巻号一覧
38 巻, 1 号
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HARUHISA YOSHIKAWA1951 年 38 巻 1 号 p. 1-5
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリー1. Hemochromogene-like component of cytochrome, cytochrome b', is autoxidizable like as cytochrome b.
2. The level of oxidation-reduction potential of cytochrome b' is approximately -0.13 volt.
3. The meaning of such lower potential of cytochrome b' than that of cytochrome b has been discussed.抄録全体を表示PDF形式でダウンロード (293K) -
SHIMPEI ARAYA, MOSABURO KOBAYASHI1951 年 38 巻 1 号 p. 7-18
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリーThe following results were obtained by modifying the biuret reaction to a weak alkali.
(1) The reactivity of the peptide linkage part of various protein (ovalbumin, serum albumin, serum globulin) is clearly increased due to denaturation by heat, urea, etc.
(2) But when the biuret reaction is examined after the protein is acted upon by formaldehyde, the result is opposite to the case without the addition of formaldehyde, and the reactivity of denatured protein is lower than the native protein.
(3) The influence of denaturation is seen much more delicately on the peptide linkage part than on the SH group. Therefore, this weak alkali biuret reaction represents the configuration of protein very delicately. However, as this reaction is influenced by many secondary factors, this point must be considered very carefully.
The authors wish to express their thanks to Prof. S. Miyamoto (Tokyo Medico-Dental University) and Prof. R. I t o (Nihon University) for their interest and encouragement in carrying out this investigation. The authors are also indebted to the Ministry of Education for the Research Fund for Science.抄録全体を表示PDF形式でダウンロード (720K) -
KOICHI ANAN1951 年 38 巻 1 号 p. 19-29
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリー1. Crystalline beef liver catalase showed the peroxidatic activity with benzidine method, when the ratio of [hematin iron]/[hydrogen peroxide] was more than about 10-3.
2. From manometric experiments, very little peroxidatic oxidation of ethanol, and pyrogallol by catalase was demonstrated.
3. In the experiments of the peroxidatic oxidation of ethanol or of nitrite by catalase, the rate of the added hydrogen peroxide was controlled by a glass-needle with a capillary. Various concentrations of hydrogen peroxide were added continuously through the capillary at different rates. It is observed that “the slower is the addition of hydrogen peroxide, and also the lower is the concentration of added hydrogen perrxide, the more is the amount of ethanol or nitrite oxidiz-ed.”
4. The attempts to demonstrate the peroxidatic activity by attack-ing catalase molecule with heart, enzymes, urea, or cyanide, were un-successful.
5. The conditions of the peroxidatic reaction of catalase with hydrogen peroxide obtained in this paper, were discussed in relation to the reaction mechanisms of catalase.
Tands are due to Prof. K. Kodama for his grateful advice and to Dr. S. Tanaka for his kind suggestions.抄録全体を表示PDF形式でダウンロード (691K) -
XIX. A SYNTHESIS OF 2-DESOXY-D-RIBOSEKIYOHIKO OHTA1951 年 38 巻 1 号 p. 31-35
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリーPDF形式でダウンロード (1093K) -
TÔRU ISHII1951 年 38 巻 1 号 p. 37-43
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリー1. The alloxan-treatment of adrenalectomized rabbits caused almost no elevation of blood sugar.
2. When alloxan-treated adrenalectomized rabbits were injected with glucose, the recovery of blood sugar level was somewhat retarded, and the elevation of blood pyruvate or lactate during the hyperglycemic phase, which was observed on the rabbits not treated with alloxan, was not observed.
3. As the previous communication (1) indicates, when normal rabbits were treated with alloxan, the initial hyperglycemia took place and no decrease of blood pyruvate and lactate was observed during the following hypoglycemic phase. Now, when adrenalectomized rab-bits were treated with alloxan, this initial hyperglycemia was not distinctly observed, and the blood pyruvate and lactate decreased during the following hypoglycemic phase.
