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2014 Volume 63 Issue 6 Pages
Cover11-
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Article type: Index
2014 Volume 63 Issue 6 Pages
Toc5-
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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Kenji Matsumoto
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2014 Volume 63 Issue 6 Pages
737-742
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Tetsuya Terada
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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Takahiko Horiuchi
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2014 Volume 63 Issue 6 Pages
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Koichi Fukunaga
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2014 Volume 63 Issue 6 Pages
754-757
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Tamotsu Ebihara
Article type: Article
2014 Volume 63 Issue 6 Pages
758-763
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Kazumi Fukagawa
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2014 Volume 63 Issue 6 Pages
764-766
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Masafumi Sakashita, Yuka Makino, Emico Noguchi, Tomomitsu Hirota, Mayu ...
Article type: Article
2014 Volume 63 Issue 6 Pages
767-774
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Akiko Sugiyama, Reiko Kishikawa, Terufumi Shimoda, Haruko Nishie, Kiyo ...
Article type: Article
2014 Volume 63 Issue 6 Pages
775-786
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Background: Immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA) supplemented soap has been a serious social issue. We investigated the significance of challenge test and other tests not only to diagnose HWP-IWA but to know the symptoms of each patients. Methods: From January 2010 to June 2012, we performed challenge test in 41 cases with positive prick test of Glupearl 19S^[○!R], a major allergic HWP found in Cha no Shizuku^[○!R]. Results: Thirty nine of 41 cases were challengetest positive. In two patients who showed positive skin prick test but negative for challenge test, titer of specific IgE antibody and/or basophil histamine release test against Glupearl 19S^[○!R] revealed positive reaction. Conclusion: Challenge test is not included in indispensable examinations for the diagnosis of HWP-IWA in the recommended guidelines. However, challenge test is still a useful tool for assessing actual severity of each patient's symptoms and determining the timing of cessation of wheat avoidance. In addition, combined check-up with several laboratory examination and challenge test may help appropriate diagnosis of HWP-IWA.
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Kyohei Kiyota, Yuka Fujiwara, Kazuto Adachi, Makoto Kameda, Kazuhiko A ...
Article type: Article
2014 Volume 63 Issue 6 Pages
787-793
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Background: In May 2012, two schoolchildren developed allergic symptoms after eating a school meal of fried bread in Osaka, Japan. One specific raw material, milk, should not be present in fried bread. However, we suspected the unintentional mixing of milk in the bread manufacturing process. Our aim was to verify the reason if this was so. Methods: We first manufactured bread that contained milk as one of its components. We then thoroughly cleaned the manufacturing line except for the dough divider and, as per the revised instruction manual, continuously manufactured bread that did not contain milk. In this manner, we tried to simulate the conditions at the time of the incident. Casein is a major milk protein. We, therefore, determined casein concentration in the milk-free bread, using casein enzyme-linked immunosorbent assay. Results: We observed casein levels higher than 1000 ppm in the initial lots of breads, but lower levels in the later lots. Casein levels also decreased upon frying of bread. Conclusion: High casein levels, which were observed in the earlier lots of breads, were lower in the later lots. In the manufacturing line, the remnants of the bread dough that contained milk presumably got mixed with the dough used in the subsequent manufacture of milk-free bread.
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Ryoji Seki, Yasuhiro Nagatomo, Tetsuro Yamaguchi, Shiro Matsumoto
Article type: Article
2014 Volume 63 Issue 6 Pages
794-804
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Objectives: To decrease the number of asthma deaths occurring in Miyazaki Prefecture in Japan by promoting guideline-based treatment through the bronchial asthma forum. Methods: A self-completed questionnaire survey of adult asthma patients was conducted in Miyazaki Prefecture during the same season for 10 consecutive years from 1999 to 2008. Results: A total of 7899 responses were collected from medical institutions throughout the prefecture. In the course of 10 years, the doses of the drugs used for long-term management, including inhaled steroids, long-acting inhaled β2-stimulants, and leukotriene receptor antagonists, increased year after year. Consequently, the frequency of asthma symptoms declined and there was a decrease in the use of short-acting inhaled β2-stimulants, parenteral aminophylline, and slow-release theophylline preparations in response to this trend. Prescription rate of inhaled steroids and patients satisfaction was higher in the facilities of specialists than non-specialists. In patients with rhinitis symptoms, asthma was improved by concurrently treating both rhinitis and asthma in the survey of 2008. Conclusions: Asthma treatment based on the guideline was increasing in Miyazaki Prefecture, and this may have resulted in the improvement of asthma symptoms, increased patient satisfaction, and more importantly, a decrease in the number of asthma deaths.
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[in Japanese]
Article type: Article
2014 Volume 63 Issue 6 Pages
805-806
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[in Japanese]
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2014 Volume 63 Issue 6 Pages
807-808
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[in Japanese]
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2014 Volume 63 Issue 6 Pages
809-810
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
811-812
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
813-814
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
818-819
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
820-821
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
825-830
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
838-842
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2014 Volume 63 Issue 6 Pages
843-847
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
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Article type: Appendix
2014 Volume 63 Issue 6 Pages
861-863
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2014 Volume 63 Issue 6 Pages
864-865
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2014 Volume 63 Issue 6 Pages
866-871
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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Article type: Bibliography
2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
881-882
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
885-887
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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2014 Volume 63 Issue 6 Pages
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