AND RISK MANAGEMENT
    Naoto Hiranuma
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1284-1287
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1284
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  • QUALITY OF LIFE IN PATIENTS WITH JAPANESE CEDAR POLLINOSIS : USING THE SF-8 HEALTH STATUS QUESTIONNAIRE (JAPANESE VERSION)
    Tsukasa Fujii, Satoshi Ogino, Hiroe Arimoto, Morihiro Irifune, Nobuko ...
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1288-1294
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1288
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    Background: The number of patients with Japanese cedar pollinosis (JCP) is increasing, and now, has extended up to about 15% of the Japanese. It is reported that the QOL is an important outcome in the JCP treatment. This study aimed to evaluate the QOL in patients with JCP by means of the SF-8 Health Survey (Japanese Version), a new, even shorter generic health survey. Methods: 411 patients with JCP who visited 10 ENT clinics in Osaka from March 14 to March 26 (peak pollen season) were questioned, and 204 patients without any treatments in this season were engaged in this study as subjects. In this study, the QOL scores were evaluated using the SF-8. This is an 8-item version of the SF-36 that yields a comparable 8-dimension health profile and comparable estimates of summary scores for the physical and mental components of health. Results: The QOL score depressed in the patients with JCP compared with healthy subjects (Japanese national norms). Both Mental Component Score (MCS) and Physical Component Score (PCS) scores decreased more in females than in males. In females, MCS were significantly lower than national norms. The older the patients were, the lower PCS scores were showed. The severity of nasal symptoms influenced the PCS scores. Conclusion: These results showed the tendency similar to the early studies using SF-36 questionnaire. The sensitivity of SF-8 in the individual is not better than that of other specific QOL questionnaires, but SF-8 can be answered in a short time compared with other questionnaires including SF-36. We suggested that SF-8 become a useful questionnaire in the future.
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  • CLINICAL REVIEW ON PATIENTS WHO DEVELOPED SEIZURES DURING THEOPHYLLINE : Administration: Relationships with Seizure-Predisposing Factors
    Yasuhei Odajima, Hiroshi Nakano, Tetsuji Kato
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1295-1303
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1295
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    Objective: In recent years, attempts have been made to broadly deem seizures developing during theophylline administration as theophylline-related seizures. Consequently, a tendency to consider all the seizures attributable to theophylline has occurred. We investigated background factors in pediatric patients with seizures to examine the involvement of theophylline in the event. Methods: Of adverse events developing during theophylline administration which were reported by two theophylline preparation manufacturers between October 1987 and April 2004, we investigated underlying disease, regimen, outcome, and other items in 255 patients with seizures provoked by oral preparations and in 79 patients with seizures provoked by intravenous preparations. Results: The most predominant factors were represented by neurological predispositions, e.g., epilepsy, and by a history of fits prior to the onset of seizures in not less than two-thirds of pediatric patients with seizures who were receiving theophylline. Furthermore, not less than 90% of pediatric patients who remained with sequelae and who died had the factors. Our investigation revealed that the factors developed predominantly when the relevant patients presented fever, aged under 3 years and had history of seizures. Conclusions: Therefore, we consider that advertence to this point is most important in administering theophylline safely.
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  • ENHANCEMENT OF NONSTEROIDAL, ANTI-INFLAMMATORY DRUGS AND PREVENTIVE EFFECT OF ANTIHISTAMINES AND DISODIUM CROMOGLYCATE ON WHEAT ALLERGY
    Naoko Inomata, Kazuko Nakamura, Yumiko Yamane, Hiroyuki Fujita, Momoko ...
