Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 63, Issue 9
Displaying 1-26 of 26 articles from this issue
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  • [title in Japanese]
    Article type: Cover
    2014 Volume 63 Issue 9 Pages Cover17-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.Cover17
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    Article type: Index
    2014 Volume 63 Issue 9 Pages Toc8-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.Toc8
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages App20-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.App20
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  • DEVELOPMENT OF THE STUDIES ON ENVIRONMENTAL CHEMICALS AND ALLERGY
    Akiko Honda, Eiko Koike, Rie Yanagisawa, Ken-Ichiro Inoue, Hirohisa Ta ...
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1205-1214
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1205
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1215-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1215
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  • PRACTICAL GUIDELINE FOR ALLERGIC RHINITIS 2014 (7^<TH> EDITION) : POINTS OF REVISION-PROPHYLACTIC TREATMENT FOR CEDAR POLLINOSIS-
    Yoshitaka Okamoto
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1216-1222
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1216
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  • REGENERATIVE MEDICINE BY CELL SHEET TECHNOLOGY : THE REGENERATION FOR STRATIFIED EPITHELIAL TISSUES
    Ryo Takagi, Masayuki Yamato, Teruo Okano
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1223-1228
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1223
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  • JAPANESE SOCIETY OF ALLERGOLOGY TASK FORCE REPORT ON STANDARDIZATION OF HOUSE DUST MITE ALLERGEN VACCINES
    Toshiro Takai, Yoshitaka Okamoto, Kimihiro Okubo, Makoto Nagata, Masah ...
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1229-1240
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1229
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    Background: In the 1990s, the Japanese Society of Allergology (JSA) standardized Japanese cedar pollen allergen vaccines. In the present study, the task force for house dust mite (HDM) allergen standardization of the Committee for Allergens and Immunotherapy of JSA reports the standardization of HDM allergen vaccines in Japan. Methods: In vivo allergenic potency was determined by intradermal testing of 51 Japanese adults with positive serum specific IgE to HDM allergens. In vitro total IgE binding potency was analyzed by the competitive ELISA using a pooled serum, with sera obtained from 10 allergic patients. Concentrations of HDM group 1 (Der 1) and group 2 major allergens in eight HDM allergen extracts were measured by sandwich ELISAs. Correlation between the in vitro total IgE binding potency and major allergen levels was analyzed. Results: We selected a JSA reference HDM extract and determined its in vivo allergenic potency. The in vitro total IgE binding potency significantly correlated with Der 1 content, group 2 allergen content, and their combined amount, indicating that measurement of major allergen contents can be used as a surrogate in vitro assay. Conclusions: The task force determined the in vivo allergenic potency (100000JAU/ml) and Der 1 content (38.5μg/ml) of the JSA reference HDM extract, selected the measurement of Der 1 content as the surrogate in vitro assay, and decided that manufacturers can label a HDM allergen extract as having a titer of 100000JAU/ml if it contains 22.2-66.7μg/ml of Der 1.
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  • COMPARISON OF EXHALED NITRIC OXIDE LEVELS MEASURED BY TWO OFFLINE METHODS AND THE NO BREATH^[○!R] METHOD IN JAPAN
    Jun Ito, Takahiro Tsuburai, Ryo Atsuta, Kentaro Watai, Masanori Fukuha ...
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1241-1249
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1241
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    Background: The fraction of exhaled nitric oxide (FeNO) is a useful marker of eosinophilic airway inflammation in asthmatics. Clinical application of FeNO measurement in Japan is expected increase because the procedure is now covered through health insurance. However, the measurement system used is known to affect FeNO results, and it remains unknown whether results from offline methods correlate with those from traditional online methods, such as NO breath^[○!R]. Methods: The study population comprised 48 patients at our hospital. FeNO levels were measured by using two offline methods (Sievers and CEIS) and a standard online method, NO breath^[○!R]. Results: FeNO_<NO breath> levels were significantly correlated with FeNO_<Sievers> (r=0.875) and FeNO_<CEIS> (r=0.888) levels. FeNO_<NO breath> levels were nearly equal to FeNO_<Sievers> results (FeNO_<NO breath>=1.05×FeNO_<Sievers>), but both of these levels were lower (p=0.02) than FeNO_<CEIS> data (FeNO_<NO breath>=0.74×FeNO_<CEIS>). A Bland-Altman plot of values obtained by the NO breath^[○!R] and Sievers methods revealed that the NO breath^[○!R] result was lower than the Sievers level when FeNO was low but was higher than the Sievers level when FeNO was high. Conclusion: Differences exist in the levels of FeNO measurement by three methods (two offline methods and NO breath^[○!R]): conversion equations are needed to compare the FeNO levels obtained by using these three methods. In addition, NO breath^[○!R] may be more useful to distinguish asthmatic patients from non-asthmatics, compared with Sievers method.
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  • QUESTIONNAIRE-BASED STUDY ON THE KEY TO THE GUIDANCE TO THE PATIENTS WITH ATOPIC DERMATITIS BY PHARMACIST
    Sakae Kaneko, Takeyasu Kakamu, Hiroaki Matsuo, Koji Naora, Eishin Mori ...
