In the present paper, data are presented on the distribution of the total fatty acids, the total cholesterol and lipoid phosphorous in the blood, liver, lung, kidney, spleen, heart- and skeleton muscle of anemic rabbits, and the following conclusions are drawn.
1. Lipemia was observed in case of the phenyl-hydrazine anemia only in a rabbit where anemia was most highly developed prior to death, whereas in case of the bleeding anemia in almost all the test animals even where anemia was not so advanced as because of the hydrazine poisoning.
2. In the bleeding anemia, the concentration of the total fatty acids in the whole blood was high in every stage of recovery from anemia. The fact that the fat content in the whole blood was yet high in almost recovered ones, in spite of the normal content in the plasma, indicates that even after the recovery from anemia, blood cells were much charged with fat.
3. In the bleeding anemia, the content of fat in the spleen was also increased till a certain stage of recovery from anemia. The high content of fat returned t onormal after the disappearance of lipemia in the blood plasma. The size of the spleen was not varied thereby. In the phenyl-hydrazine anemia the size of the spleen enlarged itself greatly and the content of fat was not changed on the contrary.
4. Lipemia was not necessarily accompanied by increase or decrease of fat in the liver. In the lipemi a of the phenyl-hydrazine anemia and in the earlier stage of the bleeding anemia the content of fat in the liver was increased as a rule, compared with the non-anemic rabbits.
5. An abnormally high content of fat was observed in lung, kidney, heart and skeleton muscle in cases of partial recovery from bleeding anemia.
6. No definite results were obtained about the distribution of cholesterol throughout the whole experiment. Only in the severest cases of lipemia, in two kinds of anemia, cholesterol increased remarkably in the heart muscle.
7. In respect to lipoid P. there was not observed any remarkable varia-tion.
The author offers many thanks to Dr. Osato for his helpful advice in carrying out this investigation.
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