Bulletin of the Chemical Society of Japan
Online ISSN : 1348-0634
Print ISSN : 0009-2673
ISSN-L : 0009-2673
90 巻 , 8 号
選択された号の論文の13件中1~13を表示しています
Vol. 90 Commemorative Account: Self-Organization
Award Account
The Chemical Society of Japan Award for Creative Work for 2015
  • Kazunori Matsuura
    2017 年 90 巻 8 号 p. 873-884
    発行日: 2017/08/15
    公開日: 2017/08/15
    ジャーナル 認証あり

    This account discusses construction strategies for various functional biomaterials based on the designed self-assembly of biomolecules. Novel glycoclusters with regular intervals were developed by self-assembly of carbohydrate-conjugated oligodeoxyribonucleotides (ODNs) with the half-sliding complementary ODNs. Complexes of carbohydrate-modified DNA and lectin afforded a new regulation system for gene expression. DNA three-way junctions bearing self-complementary sticky-ends were self-assembled into nanometer-to-micrometer-sized spherical structures depending on the concentration. The three-way component design was extended to the design of an artificial trigonal peptide conjugate. The trigonal peptide conjugates bearing β-sheet-forming peptides or glutathione self-assembled into nano-sized spherical assemblies. Self-assembly of β-annulus peptide derived from tomato bushy stunt virus afforded artificial viral capsids, which can encapsulate and be modified with various molecules.

    This account discusses construction strategies for various functional biomaterials, such as novel glycoclusters along DNA, nucleo-spheres, and virus-like peptide nanospheres, based on the designed self-assembly of biomolecules. Fullsize Image
     
 
  • Daisuke Fukushi, Akira Sato, Kayo Yoshida, Masaaki Kitano
    2017 年 90 巻 8 号 p. 885-892
    発行日: 2017/08/15
    公開日: 2017/08/15
    ジャーナル 認証あり

    We have prepared visible-light-sensitive tungsten oxide (WO3) nanoparticle photocatalysts by a thermal plasma method and subsequent annealing treatment. The WO3 photocatalysts effectively decomposed acetaldehyde under visible-light irradiation and the activity increased with the annealing temperature. The WO3 annealed at 600 °C exhibited fivefold higher photocatalytic activity than nitrogen-doped TiO2 and commercial WO3. The high photocatalytic activity of the WO3 nanoparticles was attributed to their high crystallinity and large surface area. It was also found that the acetaldehyde decomposition rate over the WO3 nanoparticles was significantly enhanced by the addition of metal oxides such as ZrO2. The ZrO2 additive functions as an adsorbent of the acetic acid (reaction intermediate) to remove the acetic acid from the WO3 surface. Furthermore, the complete oxidation of acetaldehyde into CO2 and H2O was achieved using a Ru (0.02 wt%)-loaded WO3-ZrO2 mixed oxide under visible-light irradiation, and this catalyst exhibited excellent durability for the reaction.

BCSJ Award Article
  • Seiya Katahara, Shoichiro Kobayashi, Kanami Fujita, Tsutomu Matsumoto, ...
    2017 年 90 巻 8 号 p. 893-904
    発行日: 2017/08/15
    公開日: 2017/08/15
    ジャーナル 認証あり

    This article describes the full details of our reductive approach to nitrones from amides. Reduction of N-siloxyamides with the Schwartz reagent [Cp2ZrHCl], followed by addition of an acid provided functionalized nitrones. The developed conditions were then extended to a catalytic version with the Vaska complex [IrCl(CO)(PPh3)2] and (Me2HSi)2O starting from N-hydroxyamides. 1H NMR studies of the Ir-catalyzed reaction revealed that the developed conditions promoted two different types of catalytic reactions including dehydrosilylation of an N-hydroxyl group and subsequent hydrosilylation of an amide carbonyl. A salient feature of our methods is their high chemoselectivity in the presence of a variety of functional groups. In addition, our reductive methods enabled concise synthesis of cyclic and macrocyclic nitrones, which are known to be challenging compounds to access by conventional methods.

    Full details of our reductive approach to nitrones are reported. Reduction of N-siloxyamides with the Schwartz reagent, followed by addition of an acid or TBAF provided functionalized nitrones. The developed conditions were extended to a catalytic version starting from N-hydroxyamides. Fullsize Image
     
 
Vol. 90 Commemorative Paper: Self-Organization
 
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