生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
39 巻 , 2 号
通巻222号
選択された号の論文の13件中1~13を表示しています
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  • 柏柳 誠, 栗原 堅三
    1999 年 39 巻 2 号 p. 86-91
    発行日: 1999/03/25
    公開日: 2000/04/12
    ジャーナル フリー
    G-protein coupled receptors (GCR) have been cloned from olfactory, vomeronasal and taste organs. Roles of these receptors in these organs are discussed. Olfactory and gustatory responses are induced via cAMP-dependent pathway, IP3-dependent pathway and second messenger-independent pathway. A single olfactory cell responds to various species of odorants, although a single olfactory cell has only one type of GCR. The responses of mammalian vomeronasal receptor cells to pheromones are induced via IP3. A single rat vomeronasal receptor cell responds only to one species of urine which contains pheromones. The receptor mechanisms of sweet, bitter and umami substances are discussed.
  • 高野 和文, 舩橋 順, 油谷 克英
    1999 年 39 巻 2 号 p. 92-96
    発行日: 1999/03/25
    公開日: 2000/04/12
    ジャーナル フリー
    Mutant proteins are useful for study of protein stability. However, it is difficult to explain the changes in stability due to mountain, because contributions of amino acid residues to the conformational stability are quite different, depending on their location. In order to quantify directly the contribution of several factors to the conformational stability of a protein, we determined the thermodynamic parameters of denaturation and the crystal structures for more than 60 mutant human lysozymes. Analyzing this database (stability/structure database), the contribution of some factors to conformational stability of a protein, such as hydrophobic effect, hydrogen bond, and water molecule, could be estimated.
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