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1250-1257
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1250
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    Background and Objective: Atopic dermatitis is a condition with a chronic or recurrent course that requires continued treatment, meaning that patients must be provided with instructions that fit their lifestyle. Surveys of doctors and patients have revealed the importance of instructions on how to apply topical medication. Here we conducted a survey of the instructions provided by pharmacists, who play an important role in educating patients on how to apply topical medication. Methods: Questionnaires were distributed to clinics and dispensing pharmacies in Shimane and Hiroshima prefectures. The questionnaire format comprised selecting each matter on which instructions are provided. Results: A total of 548 questionnaires (response rate, 13.8%) were collected and analyzed. Concerning topical steroids, the most frequently instructed item was "Explanation of application site" (86%), followed by "Explanation of number and timing of applications" (68%). Only 45% chose "Instruction to apply a small amount to avoid side effects." For tacrolimus ointment, "Explanation of tingling sensation" (as a side effect) was the most frequently selected item (52%), and "Instruction by using a brochure" (27.3%) was more commonly selected for tacrolimus ointment than for steroids and emollients. "Demonstrate the application method by means of actual application" was selected by few respondents for any topical medication. Regarding what they wanted from doctors, many respondents wrote in the section for their own comments that they would like a clear description of the method of use and dose and indications of the amount to be applied. Failure included times when patients failed to apply medication correctly due to inadequate instructions and an insufficient explanation of side effects. Conclusion: Instructions vary among patients and professions, but good instructions lead to good results. Cross-tabulation showed that pharmacists who are aware of the guidelines of atopic dermatitis offer significantly more instructions in a range of areas, suggesting that the first important task is to spread awareness of these guidelines among them.
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  • A CASE OF ANAPHYLAXIS INDUCED BY GELATIN-CONTAINED GEL CAPSULE COLD MEDICINE
    Masako Tanaka, Naoko Inomata, Midori Matsuura, Shuichi Ishida, Aki Suz ...
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1258-1264
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1258
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    We report here a 20-year old woman who referred to our clinic for identify the responsible antigen of anaphylaxis. Five days before the reaction, she had a cold and had taken a gel capsule cold medicine, Stona IB Gel^[○!R]. On the day of the reaction, she took a dose of Stona IB Gel^[○!R] after eating yogurt. Five minutes after oral administration, she developed a heat sensation and pruritus on her neck, with flushing, abdominal pains, breathing difficulties, and syncope. The specific IgE antibodies measured by ImmunoCAP^[○!R] were all negative except for gelatin. Prick-prick skin testing revealed positive responses to Stona IB Gel^[○!R], gelatin KS and gelatin RP600, of which the latter two were included in the Stona IB Gel^[○!R] capsule. From these test results, she was diagnosed with anaphylaxis due to gelatin, and to date she has had no further allergic symptoms since avoiding foods containing gelatin. In infancy she had received four vaccinations against diphtheria, pertussis and tetanus, which contained gelatin as a stabilizer. However, she had not developed allergic symptoms until this time. We hypothesize that she might be sensitized to gelatin by taking Stona IB Gel^[○!R] during the preceding 4 days. This is the first case of anaphylaxis from the ingestion of an oral medication containing gelatin in Japan. Allergic reactions to gelatin are comparatively rare, but according to the past reports, the reactions were severe. Since many kinds of foods, cosmetics, pharmaceutical products, and medication contain gelatin, it is important to be aware of gelatin allergy.
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  • A CASE OF CLINICALLY DIAGNOSED EOSINOPHILIC BRONCHIOLITIS
    Yosuke Miura, Yoshio Tomizawa, Tomohito Kuwako, Mai Tomizawa, Gen Taka ...
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1265-1270
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1265
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    A 71-year-old man was referred to our hospital because of an intractable productive cough. Although he was treated for bronchial asthma, the symptom did not improve. Furthermore, since he developed progressive dyspnea and hypoxemia, he was admitted to our hospital. Marked eosinophilia in a blood test and sputum, poorly defined centrilobular nodules throughout the bilateral lung fields in a chest CT scan, and mixed ventilatory impairment in a spirometric test were revealed. Thoracoscopic lung biopsy and bronchoalveolar lavage were not conducted because of progressive respiratory failure. Therefore, we clinically diagnosed eosinophilic bronchiolitis, and immediately administered oral prednisolone (30mg daily). His symptoms and examination findings rapidly improved. This case suggests that eosinophilic bronchiolitis should be taken into consideration for differential diagnoses of eosinophilic lung disease and obstructive lung disease, and marked eosinophilia in sputum may be one of the useful tools for diagnosis of this disease when invasive examinations are inadequate.
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1271-1272
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1271
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1273-1274
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1273
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    2014 Volume 63 Issue 9 Pages 1275-1276
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1275
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1277-1278
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1277
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1279-1280
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1279
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1281-1282
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1281
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1283-1285
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1283
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1285-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1285_1
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1285-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1285_2
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1286-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1286
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1287-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1287_1
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1287-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1287_2
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  • [title in Japanese]
    Article type: Appendix
    2014 Volume 63 Issue 9 Pages 1287-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.1287_3
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  • [title in Japanese]
    Article type: Cover
    2014 Volume 63 Issue 9 Pages Cover18-
    Published: November 01, 2014
    Released on J-STAGE: February 10, 2017
    DOIhttps://doi.org/10.15036/arerugi.63.Cover18
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