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2007 Volume 56 Issue 11 Pages
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Article type: Cover
2007 Volume 56 Issue 11 Pages
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Article type: Appendix
2007 Volume 56 Issue 11 Pages
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Article type: Appendix
2007 Volume 56 Issue 11 Pages
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Masafumi Iijima
Article type: Article
2007 Volume 56 Issue 11 Pages
1341-1345
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Mikiko Tohyama, Koji Hashimoto
Article type: Article
2007 Volume 56 Issue 11 Pages
1346-1350
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2007 Volume 56 Issue 11 Pages
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Kiyoshi Nishioka
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2007 Volume 56 Issue 11 Pages
1352-1355
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Minoru Okuda
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2007 Volume 56 Issue 11 Pages
1356-1360
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Tadao Enomoto
Article type: Article
2007 Volume 56 Issue 11 Pages
1361-1365
Published: November 30, 2007
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Atsushi Yuta, Yukiko Miyamoto, Reiko Hattori, Hitomi Ogihara, Kazuhiko ...
Article type: Article
2007 Volume 56 Issue 11 Pages
1366-1371
Published: November 30, 2007
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Background: We studied medical economic efficacy and influence by the different number of pollen scattering in patients treated with allergen-specific immunotherapy for Japanese cedar pollinosis. Methods: We calculated medical treatment costs and the medicine expense from medical records in eighteen cedar pollinosis patients treated with allergen-specific immunotherapy (IT-G) and with medications (M-G). We examined with the same patients for three years of different pollen scattering, mass scattering year (2005), moderate scattering year (2003), a few scattering year (2004). Furthermore, satisfaction of treatment and symptom score measured by visual analog scale in both subjects was studied in a mass scattering year. Results: Total medical costs at hospital was cheaper in IT-G than in M-G. The result was depended on prescribed medical costs. In addition, prescribed medicine agents and total medical costs did not increase by the mass scattering year of pollen. Satisfaction of treatment and symptom score in IT-G was better than that in M-G. Conclusion: Immunotherapy had a benefit on a medical economy.
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Masaru Kishida, Hiroki Nakazono, Rei Kuroiwa, Hidenori Dokai, Junko Na ...
Article type: Article
2007 Volume 56 Issue 11 Pages
1372-1377
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Background: Relationship between post administrative changes in plasma drug levels and bronchodilation remains unknown. In this study, we measured plasma levels of procaterol, a β_2-agonist, when being inhaled through nebulizers in children with bronchial asthma to examine relationship between improvement of pulmonary function and the plasma levels. Method: Six asthmatic children with the mean age of 9.8 years, inhaled 0.3ml of 0.01% procaterol solution through a nebulizer. We examined changes in pulmonary function and plasma procaterol levels before and after inhalation. Results: Procaterol was detected in the plasma 2 minutes after inhalation when it already rose to the maximum level, and kept the steady until showing a decline in 30 minutes. The measured highest value was 87.8±45.1pg/ml. FEV_<1.0> remarkably increased 2 miminutes after ihalation and was maintained until 60 minutes after inhalation. Other lung function parameters also improved. There was no significant change in the heart rate, but serum potassium concentrations significantly dropped in all patients 60 minutes after inhalation. Conclusion: Plasma procaterol levels promptly rose to the peak at 2 minutes after inhalation and decreased 30 minutes later. Improvement of pulmonary function started promptly at minutes after inhalation and it became a peak 60 minutes later.
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Satoshi Sato, Hisashi Kawashima, Yasuyo Kashiwagi, Nobuhisa Ushio, Mak ...
Article type: Article
2007 Volume 56 Issue 11 Pages
1378-1383
Published: November 30, 2007
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Background: Chlamydia pneumoniae is a frequent causative agent of acute respiratory disease and has been recently reported as a possible cause of asthma. We investigated the prevalence of C. pneumoniae infections in childhood patients with acute exacerbations of asthma. Method: One hundred twenty-six childhood patients with acute exacerbations of asthma, 77 with acute bronchitis and 22 Respiratory syncytial virus infections were studied. Serum samples were obtained and tested for C. pneumoniae-specific IgM antibody by Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: C. pneumoniae IgM-positive results were observed in 48.4% (Index value≧1.60) and 23% (Index value≧1.10) of patients with acute exacerbations of asthma. The prevalence of C. pneumoniae-specific IgM was significantly higher in asthma cases than in other subjects (p<0.05). Conclusion: Our data suggest that C. pneumoniae infection may trigger acute exacerbations of childhood asthma.
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Masayuki Nakayama, Masashi Bando, Tatsuya Hosono, Hideaki Yamasawa, Sh ...
Article type: Article
2007 Volume 56 Issue 11 Pages
1384-1389
Published: November 30, 2007
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Background: Our aim is to evaluate the significance of DLST by Shosaikoto. Methods: We clinically evaluated 3 cases of drug-induced pneumonia assumed to be caused by Shosaikoto, and we performed DLST of Shosaikoto for healthy controls, and compared the data with drug-induced pneumonia cases of Shosaikoto. Results: As clinical characteristics of 3 cases, 2 cases were positive for hepatitis C virus antibody, and 1 case was positive for DLST of Shosaikoto. The observed chest high-resolution CT (HRCT) findings showed hypersensitivity pneumonia (HP) pattern in all 3 cases. Prognosis was good in all 3 cases. DLST of Shosaikoto was positive in 27.5% of healthy controls. Stimulation index (S.I.) of DLST in drug-induced pneumonia cases increased depending on drug dilution density, compared to that of healthy controls. Conclusion: DLST of Shosaikoto showed high false-positive rate. However, we may be able to distinguish the true-positive cases with the false-positive cases by comparing the S.I. of DLST according to drug dilution density.
