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2013 Volume 62 Issue 12 Pages
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Article type: Index
2013 Volume 62 Issue 12 Pages
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
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2013 Volume 62 Issue 12 Pages
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Kentaro Machida, Hiromasa Inoue
Article type: Article
2013 Volume 62 Issue 12 Pages
1565-1574
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Takashi Satoh, Shizuo Akira
Article type: Article
2013 Volume 62 Issue 12 Pages
1575-1582
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2013 Volume 62 Issue 12 Pages
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Hidehisa Saeki
Article type: Article
2013 Volume 62 Issue 12 Pages
1584-1590
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Hisanori Umehara, Tomomi Sato, Takuji Nakamura, Masao Tanaka
Article type: Article
2013 Volume 62 Issue 12 Pages
1591-1597
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Noriko Shibuya, Emiko Saito, Chitose Karasawa
Article type: Article
2013 Volume 62 Issue 12 Pages
1598-1610
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BACKGROUND: A recent study hypothesized that a skin-mediated immune response leads to atopic sensitization. However, prospective studies investigating sensitization during infancy are limited. METHODS: This cohort study included unselected infants born at NTT Medical Center Tokyo between March 2008 and February 2009. At age 3, 6, 9, and 12 months, they underwent physical examinations and a skin prick test (SPT). Associations of predictor variables with sensitization, atopic dermatitis (AD), and food allergy (FA) at ⪯ 1 year were analyzed. RESULTS: Of 317 infants, the SPT was positive in 25 (8%) at 3 months and 133 (42%) at least once. Of the SPT-positive infants at 3 months, 19 (76%) had atopic diseases at ⪯ 1 year (OR, 13.9; 95% 95% CI, 5.3-36.6). The presence of dermatitis at ⪯ 3 months was significantly associated with sensitization (aOR, 3.0; 95%CI, 1.8-5.0), AD (aOR, 13.0; 95%CI, 4.5-37.3), and FA (aOR, 28.4; 95%CI, 3.3-240.6) by the age of 1 year. Point prevalence of sensitization paralleled the incidence of dermatitis. Almost all FA infants had experienced dermatitis at ≤ 3 months. In infants with dermatitis at ⪯ 3 months, breast-feeding was significantly associated with sensitization (OR, 2.5; p = 0.005) and FA (OR, 3.0; p = 0.004). Infants without eczema at ⪯ 3 months rarely developed AD or FA. CONCLUSIONS: The presence of dermatitis in the first few months after birth is a strong risk factor for atopic sensitization and PA during the first year of life.
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Akinori Ishihara, Hisashi Wakayama, Tomohiko Ogasawara, Miho Shimizu, ...
Article type: Article
2013 Volume 62 Issue 12 Pages
1611-1622
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Background: We analysed the patient characteristics among adult asthmatics hospitalized to our hospital to clearfy the residual problems in the prevention and treatment of asthma. Methods: We identified the adult asthmatics hospitalized to our hospital during the period A: Jan 2004-Dec2005 and the period B: Jan 2009-Dec2010 and analysed retrospectively around age, smoking history, and the use of ICS (including combination medicine) and so on. Results: The total patient numbers were A: 161 and B: 88, decreasing to almost half. The rates of the patients older than 65 years were equivalent between the 2 groups. Categorized according to age, in the group <65 years old, the rates of ICS use were A: 22.9% and B: 35.8% and the current smoking rates were A: 42.7% and B: 49.1% respectively. In the group 65 ≦ years old, the rates of ICS use were A: 46.2% and B: 48.6%, and the current smoking rates were A: 19.7% and B: 22.9%. Conclusion: In the group <65 years old, ICS has become more popular but smoking rate has increased among hospitalized adult asthmatics. It is estimated that smoking leads to reduce the effect of ICS and the strategy of smoking cessation will be needed to reduce acute exacerbations. In the group 65 ≦ years old, ICS is relatively more popular than youth and smoking rate is limited. Asthma among elder people may be refractory and more efficient strategies must be required.
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Atsushi Yuta, Yukiko Ogawa
Article type: Article
2013 Volume 62 Issue 12 Pages
1623-1630
Published: December 30, 2013
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Long-term use of decongestant nasal spray (alpha adrenergic agonist) causes nasal congestion by rhinitis medicamentosa. Subjects and methods: We clinically reviewed the cases of 33 patients of rhinitis medicamentosa (23 men, 10 women; mean age, 44.4 ± 15.6 years) treated with nasal steroid sprays instead of decongestant nasal sprays in our clinic from October, 2011 to December, 2012. Results: Periods of drug use were generally long. Only 7 cases had a duration of use less than 1 year, and about half (48.5%) had a duration of use longer than 2 years. Causes of use included acute inflammation (n = 6), chronic rhinosinusitis (n = 2), and allergic rhinitis (n = 20) and unknown cause (n = 5). About two-third of the patients failed to answer questions concerning their use of decongestant nasal spray in a questionnaire prior to examination; therefore, careful observation was necessary. Among the 33 cases, 31 were followed up, all of whom showed improvement and stopped using decongestant nasal spays within 4 weeks. Periods for recovery were as follows: 3 days in 19 cases (61.3%) and 1 week in 25 cases (80.6%). Duration of drug use did not correlate with the period required for recovery; therefore, these results suggest that patients with long-term drug use are able to improve quickly. Conclusion: Rhinitis medicamentosa with nasal congestion appears readily reversible with suitable treatment.
