Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 64, Issue 2
Displaying 1-10 of 10 articles from this issue
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Allergology Course For Allergy Specialists -17th Molecular targets for the treatment of immune and allergic diseases
One Point Reviews of Allergy Guidelines
Review Article
Original Article
  • SHORT-TERM EFFECTS OF AIR POLLUTANTS ON PULMONARY FUNCTION IN ADOLESCENT WITH A HISTORY OF ASTHMA OR ALLERGIES
    Yoshiko Yoda, Hiroshi Takagi, Junko Wakamatu, Naruhito Otani, Masayuki ...
    2015 Volume 64 Issue 2 Pages 128-135
    Published: 2015
    Released on J-STAGE: September 30, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.128
    JOURNAL FREE ACCESS
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    Background: Transboundary pollution including airborne fine particulate matter (PM2.5) has been attracting attention in recent years and its health effects are concerned. We evaluated the short-term effects of air pollutants on pulmonary function among young students. Methods: Forced expiratory volume in 1 second (FEV1) and peak expiratory flow (PEF) were examined every morning for 1 month in 37 students who attend a school in a remote island of the Seto Inland Sea. The concentrations of fine and coarse particles (PM2.5 and PM10-2.5 ), optical black carbon (OBC) and nitrogen dioxide (NO2) were measured on the rooftop of the school. Results: The change in PEF was significantly associated with an increase in the prior 24-h average concentration of PM2.5 among subjects with a history of asthma (-42.5L/min [95% confidence interval (CI): -77.0, -8.1], for an interquartile rage increase of 17.6μg/m3). Negative associations between pulmonary function and the concentrations of NO2 and OBC were observed as well. On the other hand, among the subjects with a history of allergy other than asthma and those without such history, negative association between air pollutants and pulmonary function was not observed. Conclusions: Subjects with a history of asthma are considered to be more affected by short-term exposure to air pollutants.
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  • UTILITY OF THE ALLERPORT® HRT IN THE DIAGNOSIS OF HEN'S EGG ALLERGY: A PEDIATRIC MULTICENTER CHALLENGE STUDY
    Sakura Sato, Komei Ito, Atsuo Urisu, Naoto Kando, Tomoko Nakagawa, Iku ...
    2015 Volume 64 Issue 2 Pages 136-148
    Published: 2015
    Released on J-STAGE: September 30, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.136
    JOURNAL FREE ACCESS
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    Purpose  This study aimed to evaluate the utility of the Allerport® HRT in the diagnosis of hen's egg allergy.  Method  We enrolled 51 subjects who underwent the Allerport® HRT before an oral food challenge (OFC) consisting of heated egg. Blood samples were collected within three months prior to OFC to measure histamine release (HR) and specific IgE antibody titers. We examined whether the Allerport® HRT was useful as a means of diagnosing hen's egg allergy and predicting severity of induced symptoms.  Of 51 subjects, three whose OFC results were not valid**1** and 13 who were classified as “low responders” to the Allerport® HRT (%HR due to anti-IgE below 20%) were excluded. Of the remaining 35 subjects (average age: 4 years), 23 showed positive reactions to the OFC. Quantities of histamine released in spontaneous HR and egg white (EW)- and ovomucoid (OVM)-induced HR were significantly higher in patients with positive reactions. In our receiver operating characteristic analysis, the area under the curve for %HR against 6ng/ml of EW was 0.9601 and that against 3ng/ml of OVM was 0.9022. The cutoff value was 15.0% for EW and 3.7% for OVM. The sensitivity was 95.7% for EW and 91.3% for OVM, and the specificity was 83.3% for EW and 58.3% for OVM. %HR correlated well with the severity of induced symptoms in the OFC.  Conclusion  Allerport® HRT is useful for the diagnosis of hen's egg allergy, and may also aid in predicting the severity of induced symptoms.
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Case Report
  • A CASE OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS CAUSED BY INGESTION OF ORANGE
    Rintaro Ono, Chikako Motomura, Nobue Takamatsu, Yasuto Kondo, Yuko Aka ...
    2015 Volume 64 Issue 2 Pages 149-155
    Published: 2015
    Released on J-STAGE: September 30, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.149
    JOURNAL FREE ACCESS
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    The patient was a 10-year-old girl who presented with a history of anaphylactic episodes on three occasions, that developed in association with exercise after she ate citrus fruit. She underwent tolerance tests, as food-dependent exercise-induced anaphylaxis (FDEIA) induced by citrus fruit was suspected. The result of the test for the combination of intake of oranges and exercise was negative. The patient presented with swollen eyelid and wheezing following combined intake of orange and aspirin, based on which she was diagnosed as having FDEIA. Many patients developing an allergic reaction to fruit are diagnosed as having oral allergy syndrome (OAS), and only few cases of FDEIA are reported. Immunoblot tests revealed antigens of 9kDa, 39kDa and 53kDa in this patient, and an inhibition study with oranges revealed that the 39kDa and 53kDa antigens were probably antigenspecific allergens. Although the studied patient showed a strongly positive result for IgE antibodies specifically directed at cedar pollen, no common antigenicity with cedar pollen could be recognized. The final diagnosis was a type of FDEIA caused by 39kDa and 53kDa proteins, which are different from antigens previously identified in patients with citrus fruits allergy. It should be the first report of such a case.
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