Japanese Journal of Allergology
Online ISSN : 1347-7935
Print ISSN : 0021-4884
ISSN-L : 0021-4884
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Volume 64, Issue 9
Displaying 1-13 of 13 articles from this issue
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Allergology Course For Allergy Specialists —Barrier destruction and allergy
One Point Reviews of Allergy Guidelines
Review Article
Feature Articles
Original Article
  • FACTORS ASSOCIATED WITH THE PRESENCE OF ALLERGEN-SPECIFIC IgE RESPONSES IN ASTHMA PATIENTS WHO HAD NO IgE RESPONSES DETECTABLE BY MAST-26
    Hiroaki Iijima, Yoshiko Kaneko, Hironori Masuko, Hideyasu Yamada, Yohe ...
    2015 Volume 64 Issue 9 Pages 1242-1253
    Published: 2015
    Released on J-STAGE: December 08, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1242
    JOURNAL FREE ACCESS
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    Aim: To elucidate the characteristics of patients with asthma who have specific IgE responses to inhaled allergens detected by ImmunoCAP, which is not detectable by MAST-26. Methods: A total of 168 patients with adult asthma who reside in the Kanto region were recruited. Levels of total serum IgE and allergen specific IgE antibodies towards 14 common inhaled allergens (MAST-26) were measured. Among these samples, 48 patients with no detectable allergen-specific IgE (group A) and 44 patients with strong sensitization to Dermatophagoides farinae (group B) were selected for further assessment of their sensitization to inhaled allergens such as cockroach and moth using ImmunoCAP. Results: In group A, ImmunoCAP detected specific IgE responses to some inhaled allergens in 27.1% of the patients. The strongest predictive factor for the presence of allergen-specific IgE responses detected by ImmunoCAP was elevated levels of total serum IgE (p=0.0007). In group B, the presence of IgE responses specific to cockroach or moth by ImmunoCAP were found in 27.8% or 52.3% of the patients, respectively. The predictive factor for the presence of these positive IgE responses was also elevated levels of total serum IgE (p=0.0003). Conclusion: Asthma patients with no detectable specific IgE responses to any inhaled allergens by MAST-26 may be still sensitized to common inhaled allergens, including cockroach and moth. Thus, the presence of allergen-specific IgE responses may be re-assessed by ImmunoCAP in patients with asthma, especially when patients have higher levels of total serum IgE.
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  • RESPIRATORY IMPEDANCE MEASURING BY MostGraph-01 IS AFFECTED BY OBESITY
    Zen Isobe, Kenichirou Hara, Toshitaka Maeno
    2015 Volume 64 Issue 9 Pages 1254-1260
    Published: 2015
    Released on J-STAGE: December 08, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1254
    JOURNAL FREE ACCESS
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    Background: The forced oscillation technique (FOT) is a noninvasive method of measuring respiratory impedance, which includes respiratory system resistance (Rrs) and reactance (Xrs). The MostGraph-01 FOT device recently became clinically available in Japan, but standard impedance values for this device have not been determined in Japan. Objective: To assess the correlation between spirometry parameters and respiratory impedance in obese (body mass index [BMI] >=25) and non-obese (BMI<25) subjects. Methods: Clinical data were collected from 63 subjects without respiratory diseases who underwent spirometry and MostGraph-01 from January to October 2014. We investigated the correlation between spirometry parameters and respiratory impedance, and assessed the differing correlations among obese and non-obese subjects. Results: The Rrs at 5Hz (R5) was significantly correlated with vital capacity (VC), forced vital capacity (FVC), and forced expiratory volume in 1 second (FEV1). The Xrs at 5Hz (X5), frequency of resonance (Fres), and low-frequency reactance area (ALX) were significantly correlated with the VC, FVC, and FEV1. Obese subjects showed a significantly lower X5 (median, -0.68cmH2O/l/s vs. -0.35), higher Fres (median, 9.76Hz vs. 7.46), and higher ALX (median, 2.65cmH2O/l vs. 1.24) compared to non-obese subjects. Moreover, the VC, FVC, and FEV1 were more highly correlated with R5, X5, Fres, and ALX in nonobese subjects than in obese subjects. A p value of less than 0.05 was considered statistically significant. Conclusion: For MostGraph-01, it is suggested that obesity may influence Xrs rather than Rrs.
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  • ANALYSIS OF PRIMARY TREATMENT AND PROGNOSIS OF SPONTANEOUS URTICARIA IN A LOCAL CLINIC OF OFFICE DERMATOLOGY
    Toshihiko Tanaka, Makiko Hiragun, Michihiro Hide, Takaaki Hiragun
    2015 Volume 64 Issue 9 Pages 1261-1268
    Published: 2015
    Released on J-STAGE: December 08, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1261
    JOURNAL FREE ACCESS
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    Background: Prognosis of spontaneous urticaria in association with early treatment remained unclear. In this study, we retrospectively studied the prognosis of acute spontaneous urticaria in relation to age and treatments in a local clinic of dermatology. Methods: Out of 5000 patients who visited an office dermatology clinic, clinical records of patients with spontaneous urticaria were extracted. Their prognosis and the relation to age and treatments were analyzed by the Kaplan-Meier method and generalized Wilcoxon test. Results: Among 386 patients diagnosed as spontaneous urticaria, 284 patients (73.6%) had begun treatments within a week after the onset. The non-remission rates of them after one week, four week and one year from the onset were 26.8%, 15.0% and 6.7%, respectively. The non-remission rate of patients who were 20-years-old or younger by one year after the onset of urticaria, was significantly lower than that of patients older than 20-years-old. No apparent relations between the remission rate and sex or the use of steroids was detected. However, the non-remission rate of urticaria that was treated with a standard dose of antihistamine was lower than that treated with additional medications. Conclusion: Most patients who began treatments within one week from the onset remitted shortly. However approximately 7% of them continued to suffer from symptoms for more than a year. Such prolongation tends to be seen among patients who required other medications in addition to standard dose of antihistamine.
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Case Report
  • DRUG-INDUCED LUPUS CAUSED BY LONG TERM MINOCYCLINE TREATMENT FOR ACNE VULGARIS
    Shunichiro Hanai, Takeo Sato, Koichi Takeda, Katsuya Nagatani, Masahir ...
    2015 Volume 64 Issue 9 Pages 1269-1273
    Published: 2015
    Released on J-STAGE: December 08, 2015
    DOIhttps://doi.org/10.15036/arerugi.64.1269
    JOURNAL FREE ACCESS
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    An 18-year-old Japanese girl had received oral minocycline 200mg daily for treatment of acne vulgaris since 16 years old. She had a fever three months before admission, followed by joint pains in her knees, elbows and several proximal interphalangeal joints one month before admission. She was referred to our hospital because of a high serum level of anti-DNA antibody. She had already discontinued oral minocycline five weeks before admission, because she missed her medication refilled. On admission, the arthralgia and fever spontaneously resolved, and there were no laboratory evidence of hypocomplementemia and cytopenia. She had neither erythema nor internal organ involvements. Because her symptoms subsided spontaneously after the cessation of minocycline, she was considered to have drug-induced lupus. Both the arthralgia and fever did not relapse, and anti-ds DNA antibody returned to normal during a follow-up period without treatment. There are few reports of drug-induced lupus caused by minocycline in Japan. This case highlights the importance of considering minocycline-induced lupus.
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