Japanese Journal of Allergology

Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884

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Volume 58, Issue 5

Displaying 1-43 of 43 articles from this issue

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[title in Japanese]

Article type: Cover
2009 Volume 58 Issue 5 Pages Cover13-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.Cover13

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[title in Japanese]

Article type: Index
2009 Volume 58 Issue 5 Pages Toc7-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.Toc7

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages App26-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.App26

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

Article type: Article
2009 Volume 58 Issue 5 Pages 481-490
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.481

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TOPICAL CORTICOSTEROIDS : HOW TO USE IN CLINICAL PRACTICE

Masutaka Furue

Article type: Article
2009 Volume 58 Issue 5 Pages 491-497
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.491

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 498-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.498

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TACROLIMUS OINTMENT FOR THE TREATMENT OF ATOPIC DERMATITIS

Mamitaro Ohtsuki

Article type: Article
2009 Volume 58 Issue 5 Pages 499-506
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.499

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THE BRIEF COMMENTARY ON JAPANESE PEDIATRIC GUIDELINES FOR THE TREATMENT AND MANAGEMENT OF BRONCHIAL ASTHMA 2008 : Early Intervention and Management

Tsutomu Iwata

Article type: Article
2009 Volume 58 Issue 5 Pages 507-511
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.507

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MEASUREMENT OF RESPIRATORY FUNCTION AND BRONCHIAL HYPERRESPONSIVENESS IN CHILDREN

Hiroyuki Mochizuki

Article type: Article
2009 Volume 58 Issue 5 Pages 512-518
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.512

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CHRONIC COUGH : EOSINOPHILIC LOWER AIRWAY DISORDERS

Masaki Fujimura

Article type: Article
2009 Volume 58 Issue 5 Pages 519-523
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.519

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SINGLE BLIND FOOD CHALLENGE USING DRIED FOOD POWDER : 1st Report. Raw Whole Egg and Egg Yolk

Takatsugu Komata, Akinori Shukuya, Takanori Imai, Hiroshi Tachimoto, M ...

Article type: Article
2009 Volume 58 Issue 5 Pages 524-536
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.524

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Aim: We have analyzed data of raw whole egg and egg yolk challenges performed in single-blinded manner. Subjects and Methods: We have performed 92 whole egg challenges and 109 egg yolk challenges in admission from 1995 to 2005. Results: The positive rate of whole egg challenges was 76.1%, and the most frequent symptoms seen during challenges involved gastrointestinal (GI) system, followed by skin, and respiratory system. The rate of anaphylaxis was 4.3%. Among 70 raw-egg positive cases, 62 heated-egg challenges were performed in open manner, which resulted in 18 negative cases (29%) against it. When we compared IgE CAP RAST against egg white between challenge positive cases and negative ones, IgE CAP RAST against egg white was significantly higher in positive group. With regards to yolk egg challenges, positive rate was 23.9%, and evoked symptoms were most frequently seen in skin, followed by GI system, and respiratory system. No case of anaphylaxis was observed. Conclusions: Single-blinded challenge tests against whole egg and egg yolk were useful for the diagnosis of pediatric egg allergy. IgE CAP RAST against egg white was useful when we considered timing of egg challenge tests. Among raw egg allergies, around 30% of patients could eat heated-whole egg. In order to improve egg allergy patients' quality of life, it is important to first introduce egg yolk challenges followed by heated-whole egg challenges, and finally raw-egg challenges, if it is necessary, in blinded manner.

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ANALYSIS OF TREATMENTS AND DECEADED CASES OF SEVERE ADVERSE DRUG REACTIONS : ANALYSIS OF 46 CASES OF STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS

Yumiko Yamane, Michiko Aihara, Satoko Tatewaki, Setsuko Matsukura, Tak ...