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Kenichiro Komiyama, Ai Masumoto, Fuyumi Nishihara, Takehito Kobayashi, ...
Article type: Article
2013 Volume 62 Issue 12 Pages
1631-1641
Published: December 30, 2013
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Background: ImmunoCAP^[○!R] Rapid is a rapid test kit to measure the allergen-specific IgE to the eight major inhalation allergen (cat, mite, orchard grass, ragweed, wormwood, dog, cockroach, Japan cedar). Methods: We performed ImmunoCAP^[○!R] Rapid 83 patients with allergic disease (26 males, 57 females, median aged 43 years, 53 of asthma, 43 of allergic rhinitis) in our allergy center. ImmunoCAP^[○!R] Rapid results were compared with those of skin prick test (SPT). Results: Although total positive allergens of SPT were higher than that of ImmunoCAP^[○!R] Rapid (26.5% vs 22.5%, p< 0.05), there was no significantly difference of each positive allergen between two tests. The rate of ImmunoCAP^[○!R] Rapid to Japan cedar was almost equivalent to SPT in all patients (68.7% vs 55.4%, p = 0.07). In contrast, the rate of ImmunoCAP^[○!R] Rapid to Japan cedar was higher than SPT in patients with rhinitis (90.4% vs 71.4%, p<0.05). Efficiency between ImmunoCAP^[○!R] Rapid and SPT was 86.4%, sensitivity was 66.9%, and specificity was 93.4%. The reactivity of ImmunoCAP^[○!R] Rapid to allergens significantly correlated with sizes of SPT (erythema: r = 0.645, urticaria: r = 0.657 Conclusion: Although identification rate in the screening ImmunoCAP^[○!R] Rapid slightly inferior to SPT, this test system was useful for diagnosis of Japan cedar and mite.
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Atsushi Kamijo, Tomoyuki Soma, Yoshitaka Uchida, Ryuichiro Araki, Take ...
Article type: Article
2013 Volume 62 Issue 12 Pages
1642-1650
Published: December 30, 2013
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Introduction: Allergic rhinitis and asthma are often comorbid, and allergic rhinitis has been shown to be a risk factor for asthma in adults and children. Recently, the prevalence of allergic rhinitis among bronchial asthma (BA) patients was reported to be 67.3% in Japan. However, seasonal variation in the prevalence of rhinitis in Japan remains unclear. Objectives and Methods: To investigate the seasonal differences in comorbid allergic rhinitis among asthmatic patients, a survey of BA outpatients aged six years and older was conducted at the Allergy Center, Saitama Medical University. In total, 150 patients (mean age, 43.8 ± 21.8 years old) in summer 2012 and 181 patients (mean age, 48.7 ± 18.3 years old) in spring 2013 completed the Self Assessment of Allergic Rhinitis and Asthma (SACRA) questionnaire. Results: The prevalence of allergic rhinitis in BA patients was 50% in the summer of 2012 and 85.6% in the spring of 2013, indicating a significant seasonal variation. Control of asthma was significantly poorer in both seasons in patients with rhinitis compared to those without rhinitis. Furthermore, in patients with moderate/severe-persistent rhinitis, control of asthma was significantly worse than in patients with mild-intermittent rhinitis in spring 2013, but not in summer 2012. Conclusion: Although the comorbidity rate of rhinitis among BA patients was greater in the spring than in the summer, rhinitis is thought to be closely related with asthma control regardless of the season.
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[in Japanese]
Article type: Article
2013 Volume 62 Issue 12 Pages
1651-1652
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1653-1664
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1665-1670
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2013 Volume 62 Issue 12 Pages
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2013 Volume 62 Issue 12 Pages
1672-1674
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1675-1676
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1677-1680
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2013 Volume 62 Issue 12 Pages
1681-1682
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1683-1688
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1689-1693
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1694-1695
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Article type: Appendix
2013 Volume 62 Issue 12 Pages
1696-1700
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2013 Volume 62 Issue 12 Pages
1701-1702
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2013 Volume 62 Issue 12 Pages
1703-1709
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2013 Volume 62 Issue 12 Pages
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2013 Volume 62 Issue 12 Pages
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Article type: Index
2013 Volume 62 Issue 12 Pages
1718-1729
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Article type: Index
2013 Volume 62 Issue 12 Pages
1730-1733
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Article type: Index
2013 Volume 62 Issue 12 Pages
1734-1736
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2013 Volume 62 Issue 12 Pages
1737-1738
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2013 Volume 62 Issue 12 Pages
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Article type: Cover
2013 Volume 62 Issue 12 Pages
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