Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 64, Issue 10
Displaying 1-11 of 11 articles from this issue
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Allergology Course For Allergy Specialists —Barrier destruction and allergy
One Point Reviews of Allergy Guidelines
Original Article
  • TRANSITION OF AIRBORNE FUNGI DURING 20-YEARS FROM 1993 TO 2013 IN SAGAMIHARA
    Akemi Saito, Minako Takatori, Kousuke Takatori, Masami Taniguchi
    2015 Volume 64 Issue 10 Pages 1313-1322
    Published: 2015
    Released on J-STAGE: December 29, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1313
    JOURNAL FREE ACCESS
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    Background: Airborne fungi have been surveyed every week during the 20 years from 1993 to 2013 in Sagamihara. This is a follow up of 1983 to 1992 survey at the same sampling station, using the same methods.  Objective: We analyzed the transition of airborne fungi of 20-years.  Methods: Using a settle plate method, air sampling was performed by exposing 90mm settle plates containing potato dextrose agar to the air for 10 min. The plates were incubated at 25℃ for 7-14 days. The fungi were identified and counted.  Results: The average of number total fungi colonies during 20 years were 507 colony forming units (CFU)/5 plate every year. The most common fungi found, except for yeasts and sterile mycelium, were Cladosporium, Alternaria, Penicillium, Ulocadium, Fusarium, Arthrinium, Epicoccum, Aureobasidium, Curvularia, Nigrospora and Aspergillus. A significant correlation was observed between the number total fungi clonies and number of Cladosporium colonies. Although Alternaria, Arthrinium, Epicoccum and Curvularia were significantly reduced as compared 10 years from 1983 to 1992, Cladosporium and Penicillium were comparable.  Conclusion: Cladosporium was most predominant fungi during the 20 years. This study is very valuable in that the transition of airborne fungi revealed by long-term measurement.
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  • CLINICAL EFFICACY OF SUBLINGUAL IMMUNOTHERAPY FOR JAPANESE CEDAR POLLINOSIS IN THE FIRST FOLLOW-UP YEAR
    Atsushi Yuta, Yukiko Ogawa, Yusuke Suzuki, Masahiko Arikata, Hideaki K ...
    2015 Volume 64 Issue 10 Pages 1323-1333
    Published: 2015
    Released on J-STAGE: December 29, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1323
    JOURNAL FREE ACCESS
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    The first drug of sublingual immunotherapy (SLIT) for Japanese Cedar pollinosis (JCP) was purchased in 2014.  Purpose: The purpose of this study is to clear the clinical efficacy of SLIT by comparing with other therapies, such as subcutaneous immunotherapy (SCIT), or other pharmacotherapy.  Methods: We started SLIT at our clinic in October-December, 2014. We compared the clinical efficacy of 191 SLIT with 48 SCIT, 191 primary pharmacotherapy that started therapies before pollen dispersal, 141 pharmacotherapy that started therapies after pollen disposal, or 169 non-treatment in the first follow-up year. The clinical efficacy was evaluated with quality of life (QOL) scores by Japanese rhino-conjunctivitis QOL questionnaire (JRQLQ No1), symptoms of nose and eye by visual analog scale (VAS), symptom scores and combined symptom-medication scores (SMS).  Results: Mild adverse events (AEs) were observed in many cases, but no patient was discontinued by AEs in SLIT patients. Five cases by unknown reasons and 3 cases by inevitable reasons were dropped out before pollen. Adherence of SLIT was 89±12%. SCIT was better than SLIT in most assessments, but not significant. Both SCIT and SLIT were significantly better than other pharmacotherapy. Patients, whose symptom scores of nose and eye were 0 or 1 point without any rescue drugs, accounted for 16.8% of total SLIT in the first follow-up year.  Conclusion: SCIT was slightly better than SLIT in reducing symptoms and SMS of JCP, and in improving QOL. However, the differences were not significant. SLIT was significantly effective than other pharmacotherapies.
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Case Report
  • THREE CASES OF DRUG-INDUCED PNEUMONIA CAUSED BY MESALAZINE
    Norimichi Akiyama, Koshi Yokomura, Tsuyoshi Nozue, Takefumi Abe, Takas ...
    2015 Volume 64 Issue 10 Pages 1334-1340
    Published: 2015
    Released on J-STAGE: December 29, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1334
    JOURNAL FREE ACCESS
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    We report three cases of drug-induced pneumonia caused by mesalazine. They were all diagnosed as ulcerative colitis and treated with mesalazine orally. Our three cases and literature review revealed that mesalazine-induced pneumonia resemble like eosinophilic pneumonia or organizing pneumonia and that have good prognosis with drug cessation or administration of corticosteroid. The patient of ulcerative colitis is increasing every year and it is anticipated that the patient with mesalazine-induced pneumonia may also increase. In the treatment of ulcerative colitis with mesalazine, we should pay attention with patient's cough or fever for early detection of drug-induced pneumonia.
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  • THREE CASES OF ACCIDENTAL AUTO-INJECTION OF ADRENALINE
    Noriyuki Yanagida, Katsuhito Iikura, Kiyotake Ogura, Ling-jen Wang, To ...
    2015 Volume 64 Issue 10 Pages 1341-1347
    Published: 2015
    Released on J-STAGE: December 29, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1341
    JOURNAL FREE ACCESS
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    Purpose: Reports on accidental auto-injection of adrenaline are few. We encountered three cases of accidental injection of adrenaline. In this study, we have examined and reported the clinical courses and symptoms of our cases.  Case: Case 1 involved a female physician in her 50s who had attended an explanatory meeting on auto-injection of adrenaline. She mistook EpiPen® to be the EpiPen trainer and accidentally injected herself with 0.3mg EpiPen®. Her systolic/diastolic pressure peaked at 7 min to reach 144/78mmHg and decreased to 120/77mmHg at 14 min. Except for palpitation after 7 min, the only subjective symptom was local pain at the injection site. Case 2 was noted in a 6-year-old boy. He accidentally pierced his right forefinger with 0.15mg EpiPen®, and after 20 min, his right forefinger was swollen. The swelling improved 80 min after the accidental injection. Case 3 was noted in a 4-year-old girl. She accidentally injected herself with 0.15mg EpiPen®. Her systolic/diastolic pressure peaked at 23 min to reach 123/70mmHg and decreased to 96/86mmHg at 28 min.  Discussion/Conclusion: Severe adverse effects of accidental auto-injection of adrenaline were not observed in these three cases. Our findings suggest that while handling adrenaline auto-injectors, we should keep in mind the possibility of accidental injection.
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Letter to the Editor
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