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1304-1311
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1304
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    Background: Aspirin has been known to be an enhancer to wheat allergy, including wheat-dependent, exercise-induced anaphylaxis. Objective: To investigate whether nonsteroidal, anti-inflammatory drugs (NSAIDs) other than aspirin would enhance allergic reactions after wheat ingestion and whether antihistamines and disodium cromoglycate would prevent these reactions. Methods: Seven cases, whose reactions after wheat ingestion were enhanced by aspirin on challenge tests, were enrolled. Skin prick tests (SPT) and CAP-RAST were undergone for wheat and gluten. We used challenge tests of wheat after pretreatment of NSAIDs and preventive drugs. Results: Four cases were diagnosed with wheat allergy, 3 cases had wheat-dependent, salicytilic acid-induced anaphylaxis. SPT and CAP-RAST were positive for wheat and gluten in 5 of 7 cases and 4 of 7 cases, respectively. Dicrofenac enhaced the allergic reactions after wheat ingestion in 1 of 2 cases, whereas etodolac failed to enhance the symptoms in all 5 cases performed. Furthermore, disodium cromoglycate could not completely prevent the allergic reaction in all 4 cases and even enhanced the reaction in 1 case of them. To see an inhibitory effect of antihistamines on the symptoms, fexofenadine (in 2, 1 and 1 case, respectively), olopatadine, and chlorpheniramine were administrated before the challenge test, and as a result these drugs were found to have inhibitory effects on the allergic reaction. Conclusion: In this study, it was suggested that etodolac might be a relatively safe anti-inflammatory drug on wheat allergy and antihistamines could prevent allergic reactions more than DSCG in patients with wheat allergy.
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  • PREVALENCE OF SENSITIZATION OF JAPANESE CEDAR POLLEN IN CHILDREN FROM INFANCY TO ADOLESCENCE
    Sawako Masuda, Takao Fujisawa, Kosei Iguchi, Jun Atsuta, Yukiko Noma, ...
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1312-1320
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1312
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    Background: In Japan, morbidity of Japanese cedar pollinosis has dramatically increased, especially in children. However, little is known about the prevalence of pollinosis and sensitization to Japanese cedar pollen (JCP) in young children. Objective: The aim of this study is to investigate the prevalence of sensitization to JCP in allergic and nonallergic children from infancy to adolescence. Methods: Two hundred forty three children with allergic diseases (age 8 months-16 years, mean 5 years) and 137 children without allergic diseases (age 1 month-15 years, mean 4 years) were recruited. Their specific IgE to JCP, house dust mite, orchard grass pollen, egg white, and milk were measured with the CAP-RAST system. A questionnaire was filled out by their parents. Results: The percentage of positive (&ge;2) CAP-RAST to JCP was 47.1% in children with allergic diseases and 19.9% in children without allergic diseases. In children with allergic diseases, the ratio had risen rapidly from 3 to 5 years old. In children without allergic diseases, the ratio of JCP sensitization has gradually increased from the infancy to adolescence. The youngest child who had been sensitized to JCP was 23-month-old boy with atopic dermatitis. The proportion of children who were born from January to march was significantly higher in JCP sensitized group than JCP non-sensitized group. The ratio of house dust mite and orchard grass pollen sensitization was higher in JCP sensitized group than those in JCP non-sensitized group. Conclusion: Large number of children acquire sensitization to JCP in their preschool age. We need to develop the way how to protect JCP sensitization in the early stage of life.
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  • RELATIONSHIPS BETWEEN ORAL ALLERGY SYNDROME AND SENSITIZATION TO POLLEN ANTIGEN, ESPECIALLY TO MUGWORT
    Kohji Asakura, Tomo Honma, Nochikazu Yamazaki, Tadataka Ishikawa
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1321-1326
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1321
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    Background: In order to know the relationships between mugwort pollinosis and oral allergy syndrome (OAS), an etiological study was performed at Muroran City, where mugwort is the most frequent cause of pollinosis. Methods: Allergic rhinitis patients positive to serum IgE to birch, mugwort or grass pollen visited to the outpatient-clinic of Otorhinolaryngology of Muroran City General Hospital from 1998 to 2002, were studied by a questionnaire concerning a past-history of OAS. Results: The prevalence of OAS was significantly higher in patients positive to serum IgE antibody specific to birch pollen or mugwort pollen than those negative to each pollen-specific antibody (birch; 54.5 vs 23.5%, p<0.0001, mugwort; 41.0 vs 21.5%,p<0.01). The main causative foods were fruits of rose family in patients with only birch pollen-specific IgE antibody, and were those other than rose family, such as kiwi, melon, orange, celery and onion in those with only mugwort pollen-specific IgE antibody. The patients group with high Lumiward score to mugwort pollen tended to include severe OAS cases. Conclusion: A close relationship was suggested between mugwort pollen sensitization and OAS.