Article type: Article
2009 Volume 58 Issue 5 Pages 537-547
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.537

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Background: Systemic administration of corticosteroid, plasmapheresis and high-dose immunoglobulin therapy (IVIG) are the main treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Objective: To evaluate the effects of the treatments of SJS and TEN. Methods: Twenty-seven cases of SJS and 19 cases of TEN treated in our hospitals from 2000 to 2007 were analyzed. Results: Corticosteroid was administered systemically in all cases except one case of TEN which developed methicillin resistant staphylococcus aureus (MRSA) pneumoniae before the onset of the eruption. Methylprednisolone (mPSL) pulse therapy (1000mg/day) or mini pulse therapy (less than 600mg/day of mPSL) was selected by 8 cases of SJS and 9 cases of TEN. Combination of plasmapheresis or IVIG with corticosteroid therapy was performed in 3 cases of SJS and 8 cases of TEN. The mortality rate of patient with SJS was 3.7% (1 case), and with TEN was 21.1% (4 cases). The deceased case of SJS had been treated with corticosteroid alone and died for acute respiratory disorder after 24 days from the onset of the eruption. Four deceased cases of TEN were treated with corticosteroids with or without IVIG, and 2 of them merged sepsis. Conclusions: Although corticosteroids may enhance the risk of sepsis, prompt treatment with systemic corticosteroids seems to reduces morbidity and improves outcome of SJS and TEN patients.

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A CLINICAL STUDY OF ADMITTED THE REVIEW OF CASES OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS

Ryosuke Matsumoto, Teruhiro Ogawa, Takuma Makino, Mitsuhiro Okano

Article type: Article
2009 Volume 58 Issue 5 Pages 548-553
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.548

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Background: Food-dependent exercise-induced anaphylaxis (FDEIA) is characterized by anaphylactic symptoms after eating certain foods, followed by exercise. As we examine more patients who have pollinosis, we have more opportunities to see allergic disease such as FDEIA, OAS, and so on. Methods: We performed a retrospective analysis of six cases, diagnosed FDEIA for this three years. Results: Of six cases, the ages are 8 to 47 years old, and the trigger allergens were wheat, shrimp, and grapefruit. The trigger exercises were running, volleyball, as well as taking a bath. In four cases, the patients had history of allergic disease such as atopic dermatitis, allergic rhinitis, and so on. In two cases of wheat-dependent exercise-induced anaphylaxis, the IgE levels for ω5-gliadin (a major wheat allergen) in a RAST were positive. Conclusion: Of six cases diagnosed FDEIA, the trigger allergens were wheat, shrimp, and grapefruit. In cases of wheat-dependent exercise-induced anaphylaxis, the IgE levels for ω5-gliadin in a RAST were positive. After the food allergen has been identified, we advised strict restrictions on ingestion of trigger allergens in the case of shrimp and grapefruit, and on any exercise after eating foods containing wheat flour in the case of wheat.

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POTENTIAL MECHANISMS OF AIRWAY REMODELING INITIATED BY ACTIVATED THROMBIN IN ASTHMA

Hiroshi Kanazawa, Shigenori Kyoh, Yoshihiro Tochino, Toyoki Kodama, Ka ...

Article type: Article
2009 Volume 58 Issue 5 Pages 554-559
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.554

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Background: High expression of vascular endothelial growth factor (VEGF) induces subepithelial fibrosis associated with angiogenesis in asthma. Thrombin is recognized as a new candidate mediating airway remodeling. Therefore, this study was designed to determine the potential mechanisms of airway remodeling initiated by activated thrombin in asthma. Methods: Levels of biochemical parameters in induced sputum were examined in 21 asthmatic patients and 11 normal controls. Results: Thrombin activity in induced sputum was significantly higher in asthmatic patients than in normal controls (normal controls: median [range] 1.26 (0.93-2.42)U/mL; asthmatic patients: 3.67 (1.15-10.2)U/mL, p<0.0001). VEGF level in induced sputum was positively correlated with thrombin activity in all study subjects. Levels of basic fibroblast growth factor (bFGF), which is a major profibrotic factor, were also significantly higher in asthmatic patients than in normal controls. Moreover, thrombin activity was significantly correlated with bFGF level in all study subjects. We also observed a significant correlation between bFGF and procollagen type III peptide level. Conclusion: Increase in VEGF level leads to up-regulation of thrombin activity in asthmatic airways, and this elevated thrombin activity induces elevation of bFGF level. It will become to be a new strategy of asthma therapy to attenuate thrombin activity for the regulation of airway remodeling.

