Elucidation of interrelationship among sequence, structure, function, and evolution of a family of genes or gene products is a central theme of modern molecular biology. Multiple sequence alignment is a powerful tool for such many-sided studies. We have developed a new strategy called "doubly nested randomized iterative method" to tackle this computationally hard problem. When tested upon structural alignments as references, our method was proven to perform significantly better than currently most popular methods. Our method will be applicable to a variety of problems, such as phylogenetic reconstruction, and prediction of functionally important regions and higher order structures of proteins.
In the fovea of the primate retina, there are different image and color coding pathways characterized by their synaptic convergence and divergence onto midget, parasol, and bistratified ganglion cells. The midget pathway specializes in processing fine images and red or green color. The parasol pathway sensibly works for coarse images. The bistratified cell encodes the blue/yellow color opponency. All pathways are arranged in the narrow space to form the highly integrated foveal center.
We have been studying on the quantitative evaluation of mechanical strength of human bones with an impulse response method for the last 10 years. In this paper, the following subjects are described: (1) basic experiments for applying an impulse response method to assesment of the fracture healing and (2) clinical experiments on evaluation of the fracture healing.