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  • CLINICAL EFFECTS OF OLOPATADINE HYDROCHLORIDE ON PRURITIS IN SKIN DISEASES
    Mariko Niide, Yukari Okubo, Ryokichi Irisawa, Ryoji Tsuboi
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1327-1336
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1327
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    Objective: The clinical effects of second generation antihistamines on pruritis caused by various skin diseases were examined by keeping a daily record of their effects. Methods: Five mg of olopatadine hydrochloride (Allerock^[○!R]) was admininstered to the subjects twice daily. The severity of the pruritis and the scratch scars were scored before, and then 2 weeks and 4 weeks after, commencement of treatment. The severity of the pruritis during the day and night was measured by using a visual analogue scale (VAS), and a daily 'itch score' was recorded in an 'itch diary.' Results: The itch scores for both day and night, as well as the scratching scores, the VAS values and the 'itch score,' significantly decreased after administration of olopatadine. The VAS value was significantly correlated with the itch scores and patient responses in the medical interview. Statistical analysis showed that there was a prompt alleviation of the pruritis in uriticaria a day after administration, followed by asteatotic dermatitis and atopic dermatitis, in the order of improvement, within the next several days. Conclusion: The VAS value for pruritis was highly correlated with the itch score, showing that the VAS value was suitable for evaluating daily changes in the severity of pruritis. These results suggest that second generation antihistamines like olopatadine hydrochloride, which showed a prompt response to histamine, are effective against pruritis in uriticaria, and that continuous use of these antihistamines is effective against pruritis in other forms of skin disease, such as asteatotic dermatitis and atopic dermatitis in which other chemical mediators besides histamine may be the triggers for pruritis.
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  • AGE DISTRIBUTION OF TRANSEPITHELIAL WATER LOSS IN HUMAN NASAL MUCOSA
    Masato Miwa, Noriyuki Nakajima, Takashi Hirose, Yoko Iwasaki, Atsushi ...
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1337-1339
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1337
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    Background: Dry nose is a common complaint in the elderly. Age distribution of transepithelial water loss of human nasal mucosa (TEWL) value was evaluated in this study. Methods: Eighty-eight volunteers (50 men and 30 women) ranging from 10 to 75 years old were recruited for this study. Measurement of TEWL was performed on the inferior nasal turbinate. TEWL was measured with an evaporation meter applying Fick's law (Tewameter TM 300; Courage and Khazaka, Cologne, Germany). Results: TEWL value tends to increase in order of age, indicating that the barrier function of epithelium may decline with age. Conclusion: The measurement of transepithelial water loss should be contributed to assess the efficiency of nasal mucosal barrier disorders in the elderly.
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  • ASTHMA INSIGHTS & REALITY IN JAPAN 2005
    Mitsuru Adachi, Ken Ohta, Akihiro Morikawa, Sankei Nishima
    Article type: Article
    2006 Volume 55 Issue 10 Pages 1340-1343
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1340
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    Background: This Asthma Insights & Reality in Japan survey was conducted to access the achievement of asthma control by patients and current status of asthma treatment in 2005. Methods: This was cross-sectional, randomized- digit-dial household telephone survey, conducted between September and December 2005. Results: A total 400 adults (mean 52.2 years) and 400 parents of children (mean 8.2 years) with asthma were interviewed by telephone. More than 40% of these patients reported having daytime asthma symptoms and over 30% in nighttime symptoms with awakening. Asthma episodes, i.e. hospitalization, emergency room visit, unscheduled visit, work/school absence were observed in 7, 4, 33, 29% of total patients during the past year, respectively. Eighteen percent of adult and 8% of children were used inhaled corticosteroid. Awareness of peak-flow meter and experience of lung function test were low. Conclusion: The rate of patients who experienced asthma symptoms or episodes were tended to decrease, and use of inhaled corticosteroids seemed to be increased since 2002 when a similar survey took place. However, asthma remains poorly controlled and the current level is still far from achieving the goal of asthma management objected by the Japanese guidelines. Further dissemination of standardize therapy in compliance with the guideline is required.
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1344-1361
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1344
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1362-1363
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1362
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1364-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1364_1
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1364-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1364_2
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1365-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1365_1
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1365-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1365_2
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1366-1367
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1366
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1368-1369
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1368
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1370-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1370
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1371-1372
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1371
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1372-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1372
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1373-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1373
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1374-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1374
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1375-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1375_1
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1375-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1375_2
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  • [title in Japanese]
    Article type: Appendix
    2006 Volume 55 Issue 10 Pages 1375-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.1375_3
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  • [title in Japanese]
    Article type: Cover
    2006 Volume 55 Issue 10 Pages Cover6-
    Published: October 30, 2006
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.55.Cover6
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