生物物理
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
47 巻 , 1 号
通巻269号
選択された号の論文の15件中1~15を表示しています
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  • 佐藤 哲也, 山西 芳裕, 金久 實, 藤 博幸
    2007 年 47 巻 1 号 p. 004-011
    発行日: 2007年
    公開日: 2007/02/21
    ジャーナル フリー
    A distance matrix is a set of genetic distances between all possible pairs of proteins under consideration, and is used to construct a phylogenetic tree by the distance matrix method. Pazos and Valencia (2001) have developed a method to predict protein-protein interaction by evaluating the similarity of the distance matrices, under the assumption that the phylogenetic trees of interacting proteins resemble each other through co-evolution. It is known, however, that the prediction includes many false positives. We postulated that the cause of the false positives is the background similarity of the phylogenetic relationship of the source organisms. We have developed a method to exclude such information from the distance matrices with a projection operator. The number of false positives was drastically reduced from the prediction by evaluating the similarity between the residuals after the projection operation.
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世界の生物物理学
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