生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
45 巻, 4 号
通巻260号
選択された号の論文の12件中1~12を表示しています
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  • 田浦 太志, 正山 祥生, 森元 聡
    2005 年45 巻4 号 p. 178-184
    発行日: 2005年
    公開日: 2005/07/25
    ジャーナル フリー
    Cannabis sativa produces novel secondary metabolites called cannabinoids. Among them, Δ1-tetrahydrocannabinol (THC), the psychoactive component of this plant, has attracted a great deal of attention, because this cannabinoid is shown to exert a variety of therapeutic activities such as the relief of nausea caused by cancer chemotherapy. To reveal the mechanism of THC formation in Cannabis sativa, we attempted biosynthetic studies. Consequently, we established that Δ1-tetrahydrocannabinolic acid (THCA), the precursor of THC, is derived from cannabigerolic acid and that this reaction is catalyzed by the novel oxidocyclase, THCA synthase. Here, we show the biochemical and structural properties of THCA synthase.
  • 海老原 史樹文, 安尾 しのぶ, 吉村 崇
    2005 年45 巻4 号 p. 185-191
    発行日: 2005年
    公開日: 2005/07/25
    ジャーナル フリー
    Although photoperiodic response has been an object of study for a long time, little is known about molecular mechanisms underlying this phenomenon. Recently, we have identified the gene (Dio2) which regulates photoperiodic response in gonadal growth in birds and possibly in mammals. Prolactin secretion is also regulated by photoperiod. However, the mechanisms of this response are different from those of gonadal response. Here, we overview current knowledge about vertebrate photoperiodic response, providing our recent results on molecular studies.
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