生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
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42 巻, 5 号
通巻243号
選択された号の論文の9件中1～9を表示しています
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  • 痛み情報伝達はシナプスで制御される
    熊本 栄一
    原稿種別: 研究論文
    専門分野: 情報学
    2002 年42 巻5 号 p. 218-223
    発行日: 2002年
    公開日: 2002/10/02
    DOIhttps://doi.org/10.2142/biophys.42.218
    ジャーナル フリー
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    Dorsal horn, especially substantia gelatinosa(SG; lamina II), neurons in the spinal cord are known to play an important role in regulating pain transmission to the central nervous system from the periphery. The SG neurons receive excitatory(glutamatergic)and inhibitory transmission in a mono- or polysynaptic manner through myelinated Aδ and unmyelinated C primary-afferent fibers. The excitatory transmission is negatively modulated by extrinsic or intrinsic substances through a pre- and/or postsynaptic mechanism, resulting in a relief of pain sensation. It is concluded that pain transmission is regulated at the synapse by a cellular mechanism similar to that in learning and memory.
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  • ゲノム情報からタンパク質立体構造予測へ
    －GTOPデータベースの構築とそれを利用した応用研究－
    西川 建
    原稿種別: 研究論文
    専門分野: 情報学
    2002 年42 巻5 号 p. 224-229
    発行日: 2002年
    公開日: 2002/10/02
    DOIhttps://doi.org/10.2142/biophys.42.224
    ジャーナル フリー
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    Having a huge amount of genome sequence data, we have aimed to analyze the data and provide reliable information extracted for biological scientists. Focusing on the protein structure prediction, we have so far analyzed 70 organisms whose complete genomes were sequenced. The main tool employed was PSI-BLAST, a homology search method much more powerful than the conventional ones such as FASTA/BLAST. The fraction of all ORFs in a genome, predictable of their 3D structure, turned out to be as high as 40-50%. All the data analyzed were compiled in a database called GTOP(http://spock.genes.nig.ac.jp/~genome/gtop.html). As an application study of GTOP, a way to identify a significant number of pseudogenes in E. coli is also described.
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  • ヘムを活性中心とするセンサータンパク質の構造と機能
    青野 重利
    原稿種別: 研究論文
    専門分野: 情報学
    2002 年42 巻5 号 p. 230-235
    発行日: 2002年
    公開日: 2002/10/02
    DOIhttps://doi.org/10.2142/biophys.42.230
    ジャーナル フリー
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    Heme-based sensor proteins have become known to be a new member of hemeproteins in which the heme acts as the active center for sensing gas molecules such as O2, CO, and NO. HemAT and CooA are the O2 and CO sensor proteins, respectively. HemAT is a signal transducer protein in the aerotaxis control system in Bacillus subtilis. CooA is a transcriptional activator that regulates the expression of some proteins responsible for CO metabolism in Rhodospirillum rubrum. Here, the structure and function of HemAT and CooA are reviewed.
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  • 神経細胞の機能を個体レベルで解析する新しい方法
    －ショウジョウバエ温度感受性ダイナミンを用いて特定の化学神経伝達を可逆的に阻害する－
    北本 年弘
    原稿種別: 研究論文
    専門分野: 情報学
    2002 年42 巻5 号 p. 236-241
    発行日: 2002年
    公開日: 2002/10/02
    DOIhttps://doi.org/10.2142/biophys.42.236
    ジャーナル フリー
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    I have established a novel approach for disrupting chemical neurotransmission rapidly and reversibly in a temporally and spatially restricted manner in the intact Drosophila nervous system. The Gal4/UAS system is used to direct expression of temperature-sensitive dynamin in restricted neuronal subsets and neurotransmission from the targeted neurons is then blocked by a mild temperature shift. This approach, together with the advanced Drosophila behavioral genetics, has provided new insight into the neuronal mechanisms underlying higher-order brain functions including associative learning and sexual orientation.
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