This work was supported by a grant from the Department of Educa-tion for Scientific Research. The author gratefully acknowledges the guidance and helpful advice of Prof. N. Shimazono.抄録全体を表示PDF形式でダウンロード (412K) -
HISAO KAWAGOE1951 年 38 巻 1 号 p. 45-68
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリーPDF形式でダウンロード (1577K) -
III. BENZENE, PYRIDINE AND THIAZOLE DERIVATIVESYOSHIAKI MIURA1951 年 38 巻 1 号 p. 69-74
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリーThe author tested thirty five compounds of benzene, pyridine and thiazole derivatives against Mycobact. tuberculosis var. Gallinaceum. Among these, only 2-butoxy, 5-amino pyridine or benzene derivatives are highly active in synthetic medium, but inactive in Kirchner's Medium. The mode of action of some compounds are discussed.
The author is most grateful to Prof. K. Kodama and Prof. M. Ishidate for their helpful advises and especially to Dr. Y. Yamamoto who gave generously the almost all compounds used in the study of this series.抄録全体を表示PDF形式でダウンロード (294K) -
YASUYUKI OGURA1951 年 38 巻 1 号 p. 75-84
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリー1. The glucose dehydrogenase extracted from Aspergillus oryzae oxidizes D-glucose to D-gluconate in the presence of a suitable hydrogen acceptor. This reaction can take place in the absence of phosphate. On the other hand, 6-phospho-D-glucose was oxidized much more slowly than D-glucose. From these facts it was concluded that the enzyme oxidizes D-glucose directly without the participation of phosphate.
2. The rate of reduction of thionine in the presence of glucose was not modified by the addition of gluconate. Nor did the addition of gluconate cause any sign of reoxidation of thionine which had been totally reduced by the oxidation of glucose through the enzyme. The enzymatic oxidation of glucose to gluconate may, therefore, be regarded as being practically an irreversible process.
3. The change of redox-potential in the reaction system (in the presence of various redox-dyes) was followed potentiometrically. It was found that the existence of gluconate in the reaction medium did not exert any influence upon the time course of the potential change. In all cases the potential decreased more or less rapidly up to a certain value and from that point it continued to drop quite slowly but steadily without attaining any final value even after fifty hours. The bending point of the potential-time curve was found to correspond fairly well with the E0'-value of the dyestuff which was most readily reduced among the dyestuffs used.
4. The reduction of those dyestuffs which by themselves are only slowly or practically not reduced by the enzyme system can be accelerated by the addition of easily reducible redox-dyes. For this accelerating effect, however, the necessary condition is that the difference in E0'-values of suitable and unsuitable dyes should not surpass a certain limit.
(For example the limit is ΔE0'=0.140 volts when thionine was used as suitable hydrogen acceptor.) It was briefly discussed that all the facts pertaining to the mutual action between the enzyme system in question and the various redox-dyes studied are to be interpreted from kinetic rather than from a thermodynamic standpoint.
In conclusion, I wish to express my thanks to Prof. H. Tamiya for his constant encouragement and suggestions during the course of this research.抄録全体を表示PDF形式でダウンロード (653K) -
SATSUKI EGUCHI1951 年 38 巻 1 号 p. 85-89
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリーFrom the hydrolysate of the whole proteins of Mycobacterium tuberculosis, (human strain) the following 17 amino acids were isolated or estimated: glycine, alanine, valine, leucine, serine, threonine, cystine, methionine, phenylalanine, tyrosine, tryptophan, proline, histidine, lysine, arginine, aspartic acid, and glutamic acid.
The presence of α-amino butyric acid was confirmed by paper chromatography.
The presence of a relatively large quantity of methionine, leucine, valine, lysine, and threonine, each an indispensable amino acid for human nutrition, is worthy of notice.抄録全体を表示PDF形式でダウンロード (271K) -
SHOYO SAKAGUCHI1951 年 38 巻 1 号 p. 91
発行日: 1951年
公開日: 2008/11/18
ジャーナル フリーPDF形式でダウンロード (73K)
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