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Zen Isobe, Tatsuo Suga, Shigeto Hamaguchi, Kenichirou Hara, Nozomi Aok ...
Article type: Article
2007 Volume 56 Issue 11 Pages
1390-1396
Published: November 30, 2007
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A 58-year-old woman had a productive cough but not from bronchial asthma. A chest radiograph revealed infiltrative shadows in right middlelung field on September, 2004. Aspergillus fumigatus was detected in a sputum culture. She was treated with oral itraconazole. After the treatment, infiltrative shadows on her chest radiograph disappeared. On October 2005, her peripheral blood showed eosinophilla, a high serum level of total immunoglobulin E (IgE), and a chest radiograph revealed new infiltrative shadows in both lung fields. A chest computed tomography revealed multiple nodular shadows and central bronchiectasis. We detected a mucoid plug which showed a large number of eosinophils pathologically by bronchoscopy. Aspergillus niger was detected in a bronchial lavage fluid. We therefore made a diagnosis of allergic bronchopulmonary aspergillosis (ABPA). The decreases of peripheral blood eosinophils and a serum IgE level were recognized and multiple nodular shadows disappeared by reinstitution of itraconazole. However, a chest computed tomography revealed new infiltrative shadows. Therefore, we treated her with the concomitant administration of oral itraconazole and inhaled corticosteroid. All laboratory data and image findings were improved. It is critical to consider the both aspects of allergy and infection in the treatment for ABPA.
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Akiko Kijima, Hiroshi Nishino, Jiro Umeda, Yoko Kataoka
Article type: Article
2007 Volume 56 Issue 11 Pages
1397-1402
Published: November 30, 2007
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Two cases of generalized urticaria after the dental treatment were reported. These cases had clearly positive RAST to formaldehyde, whereas skin prick testings were negative. We diagnosed them as type I allergy due to formaldehyde. Immediate type formaldehyde allergy is not widely recognized as a major allergic complication of dental treatment. Previous reports of immediate allergy to formaldehyde in dental treatment were reviewed. The characteristics are the followings, first, it tends to represent severe symptom like anaphylaxis, second, the symptom often appears a few hours later than usual cases of anaphylaxis. Allergen tests show highly positive ratio to formaldehyde RAST, whereas skin prick test often shows false negative. Assessment of specific IgE to formaldehyde is a useful and a diagnostic measurement, and is recommended in patients at risk.
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Yasusuke Kawada, Tetsuya Takamasu, Chisato Inuo, Hiroyuki Aikawa, Kazu ...
Article type: Article
2007 Volume 56 Issue 11 Pages
1403-1407
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We present a 15 years old boy who experienced unusual symptoms for pollen allergy, and successfully treated by rush immunotherapy. The patient started to complain erythema and edema on his face and serous rhinorrhea at 10 years old when going out. He entered baseball team at junior high school, and subsequently experienced choking sensation, dyspnea, face edema, and it was sometimes impossible to continue play. He was diagnosed as bronchial asthma at some hospital, and prescribed many anti-asthma medications including inhaled corticosteroid, which did not take effect. His symptoms deteriorated in summer and ameliorated in winter. When he was 15 years old, he was referred to us by a pediatrician for reassessment of his symptoms. Flow-volume curve was normal, and bronchial provocation test (acetylcholine and histamine), and exercise challenge were negative. IgE antibodies specific to grass pollens were highly positive. We made a diagnosis of pollinosis to grass pollens instead of bronchial asthma. Oral antihistamines and intranasal corticosteroid partially improved his symptoms. We started rush-immunotherapy of grass-pollens (oats and bromegrass), Japanese cedar, and ragweed. His symptoms improved dramatically on the next season of grass pollens.
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[in Japanese]
Article type: Article
2007 Volume 56 Issue 11 Pages
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2007 Volume 56 Issue 11 Pages
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2007 Volume 56 Issue 11 Pages
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2007 Volume 56 Issue 11 Pages
1447-1451
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2007 Volume 56 Issue 11 Pages
1452-1453
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2007 Volume 56 Issue 11 Pages
1454-1458
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2007 Volume 56 Issue 11 Pages
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Article type: Appendix
2007 Volume 56 Issue 11 Pages
1460-1462
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Article type: Appendix
2007 Volume 56 Issue 11 Pages
1463-1464
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Article type: Appendix
2007 Volume 56 Issue 11 Pages
1465-1466
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Article type: Appendix
2007 Volume 56 Issue 11 Pages
1467-1468
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Article type: Appendix
2007 Volume 56 Issue 11 Pages
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2007 Volume 56 Issue 11 Pages
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2007 Volume 56 Issue 11 Pages
1470-1471
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2007 Volume 56 Issue 11 Pages
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2007 Volume 56 Issue 11 Pages
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2007 Volume 56 Issue 11 Pages
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Article type: Cover
2007 Volume 56 Issue 11 Pages
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