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A FATAL CASE OF DRUG-INDUCED HYPERSENSITIVITY SYNDROME DUE TO ALLOPURINOL

Eiichi Gyotoku, Takashi Iwamoto, Makoto Ochi

Article type: Article
2009 Volume 58 Issue 5 Pages 560-566
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.560

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A 83-years-old Japanese woman visited our hospital, complaining of fever, erythema over the entire body and erosion on the lips after taking allopurinol for a month. Laboratory examinations showed liver dysfunction and renal failure. The histological study showed dense lymphocytic and eosinophilic perivascular infiltrations in the upper dermis at the erythematous lesion. We withdrew administration and started steroid pulse therapy. The eruption subsided after a week, but liver dysfunction was not controlled by treatment with corticosteroid (PSL 15mg/day). She suffered from sepsis and DIC, and despite of intensive therapy, she died of the disease. We measured blood concentration of allopurinol and oxypurinol after stopping drug administration. Blood concentration of oxypurinol was high for nine days at that time. We diagnosed this case as DIHS due to allopurinol because of a significant increase of anti HHV-6 and CMV IgG titer.

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THROMBOTIC THROMBOCYTOPENIC PURPURA WITH MIXED CONNECTIVE TISSUE DISEASE. A CASE REPORT

Naomi Kajita, Yoshinao Muro, Akihiro Tomita, Kanji Hirashima, Tadashi ...

Article type: Article
2009 Volume 58 Issue 5 Pages 567-572
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.567

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We reported a very rare case of mixed connective tissue disease (MCTD) with thrombotic thrombocytopenic purpura (TTP). The patient was a 24-year-old female who admitted to our hospital in February 2007 because of swelling of her fingers and Raynaud's phenomenon, and was diagnosed as MCTD. Her symptom was improved with the oral administration of prednisolone 10mg/day. In September 2007, her blood examination test showed remarkable thrombocytopenia and hemolytic anemia. A significant number of schistocytes were observed in her peripheral blood smear, and a disintegrin-like and metalloproteinase with thrombospondin type1 motifs13 (ADAMTS13) activity in her serum was below the measurement sensitivity, resulted in the diagnosis of TTP. Seven-time plasma exchanges so far cured TTP clinically without any relapse, with remarkable improving of all laboratory data relating to TTP.

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 573-574
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.573

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 575-576
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.575

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 577-583
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.577

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 584-590
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.584

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 591-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.591

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 592-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.592_1

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 592-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.592_2

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 593-594
Published: May 30, 2009
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DOIhttps://doi.org/10.15036/arerugi.58.593

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 595-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.595

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 596-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.596_1

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 596-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.596_2

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 597-598
Published: May 30, 2009
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DOIhttps://doi.org/10.15036/arerugi.58.597

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 598-599
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.598

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 600-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.600

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 601-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.601

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 602-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.602

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 603-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.603

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 604-605
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.604

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 606-608
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.606

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 608-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.608_1

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 608-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.608_2

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 609-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.609

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 610-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.610

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 611-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.611_1

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 611-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.611_2

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[title in Japanese]

Article type: Appendix
2009 Volume 58 Issue 5 Pages 611-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.611_3

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[title in Japanese]

Article type: Cover
2009 Volume 58 Issue 5 Pages Cover14-
Published: May 30, 2009
Released on J-STAGE: February 10, 2017

DOIhttps://doi.org/10.15036/arerugi.58.Cover14

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