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Article type: Cover
2014 Volume 63 Issue 10 Pages
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Article type: Index
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Michitaka Tanaka, Ken-ichiro Inoue, Hirohisa Takano
Article type: Article
2014 Volume 63 Issue 10 Pages
1289-1297
Published: December 01, 2014
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Yoichi Nakamura
Article type: Article
2014 Volume 63 Issue 10 Pages
1298-1303
Published: December 01, 2014
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Takayuki Fukuzumi
Article type: Article
2014 Volume 63 Issue 10 Pages
1304-1310
Published: December 01, 2014
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Norito Katoh
Article type: Article
2014 Volume 63 Issue 10 Pages
1312-1316
Published: December 01, 2014
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Kimihiro Okubo
Article type: Article
2014 Volume 63 Issue 10 Pages
1317-1324
Published: December 01, 2014
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Tetsuri Kondo, Toshimori Tanigaki, Makoto Hibino, Motoki Ohe, Sakurako ...
Article type: Article
2014 Volume 63 Issue 10 Pages
1325-1329
Published: December 01, 2014
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Background: Flow resistance of dry powder inhaler (DPI) is important information when physician choose a suitable DPI to individual patient. We previously reported flow resistances of several DPIs and training devices. In the present in vitro study, we measured resistances of new DPIs and new trainers. Method: Flow resistances were obtained from driving pressure and flow through the devices. Results: All devices had parabolic relationships between the driving pressure and flow. Resistances were: 8.44±0.45×10^<-2> (mean±SD) for Elipta^[○!R], 5.53±0.13×10^<-2> for Breezhaler^[○!R], 7.27±0.40×10^<-2> for new Diskhaler^[○!R], 12.15±0.40×10^<-2> for Swinghaler^[○!R], 7.07±0.24×10^<-2> for new Diskus trainer, 8.72±0.4.5×10^<-2> (√<cmH_2O>/L/min) for Elipta trainer. Sounding threshold of Diskus trainer was 38.1±5.1 and that of Elipta trainer was 39.9 (meidan) L/min. Interpretations: In change from Diskus^[○!R] to Elipta^[○!R], flow instruction is not necessary. Breezhaler^[○!R] is a suitable DPI for patients with low pulmonary function but patients should be alert to avoid excessively high inhalational flow. In flow instruction, a flow higher than trainer sounding should be advised.
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Yasunori Ito, Masaki Shimomura, Fumika Tokunaga, Takaaki Meguro, Shiro ...
Article type: Article
2014 Volume 63 Issue 10 Pages
1330-1337
Published: December 01, 2014
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Background: Among the casein components, αs-casein (αs-CAS) is considered the major allergen in Japan, and there are very few reports on the allergenicity of β-casein (β-CAS). In this study, we compared the allergenicity of β-CAS with that of αs-CAS in Japanese children with cow milk allergy (CMA). Method: The allergenicity of αs-CAS and β-CAS in 29 CMA patients and 11 control subjects was assessed using the basophil activation test (BAT). The accuracy of the BAT to distinguish the patients with CMA from the control subjects was estimated using a receiver operating characteristic (ROC) analysis and was expressed as the area under the curve (AUC). Results: BAT results for CM were positive in 93.1% of the CMA patients. The results of the β-CAS-BAT and αs-CAS-BAT were found to be positive in 86.2% and 69.0% of the CMA patients, respectively, however, the difference was not significant. The AUC for the β-CAS-BAT was 0.893, which was not significantly different from that for the αs-CAS-BAT (0.859). Conclusions: These results suggest that the allergenicities of β-CAS and αs-CAS are similar in Japanese patients with CMA.
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Junko Saji, Motonaka Arai, Takahito Yamamoto, Masamichi Mineshita, Ter ...
Article type: Article
2014 Volume 63 Issue 10 Pages
1338-1347
Published: December 01, 2014
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Background: The efficacy of anti-IgE antibody, omalizumab, was studied in patients with severe bronchial asthma. There have been reports stating that although omalizumab could not improve objective results, it has shown improvements in subjective symptoms of patients. The aim of this study is to evaluate the efficacy of omalizumab in severe bronchial asthma. Methods: Thirteen patients were enrolled. Omalizumab was administered subcutaneously every 2 or 4 weeks based on serum IgE level and body weight of each patient. Pulmonary function tests, Asthma Control Test (ACT), Asthma Health Questionnaire-JAPAN (AHQ-JAPAN), number of emergency visits and dosage of methylprednisolone during a 16-week period were compared to the previous year. We examined the correlations between respiratory function, and ACT and AHQ-JAPAN. Results: Treatment with omalizumab did not improve lung function. AHQ and ACT over the 16-week period significantly improved compared to baseline (p< 0.01). The number of emergency visit and doses of methylprednisolone were significantly reduced compared to the previous year (p<0.01). Conclusion: Although treatment with omalizumab could not improve lung function, AHQ and ACT during the 16-week study period had significantly improved compared to baseline. Omalizumab significantly reduced the number of emergency visits and dosages of methylprednisolone.
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Yuri Kinoshita, Kazuhisa Fujimoto, Min Lee, Rie Shinohara, Yukihiro Ko ...
Article type: Article
2014 Volume 63 Issue 10 Pages
1348-1352
Published: December 01, 2014
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We report 2 cases of immediate allergies to Anisakis after ingestion of seafood. In case 1, after ingestion of flatfish, sea bream and mackerel, wheals and dyspnea occurred. Result of ImmunoCAP was class 5 for Anisakis. ELISA for specific IgE showed that the patient serum strongly reacted to Ani s 12. In case 2, after ingestion of flatfish and yellowtail, pruritus and dyspnea occurred. Result of ImmunoCAP was class 6 for Anisakis. ELISA for specific IgE showed that the patient serum reacted to Ani s 1, 4, 6 and 12. In both cases, skin prick tests were negative for suspected seafoods. These data suggests the possibility Ani s 12 is a major allergen of Anisakis allergy besides Ani s 1, 2 and 7. Ani s 12 is an allergen that was first reported in 2011. The reactivity of Ani s 12 specific IgE with ELISA may become useful for the diagnosis of Anisakis allergy.
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[in Japanese]
Article type: Article
2014 Volume 63 Issue 10 Pages
1353-1363
Published: December 01, 2014
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[in Japanese]
Article type: Article
2014 Volume 63 Issue 10 Pages
1364-1365
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[in Japanese]
Article type: Article
2014 Volume 63 Issue 10 Pages
1366-1367
Published: December 01, 2014
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[in Japanese], [in Japanese]
Article type: Article
2014 Volume 63 Issue 10 Pages
1368-1369
Published: December 01, 2014
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
1370-1379
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
1381-1382
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
1384-1385
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
1386-1387
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Article type: Index
2014 Volume 63 Issue 10 Pages
1388-1398
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Article type: Index
2014 Volume 63 Issue 10 Pages
1399-1402
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Article type: Index
2014 Volume 63 Issue 10 Pages
1403-1406
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
1407-1408
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
1409-1411
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Appendix
2014 Volume 63 Issue 10 Pages
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Article type: Cover
2014 Volume 63 Issue 10 Pages
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Published: December 01, 2014
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