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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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Hajime Shindo, Maiko Tanaka, Michihiro Hide
Article type: Article
2011 Volume 60 Issue 6 Pages
667-675
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Junichi Chihara, Wataru Ito
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2011 Volume 60 Issue 6 Pages
676-681
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2011 Volume 60 Issue 6 Pages
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Hironobu Ihn
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2011 Volume 60 Issue 6 Pages
683-686
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Hiroki Takahashi, Motohisa Yamamoto, Yasuyoshi Naishiro
Article type: Article
2011 Volume 60 Issue 6 Pages
687-691
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Yoshitomo Motomura, Sho Yamasaki
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2011 Volume 60 Issue 6 Pages
692-698
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Maki Moriya, Michiko Aihara, Rie Hirota, Yuko Hirata, Naoko Ikinaga, N ...
Article type: Article
2011 Volume 60 Issue 6 Pages
699-707
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Background: The pathogenesis of urticaria and angioedema induced by non-steroidal anti-inflammatory drugs (NSAIDs) is still obscure. We analyzed the clinical characteristics of patients with NSAIDs-induced urticaria and angioedema without asthma in Japan. Methods: We retrospectively collected the cases of NSAIDs-induced urticaria and angioedema from Japanese medical journals in 2000-2009. Results: Seventy-six patients were analyzed. The male/female ratio was 1:2.5 and the mean age was 38.1 years. Urticaria was most frequent clinical manifestation in 3 groups; urticaria alone, urticaria and angioedema, and angioedema alone. Time interval from drug administration to onset was 5 minutes to 48 hours by aspirin at a dose of 25-1000mg. Skin prick test was performed with aspirin in 33 patients, and the results were negative in all patients. Meloxicam, a selective cyclooxygenase-2 (COX-2) inhibitor, and celecoxib, a new selective COX-2 inhibitor, were administered safely in 4 of 6 patients and in 2 of 3 patients with NSAIDs-induced urticaria, respectively. These drugs were administered safely in all administered patients with NSAIDs-induced angioedema. Tiaramidehydrochroride (a basic COX-1 inhibitor) was safely used in 23 administered patients with NSAIDs-induced angioedema. Leukotriene receptor antagonists were effective in 2 of 5 patients administered, but aggravated symptoms in the others. Conclusion: Diversity of NSAIDs-induced urticaria and angioedema was shown in this study. Pathogenesis of NSAIDs-induced urticaria and angioedema without asthma seems to be different from that of NSAIDs-induced asthma.
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Susumu Harada, Tatsuya Moriyama, Akira Tanaka
Article type: Article
2011 Volume 60 Issue 6 Pages
708-713
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Two young women were suffered from several symptoms after the intake of royal jelly at their first time. According to the positive skin prick test reactions of raw royal jelly, royal jelly allergy was diagnosed. As the reasons why the symptoms appeared at the time of their first intake, we guessed the possibility that 1) they had been sensitized for royal jelly formerly, or 2) their symptoms were induced by the cross-reactivity between royal jelly and other allergens such as bee, honey and pollens. As to our cases, no related allergens were found in one case, but in another case co-existance of mugwort allergy was suspected from the results of both skin prick test and specific IgE titers. Originally royal jelly allergy has been regarded as class 1 allergic reaction developed by the sensitization of itself. But we speculated the possibility that there can also be cases of class 2 royal jelly allergy by the mechanism of cross-reaction with pollens.
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Article type: Appendix
2011 Volume 60 Issue 6 Pages
714-715
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Article type: Appendix
2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
723-724
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
759-761
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2011 Volume 60 Issue 6 Pages
762-763
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2011 Volume 60 Issue 6 Pages
764-769
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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2011 Volume 60 Issue 6 Pages
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